Trypanosoma cruzi: Effect and mode of action of nitroimidazole and nitrofuran derivatives

Biochemical Pharmacology

Volumn 65, Issue 6, 2003, Pages 999-1006

  Maya, Juan Diego ^a   Bollo, Soledad ^b   Nuñez Vergara, Luis J ^b   Squella, Juan A ^b   Repetto, Yolanda ^a   Morello, Antonio ^a   Périé, Jacques ^c   Chauvière, Gérard ^c  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UPS)   (France)

Author keywords

Intracellular trypanothione scavengers; Nitroheterocycles; Redox cycling; Respiration inhibitors; Thiols depletion; Trypanosoma cruzi

Indexed keywords

1 METHYL 2 (5 ACETAMIDO 1,3,5 THIADOZOLYL) 5 NITROIMIDAZOLE; 1 METHYL 2 (5 AMINO 1,3,4 OXADIOZOLYL) 5 NITROSOIMIDAZOLE; 1 METHYL 2 (5 TRIFLUOROMETHYLACETAMIDO 1,3,5 THIADIAZOLYL) 5 NITROIMIDAZOLE; 2 (5 AMINO 1,3,4 OXADIAZOLYL) 5 NITROFURAN; 2 (DIMETHYLAMINO) 4' [(1 METHYL 2 NITROIMIDAZOL 5 YL)METHOXY]ACETANILIDE; 2 AMINO 5 (1 METHYL 5 NITRO 2 IMIDAZOLYL) 1,3,4 THIADIAZOLE; 2 FORMYL 5 NITROFURAN SEMICARBAZINE; 4 NITROIMIDAZOLE; ACETANILIDE DERIVATIVE; CHEMICAL COMPOUND; NIFURTIMOX; NITROFURAN DERIVATIVE; NITROIMIDAZOLE; NITROIMIDAZOLE DERIVATIVE; NITROSO DERIVATIVE; RO 150216; SCAVENGER; THIOL; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DETOXIFICATION; DRUG EFFECT; DRUG MECHANISM; INHIBITION KINETICS; INTRACELLULAR SPACE; MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTOZOON; RESPIRATORY SYSTEM; TRYPANOSOMA CRUZI;

EID: 0037443505     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01663-5     Document Type: Article

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