Nutraceuticals and atherosclerosis: Human trials

Cardiovascular Therapeutics

Volumn 28, Issue 4, 2010, Pages 202-215

  Badimon, Lina ^a,b,c   Vilahur, Gemma ^a,b   Padro, Teresa ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c IUAB HSCSP Fundacion Jesus Serra   (Spain)

Author keywords

Antioxidants; Lipids disorder atherosclerosis; Nutraceuticals; Obesity

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CHOLESTIN; HIGH DENSITY LIPOPROTEIN; LINOLEIC ACID; LINOLENIC ACID; NUTRACEUTICAL; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; SIMVASTATIN; CARDIOVASCULAR AGENT;

ATHEROSCLEROSIS; CANCER PREVENTION; CARDIOVASCULAR EFFECT; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; DIET SUPPLEMENTATION; DIETARY FIBER; EXERCISE; FAT INTAKE; FATTY ACID METABOLISM; FRUIT; GENE EXPRESSION REGULATION; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LIFESTYLE; LIFESTYLE MODIFICATION; LIPID PEROXIDATION; OBESITY; OUTCOME ASSESSMENT; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SECONDARY PREVENTION; VEGETABLE; WINE; CLINICAL TRIAL (TOPIC); DIET; EVIDENCE BASED MEDICINE; FUNCTIONAL FOOD; TREATMENT OUTCOME;

ATHEROSCLEROSIS; CARDIOVASCULAR AGENTS; CLINICAL TRIALS AS TOPIC; DIET; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; FUNCTIONAL FOOD; HUMANS; RISK FACTORS; TREATMENT OUTCOME;

EID: 77954371866     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2010.00189.x     Document Type: Review

References (112)

