Human immunodeficiency virus type 1 strains R5 and X4 induce different pathogenic effects in hu-PBL-SCID mice, depending on the state of activation/differentiation of human target cells at the time of primary infection

Journal of Virology

Volumn 73, Issue 8, 1999, Pages 6453-6459

  Fais, Stefano ^a   Lapenta, Caterina ^a   Santini, Stefano M ^a   Spada, Massimo ^a   Parlato, Stefania ^a   Logozzi, Mariantonia ^a   Rizza, Paola ^a   Belardelli, Filippo ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMORY CELL; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TARGET CELL; VIRUS ACTIVATION; VIRUS CELL INTERACTION; VIRUS RECOMBINANT; VIRUS REPLICATION;

EID: 0032795283     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.8.6453-6459.1999     Document Type: Article

References (51)

1. Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955-1958.
2. Bentwich, Z., A. Kalinkovich, and Z. Weissman. 1995. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol. Today 16:187-191.
3. Berger, E. A., R. W. Doms, E. M. Fenyo, B. T. M. Korber, D. Littman, J. P. Moore, Q. J. Sattentau, H. Schuitemaker, J. Sodrosky, and R. A. Weiss. 1998. A new classification for HIV-1. Nature 391:240.
4. Bleul, C. C., L. Wu, J. A. Hoxie, T. A. Springer, and C. R. Mackay. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925-1930.
5. Casella, C. R., and T. H. Finkel. 1997. Mechanisms of lymphocyte killing by HIV. Curr. Opin. Hematol. 4:24-31.
6. Chun, T. W., D. Engel, M. M. Berrey, T. Shea, L. Corey, and A. S. Fauci. 1998. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA 95:8869-8873.
7. Clapham, P. R. 1997. HIV and chemokines: ligands sharing cell-surface receptors. Trends Cell Biol. 7:264-268.
8. De Maria, R., S. Fais, M. Silvestri, L. Frati, F. Pallone, A. Santoni, and R. Testi. 1993. Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes. Eur. J. Immunol. 23:3104-3108.
9. D'Souza, M. P., and V. A. Harden. 1996. Chemokines and HIV-1 second receptors. Nat. Med. 12:1293-1300.
10. Duchosal, M. A., P. J. McConahey, C. A. Robinson, and F. J. Dixon. 1990. Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. J. Exp. Med. 172:985-988.
11. Fauci, A. S., G. Pantaleo, S. Stanley, and O. Weissman. 1996. Immunopathogenic mechanism of HIV infection. Ann. Intern. Med. 124:654-663.
12. Finzi, D., M. Hermankova, T. Pierson, L. M. Carruth, C. Buck, R. E. Chaisson, T. C. Quinn, K. Chadwick, J. Margolick, R. Brookmeyer, J. Gallant, M. Markowitz, D. D. Ho, D. D. Richman, and R. F. Siliciano. 1997 Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-1300.
13. Folks, T. M., D. Powell, M. Lightfoote, S. Koenig, A. S. Fauci, S. Benn, A. Rabson, D. Daugherty, H. E. Gendelman, M. D. Hoggan, S. Venkayesan, and M. A. Martin. 1986. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immune deficiency syndrome retrovirus. J. Exp. Med 164:280-290.
14. Gulizia, R. J., J. A. Levy, and D. E. Mosier. 1996. The envelope gp120 gene of human immunodeficiency virus type 1 determines the rate of CD4-positive T-cell depletion in SCID mice engrafted with human peripheral blood leukocytes. J. Virol. 70:4184-4187.
15. Karlsson, G. B., M. Halloran, D. Schenten, J. Lee, P. Racz, K. Tenner-Racz, J. Manola, R. Gelman, B. Etemad-Moghadam, E. Desjardins, R. Wyatt, N. P. Gerard, L. Marcon, D. Margolin, J. Fanton, M. K. Axthelm, N. L. Letvin, and J. Sodroski. 1998. The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. J. Exp. Med. 188:1159-1171.
16. Kollmann, T. R., M. Pettoello-Mantovani, X. Zhuang, A. Kim, M. Hachamovitch, P. Smarnworawong, A. Rubinstein, and H. Goldstein. 1994. Disseminated human immunodeficiency virus-1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1. J. Exp. Med. 179:513-522.
17. Krams, S. H., K. Dorshkind, and M. E. Gershwin. 1989. Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J. Exp. Med. 170:1919-1930.
18. Lapenta, C., M. Boirivant, M. Marini, S. M. Santini, M. Logozzi, M. Viora, F. Belardelli, and S. Fais. 1999. Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection. Eur. J. Immunol. 29:1202-1208.
19. Lapenta, C., S. Fais, P. Rizza, M. Spada, M. Logozzi, S. Parlato, S. M. Santini, M. Pirillo, F. Belardelli, and E. Proietti. 1997. U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies. Antivir. Res. 36:81-90.
20. + T-cell differentiation in pathogenesis of AIDS, J. Virol. 72:10323-10327.
21. Lifson, J. D., M. A. Nowak, S. Goldstein, J. L. Rossio, A. Kinter, G. Vasquez, T. A. Wiltrout, C. Brown, D. Schneider, L. Wahl, A. L. Lloyd, J. Williams, W. R. Elkins, A. S. Fauci, and V. M. Hirsch. 1997. The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection. J. Virol. 71:9508-9514.
22. McCune, J. M., R. Namikawa, H. Kanemisha, L. D. Shultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 24:1632-1639.
23. McCune, J. M. 1997. Animal models of HIV-1 disease. Science 278:2141-2142.
24. Moore, J. P., A. Trkola, and T. Dragic. 1997. Co-receptors for HIV-1 entry. Curr. Opin. Immunol. 9:551-562.
