Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

Biochemical Pharmacology

Volumn 58, Issue 11, 1999, Pages 1791-1799

  Blumenstiel, Klaus ^a   Schöneck, Ralf ^a   Yardley, Vanessa ^b   Croft, Simon L ^b   Krauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Chagas' disease; Lipoamide dehydrogenase; Nitrofurans; Redox cycling; Trypanosoma cruzi; Trypanothione reductase

Indexed keywords

DIHYDROLIPOAMIDE DEHYDROGENASE; FLAVOPROTEIN; GLUTATHIONE REDUCTASE; NIFUROXAZIDE; NIFUROXIME; NITROFURAN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE; TRYPANOTHIONE;

ANIMAL CELL; ARTICLE; CATALYSIS; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SUBSTRATE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REDUCTION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CELLS, CULTURED; DIHYDROLIPOAMIDE DEHYDROGENASE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FEMALE; HUMANS; MACROPHAGES, PERITONEAL; NADH, NADPH OXIDOREDUCTASES; NAPHTHOQUINONES; NITROFURANS; OXIDATION-REDUCTION; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI;

EID: 0345035516     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00264-6     Document Type: Article

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