Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.

Biochemistry

Volumn 49, Issue 27, 2010, Pages 5624-5633

  Logan, Todd ^a   Clark, Lindsay ^a,b   Ray, Soumya S ^a,b  

^a The Harvard Center for Neurodegeneration & Repair   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERIC STRUCTURE; DISULFIDE BONDS; DISULFIDE BRIDGE; DISULFIDE LINKAGES; MD SIMULATION; PARKINSON'S DISEASE; SCAVENGE REACTIVE OXYGEN SPECIES; STRUCTURAL STUDIES; SYNUCLEIN; THERMAL DENATURATIONS;

AMINO ACIDS; OXYGEN; RESTORATION;

DISEASES;

ALANINE; ALPHA SYNUCLEIN; CHAPERONE; CYSTEINE; DISULFIDE; DJ 1 PROTEIN; ISOLEUCINE; LEUCINE; METHIONINE; MUTANT PROTEIN; PROLINE; REACTIVE OXYGEN METABOLITE; THREONINE; VALINE; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; PROTEIN; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; DISULFIDE BOND; FAMILIAL DISEASE; HUMAN; LOSS OF FUNCTION MUTATION; MOLECULAR DYNAMICS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SIMULATION; CHEMISTRY; GENETIC DISORDER; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ALPHA-SYNUCLEIN; CYSTEINE; GENETIC DISEASES, INBORN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR CHAPERONES; MUTATION; ONCOGENE PROTEINS; PARKINSON DISEASE; PROTEIN STRUCTURE, TERTIARY; PROTEINS;

EID: 77954733200     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902164h     Document Type: Article

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