Regulation of the phagocyte NADPH oxidase activity: Phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox

FASEB Journal

Volumn 23, Issue 4, 2009, Pages 1011-1022

  Raad, Houssam ^a   Paclet, Marie Hélène ^b   Boussetta, Tarek ^a   Kroviarski, Yolande ^c   Morel, Françoise ^b   Quinn, Mark T ^d   Gougerot Pocidalo, Marie Anne ^a,c   Dang, Pham My Chan ^a   El Benna, Jamel ^a,e  

^a INSERM   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

^c BICHAT HOSPITAL   (France)

^d MONTANA STATE UNIVERSITY   (United States)

^e CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Cytochrome b558; Inflammation; Innate immunity; Neutrophils; PMN

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; DIHYDROLIPOAMIDE DEHYDROGENASE; FLAVOPROTEIN; GLYCOPROTEIN GP 91; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN; PROTEIN KINASE C; PROTEIN P47; PROTEIN P67; RAC2 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; NEUTROPHIL CYTOSOL FACTOR 67K; RAC PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STIMULATION; CHRONIC GRANULOMATOUS DISEASE; CYTOSOL; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; NEUTROPHIL; PEPTIDE MAPPING; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; BINDING SITE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION;

BINDING SITES; CYTOSOL; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; NADPH OXIDASE; NEUTROPHILS; PHAGOCYTES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; RAC GTP-BINDING PROTEINS;

EID: 65349153053     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-114553     Document Type: Article

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