Discriminant analysis indicates a single sperm protein (SP22) is predictive of fertility following exposure to epididymal toxicants

Journal of Andrology

Volumn 18, Issue 2, 1997, Pages 139-150

  Klinefelter, G R ^a   Laskey, J W ^a   Ferrell, J ^a   Suarez, J D ^a   Roberts, N L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

biomarker; Epididymis

Indexed keywords

CELL PROTEIN; EPICHLOROHYDRIN; ETHYLENE GLYCOL DIMESYLATE; HYDROXYFLUTAMIDE; MESYLMESYLIC ACID 2 CHLOROETHYL ESTER; TESTOSTERONE; TOXIC SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DRUG EXPOSURE; EPIDIDYMIS; FEMALE; INTRAUTERINE INSEMINATION; MALE; MALE FERTILITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SPERM; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL;

ANIMALS; BIOLOGICAL MARKERS; DISCRIMINANT ANALYSIS; EPIDIDYMIS; FEMALE; FERTILITY; INSEMINATION, ARTIFICIAL; MALE; MESYLATES; PREDICTIVE VALUE OF TESTS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SPERM MOTILITY; SPERMATOZOA; SULFIDES;

EID: 0030919860     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Amann RP. The use of animal models for detecting specific alterations in reproduction. Fundam Appl Toxicol 1986;2:13-26.
2. Amann RP, Hammerstedt RH. In vitro evaluation of sperm quality: an opinion. J Androl 1993;14:397-406.
3. Amann RP, Hammerstedt RH, Veeramachaneni DNR. The epididymis and sperm maturation: a perspective. Reprod Fertil Dev 1993;5:361-381.
4. Cooper ERA, Jones AR, Jackson H. Effects of α-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat. J Reprod Fertil 1974;38:379-386.
5. de las Heras MA, Suescun MO, Calandra RS. Ornithine decarboxylase activity as a marker of androgen and antiandrogen action in the rat epididymis. J Reprod Fertil 1988;83:177-183.
6. Dhar JD, Setty BS. Studies on the physiology and biochemistry of mammalian epididymis: effect of flutamide, a nonsteroidal antiandrogen, on the epididymis of the rat. Fertil Steril 1976;27:566-576.
7. Dhar JD, Srivastava SR, Setty BS. Flutamide as an androgen antagonist on epididymal function in the rat. Andrologia 1982;14:55-61.
8. Dyson AL, Orgebin-Crist M-C. Effect of hypophysectomy, castration, and androgen replacement upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 1973;93:391-402.
9. Ewing LL, Desjardins C, Irby DC, Robaire B. Synergistic interaction of T and oestradiol inhibits spermatogenesis in rats. Nature 1977;269:409-411.
10. Jackson H, Fox BW, Craig AW. Antifertility substances and their assessment in the male rodent. J Reprod Fertil 1961;2:447-465.
11. Jones AR, Davies P, Edwards K, Jackson H. Antifertility effects and metabolism of alpha- and epichlorohydrin in the rat. Nature 1969;224:83.
12. Klinefelter, GR, Gray, LE, Suarez, JD. The method of sperm collection significantly influences sperm motion parameters following ethane dimethanesulphonate administration in the rat. Reprod Toxicol 1990;5:39-44.
13. Klinefelter GR. Laskey JW, Kelce WR, Ferrell J, Roberts NL, Suarez JD, Slott V. Chloroethylmethanesulphonate-induced effects on the epididymis seem unrelated to altered Leydig cell function. Biol Reprod 1994a;51:82-91.
14. Klinefelter GR, Laskey JW, Perreault SD, Ferrel J, Jeffay S, Suarez J, Roberts N. The ethane dimethanesulphonate-induced decrease in the fertilizing ability of cauda epididymal sperm is independent of the testis. J Androl 1994b;15:318-327.
15. Klinefelter GR, Roberts NL, Suarez J. Direct effects of ethane dimethanesulphonate on epididymal function in adult rats. J Androl 1992;13:409-421.
16. Linder RE, Strader LF, Slott VL, Suarez JD. Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants. Reprod Toxicol 1992;6:491-505.
17. Peets EA, Henson MF, Neri R. On the mechanism of the antiandogenic action of flutamide (α-α-α-trifluoro-2-methyl-4-nitro-m-proprionotoluidide) in the rat. Endocrinology 1974;94:532-540.
18. Poyet P, Labrie F. Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate. Mol Cell Endocrinol 1985;42:283-288.
19. Robb GW, Amann RP, Killian GJ. Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J. Reprod Fertil 1978;54:103-107.
20. SAS Institute. Statistical Analysis Systems User's Guide: Basics, Version 6. Gary, North Carolina: SAS Institute, Inc; 1985.
21. Slott VL, Suarez JD, Simmons JE, Perreault SD. Acute inhalation exposure to epichlorohydrin transiently decreases rat sperm velocity. Fundam Appl Toxicol 1990;15:597-606.
22. Toth GP, Zenick H, Smith MK. Effects of epichlorohydrin on male and female reproduction in Long-Evans rats. Fundam Appl Toxicol 1989;13:16-25.