메뉴 건너뛰기




Volumn 5, Issue 7, 2010, Pages 655-671

Improvement of drug-like properties of peptides: The somatostatin paradigm

Author keywords

Cyclization; Drug like properties; N methylation; Peptides; Somatostatin

Indexed keywords

ANGIOPEPTIN; CYCLO(PROLYLPHENYLALANYL DEXTRO TRYPTOPHYLLYSYLTHREONYLPHENYLALANYL); DEXTRO PHENYL C(CYSTEINYLPHENYL DEXTRO TRYPTOPHYLLYSYLTHREONYLCYSTEINYL)THREONINAMIDE; OCTREOTIDE; PASIREOTIDE; PEPTIDE; PTR 3046; PTR 3173; PTR 3205; SEGLITIDE; SOMATOSTATIN; SOMATOSTATIN 14; SOMATOSTATIN 28; SOMATOSTATIN DERIVATIVE; TYROSYL C(CYSTEINYLPHENYL DEXTRO TRYPTOPHYLLYSYLTHREONYLCYSTEINYL)THREONINAMIDE; UNCLASSIFIED DRUG; VAPREOTIDE;

EID: 77953717986     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2010.493935     Document Type: Review
Times cited : (55)

References (116)
  • 1
    • 0037082199 scopus 로고    scopus 로고
    • The emerging importance of predictive ADME simulation in drug discovery
    • Beresford AP, Selick HE, Tarbit MH. The emerging importance of predictive ADME simulation in drug discovery. Drug Discov Today 2002;7(2):109-116
    • (2002) Drug Discov Today , vol.7 , Issue.2 , pp. 109-116
    • Beresford, A.P.1    Selick, H.E.2    Tarbit, M.H.3
  • 2
    • 35548954739 scopus 로고    scopus 로고
    • Improving early drug discovery through ADME modelling: An overview
    • Wishart DS. Improving early drug discovery through ADME modelling: an overview. Drugs R D 2007;8(6):349-362
    • (2007) Drugs R D , vol.8 , Issue.6 , pp. 349-362
    • Wishart, D.S.1
  • 3
    • 6444234760 scopus 로고    scopus 로고
    • The role of the medicinal chemist in drug discovery - Then and now
    • Lombardino JG, Lowe JA III. The role of the medicinal chemist in drug discovery-then and now. Nat Rev 2004;3(10):853-862
    • (2004) Nat Rev , vol.3 , Issue.10 , pp. 853-862
    • Lombardino, J.G.1    Lowe III, J.A.2
  • 4
    • 0042330313 scopus 로고    scopus 로고
    • ADME-Tox in drug discovery: Integration of experimental and computational technologies
    • Yu H, Adedoyin A. ADME-Tox in drug discovery: integration of experimental and computational technologies. Drug Discov Today 2003;8(18):852-861
    • (2003) Drug Discov Today , vol.8 , Issue.18 , pp. 852-861
    • Yu, H.1    Adedoyin, A.2
  • 5
    • 0037376928 scopus 로고    scopus 로고
    • Pharmaceutical profiling in drug discovery
    • Kerns EH, Di L. Pharmaceutical profiling in drug discovery. Drug Discov Today 2003;8(7):316-323
    • (2003) Drug Discov Today , vol.8 , Issue.7 , pp. 316-323
    • Kerns, E.H.1    Di, L.2
  • 6
    • 0035468033 scopus 로고    scopus 로고
    • Physicochemical profiling (solubility, permeability and charge state)
    • Avdeef A. Physicochemical profiling (solubility, permeability and charge state). Curr Top Med Chem 2001;1(4):277-351
    • (2001) Curr Top Med Chem , vol.1 , Issue.4 , pp. 277-351
    • Avdeef, A.1
  • 7
    • 0037413569 scopus 로고    scopus 로고
    • Surface descriptors for protein-ligand affinity prediction
    • Zamora I, Oprea T, Cruciani G, et al. Surface descriptors for protein-ligand affinity prediction. J Med Chem 2003;46(1):25-33
    • (2003) J Med Chem , vol.46 , Issue.1 , pp. 25-33
    • Zamora, I.1    Oprea, T.2    Cruciani, G.3
  • 8
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs - Barriers and developments
    • Hamman JH, Enslin GM, Kotze AF. Oral delivery of peptide drugs-Barriers and developments. Biodrugs 2005;19(3):165-177
    • (2005) Biodrugs , vol.19 , Issue.3 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 9
    • 0025989573 scopus 로고
    • Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro
    • Samanen J, Ali F, Romoff T, et al. Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J Med Chem 1991;34(10):3114-3125
    • (1991) J Med Chem , vol.34 , Issue.10 , pp. 3114-3125
    • Samanen, J.1    Ali, F.2    Romoff, T.3
  • 10
    • 39749193898 scopus 로고    scopus 로고
    • Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity
    • Hess S, Linde Y, Ovadia O, et al. Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. J Med Chem 2008;51(4):1026-1034
    • (2008) J Med Chem , vol.51 , Issue.4 , pp. 1026-1034
    • Hess, S.1    Linde, Y.2    Ovadia, O.3
  • 11
    • 0020163940 scopus 로고
    • Conformation and biological activity of cyclic peptides
    • Kessler H. Conformation and biological activity of cyclic peptides. Angew Chem Int Ed Engl 1982;21(7):512-523
    • (1982) Angew Chem Int Ed Engl , vol.21 , Issue.7 , pp. 512-523
    • Kessler, H.1
  • 12
    • 0015515460 scopus 로고
    • Preliminary observations on the mechanism of action of somatostatin, a hypothalamic factor inhibiting the secretion of growth hormone
    • Vale W, Brazeau P, Grant G, et al. Preliminary observations on the mechanism of action of somatostatin, a hypothalamic factor inhibiting the secretion of growth hormone. C R Acad Sci Hebd Seances Acad Sci D 1972;275(25):2913-2916
    • (1972) C R Acad Sci Hebd Seances Acad Sci D , vol.275 , Issue.25 , pp. 2913-2916
    • Vale, W.1    Brazeau, P.2    Grant, G.3
  • 13
    • 0346328229 scopus 로고    scopus 로고
    • Opportunities in somatostatin research: Biological, chemical and therapeutic aspects
    • Weckbecker G, Lewis I, Albert R, et al. Opportunities in somatostatin research: biological, chemical and therapeutic aspects. Nat Rev Drug Discov 2003;2(12):999-1017
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.12 , pp. 999-1017
    • Weckbecker, G.1    Lewis, I.2    Albert, R.3
  • 14
    • 0029114410 scopus 로고
    • Molecular biology of somatostatin receptors
