Unfolding crystallins: The destabilizing role of a β-hairpin cysteine in βB2-crystallin by simulation and experiment

Protein Science

Volumn 14, Issue 5, 2005, Pages 1282-1292

  Macdonald, James T ^a   Purkiss, Andrew G ^a   Smith, Myron A ^a   Evans, Paul ^a   Goodfellow, Julia M ^a   Slingsby, Christine ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

crystallin fold; Age related cataract; Essential dynamics; Principal components analysis; Protein molecular dynamics simulation; Protein stability; Protein unfolding rates

Indexed keywords

BETA B2 CRYSTALLIN; BETA CRYSTALLIN; CRYSTALLIN; CYSTEINE; MUTANT PROTEIN; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; HIGH TEMPERATURE; IN VITRO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; SIMULATION; WILD TYPE;

CIRCULAR DICHROISM; CRYSTALLINS; CYSTEINE; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN DENATURATION;

RODENTIA;

EID: 17744391285     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.041227805     Document Type: Article

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