Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease

Biochemistry

Volumn 47, Issue 36, 2008, Pages 9380-9393

  Anderson, Peter C ^a   Daggett, Valerie ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AMINO ACIDS; DIMERIZATION; DYNAMICS; MOLECULAR DYNAMICS; POLYMORPHISM; QUANTUM CHEMISTRY; STABILITY; SURFACE CHEMISTRY;

DIMER INTERFACES; HYDROPHOBIC SURFACES; WILD-TYPE;

HYDROPHOBICITY;

DJ 1 PROTEIN; HELICASE; L166P PROTEIN; LEUCINE; PROLINE; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; GENE; GENE MUTATION; HUMAN; HYDROPHOBICITY; L166P DJ 1 GENE; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; DIMERIZATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MUTATION, MISSENSE; ONCOGENE PROTEINS; PARKINSON DISEASE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY;

EID: 51549105301     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800677k     Document Type: Article

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