    • Reisine T, Bell GI. Molecular biology of somatostatin receptors. Endocr Rev 1995;16(4):427-442
    • (1995) Endocr Rev , vol.16 , Issue.4 , pp. 427-442
    • Reisine, T.1    Bell, G.I.2
  • 15
    • 2442701779 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes: Basic pharmacology and tissue distribution
    • Corleto VD, Nasoni S, Panzuto E, et al. Somatostatin receptor subtypes: basic pharmacology and tissue distribution. Dig Liver Dis 2004;36:S8-16
    • (2004) Dig Liver Dis , vol.36
    • Corleto, V.D.1    Nasoni, S.2    Panzuto, E.3
  • 16
    • 0031610470 scopus 로고    scopus 로고
    • Discovery and development of somatostatin agonists
    • Borchardt RTRMF, Sawyer TK, Smith PL, editors, Plenum Press, Case Histories NY
    • Marbach PB, Bodmer W, Briner D, et al. Discovery and development of somatostatin agonists. In: Borchardt RTRMF, Sawyer TK, Smith PL, editors, Integration of pharmaceutical discovery and development. Plenum Press, Case Histories NY; 1998. p. 183-209
    • (1998) Integration of Pharmaceutical Discovery and Development , pp. 183-209
    • Marbach, P.B.1    Bodmer, W.2    Briner, D.3
  • 17
    • 0028605847 scopus 로고
    • Differential expression of five somatostatin receptor subtypes, SSTR1-5, in the CNS and peripheral tissue
    • Raulf F, Perez J, Hoyer D, et al. Differential expression of five somatostatin receptor subtypes, SSTR1-5, in the CNS and peripheral tissue. Digestion 1994;55(Suppl 3):46-53
    • (1994) Digestion , vol.55 , Issue.SUPPL. 3 , pp. 46-53
    • Raulf, F.1    Perez, J.2    Hoyer, D.3
  • 18
    • 0028955742 scopus 로고
    • Classification and nomenclature of somatostatin receptors
    • Hoyer D, Bell GI, Berelowitz M, et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 1995;16(3):86-88
    • (1995) Trends Pharmacol Sci , vol.16 , Issue.3 , pp. 86-88
    • Hoyer, D.1    Bell, G.I.2    Berelowitz, M.3
  • 20
    • 85011465009 scopus 로고    scopus 로고
    • Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary
    • Mezey E, Hunyady B, Mitra S, et al. Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology 1998;139(1):414-419
    • (1998) Endocrinology , vol.139 , Issue.1 , pp. 414-419
    • Mezey, E.1    Hunyady, B.2    Mitra, S.3
  • 21
    • 0032908805 scopus 로고    scopus 로고
    • Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: A quantitative double-label immunohistochemical analysis
    • Kumar U, Sasi R, Suresh S, et al. Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes 1999;48(1):77-85
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 77-85
    • Kumar, U.1    Sasi, R.2    Suresh, S.3
  • 22
    • 0033304716 scopus 로고    scopus 로고
    • Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic beta-cells
    • Mitra SW, Mezey E, Hunyady B, et al. Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic beta-cells. Endocrinology 1999;140(8):3790-3796
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3790-3796
    • Mitra, S.W.1    Mezey, E.2    Hunyady, B.3
  • 23
    • 0024213731 scopus 로고
    • Oncological applications of somatostatin analogues
    • Schally AV. Oncological applications of somatostatin analogues. Cancer Res 1988;48(24 Pt 1):6977-6985
    • (1988) Cancer Res , vol.48 , Issue.24 PART 1 , pp. 6977-6985
    • Schally, A.V.1
  • 24
    • 0035078132 scopus 로고    scopus 로고
    • Somatostatin analogs for cancer treatment and diagnosis: An overview
    • Scarpignato C, Pelosini I. Somatostatin analogs for cancer treatment and diagnosis: an overview. Chemotherapy 2001;47(Suppl 2):1-29
    • (2001) Chemotherapy , vol.47 , Issue.SUPPL. 2 , pp. 1-29
    • Scarpignato, C.1    Pelosini, I.2
  • 25
    • 0031941299 scopus 로고    scopus 로고
    • Mechanisms of antineoplastic action of somatostatin analogs
    • Pollak MN, Schally AV. Mechanisms of antineoplastic action of somatostatin analogs. Proc Soc Exp Biol Med 1998;217(2):143-152
    • (1998) Proc Soc Exp Biol Med , vol.217 , Issue.2 , pp. 143-152
    • Pollak, M.N.1    Schally, A.V.2
  • 26
    • 0035084694 scopus 로고    scopus 로고
    • Antiproliferative effect of somatostatin and analogs
    • Bousquet C, Puente E, Buscail L, et al. Antiproliferative effect of somatostatin and analogs. Chemotherapy 2001;47(Suppl 2):30-39
    • (2001) Chemotherapy , vol.47 , Issue.SUPPL. 2 , pp. 30-39
    • Bousquet, C.1    Puente, E.2    Buscail, L.3
  • 27
    • 6044276093 scopus 로고    scopus 로고
    • Future aspects of somatostatin-receptor-mediated therapy
    • Oberg K. Future aspects of somatostatin-receptor-mediated therapy. Neuroendocrinology 2004;80(Suppl 1):57-61
    • (2004) Neuroendocrinology , vol.80 , Issue.SUPPL. 1 , pp. 57-61
    • Oberg, K.1
  • 28
    • 0020669339 scopus 로고
    • In vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat
    • Patel YC, Wheatley T. In vivo and in vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat. Endocrinology 1983;112(1):220-225
    • (1983) Endocrinology , vol.112 , Issue.1 , pp. 220-225
    • Patel, Y.C.1    Wheatley, T.2
  • 29
    • 70350324543 scopus 로고    scopus 로고
    • Efficacy of long-term lanreotide treatment in patients with acromegaly
    • Toledano Y, Rot L, Greenman Y, et al. Efficacy of long-term lanreotide treatment in patients with acromegaly. Pituitary 2009;12(4):285-293
    • (2009) Pituitary , vol.12 , Issue.4 , pp. 285-293
    • Toledano, Y.1    Rot, L.2    Greenman, Y.3
  • 30
    • 0007296407 scopus 로고
    • Synthesis and biological-activity of highly potent octapeptide analogs of somatostatin
    • Cai RZ, Szoke B, Lu R, et al. Synthesis and biological-activity of highly potent octapeptide analogs of somatostatin. PNAS 1986;83(6):1896-1900
