In situ generation of Fmoc-amino acid chlorides using bis- (trichloromethyl)carbonate and its utilization for difficult couplings in solid-phase peptide synthesis

Journal of Peptide Research

Volumn 53, Issue 5, 1999, Pages 507-517

  Falb, E ^a   Yechezkel, T ^a   Salitra, Y ^a   Gilon, Chaim ^b  

^a Peptor Ltd   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Acid chlorides; Backbone cyclic peptides; Bis (trichloromethyl)carbonate; Difficult couplings; N alkylated amino acids; Solid phase peptide synthesis

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; AMINO ACID DERIVATIVE; CARBONIC ACID; CHLOROFORM;

ARTICLE; CONFORMATIONAL TRANSITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ALKYLATION; AMINO ACIDS; CARBOXYLIC ACIDS; CHLORIDES; FLUORENES; PEPTIDES, CYCLIC; PHOSGENE;

EID: 0033041516     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00049.x     Document Type: Article

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