Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages

Journal of Virology

Volumn 78, Issue 13, 2004, Pages 6915-6926

  Peters, Paul J ^a   Bhattacharya, Jayanta ^a   Hibbitts, Samantha ^b,e   Dittmar, Matthias T ^b,f   Simmons, Graham ^b,g   Bell, Jeanne ^c   Simmonds, Peter ^d   Clapham, Paul R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f Abteilung Virologie   (Germany)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 INHIBITOR; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN EXPRESSION; ARTICLE; AUTOPSY; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE AMPLIFICATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 R5; HUMAN TISSUE; LYMPH NODE; MACROPHAGE; MACROPHAGE ACTIVATION; MICROGLIA; MOLECULAR CLONING; NEUROLOGICAL COMPLICATION; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; TISSUE SPECIFICITY; VIROGENESIS; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS REPLICATION;

AIDS DEMENTIA COMPLEX; AMINO ACID SEQUENCE; ANTIGENS, CD4; BRAIN; CELL FUSION; CELLS, CULTURED; GENE PRODUCTS, ENV; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; LYMPH NODES; MACROPHAGES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHENOTYPE; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5;

EID: 2942687021     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.13.6915-6926.2004     Document Type: Article

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