    • (1986) PNAS , vol.83 , Issue.6 , pp. 1896-1900
    • Cai, R.Z.1    Szoke, B.2    Lu, R.3
  • 31
    • 77953701411 scopus 로고    scopus 로고
    • Receptor gene family -subtype selectivity for ligand binding
    • Srikant CB, editor, Klower Academic Publishers, Boston
    • Hannon JPBCW, Hoyer G, Somatostatin D. Receptor gene family -subtype selectivity for ligand binding. In: Srikant CB, editor, Somatostatin. Klower Academic Publishers, Boston; 2004. p. 87
    • (2004) Somatostatin , pp. 87
    • Jpbcw, H.1    Hoyer, G.2    Somatostatin, D.3
  • 32
    • 0028157119 scopus 로고
    • Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells
    • Hofland LJ, van Koetsveld PM, Waaijers M, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology 1994;134(1):301-306
    • (1994) Endocrinology , vol.134 , Issue.1 , pp. 301-306
    • Hofland, L.J.1    Van Koetsveld, P.M.2    Waaijers, M.3
  • 33
    • 0030690974 scopus 로고    scopus 로고
    • Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors
    • Shimon I, Yan X, Taylor JE, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest 1997;100(9):2386-2392
    • (1997) J Clin Invest , vol.100 , Issue.9 , pp. 2386-2392
    • Shimon, I.1    Yan, X.2    Taylor, J.E.3
  • 34
    • 17744364678 scopus 로고    scopus 로고
    • Novel long-acting somatostatin analog with endocrine selectivity: Potent suppression of growth hormone but not of insulin
    • Afargan M, Janson ET, Gelerman G, et al. Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin. Endocrinology 2001;142(1):477-486
    • (2001) Endocrinology , vol.142 , Issue.1 , pp. 477-486
    • Afargan, M.1    Janson, E.T.2    Gelerman, G.3
  • 35
    • 0029802059 scopus 로고    scopus 로고
    • Drug-induced disorders of glucose metabolism. Mechanisms and management
    • Chan JC, Cockram CS, Critchley JA. Drug-induced disorders of glucose metabolism. Mechanisms and management. Drug Saf 1996;15(2):135-157
    • (1996) Drug Saf , vol.15 , Issue.2 , pp. 135-157
    • Chan, J.C.1    Cockram, C.S.2    Critchley, J.A.3
  • 36
    • 0024989834 scopus 로고
    • Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose
    • Kahn SE, Klaff LJ, Schwartz MW, et al. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J Clin Endocrinol Metab 1990;71(4):994-1002
    • (1990) J Clin Endocrinol Metab , vol.71 , Issue.4 , pp. 994-1002
    • Kahn, S.E.1    Klaff, L.J.2    Schwartz, M.W.3
  • 37
    • 34547607571 scopus 로고    scopus 로고
    • Use of octreotide acetate to prevent rebound hypoglycaemia in sulfonylurea overdose
    • Hassan Z, Wright J. Use of octreotide acetate to prevent rebound hypoglycaemia in sulfonylurea overdose. Emerg Med J 2007;24(8):580-581
    • (2007) Emerg Med J , vol.24 , Issue.8 , pp. 580-581
    • Hassan, Z.1    Wright, J.2
  • 38
    • 0034874242 scopus 로고    scopus 로고
    • Intestinal absorption of octreotide using trimethyl chitosan chloride: Studies in pigs
    • Thanou M, Verhoef JC, Verheijden JHM, et al. Intestinal absorption of octreotide using trimethyl chitosan chloride: studies in pigs. Pharm Res 2001;18(6):823-828
    • (2001) Pharm Res , vol.18 , Issue.6 , pp. 823-828
    • Thanou, M.1    Verhoef, J.C.2    Jhm, V.3
  • 39
    • 0036203977 scopus 로고    scopus 로고
    • Inhibitory effects of octreotide on luminal cholecystokinin-releasing factor, plasma cholecystokinin, and pancreatic secretion in conscious rats
    • Miyasaka K, Masuda M, Kanai S, et al. Inhibitory effects of octreotide on luminal cholecystokinin-releasing factor, plasma cholecystokinin, and pancreatic secretion in conscious rats. Pancreas 2002;24(3):269-275
    • (2002) Pancreas , vol.24 , Issue.3 , pp. 269-275
    • Miyasaka, K.1    Masuda, M.2    Kanai, S.3
  • 40
    • 43549108318 scopus 로고    scopus 로고
    • Selective agonism in somatostatin receptor signaling and regulation
    • Schonbrunn A. Selective agonism in somatostatin receptor signaling and regulation. Mol Cell Endocrinol 2008;286(1-2):35-39
    • (2008) Mol Cell Endocrinol , vol.286 , Issue.1-2 , pp. 35-39
    • Schonbrunn, A.1
  • 41
    • 34249035476 scopus 로고    scopus 로고
    • Novel insights in somatostatin receptor physiology
    • Tulipano G, Schulz S. Novel insights in somatostatin receptor physiology. Eur J Endocrinol 2007;156(Suppl 1):S3-11
    • (2007) Eur J Endocrinol , vol.156 , Issue.SUPPL. 1
    • Tulipano, G.1    Schulz, S.2
  • 42
    • 35649005900 scopus 로고    scopus 로고
    • Vasculoprotective effects of somatostatin receptor subtypes
    • Tigerstedt NM, Aavik E, Aavik S, et al. Vasculoprotective effects of somatostatin receptor subtypes. Mol Cell Endocrinol 2007;279(1-2):34-38
    • (2007) Mol Cell Endocrinol , vol.279 , Issue.1-2 , pp. 34-38
    • Tigerstedt, N.M.1    Aavik, E.2    Aavik, S.3
  • 43
    • 13944277784 scopus 로고    scopus 로고
    • Somatostatin analogs - From new molecules to new applications
    • Pawlikowski M, Melen-Mucha G. Somatostatin analogs- from new molecules to new applications. Curr Opin Pharmacol 2004;4(6):608-613
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.6 , pp. 608-613
    • Pawlikowski, M.1    Melen-Mucha, G.2
  • 44
    • 33751001270 scopus 로고    scopus 로고
    • Rationale for the use of somatostatin analogs as antitumor agents
    • Susini C, Buscail L. Rationale for the use of somatostatin analogs as antitumor agents. Ann Oncol 2006;17(12):1733-1742
    • (2006) Ann Oncol , vol.17 , Issue.12 , pp. 1733-1742
    • Susini, C.1    Buscail, L.2
  • 45
    • 3442880408 scopus 로고    scopus 로고
    • Differential expression of somatostatin receptor subtypes in hepatocellular carcinomas
