An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

Virology

Volumn 404, Issue 2, 2010, Pages 269-278

  Sterjovski, Jasminka ^a,b   Roche, Michael ^a,b   Churchill, Melissa J ^a,b   Ellett, Anne ^a   Farrugia, William ^a   Gray, Lachlan R ^a,c   Cowley, Daniel ^a,b   Poumbourios, Pantelis ^a   Lee, Benhur ^d   Wesselingh, Steven L ^b   Cunningham, Anthony L ^e   Ramsland, Paul A ^a,b,c   Gorry, Paul R ^a,b,c  

^a BURNET INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e WESTMEAD HOSPITAL   (Australia)

Author keywords

CCR5; Env; Gp120; HIV 1; Macrophage tropism; Maraviroc

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; LUCIFERASE; MARAVIROC; VIRUS ENVELOPE PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL SURFACE; CONTROLLED STUDY; DOG; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOREACTIVITY; MACROPHAGE; MOLECULAR CLONING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PRIORITY JOURNAL; PROTEIN INTERACTION; THYMOCYTE; VIRUS CELL INTERACTION; VIRUS STRAIN;

ANIMALS; CELLS, CULTURED; CYCLOHEXANES; DOGS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV FUSION INHIBITORS; HIV-1; HUMANS; MACROPHAGES; MOLECULAR BIOLOGY; PROTEIN CONFORMATION; RECEPTORS, CCR5; TRIAZOLES; VIRUS INTERNALIZATION;

EID: 77954532945     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.05.006     Document Type: Article

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