Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 10, 2005, Pages 3639-3644

  Ray, Soumya S ^a,b   Nowak, Richard J ^b,d   Brown Jr , Robert H ^a,c   Lansbury Jr , Peter T ^a,b  

^a The Harvard Center for Neurodegeneration & Repair   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Docking; Drug discovery; in silico screening; Thermodynamics; Thermopeutics

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DIMER; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; DATA BASE; DENATURATION; FAMILIAL DISEASE; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; METAL BINDING; MOLECULAR STABILITY; MOLECULE; MUTAGENESIS; PRIORITY JOURNAL; SCREENING; VALIDATION PROCESS;

AMYOTROPHIC LATERAL SCLEROSIS; BINDING SITES; DIMERIZATION; HUMANS; MUTATION; PROTEIN DENATURATION; PROTEIN FOLDING; SUPEROXIDE DISMUTASE;

EID: 14844361966     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408277102     Document Type: Article

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