    • Blaker M, Schmitz M, Gocht A, et al. Differential expression of somatostatin receptor subtypes in hepatocellular carcinomas. J Hepatol 2004;41(1):112-118
    • (2004) J Hepatol , vol.41 , Issue.1 , pp. 112-118
    • Blaker, M.1    Schmitz, M.2    Gocht, A.3
  • 46
    • 57349195981 scopus 로고    scopus 로고
    • Peptide-based probes for cancer imaging
    • Reubi JC, Maecke HR. Peptide-based probes for cancer imaging. J Nucl Med 2008;49(11):1735-1738
    • (2008) J Nucl Med , vol.49 , Issue.11 , pp. 1735-1738
    • Reubi, J.C.1    Maecke, H.R.2
  • 47
    • 0027513823 scopus 로고
    • Effect of octreotide on gall stone prevalence and gall-bladder motility in acromegaly
    • Catnach SM, Anderson JV, Fairclough PD, et al. Effect of octreotide on gall stone prevalence and gall-bladder motility in acromegaly. Gut 1993;34(2):270-273
    • (1993) Gut , vol.34 , Issue.2 , pp. 270-273
    • Catnach, S.M.1    Anderson, J.V.2    Fairclough, P.D.3
  • 48
    • 0021855165 scopus 로고
    • Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes
    • Ziegler K, Frimmer M, Kessler H, et al. Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes. Biochim Biophys Acta 1985;845(1):86-93
    • (1985) Biochim Biophys Acta , vol.845 , Issue.1 , pp. 86-93
    • Ziegler, K.1    Frimmer, M.2    Kessler, H.3
  • 49
    • 0023698942 scopus 로고
    • Azidobenzamido-008, a new photosensitive substrate for the 'multispecific bile acid transporter' of hepatocytes: Evidence for a common transport system for bile acids and cyclosomatostatins in basolateral membranes
    • Ziegler K, Frimmer M, Kessler H, et al. Azidobenzamido-008, a new photosensitive substrate for the 'multispecific bile acid transporter' of hepatocytes: evidence for a common transport system for bile acids and cyclosomatostatins in basolateral membranes. Biochim Biophys Acta 1988;945(2):263-272
    • (1988) Biochim Biophys Acta , vol.945 , Issue.2 , pp. 263-272
    • Ziegler, K.1    Frimmer, M.2    Kessler, H.3
  • 50
    • 0022809930 scopus 로고
    • Conformational prerequisites for the in vitro inhibition of cholate uptake in hepatocytes by cyclic analogs of antamanide and somatostatin
    • Kessler H, Klein M, Muller A, et al. Conformational prerequisites for the in vitro inhibition of cholate uptake in hepatocytes by cyclic analogs of antamanide and somatostatin. Angew Chem Int Ed Engl 1986;25(11):997-999
    • (1986) Angew Chem Int Ed Engl , vol.25 , Issue.11 , pp. 997-999
    • Kessler, H.1    Klein, M.2    Muller, A.3
  • 51
    • 0030870702 scopus 로고    scopus 로고
    • Evidence for octreotide subcutaneously in the treatment of acromegaly
    • Liuzzi A, Oppizzi G. Evidence for octreotide subcutaneously in the treatment of acromegaly. J Endocrinol 1997;155(Suppl 1):S61-5
    • (1997) J Endocrinol , vol.155 , Issue.SUPPL. 1
    • Liuzzi, A.1    Oppizzi, G.2
  • 52
    • 0033535079 scopus 로고    scopus 로고
    • Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization
    • Pasternak A, Pan YP, Marino D, et al. Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 1999;9(3):491-496
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.3 , pp. 491-496
    • Pasternak, A.1    Pan, Y.P.2    Marino, D.3
  • 53
    • 46749086605 scopus 로고    scopus 로고
    • Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors
    • Wolkenberg SE, Thut CJ. Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors. Curr Opin Drug Discov Dev 2008;11(4):446-457
    • (2008) Curr Opin Drug Discov Dev , vol.11 , Issue.4 , pp. 446-457
    • Wolkenberg, S.E.1    Thut, C.J.2
  • 54
    • 0032561511 scopus 로고    scopus 로고
    • Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry
    • Rohrer SP, Birzin ET, Mosley RT, et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 1998;282(5389):737-740
    • (1998) Science , vol.282 , Issue.5389 , pp. 737-740
    • Rohrer, S.P.1    Birzin, E.T.2    Mosley, R.T.3
  • 55
    • 65649136518 scopus 로고    scopus 로고
    • Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst(1)) selective analogues
    • Erchegyi J, Cescato R, Grace CR, et al. Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst(1)) selective analogues. J Med Chem 2009;52(9):2733-2746
    • (2009) J Med Chem , vol.52 , Issue.9 , pp. 2733-2746
    • Erchegyi, J.1    Cescato, R.2    Grace, C.R.3
  • 56
    • 12344288009 scopus 로고    scopus 로고
    • Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR
    • Grace CR, Durrer L, Koerber SC, et al. Somatostatin receptor 1 selective analogues: 4. Three-dimensional consensus structure by NMR. J Med Chem 2005;48(2):523-533
    • (2005) J Med Chem , vol.48 , Issue.2 , pp. 523-533
    • Grace, C.R.1    Durrer, L.2    Koerber, S.C.3
  • 57
    • 33746674999 scopus 로고    scopus 로고
    • Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR
    • Grace CR, Erchegyi J, Koerber SC, et al. Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem 2006;49(15):4487-4496
    • (2006) J Med Chem , vol.49 , Issue.15 , pp. 4487-4496
    • Grace, C.R.1    Erchegyi, J.2    Koerber, S.C.3
  • 58
    • 58149352876 scopus 로고    scopus 로고
    • Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR
    • Grace CR, Erchegyi J, Reubi JC, et al. Three-dimensional consensus structure of sst2-selective somatostatin (SRIF) antagonists by NMR. Biopolymers 2008;89(12):1077-1087
    • (2008) Biopolymers , vol.89 , Issue.12 , pp. 1077-1087
    • Grace, C.R.1    Erchegyi, J.2    Reubi, J.C.3
  • 59
    • 0345735310 scopus 로고    scopus 로고
    • Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR
