Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 12736-12746

  Kao, Yu Ya ^a   Gianni, Davide ^a   Bohl, Benjamin ^a   Taylor, Ross M ^b   Bokoch, Gary M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; CATALYSTS; ENZYME INHIBITION; ENZYMES; FLOW INTERACTIONS; ORGANIC ACIDS; OXYGEN; PROTEINS;

BIOLOGICAL PROCESSES; CONSERVED RESIDUES; CYTOPLASMIC TAILS; CYTOSOLIC; ELECTRON TRANSFERS; HUMAN NEUTROPHILS; IN CELLS; INTERACTION SITES; MUTATIONAL ANALYSIS; NADPH OXIDASES; RAC GTPASES; REGULATORY FACTORS; REGULATORY INTERACTIONS; REGULATORY MECHANISMS; SUPEROXIDE; TRUNCATION ANALYSES;

BINDING SITES;

ADENOSINE TRIPHOSPHATE; COMPLEMENTARY DNA; FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE TRANSFERASE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; HYBRID PROTEIN; RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SULFUR 35; SUPEROXIDE; ISOENZYME;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL FREE SYSTEM; CIRCULAR DICHROISM; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; ISOTOPE LABELING; NEUTROPHIL; NONHUMAN; PHAGOCYTE; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; CYTOPLASM; GENE DELETION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; CYTOPLASM; GENE DELETION; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MUTATION; NADPH OXIDASE; PROTEIN BINDING; RAC GTP-BINDING PROTEINS; SEQUENCE ALIGNMENT;

EID: 45149112512     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801010200     Document Type: Article

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