A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi

Journal of Experimental Medicine

Volumn 196, Issue 9, 2002, Pages 1241-1251

  Kubata, Bruno Kilunga ^a   Kabututu, Zakayi ^a,b   Nozaki, Tomoyoshi ^c   Munday, Craig J ^a   Fukuzumi, Shunichi ^d   Ohkubo, Kei ^d   Lazarus, Michael ^a   Maruyama, Toshihiko ^a   Martin, Samuel K ^e   Duszenko, Michael ^f   Urade, Yoshihiro ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e U S ARMY   (United States)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Chagas' disease; Chagasic drug reduction; Enzyme; PG production; Redox cycling

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ANTITRYPANOSOMAL AGENT; ARACHIDONIC ACID; BENZNIDAZOLE; BETA LAPACHONE; BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; COMPLEMENTARY DNA; CRYSTAL VIOLET; ECONAZOLE; FREE RADICAL; HYDROGEN PEROXIDE; KETOCONAZOLE; MENADIONE; MEVINOLIN; MICONAZOLE; NAPHTHOQUINONE; NIFURTIMOX; PHENAZINE METHOSULFATE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TERT BUTYL HYDROPEROXIDE;

ARTICLE; CATALYSIS; CHAGAS DISEASE; DRUG MECHANISM; DRUG METABOLISM; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BASE SEQUENCE; CATALYSIS; CYCLOOXYGENASE INHIBITORS; DINOPROST; DINOPROSTONE; DNA, PROTOZOAN; GENE EXPRESSION; HYDROXYPROSTAGLANDIN DEHYDROGENASES; INDOMETHACIN; MOLECULAR SEQUENCE DATA; NADPH DEHYDROGENASE; NAPHTHOQUINONES; OXIDATION-REDUCTION; PROSTAGLANDIN D2; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0037020868     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020885     Document Type: Article

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