    • Grace CRR, Koerber SC, Erchegyi J, et al. Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR. J Med Chem 2003;46(26):5606-5618
    • (2003) J Med Chem , vol.46 , Issue.26 , pp. 5606-5618
    • Crr, G.1    Koerber, S.C.2    Erchegyi, J.3
  • 60
    • 33749271351 scopus 로고
    • Peptoids - A new approach to the development of pharmaceuticals
    • Kessler H. Peptoids-a new approach to the development of pharmaceuticals. Angew Chem Int Ed Engl 1993;32(4):543-544
    • (1993) Angew Chem Int Ed Engl , vol.32 , Issue.4 , pp. 543-544
    • Kessler, H.1
  • 61
    • 0034624210 scopus 로고    scopus 로고
    • Synthesis, biological activities and conformational studies of somatostatin analogs
    • Mattern RH, Moore SB, Tran TA, et al. Synthesis, biological activities and conformational studies of somatostatin analogs. Tetrahedron 2000;56(50):9819-9831
    • (2000) Tetrahedron , vol.56 , Issue.50 , pp. 9819-9831
    • Mattern, R.H.1    Moore, S.B.2    Tran, T.A.3
  • 62
    • 0028033882 scopus 로고
    • Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers
    • Miller SM, Simon RJ, Ng S, et al. Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers. Bioorg Med Chem Lett 1994;4(22):2657-2662
    • (1994) Bioorg Med Chem Lett , vol.4 , Issue.22 , pp. 2657-2662
    • Miller, S.M.1    Simon, R.J.2    Ng, S.3
  • 63
    • 0029059507 scopus 로고
    • Comparison of the proteolytic susceptibilities of homologous L-amino-acid, D-amino-acid, and N-substituted glycine peptide and peptoid oligomers
    • Miller SM, Simon RJ, Ng S, et al. Comparison of the proteolytic susceptibilities of homologous L-amino-acid, D-amino-acid, and N-substituted glycine peptide and peptoid oligomers. Drug Dev Res 1995;35(1):20-32
    • (1995) Drug Dev Res , vol.35 , Issue.1 , pp. 20-32
    • Miller, S.M.1    Simon, R.J.2    Ng, S.3
  • 64
    • 0038440483 scopus 로고    scopus 로고
    • A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential
    • Lewis I, Bauer W, Albert R, et al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem 2003;46(12):2334-2344
    • (2003) J Med Chem , vol.46 , Issue.12 , pp. 2334-2344
    • Lewis, I.1    Bauer, W.2    Albert, R.3
  • 65
    • 0033851469 scopus 로고    scopus 로고
    • Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads
    • Hruby VJ, Balse PM. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Curr Med Chem 2000;7(9):945-970
    • (2000) Curr Med Chem , vol.7 , Issue.9 , pp. 945-970
    • Hruby, V.J.1    Balse, P.M.2
  • 66
    • 68249117645 scopus 로고    scopus 로고
    • Spatial screening for the identification of the bioactive conformation of integrin ligands
    • Peters T, editor, Berlin, . Springer
    • Weide T, Modlinger A, Kessler H. Spatial screening for the identification of the bioactive conformation of integrin ligands. In: Peters T, editor, Bioactive Conformation I. Springer, Berlin; 2007. p. 1-50
    • (2007) Bioactive Conformation i , pp. 1-50
    • Weide, T.1    Modlinger, A.2    Kessler, H.3
  • 67
    • 0020363575 scopus 로고
    • SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action
    • Bauer W, Briner U, Doepfner W, et al. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 1982;31(11):1133-1140
    • (1982) Life Sci , vol.31 , Issue.11 , pp. 1133-1140
    • Bauer, W.1    Briner, U.2    Doepfner, W.3
  • 68
    • 0019862208 scopus 로고
    • A potent cyclic hexapeptide analogue of somatostatin
    • Veber DF, Freidlinger RM, Perlow DS, et al. A potent cyclic hexapeptide analogue of somatostatin. Nature 1981;292(5818):55-58
    • (1981) Nature , vol.292 , Issue.5818 , pp. 55-58
    • Veber, D.F.1    Freidlinger, R.M.2    Perlow, D.S.3
  • 69
    • 42949155714 scopus 로고    scopus 로고
    • Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity
    • Grace CRR, Erchegyi J, Samant M, et al. Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity. J Med Chem 2008;51(9):2676-2681
    • (2008) J Med Chem , vol.51 , Issue.9 , pp. 2676-2681
    • Crr, G.1    Erchegyi, J.2    Samant, M.3
  • 70
    • 0020845060 scopus 로고
    • Peptide conformations 28 Relayed heteronuclear correlation spectroscopy and conformational-analysis of cyclic hexapeptides containing the active sequence of somatostatin
    • Kessler H, Bernd M, Kogler H, et al. Peptide conformations 28. Relayed heteronuclear correlation spectroscopy and conformational-analysis of cyclic hexapeptides containing the active sequence of somatostatin. JACS 1983;105(23):6944-6952
    • (1983) JACS , vol.105 , Issue.23 , pp. 6944-6952
    • Kessler, H.1    Bernd, M.2    Kogler, H.3
  • 71
    • 0038808747 scopus 로고    scopus 로고
    • Conformation of cyclic peptides.Principle concepts and the design of selectivity and superactivity in bioactive sequences by 'spatial screening
    • Kessler H, Gratias R, Hessler G, et al. Conformation of cyclic peptides. Principle concepts and the design of selectivity and superactivity in bioactive sequences by 'spatial screening'. Pure Appl Chem 1996;68(6):1201-1205
    • (1996) Pure Appl Chem , vol.68 , Issue.6 , pp. 1201-1205
    • Kessler, H.1    Gratias, R.2    Hessler, G.3
  • 72
    • 0025880146 scopus 로고
    • Arg-Gly-Asp constrained within cyclic pentapeptides - Strong and selective inhibitors of cell-adhesion to vitronectin and laminin fragment-P1
    • Aumailley M, Gurrath M, Muller G, et al. Arg-Gly-Asp constrained within cyclic pentapeptides-strong and selective inhibitors of cell-adhesion to vitronectin and laminin fragment-P1. FEBS Lett 1991;291(1):50-54
    • (1991) FEBS Lett , vol.291 , Issue.1 , pp. 50-54
    • Aumailley, M.1    Gurrath, M.2    Muller, G.3
  • 73