1. Badimon L, Vilahur G, Padro T. Lipoproteins, platelets and atherothrombosis. Rev Esp Cardiol 2009 62 : 1161 1178.
2. Hu FB, Manson JE, Willett WC. Types of dietary fat and risk of coronary heart disease: A critical review. J Am Coll Nutr 2001 20 : 5 19.
3. Erkkila AT, Schwab US, de Mello VD, et al. Effects of fatty and lean fish intake on blood pressure in subjects with coronary heart disease using multiple medications. Eur J Nutr 2008 47 : 319 328.
4. Jacobs DR, Jr., McGovern PG, Blackburn H. The US decline in stroke mortality: What does ecological analysis tell us Am J Public Health 1992 82 : 1596 1599.
5. Keys A, Menotti A, Karvonen MJ, et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986 124 : 903 915.
6. Perez-Jimenez F, Alvarez de Cienfuegos G, Badimon L, et al. International conference on the healthy effect of virgin olive oil. Eur J Clin Invest 2005 35 : 421 424.
7. Hu FB, Stampfer MJ, Manson JE, et al. Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997 337 : 1491 1499.
8. Esrey KL, Joseph L, Grover SA. Relationship between dietary intake and coronary heart disease mortality: Lipid research clinics prevalence follow-up study. J Clin Epidemiol 1996 49 : 211 216.
9. Posner BM, Cobb JL, Belanger AJ, Cupples LA, D'Agostino RB, Stokes J, 3rd. Dietary lipid predictors of coronary heart disease in men. The Framingham study. Arch Intern Med 1991 151 : 1181 1187.
10. Artaud-Wild SM, Connor SL, Sexton G, Connor WE. Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. A paradox. Circulation 1993 88 : 2771 2779.
11. Llorente-Cortes V, Estruch R, Mena MP, et al. Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis 2010 208 : 442 450.
12. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am J Clin Nutr 2003 77 : 1146 1155.
13. Diaz MN, Frei B, Vita JA, Keaney JF, Jr. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997 337 : 408 416.
14. He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: Meta-analysis of cohort studies. Lancet 2006 367 : 320 326.
15. Moreno JA, Lopez-Miranda J, Perez-Martinez P, et al. A monounsaturated fatty acid-rich diet reduces macrophage uptake of plasma oxidised low-density lipoprotein in healthy young men. Br J Nutr 2008 100 : 569 575.
16. Mata P, Varela O, Alonso R, Lahoz C, de Oya M, Badimon L. Monounsaturated and polyunsaturated n-6 fatty acid-enriched diets modify LDL oxidation and decrease human coronary smooth muscle cell DNA synthesis. Arterioscler Thromb Vasc Biol 1997 17 : 2088 2095.
17. Covas MI. Olive oil and the cardiovascular system. Pharmacol Res 2007 55 : 175 186.
18. Lavie CJ, Milani RV, Mehra MR, Ventura HO. Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol 2009 54 : 585 594.
19. Breslow JL. N-3 fatty acids and cardiovascular disease. Am J Clin Nutr 2006 83 : 1477S 1482S.
20. Ros E. Dietary cis-monounsaturated fatty acids and metabolic control in type 2 diabetes. Am J Clin Nutr 2003 78 : 617S 625S.
21. Kris-Etherton PM. AHA science advisory: Monounsaturated fatty acids and risk of cardiovascular disease. J Nutr 1999 129 : 2280 2284.
22. Bos MB, de Vries JH, Feskens EJ, et al. Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity. Nutr Metab Cardiovasc Dis 2009. doi :.
23. Salonen JT, Nyyssonen K, Salonen R, et al. Antioxidant supplementation in atherosclerosis prevention (ASAP) study: A randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000 248 : 377 386.
24. Whelton SP, He J, Whelton PK, Muntner P. Meta-analysis of observational studies on fish intake and coronary heart disease. Am J Cardiol 2004 93 : 1119 1123.
25. Pietinen P, Ascherio A, Korhonen P, et al. Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The alpha-tocopherol, beta-carotene cancer prevention study. Am J Epidemiol 1997 145 : 876 887.
26. Hu FB, Stampfer MJ, Manson JE, et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 1999 69 : 890 897.
27. Albert CM, Oh K, Whang W, et al. Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation 2005 112 : 3232 3238. (Pubitemid 43739367)
28. Campos H, Baylin A, Willett WC. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation 2008 118 : 339 345.
29. Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives. Atherosclerosis 2008 197 : 12 24.
30. He K, Song Y, Daviglus ML, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: A meta-analysis of cohort studies. Circulation 2004 109 : 2705 2711.
31. Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART). Lancet 1989 2 : 757 761.
32. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the Gissi-Prevenzione trial. Gruppo italiano per lo studio della sopravvivenza nell'infarto miocardico. Lancet 1999 354 : 447 455.
33. Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (jelis): A randomised open-label, blinded endpoint analysis. Lancet 2007 369 : 1090 1098.
34. Burr ML, Ashfield-Watt PA, Dunstan FD, et al. Lack of benefit of dietary advice to men with angina: Results of a controlled trial. Eur J Clin Nutr 2003 57 : 193 200.
35. Nilsen DW, Albrektsen G, Landmark K, Moen S, Aarsland T, Woie L. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr 2001 74 : 50 56.
36. Rauch B, Schiele R, Schneider S, et al. Highly purified omega-3 fatty acids for secondary prevention of sudden cardiac death after myocardial infarction-aims and methods of the OMEGA-study. Cardiovasc Drugs Ther 2006 20 : 365 375.
37. Lonn E, Yusuf S, Hoogwerf B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and micro-HOPE substudy. Diabetes Care 2002 25 : 1919 1927.
38. Hodis HN, Mack WJ, LaBree L, et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: The vitamin E atherosclerosis prevention study (VEAPS). Circulation 2002 106 : 1453 1459.
39. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003 78 : 965 978.
40. Normen L, Holmes D, Frohlich J. Plant sterols and their role in combined use with statins for lipid lowering. Curr Opin Investig Drugs 2005 6 : 307 316.
41. Hallikainen MA, Sarkkinen ES, Gylling H, Erkkila AT, Uusitupa MI. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 2000 54 : 715 725.
42. Clifton PM, Noakes M, Sullivan D, et al. Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. Eur J Clin Nutr 2004 58 : 503 509.
43. Executive of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001 285 : 2486 2497.
44. Lichtenstein AH, Appel LJ, Brands M, et al. of American Heart Association diet and lifestyle recommendations revision 2006. Arterioscler Thromb Vasc Biol 2006 26 : 2186 2191.
45. European Commission. General view of the scientific committee on food on the long-term effects of the intake of elevated levels of phytosterols from multiple dietary sources, with particular attention to the effects of beta-carotene, 2002. Available from : http://europa.eu.int/comm/food/fs/sc/scf/ index-en.html Assessed June 2010 O, Bohm M, Laufs U. Plant sterols as dietary supplements for the prevention of cardiovascular diseases. Dtsch Med Wochenschr 2008 133 : 1201 1204.
46. Weingartner O, Bohm M, Laufs U. Controversial role of plant sterol esters in the management of hypercholesterolaemia. Eur Heart J 2009 30 : 404 409.
47. Assmann G, Cullen P, Erbey J, Ramey DR, Kannenberg F, Schulte H. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: Results of a nested case-control analysis of the prospective cardiovascular Munster (PROCAM) study. Nutr Metab Cardiovasc Dis 2006 16 : 13 21.
48. Thiery J, Ceglarek U, Fiedler G, et al. Elevated campesterol serum levels - A significant predictor of incident myocardial infarction: Results of the population-based MONICA/KORA follow-up study 1994-2005. Circulation 2006 114 : II-884 Abstract 4099 J, Zhang J, Shi Y, Grimsgaard S, Alraek T, Fonnebo V. Chinese red yeast rice (monascus purpureus) for primary hyperlipidemia: A meta-analysis of randomized controlled trials. Chin Med 2006 1 : 4.
49. Lu Z, Kou W, Du B, et al. Effect of xuezhikang, an extract from red yeast Chinese rice, on coronary events in a Chinese population with previous myocardial infarction. Am J Cardiol 2008 101 : 1689 1693.
50. Li JJ, Lu ZL, Kou WR, et al. Beneficial impact of xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China coronary secondary prevention study (CCSPS). J Clin Pharmacol 2009 49 : 947 956.
51. Zhao SP, Liu L, Cheng YC, et al. Xuezhikang, an extract of cholestin, protects endothelial function through antiinflammatory and lipid-lowering mechanisms in patients with coronary heart disease. Circulation 2004 110 : 915 920.
52. Halbert SC, French B, Gordon RY, et al. Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. Am J Cardiol 2010 105 : 198 204.
53. Liu S, Buring JE, Sesso HD, Rimm EB, Willett WC, Manson JE. A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol 2002 39 : 49 56.
54. Oh K, Hu FB, Cho E, et al. Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women. Am J Epidemiol 2005 161 : 161 169.
55. Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary fiber reduces peripheral arterial disease risk in men. J Nutr 2003 133 : 3658 3663.
56. Pereira MA, O'Reilly E, Augustsson K, et al. Dietary fiber and risk of coronary heart disease: A pooled analysis of cohort studies. Arch Intern Med 2004 164 : 370 376.
57. Hirvonen T, Pietinen P, Virtanen M, et al. Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology 2001 12 : 62 67.
58. Hertog MG, Kromhout D, Aravanis C, et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 1995 155 : 381 386.
59. Arts IC, Hollman PC, Feskens EJ, Bueno de Mesquita HB, Kromhout D. Catechin intake and associated dietary and lifestyle factors in a representative sample of Dutch men and women. Eur J Clin Nutr 2001 55 : 76 81.
60. Geleijnse JM, Launer LJ, Van Der Kuip DA, Hofman A, Witteman JC. Inverse association of tea and flavonoid intakes with incident myocardial infarction: The Rotterdam study. Am J Clin Nutr 2002 75 : 880 886.
61. Knekt P, Jarvinen R, Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: A cohort study. BMJ 1996 312 : 478 481.
62. Ness AR, Powles JW. Fruit and vegetables, and cardiovascular disease: A review. Int J Epidemiol 1997 26 : 1 13.
63. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen elderly study. Lancet 1993 342 : 1007 1011.
64. Hertog MG, Feskens EJ, Kromhout D. Antioxidant flavonols and coronary heart disease risk. Lancet 1997 349 : 699.
65. Rimm EB, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med 1996 125 : 384 389.
66. Keli SO, Hertog MG, Feskens EJ, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: The Zutphen study. Arch Intern Med 1996 156 : 637 642.
67. Yochum L, Kushi LH, Meyer K, Folsom AR. Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am J Epidemiol 1999 149 : 943 949.
68. Sesso HD, Gaziano JM, Liu S, Buring JE. Flavonoid intake and the risk of cardiovascular disease in women. Am J Clin Nutr 2003 77 : 1400 1408. (Pubitemid 39655272)
69. Lin J, Rexrode KM, Hu F, et al. Dietary intakes of flavonols and flavones and coronary heart disease in US women. Am J Epidemiol 2007 165 : 1305 1313. (Pubitemid 47234326)
70. Hertog MG, Sweetnam PM, Fehily AM, Elwood PC, Kromhout D. Antioxidant flavonols and ischemic heart disease in a Welsh population of men: The Caerphilly study. Am J Clin Nutr 1997 65 : 1489 1494.
71. Mozaffarian D, Kumanyika SK, Lemaitre RN, Olson JL, Burke GL, Siscovick DS. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA 2003 289 : 1659 1666.
72. Anderson JW, Hanna TJ, Peng X, Kryscio RJ. Whole grain foods and heart disease risk. J Am Coll Nutr 2000 19 : 291S 299S.