25. Mosier, D. E., R. J. Gulizia, S. M. Baird, and D. B. Wilson. 1988. Transfer of functional human immune system to mice with severe combined immunodeficiency. Nature 335:256-259.
26. Mosier, D. E., R. J. Gulizia, S. M. Baird, D. B. Wilson, D. H. Spector, and S. A. Spector. 1991. Human immunodeficiency virus infection of human PBL-SCID mice. Science 25:791-794.
27. Mosier, D. E., R. J. Gulizia, P. D. MacIsaac, B. E. Torbett, and J. A. Levy. 1993. Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260:689-692.
28. Namikawa, R., K. N. Weibaecher, H. Kaneshima, E. J. Yee, and J. M. McCune. 1990. Long-term human hematopoiesis in the SCID-hu mouse. J. Exp. Med. 172:1055-1063.
29. Namikawa, R., H. Kanemisha, M. Lieberman, I. L. Weissman, and J. M. McCune. 1991. Infection of the SCID-hu mouse by HIV-I. Science 242: 1684-1686.
30. Nara, P. L., W. C. Hatch, N. M. Dunlop, W. G. Robey, L. O. Arthur, M. A. Gonda, and P. J. Fischinger. 1987. Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody. AIDS Res. Hum. Retroviruses 3:283-302.
31. Ostrowski, M. A., D. C. Krakauer, Y. Li, S. J. Justement, G. Learn, L. A. Ehler, S. K. Stanley, M. Nowak, and A. S. Fauci. 1998. Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasispecies. J. Virol. 72:7772-7784.
32. Ostrowski, M. A., S. J. Justement, A. Catanzaro, C. A. Hallahan, L. A. Ehler, S. B. Mizell, P. N. Kumar, J. A. Mican, T. W. Chun, and A. S. Fauci. 1998 Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. J. Immunol. 161:3195-3201.
33. Parlato, S., S. M. Santini, C. Lapenta, M. Spada, M. Logozzi, P. Rizza, E. Proietti, F. Belardelli, and S. Fais. Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of latently infected cells through a massive Fas-mediated autocrine suicide of uninfected cells. Importance of CD4+ T cell differentiation in the pathogenesis of HIV-1 infection. Submitted for publication.
34. Picchio, G. R., R. J. Gulizia, and D. E. Mosier. 1997. Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice. J. Virol. 71:7124-7127.
35. Picchio, G. R., R. J. Gulizia, K. Wehrly, B. Chesebro, and D. E. Mosier. 1998. The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes. J. Virol. 72:2002-2009.
36. Quinn, T. M., P. Plot, J. B. McCormick, F. M. Feinsod, H. Taelman, B. Kapita, W. Stevens, and A. S. Fauci. 1987. Serologic and immunologic studies in patients with AIDS in North America and Africa. JAMA 257: 2617-2621.
37. Rizza, P., S. M. Santini, M. Logozzi, C. Lapenta, P. Sestili, G. Gherardi, R. Lande, M. Spada, S. Parlato, F. Belardelli, and S. Fais. 1996. T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells. J. Virol. 70:7958-7964.
38. Roederer, M., P. A. Raju, D. K. Mitra, L. A. Herzenberg, and L. A. Herzenberg. 1997. HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J. Clin. Investig. 99:1555-1564.
39. Sandhu, J., B. Shipitz, S. Gallinger, and N. Hozumi. 1994. Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J. Immunol. 152:3806-3812.
40. Schnittman, S. M., H. C. Lane, J. Greenhouse, J. S. Justement, M. Baseler, and A. S. Fauci. 1990. Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc. Natl. Acad. Sci. USA 87:6058-6062.
41. Schuitemaker, H., N. A. Kootstra, R. A. Fouchier, B. Hooibrink, and F. Miedema. 1994. Productive HIV-1 infection of macrophages restricted to the cell fraction with proliferative capacity. EMBO J. 13:5929-5936.
42. Shioda, T., J. A. Levy, and C. Cheng-Mayer. 1992. Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell line and macrophage tropism of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 89:9434-9438.
43. Spins, C. A., H. E. Prince, and D. D. Richman. 1997. Preferential replication of HIV-I in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J. Clin. Investig. 99:1774-1785.
44. Stevenson, M., T. L. Stanwick, M. P. Dempsey, and C. A. Lamonica. 1990. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1551-1560.
45. Tary-Lehman, M., and A. Saxon. 1992. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J. Exp. Med. 175:503-516,
46. Tary-Lehman, M., P. V. Lehman, D. Schols, M. G. Roncarolo, and A. Saxon. 1994. Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras. J. Exp. Med. 180:1817-1827.
47. Tary-Lehman, M., A. Saxon, and P. V. Lehman. 1995. The human immune system in hu-PBL-SCID mice. Immunol. Today 16:529-533.
48. Torbett, B. E., G. Picchio, and D. E. Mosier. 1991. Hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol. Rev. 124:2-26.
49. Wolinsky, S., B. Korber, A. Neumann, M. Daniels, K. Kunstman, A. Whetsell, M. Furtado, Y. Cao, D. Ho, J. Safrit, and R. Koup. 1996. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 272:537-541.
50. Wood, T. C., B. D. Roberts, S. T. Butera, and T. M. Folks. 1997. Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells. Blood 89:1635-1641.
51. Xiao, L., D. L. Rudolph, S. M. Owen, T. J. Spira, and R. B. Lal. 1998. Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression. AIDS 12:F137-F143.