    • 0030768536 scopus 로고    scopus 로고
    • Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the alpha(V)beta(3) integrin for a new cancer therapy
    • Haubner R, Finsinger D, Kessler H. Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the alpha(V)beta(3) integrin for a new cancer therapy. Angew Chem Int Ed Engl 1997;36(13-14):1375- 1389
    • (1997) Angew Chem Int Ed Engl , vol.36 , Issue.13-14 , pp. 1375-1389
    • Haubner, R.1    Finsinger, D.2    Kessler, H.3
  • 74
    • 0033549864 scopus 로고    scopus 로고
    • N-methylated cyclic RGD peptides as highly active and selective alpha(v)beta3) integrin antagonists
    • Dechantsreiter MA, Planker E, Matha B, et al. N-methylated cyclic RGD peptides as highly active and selective alpha(v)beta (3) integrin antagonists. J Med Chem 1999;42(16):3033-3040
    • (1999) J Med Chem , vol.42 , Issue.16 , pp. 3033-3040
    • Dechantsreiter, M.A.1    Planker, E.2    Matha, B.3
  • 75
    • 0026155124 scopus 로고
    • Backbone cyclization: A new method for conferring conformational constraint on peptides
    • Gilon C, Halle D, Chorev M, et al. Backbone cyclization: a new method for conferring conformational constraint on peptides. Biopolymers 1991;31(6):745-750
    • (1991) Biopolymers , vol.31 , Issue.6 , pp. 745-750
    • Gilon, C.1    Halle, D.2    Chorev, M.3
  • 76
    • 0034888722 scopus 로고    scopus 로고
    • Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide chemistry
    • Gellerman G, Elgavi A, Salitra Y, et al. Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide chemistry. J Pept Res 2001;57(4):277-291
    • (2001) J Pept Res , vol.57 , Issue.4 , pp. 277-291
    • Gellerman, G.1    Elgavi, A.2    Salitra, Y.3
  • 77
    • 0031038621 scopus 로고    scopus 로고
    • Building units for N-backbone cyclic peptides. 3. Synthesis of protected N (alpha)-(omega-Aminoalkyl)amino acids and N(alpha)-(omega-Carboxyalkyl) amino Acids
    • Muller D, Zeltser I, Bitan G, et al. Building units for N-backbone cyclic peptides. 3. Synthesis of protected N (alpha)-(omega-Aminoalkyl)amino acids and N(alpha)-(omega-Carboxyalkyl) amino Acids. J Org Chem 1997;62(2):411-416
    • (1997) J Org Chem , vol.62 , Issue.2 , pp. 411-416
    • Muller, D.1    Zeltser, I.2    Bitan, G.3
  • 78
    • 0035718972 scopus 로고    scopus 로고
    • Synthesis of novel protected Nalpha (omega-thioalkyl) amino acid building units and their incorporation in backbone cyclic disulfide and thioetheric bridged peptides
    • Gazal S, Gellerman G, Glukhov E, et al. Synthesis of novel protected Nalpha (omega-thioalkyl) amino acid building units and their incorporation in backbone cyclic disulfide and thioetheric bridged peptides. J Pept Res 2001;58(6):527-539
    • (2001) J Pept Res , vol.58 , Issue.6 , pp. 527-539
    • Gazal, S.1    Gellerman, G.2    Glukhov, E.3
  • 79
    • 0033041516 scopus 로고    scopus 로고
    • In situ generation of Fmoc-amino acid chlorides using bis-(trichloromethyl) carbonate and its utilization for difficult couplings in solid-phase peptide synthesis
    • Falb E, Yechezkel T, Salitra Y, et al. In situ generation of Fmoc-amino acid chlorides using bis-(trichloromethyl) carbonate and its utilization for difficult couplings in solid-phase peptide synthesis. J Pept Res 1999;53(5):507-517
    • (1999) J Pept Res , vol.53 , Issue.5 , pp. 507-517
    • Falb, E.1    Yechezkel, T.2    Salitra, Y.3
  • 80
    • 0033578941 scopus 로고    scopus 로고
    • Miniaturized proteins: The backbone cyclic proteinomimetic approach
    • Kasher R, Oren DA, Barda Y, et al. Miniaturized proteins: the backbone cyclic proteinomimetic approach. J Mol Biol 1999;292(2):421-429
    • (1999) J Mol Biol , vol.292 , Issue.2 , pp. 421-429
    • Kasher, R.1    Oren, D.A.2    Barda, Y.3
  • 81
    • 0029742789 scopus 로고    scopus 로고
    • Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P
    • Byk G, Halle D, Zeltser I, et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem 1996;39(16):3174-3178
    • (1996) J Med Chem , vol.39 , Issue.16 , pp. 3174-3178
    • Byk, G.1    Halle, D.2    Zeltser, I.3
  • 82
    • 37848999397 scopus 로고    scopus 로고
    • Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability
    • Hess S, Ovadia O, Shalev DE, et al. Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. J Med Chem 2007;50(24):6201-6211
    • (2007) J Med Chem , vol.50 , Issue.24 , pp. 6201-6211
    • Hess, S.1    Ovadia, O.2    Shalev, D.E.3
  • 83
    • 15644375594 scopus 로고    scopus 로고
    • A backbone-cyclic, receptor 5-selective somatostatin analogue: Synthesis, bioactivity, and nuclear magnetic resonance conformational analysis
    • Gilon C, Huenges M, Matha B, et al. A backbone-cyclic, receptor 5-selective somatostatin analogue: synthesis, bioactivity, and nuclear magnetic resonance conformational analysis. J Med Chem 1998;41(6):919-929
    • (1998) J Med Chem , vol.41 , Issue.6 , pp. 919-929
    • Gilon, C.1    Huenges, M.2    Matha, B.3
  • 84
    • 18044405028 scopus 로고    scopus 로고
    • A bicyclic and hsst2 selective somatostatin analogue: Design, synthesis, conformational analysis and binding
    • Falb E, Salitra Y, Yechezkel T, et al. A bicyclic and hsst2 selective somatostatin analogue: design, synthesis, conformational analysis and binding. Bioorg Med Chem 2001;9(12):3255-3264
    • (2001) Bioorg Med Chem , vol.9 , Issue.12 , pp. 3255-3264
    • Falb, E.1    Salitra, Y.2    Yechezkel, T.3
  • 85
    • 0037061645 scopus 로고    scopus 로고
    • Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units
