The pentose phosphate pathway in Trypanosoma cruzi

FEMS Microbiology Letters

Volumn 234, Issue 1, 2004, Pages 117-123

  Maugeri, Dante A ^a   Cazzulo, Juan J ^a  

^a Universidad Nacional de General   (Argentina)

Author keywords

6PGDH, 6 phosphogluconate dehydrogenase; Chagas disease; G6PDH, glucose 6 phosphate dehydrogenase; Lactonase, 6 phosphogluconolactonase; Oxidative stress; Pentose phosphate pathway; PPP, pentose phosphate pathway; Subcellular localisations; Trypanosoma cruzi

Indexed keywords

CARBON DIOXIDE; ENZYME; GLUCOSE; METHYLENE BLUE; PENTOSE;

ARTICLE; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DEVELOPMENTAL STAGE; EPIMASTIGOTE; GLUCOSE INTAKE; MEASUREMENT; NONHUMAN; OXIDATIVE STRESS; PARASITE DEVELOPMENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRYPANOSOMA CRUZI;

ALDOSE-KETOSE ISOMERASES; ANIMALS; CARBOHYDRATE EPIMERASES; CARBON DIOXIDE; CARBON RADIOISOTOPES; CARBOXYLIC ESTER HYDROLASES; CYTOPLASM; ENZYME INHIBITORS; GLUCOSE; GLUCOSEPHOSPHATE DEHYDROGENASE; METHYLENE BLUE; ORGANELLES; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; PHOSPHOGLUCONATE DEHYDROGENASE; TRANSALDOLASE; TRANSKETOLASE; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 1942502299     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsle.2004.03.018     Document Type: Article

References (25)

1. Cazzulo J.J. Intermediate metabolism in Trypanosoma cruzi. J. Bioenerg. Biomemb. 26:1994;157-165.
2. Concepción J.L., Chataing B., Dubourdieu M. Purification and properties of phosphoglucose isomerases of Trypanosoma cruzi. Comp. Biochem. Physiol. Part B. 122:1999;211-222.
3. Barrett M.P. The pentose phosphate pathway and Parasitic Protozoa. Parasitol. Today. 13:1997;11-16.
4. Eicks M., Maurino V., Knappe S., Flugge U., Fischer K. The plastidic pentose phosphate translocator represents a link between the cytosolic and plastidic pentose phosphate pathway in plants. Plant Physiol. 128:2002;512-522.
5. Bublitz C., Steavenson S. The pentose phosphate pathway in the endoplasmic reticulum. J. Biol. Chem. 263(26):1988;12849-12853.
6. Antonenkov V.D. Dehydrogenases of the pentose phosphate pathway in rat liver peroxisomes. Eur. J. Biochem. 183:1989;75-82.
7. Cronin C.N., Nolan D.P., Voorheis H.P. The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei. FEBS Lett. 244:1989;26-30.
8. Phillips C., Dohnalek J., Gover S., Barrett M.P., Adams M.J. A 2.8 Å resolution structure of 6-phosphogluconate dehydrogenase from the Protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues. J. Mol. Biol. 282:1998;667-681.
9. Duffieux F., Van Roy J., Michels P.A.M., Opperdoes F.R. Molecular characterization of the first two enzymes of the pentose phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6- phophogluconolactonase. J. Biol. Chem. 275:2000;27559-27565.
10. Maugeri D.A., Cazzulo J.J., Burchmore R.J.S., Barrett M.P., Ogbunude P.O.J. Pentose phosphate metabolism in Leishmania mexicana. Mol. Biochem. Parasitol. 130:2003;117-125.
11. Raw I. Some aspects of carbohydrate metabolism of cultural forms of Trypanosoma cruzi. Rev. Inst. Med. Trop. Sao Paulo. 1:1959;192-194.
12. Funayama Sh., Funayama Si., Ito I.Y., Veiga L.A. Trypanosoma cruzi: kinetic properties of glucose-6-phosphate dehydrogenase. Exp. Parasitol. 43:1977;376-381.
13. Igoillo Esteve M., Cazzulo J.J. The 6-phosphogluconate dehydrogenase from Trypanosoma cruzi: the absence of two inter-subunit salt bridges as a reason for enzyme instability. Mol. Biochem. Parasitol. 133:2004;197-207.
14. 2 fixation studies with the culture form of Trypanosoma cruzi. Comp. Biochem. Physiol. 9:1963;105-114.
15. 14-glucose in two strains of Trypanosoma cruzi. J. Protozool. 11:1964;509-513.
16. Cazzulo J.J., Franke de Cazzulo B.M., Engel J.C., Cannata J.J.B. End products and enzyme levels of aerobic glucose fermentation in Trypanosomatids. Mol. Biochem. Parasitol. 16:1985;329-343.
17. Franke de Cazzulo B.M., Martínez J., North M.J., Coombs G.H., Cazzulo J.J. Effect of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi. FEMS Microbiol. Lett. 124:1994;81-86.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
19. 14 for the evaluation of the pathways of glucose metabolism. J. Biol. Chem. 238:1963;517-523.
20. Cannata J.J.B., Cazzulo J.J. Glycosomal and mitochondrial malate dehydrogenase in epimastigotes of Trypanosoma cruzi. Mol. Biochem. Parasitol. 11:1984;37-49.
21. Cazzulo J.J., Cazzulo Franke M.C., Franke de Cazzulo B.M. On the regulatory properties of the pyruvate kinase from Trypanosoma cruzi epimastigotes. FEMS Microbiol. Lett. 59:1989;259-264.
22. Cymeryng C., Cazzulo J.J., Cannata J.J.B. Phosphoenolpyruvate carboxykinase from Trypanosoma cruzi. Purification and physicochemical and kinetic properties. Mol. Biochem. Parasitol. 73:1995;91-101.
23. Atamna H., Pascarmona G., Guinsburg H. Hexosemonophosphate shunt activity in intact Plasmodium falciparum - infected erythrocytes and in free parasites. Mol. Biochem. Parasitol. 67:1994;78-89.
24. Augustyns K., Amssoms K., Yamani A., Rajan P.K., Haemers A. Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents. Curr. Pharm. Des. 7:2001;1117-1141.
25. Cáceres A.J., Portillo R., Acosta H., Rosales D., Quiñones W., Avilan L., Salazar L., Dubourdieu M., Michels P.A.M., Concepción J.L. Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi. Mol. Biochem. Parasitol. 126:2003;251-262.