73. Jacobs DR, Pereira MA, Meyer KA, Kushi LH. Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: The Iowa women's health study. J Am Coll Nutr 2000 19 : 326S 330S.
74. Anderson JW, Baird P, Davis RH, Jr., et al. Health benefits of dietary fiber. Nutr Rev 2009 67 : 188 205.
75. Seal CJ. Whole grains and CVD risk. Proc Nutr Soc 2006 65 : 24 34.
76. Estruch R, Martinez-Gonzalez MA, Corella D, et al. Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. J Epidemiol Community Health 2009 63 : 582 588.
77. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The alpha-tocopherol, beta carotene cancer prevention study group. N Engl J Med 1994 330 : 1029 1035.
78. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000 342 : 154 160.
79. de Gaetano G. Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomised trial in general practice. Collaborative group of the primary prevention project. Lancet 2001 357 : 89 95.
80. Rapola JM, Virtamo J, Ripatti S, et al. Effects of alpha tocopherol and beta carotene supplements on symptoms, progression, and prognosis of angina pectoris. Heart 1998 79 : 454 458.
81. Rapola JM, Virtamo J, Ripatti S, et al. Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 1997 349 : 1715 1720.
82. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge heart antioxidant study (CHAOS). Lancet 1996 347 : 781 786.
83. Heart Protection Study Collaborative Group. MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002 360 : 23 33.
84. St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979 1 : 1017 1020.
85. Hozumi T, Sugioka K, Shimada K, et al. Beneficial effect of short term intake of red wine polyphenols on coronary microcirculation in patients with coronary artery disease. Heart 2006 92 : 681 682.
86. Perez-Jimenez J, Saura-Calixto F. Grape products and cardiovascular disease risk factors. Nutr Res Rev 2008 21 : 158 173.
87. Papamichael C, Karatzis E, Karatzi K, et al. Red wine's antioxidants counteract acute endothelial dysfunction caused by cigarette smoking in healthy nonsmokers. Am Heart J 2004 147 : E5.
88. Cuevas AM, Guasch V, Castillo O, et al. A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids 2000 35 : 143 148.
89. Imhof A, Blagieva R, Marx N, Koenig W. Drinking modulates monocyte migration in healthy subjects: A randomised intervention study of water, ethanol, red wine and beer with or without alcohol. Diab Vasc Dis Res 2008 5 : 48 53.
90. Davidson MH, Maki KC, Dicklin MR, et al. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol 2009 104 : 936 942.
91. Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004 23 : 423 433.
92. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996 334 : 1145 1149.
93. Eidelman RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch Intern Med 2004 164 : 1552 1556.
94. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996 334 : 1150 1155.
95. Bleys J, Miller ER, 3rd., Pastor-Barriuso R, Appel LJ, Guallar E. Vitamin-mineral supplementation and the progression of atherosclerosis: A meta-analysis of randomized controlled trials. Am J Clin Nutr 2006 84 : 880 887 quiz 954 955.
96. Greenberg ER, Baron JA, Karagas MR, et al. Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation. JAMA 1996 275 : 699 703.
97. Zureik M, Galan P, Bertrais S, et al. Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler Thromb Vasc Biol 2004 24 : 1485 1491.
98. Cook NR, Albert CM, Gaziano JM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: Results from the women's antioxidant cardiovascular study. Arch Intern Med 2007 167 : 1610 1618.
99. Boaz M, Smetana S, Weinstein T, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): Randomised placebo-controlled trial. Lancet 2000 356 : 1213 1218.
100. Singh RB, Niaz MA, Rastogi SS, Rastogi S. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3). Am J Cardiol 1996 77 : 232 236.
101. Tomoda H, Yoshitake M, Morimoto K, Aoki N. Possible prevention of postangioplasty restenosis by ascorbic acid. Am J Cardiol 1996 78 : 1284 1286.
102. Yokoi H, Daida H, Kuwabara Y, et al. Effectiveness of an antioxidant in preventing restenosis after percutaneous transluminal coronary angioplasty: The probucol angioplasty restenosis trial. J Am Coll Cardiol 1997 30 : 855 862.
103. Fang JC, Kinlay S, Beltrame J, et al. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: A randomised trial. Lancet 2002 359 : 1108 1113.
104. Tardif JC, Cote G, Lesperance J, et al. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and probucol study group. N Engl J Med 1997 337 : 365 372.
105. Liu S, Lee IM, Ajani U, Cole SR, Buring JE, Manson JE. Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The physicians' health study. Int J Epidemiol 2001 30 : 130 135.
106. Gaziano JM, Manson JE, Branch LG, Colditz GA, Willett WC, Buring JE. A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. Ann Epidemiol 1995 5 : 255 260.
107. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993 328 : 1450 1456.
108. Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol 2003 42 : 246 252. (Pubitemid 36851413)
109. Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women. Am J Clin Nutr 2003 77 : 1390 1399. (Pubitemid 39655271)
110. Morris CD, Carson S. Routine vitamin supplementation to prevent cardiovascular disease: A of the evidence for the U.S. Preventive services task force. Ann Intern Med 2003 139 : 56 70.
111. Brigelius-Flohe R, Kluth D, Banning A. Is there a future for antioxidants in atherogenesis? Mol Nutr Food Res 2005 49 : 1083 1089.
112. Katsiki N, Manes C. Is there a role for supplemented antioxidants in the prevention of atherosclerosis? Clin Nutr 2009 28 : 3 9.