    • Gazal S, Gelerman G, Ziv O, et al. Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units. J Med Chem 2002;45(8):1665-1671
    • (2002) J Med Chem , vol.45 , Issue.8 , pp. 1665-1671
    • Gazal, S.1    Gelerman, G.2    Ziv, O.3
  • 86
    • 0347999767 scopus 로고    scopus 로고
    • Synthesis and characterization of octapeptide somatostatin analogues with backbone cyclization: Comparison of different strategies, biological activities and enzymatic stabilities
    • Besser D, Muller B, Kleinwachter P, et al. Synthesis and characterization of octapeptide somatostatin analogues with backbone cyclization: comparison of different strategies, biological activities and enzymatic stabilities. J Prakt Chem 2000;342(6):537-545
    • (2000) J Prakt Chem , vol.342 , Issue.6 , pp. 537-545
    • Besser, D.1    Muller, B.2    Kleinwachter, P.3
  • 87
    • 0031463595 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents
    • Pierson ME, Comstock JM, Simmons RD, et al. Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents. J Med Chem 1997;40(26):4302-4307
    • (1997) J Med Chem , vol.40 , Issue.26 , pp. 4302-4307
    • Pierson, M.E.1    Comstock, J.M.2    Simmons, R.D.3
  • 88
    • 0029877665 scopus 로고    scopus 로고
    • In vitro assessment of oral delivery for hexapeptide endothelin antagonists
    • Stewart BH, Reyner EL, Tse E, et al. In vitro assessment of oral delivery for hexapeptide endothelin antagonists. Life sci 1996;58(12):971-982
    • (1996) Life Sci , vol.58 , Issue.12 , pp. 971-982
    • Stewart, B.H.1    Reyner, E.L.2    Tse, E.3
  • 89
    • 57349171593 scopus 로고    scopus 로고
    • N-methylation of peptides: A new perspective in medicinal chemistry
    • Chatterjee J, Gilon C, Hoffman A, et al. N-methylation of peptides: a new perspective in medicinal chemistry. Acc Chem Res 2008;41(10):1331-1342
    • (2008) Acc Chem Res , vol.41 , Issue.10 , pp. 1331-1342
    • Chatterjee, J.1    Gilon, C.2    Hoffman, A.3
  • 90
    • 0035953312 scopus 로고    scopus 로고
    • N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity
    • Rajeswaran WG, Hocart SJ, Murphy WA, et al. N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity. J Med Chem 2001;44(9):1416-1421
    • (2001) J Med Chem , vol.44 , Issue.9 , pp. 1416-1421
    • Rajeswaran, W.G.1    Hocart, S.J.2    Murphy, W.A.3
  • 91
    • 0030936620 scopus 로고    scopus 로고
    • Site-selective N-methylation of peptides on solid support
    • Miller SC, Scanlan TS. Site-selective N-methylation of peptides on solid support. JACS 1997;119(9):2301-2302
    • (1997) JACS , vol.119 , Issue.9 , pp. 2301-2302
    • Miller, S.C.1    Scanlan, T.S.2
  • 92
    • 33644799946 scopus 로고    scopus 로고
    • Optimized selective N-methylation of peptides on solid support
    • Biron E, Chatterjee J, Kessler H. Optimized selective N-methylation of peptides on solid support. J Pept Sci 2006;12(3):213-219
    • (2006) J Pept Sci , vol.12 , Issue.3 , pp. 213-219
    • Biron, E.1    Chatterjee, J.2    Kessler, H.3
  • 93
    • 0024412409 scopus 로고
    • Blood-pressure reduction in hypertensive-diabetic rats by the somatostatin analog Mk-678
    • Hartmann J, Szemplinski M, Chen SL, et al. Blood-pressure reduction in hypertensive-diabetic rats by the somatostatin analog Mk-678. Life Sci 1989;45(3):267-274
    • (1989) Life Sci , vol.45 , Issue.3 , pp. 267-274
    • Hartmann, J.1    Szemplinski, M.2    Chen, S.L.3
  • 94
    • 41949086504 scopus 로고    scopus 로고
    • Improving oral bioavailability of peptides by multiple N-methylation: Somatostatin analogues
    • Biron E, Chatterjee J, Ovadia O, et al. Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. Angew Chem Int Ed Engl 2008;47(14):2595-2599
    • (2008) Angew Chem Int Ed Engl , vol.47 , Issue.14 , pp. 2595-2599
    • Biron, E.1    Chatterjee, J.2    Ovadia, O.3
  • 95
    • 0036282611 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormonestimulated adrenocorticotropin secretion from AtT-20 cells
    • Strowski MZ, Dashkevicz MP, Parmar RM, et al. Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormonestimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 2002;75(6):339-346
    • (2002) Neuroendocrinology , vol.75 , Issue.6 , pp. 339-346
    • Strowski, M.Z.1    Dashkevicz, M.P.2    Parmar, R.M.3
  • 96
    • 0036216889 scopus 로고    scopus 로고
    • Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment
    • Tulipano G, Soldi D, Bagnasco M, et al. Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology 2002;143(4):1218-1224
    • (2002) Endocrinology , vol.143 , Issue.4 , pp. 1218-1224
    • Tulipano, G.1    Soldi, D.2    Bagnasco, M.3
  • 97
    • 0033600778 scopus 로고    scopus 로고
    • Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells
    • Parmar RM, Chan WW, Dashkevicz M, et al. Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells. Biochem Biophys Res Commun 1999;263(2):276-280
    • (1999) Biochem Biophys Res Commun , vol.263 , Issue.2 , pp. 276-280
    • Parmar, R.M.1    Chan, W.W.2    Dashkevicz, M.3
  • 98
    • 33845480306 scopus 로고    scopus 로고
    • Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues
    • Ludvigsen E, Stridsberg M, Taylor JE, et al. Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues. Regul Pept 2007;138(1):1-9
    • (2007) Regul Pept , vol.138 , Issue.1 , pp. 1-9
    • Ludvigsen, E.1    Stridsberg, M.2    Taylor, J.E.3
  • 99
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-protein-coupled receptors
    • Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature 2009;459(7245):356-363
    • (2009) Nature , vol.459 , Issue.7245 , pp. 356-363
