Retraction: DJ-1 Modulates α-Synuclein aggregation state in a cellular model of oxidative stress: Relevance for Parkinson's disease and involvement of HSP70 (PLoS ONE (2008) 3:4 (e1884) DOI: 10.1371/journal.pone.0001884);DJ-1 modulates α-synuclein aggregation state in a cellular model of oxidative stress: Relevance for Parkinson's Disease and involvement of HSP70

PLoS ONE

Volumn 3, Issue 4, 2008, Pages

  Batelli, Sara ^a   Albani, Diego ^a   Rametta, Raffaela ^b   Polito, Letizia ^a   Prato, Francesca ^a   Pesaresi, Marzia ^a   Negro, Alessandro ^c   Forloni, Gianluigi ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; DJ 1 PROTEIN; HEAT SHOCK PROTEIN 70; HYBRID PROTEIN; HYDROGEN PEROXIDE; OXIDOPAMINE; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SPACE; MOLECULAR MECHANICS; MOLECULAR MODEL; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; BIOLOGICAL MODEL; GENE LIBRARY; GENE SILENCING; LEWY BODY; METABOLISM; PHYSIOLOGY; RECESSIVE GENE; SUBSTANTIA NIGRA; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; CELL LINE, TUMOR; DNA, COMPLEMENTARY; GENE LIBRARY; GENE SILENCING; GENES, RECESSIVE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEWY BODIES; MODELS, BIOLOGICAL; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; RNA, MESSENGER; SUBSTANTIA NIGRA;

EID: 44849093321     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0219023     Document Type: Erratum

References (38)

1. Di Monte DA (2003) The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol 2: 531-538.
2. Fahn S (2003) Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci 991: 1-14.
3. Hardy J, Cookson MR, Singleton A (2003) Genes and parkinsonism. Lancet: Neurol 2: 221-228.
4. Gosal D, Ross OA, Toft M (2006) Parkinson's disease: the genetics of a heterogeneous disorder. Eur J Neurol 13: 616-627.
5. Klein C, Schlossmatcher MG (2006) The genetics of Parkinson disease: Implications for neurological care. Nat Clin Pract Neurol. 2: 136-146.
6. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
7. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, et al. (1998) Ala30-to-pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18: 106-108.
8. Abeliovrich A, Flint Beal M (2006) Parkinsonism genes: culprits and clues. J Neurochem 99: 1062-1072.
9. Tang B, Xiong H, Sun P, Zhang Y, Wang D, et al. (2006) Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum Mol Genet 15: 1816-1825.
10. Jellinger KA (2006) The morphological basis of mental dysfunction in Parkinson's disease. J Neurol Sci [Epub ahead of print].
11. Volles MJ, Lansbury PT Jr (2003) Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinso's disease. Biochemistry 42: 7871-7878.
12. Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT (2006) Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. FASEB J 20: 2050-2057.
13. Hashimoto M, Rockenstein E, Masliah E (2003) Transgenic models of alpha-synuelein pathology: past, present, and future. Ann N Y Acad Sci 991: 171-188.
14. Fleming SM, Fernagut PO, Chesselet MF (2005) Genetic mouse models of parkinsonism: strengths and limitations NeuroRx 2: 495-503.
15. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, et al. (2003) alpha-Synuclein locus triplication causes Parkinson's disease. Science 302: 841.
16. Nishioka K, Hayashi S, Farrer MJ, Singleton AB, Yoshino H, et al. (2006) Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann Neurol 59: 298-309.
17. Lykkebo S, Jensen PH (2002) Alpha-synuclein and presynaptic function: implications for Parkinson's disease. Neuromolecular Med 2: 115-129.
18. Wersinger C, Prou D, Vernier P, Niznik HB, Sidhu A (2003) Mutations in the lipid-binding domain of aipha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity. Mol Cell Neurosci 24: 91-105.
19. Ahn M, Kim S, Kang M, Ryu Y, Kim TD (2006) Chaperone-like activities of alpha-synuclein: alpha-synuclein assists enzyme activities of esterases. Biochem Biophys Res Commun 346: 1142-1149.
20. Chandra S, Fornai F, Kwon HB, Yazdani U, Atasoy D, et al. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101: 14966-14971.
21. Bonifati V, Oostra BA, Heutink P (2004) Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. J Mol Med 82: 163-174.
22. Hedrich K, Djarmati A, Schafer N, Hering R, Wellenbrock C, et al. (2004) DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. Neurology 62: 389-394.
23. Eerola J, Hernandez D, Launes J, Hellstrom O, Hague S, et al. (2003) Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD Neurology 61: 1000-1002.
24. Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, et al. (2006) Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 281: 10816-10824.
25. Menzies FM, Yenisetti SC, Min KT (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr Biol 15: 1578-1582.
26. Yang Y, Gehrke S, Haque ME, Imai Y, Kosek J, et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci U S A 102: 13670-13675.
27. Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol 2: e362.
28. Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL (2006) The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J Mol Biol 356: 1036-1048.
29. Ved R, Saha S, Westlund B, Perier C, Burnam L, et al. (2005) Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem 280: 42655-42668.
30. Zhang L, Shimoji M, Thomas B, Moore DJ, Yu SW, et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet 14: 2063-2073.
31. Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-496.
32. Zhong N, Kim CY, Rizzo P, Geula C, Porter DR, et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem 281: 20940-20948.
33. Zhou W, Freed CR (2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J Biol Chem 280: 43150-43158.
34. Huang C, Cheng H, Hao S, Zhou H, Zhang X, et al. (2006) Heat Shock Protein 70 Inhibits alpha-Synuclein Fibril Formation via Interactions with Diverse Intermediates. J Mol Biol [Epub ahead of print].
35. Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ (2004) Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. J Biol Chem 279: 25497-25502.
36. Albani D, Peverelli E, Rametta. R, Batelli S, Veschini L, et al. (2004) Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70. FASEB J 18: 1713-1715.
37. Dietz GP, Bahr M (2004) Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci 27: 85-131.
38. Zhou W, Freed CR (2004) Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity. J Biol Chem 279: 10128-10135.