    • Rosenbaum, D.M.1    Rasmussen, S.G.2    Kobilka, B.K.3
  • 100
    • 69249206623 scopus 로고    scopus 로고
    • G protein-coupled receptor hetero-dimerization: Contribution to pharmacology and function
    • Milligan G. G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol 2009;158(1):5-14
    • (2009) Br J Pharmacol , vol.158 , Issue.1 , pp. 5-14
    • Milligan, G.1
  • 101
    • 43749115484 scopus 로고    scopus 로고
    • Dimerization of G protein-coupled receptors: New avenues for somatostatin receptor signalling, control and functioning
    • Duran-Prado M, Malagon MM, Gracia-Navarro F, et al. Dimerization of G protein-coupled receptors: new avenues for somatostatin receptor signalling, control and functioning. Mol Cell Endocrinol 2008;286(1-2):63-68
    • (2008) Mol Cell Endocrinol , vol.286 , Issue.1-2 , pp. 63-68
    • Duran-Prado, M.1    Malagon, M.M.2    Gracia-Navarro, F.3
  • 102
    • 0036780743 scopus 로고    scopus 로고
    • G-protein-coupled receptor oligomerization and its potential for drug discovery
    • George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev 2002;1(10):808-820
    • (2002) Nat Rev , vol.1 , Issue.10 , pp. 808-820
    • George, S.R.1    O'Dowd, B.F.2    Lee, S.P.3
  • 103
    • 0035958027 scopus 로고    scopus 로고
    • Homo- and heterodimerization of somatostatin receptor subtypes - Inactivation of sst(3) receptor function by heterodimerization with sst(2A)
    • Pfeiffer M, Koch T, Schroder H, et al. Homo- and heterodimerization of somatostatin receptor subtypes - Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem 2001;276(17):14027-14036
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 14027-14036
    • Pfeiffer, M.1    Koch, T.2    Schroder, H.3
  • 104
    • 34250019669 scopus 로고    scopus 로고
    • Industrial applications of solid-phase peptide synthesis - A status report
    • Verlander M. Industrial applications of solid-phase peptide synthesis - A status report. Int J Pept Res Ther 2007;13(1-2):75-82
    • (2007) Int J Pept Res Ther , vol.13 , Issue.1-2 , pp. 75-82
    • Verlander, M.1
  • 105
    • 66349097253 scopus 로고    scopus 로고
    • Opportunities and challenges of developing peptide drugs in the pharmaceutical industry
    • Danho W, Swistok J, Khan W, et al. Opportunities and challenges of developing peptide drugs in the pharmaceutical industry. Adv Exp Med Biol 2009;611:467-469
    • (2009) Adv Exp Med Biol , vol.611 , pp. 467-469
    • Danho, W.1    Swistok, J.2    Khan, W.3
  • 108
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001;46(1-3):3-26
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3
  • 109
    • 0037030653 scopus 로고    scopus 로고
    • Molecular properties that influence the oral bioavailability of drug candidates
    • Veber DF, Johnson SR, Cheng HY, et al. Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem 2002;45(12):2615-2623
    • (2002) J Med Chem , vol.45 , Issue.12 , pp. 2615-2623
    • Veber, D.F.1    Johnson, S.R.2    Cheng, H.Y.3
  • 110
    • 0025887582 scopus 로고
    • Factors influencing the pharmacokinetics of cyclosporine in man
    • Lindholm A. Factors influencing the pharmacokinetics of cyclosporine in man. Ther Drug Monit 1991;13(6):465-477
    • (1991) Ther Drug Monit , vol.13 , Issue.6 , pp. 465-477
    • Lindholm, A.1
  • 111
    • 0021923153 scopus 로고
    • Peptide conformations 31. The conformation of cyclosporin - A in the crystal and in solution
    • Loosli HR, Kessler H, Oschkinat H, et al. Peptide conformations 31. The conformation of cyclosporin-a in the crystal and in solution. Helvetica Chim Acta 1985;68(3):682-704
    • (1985) Helvetica Chim Acta , vol.68 , Issue.3 , pp. 682-704
    • Loosli, H.R.1    Kessler, H.2    Oschkinat, H.3
  • 112
    • 20844455294 scopus 로고    scopus 로고
    • Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis
    • Biron E, Kessler H. Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis. J Org Chem 2005;70(13):5183-5189
    • (2005) J Org Chem , vol.70 , Issue.13 , pp. 5183-5189
    • Biron, E.1    Kessler, H.2
  • 113
    • 66349097560 scopus 로고    scopus 로고
    • Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation
    • Chatterjee J, Ovadia O, Zahn G, et al. Highly selective cyclic hexapeptides antagonist of GPIIb-IIIa by multiple N-methylation. Adv Exp Med Biol 2009;611:209-210
    • (2009) Adv Exp Med Biol , vol.611 , pp. 209-210
    • Chatterjee, J.1    Ovadia, O.2    Zahn, G.3
  • 114
    • 77949761682 scopus 로고    scopus 로고
    • Novel method for the synthesis of urea backbone cyclic peptides using new Alloc protected glycine building units
    • Hurevich MT-G, Klein Y, Barda S, et al. Novel method for the synthesis of urea backbone cyclic peptides using new Alloc protected glycine building units. J Pept Sci 2010;16(4):178-185
    • (2010) J Pept Sci , vol.16 , Issue.4 , pp. 178-185
    • Mt-G, H.1    Klein, Y.2    Barda, S.3
  • 115
    • 0036199061 scopus 로고    scopus 로고
    • Drug design at peptide receptors - Somatostatin receptor ligands
    • Hannon JP, Nunn C, Stolz B, et al. Drug design at peptide receptors - Somatostatin receptor ligands. J Mol Neurosci 2002;18(1-2):15-27
    • (2002) J Mol Neurosci , vol.18 , Issue.1-2 , pp. 15-27
    • Hannon, J.P.1    Nunn, C.2    Stolz, B.3
  • 116
    • 0028020115 scopus 로고
    • Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5)
    • Patel YC, Srikant CB. Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 1994;135(6):2814-2817
    • (1994) Endocrinology , vol.135 , Issue.6 , pp. 2814-2817
    • Patel, Y.C.1    Srikant, C.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.