Selective agonism in somatostatin receptor signaling and regulation

Molecular and Cellular Endocrinology

Volumn 286, Issue 1-2, 2008, Pages 35-39

  Schonbrunn, Agnes ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Biased agonism; Receptor desensitization; Receptor internalization; Receptor signaling; Somatostatin analogs; Somatostatin receptors; Stimulus trafficking

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PERTUSSIS TOXIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR;

ARTICLE; CELL SURFACE; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG RECEPTOR BINDING; ENDOCYTOSIS; HORMONE BINDING; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY;

EID: 43549108318     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.09.009     Document Type: Article

References (44)

1. S. Arena A. Pattarozzi A. Massa J.P. Esteve R. Iuliano A. Fusco C. Susini T. Florio An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase{eta} Mol. Endocrinol. 21 2007 229 246
2. V. Beaumont M.B. Hepworth J.S. Luty E. Kelly G. Henderson Somatostatin receptor desensitization in NG108-15 cells. A consequence of receptor sequestration J. Biol. Chem. 273 1998 33174 33183
3. C. Bousquet Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway EMBO J. 25 2006 3943 3954
4. S. Brasselet S. Guillen J.P. Vincent J. Mazella beta-Arrestin is involved in the desensitization but not in the internalization of the somatostatin receptor 2A expressed in CHO cells FEBS Lett. 516 2002 124 128
5. R. Cescato Internalization of sst2, sst3 and sst5 receptors: effects of somatostatin agonists and antagonists J. Nucl. Med. 47 2006 502 511
6. Z. Csaba P. Dournaud Cellular biology of somatostatin receptors Neuropeptides 35 2001 1 23
7. S.M. Dewire S. Ahn R.J. Lefkowitz S.K. Shenoy beta-Arrestins and cell signaling Ann. Rev. Physiol. 69 2007 483 510
8. G. Elberg R.W. Hipkin A. Schonbrunn Homologous and heterologous regulation of somatostatin receptor 2 Mol. Endocrinol. 16 2002 2502 2514
9. M. Engstrom J.M. Savola S. Wurster Differential efficacies of somatostatin receptor agonists for G-protein activation and desensitization of somatostatin receptor subtype 4-mediated responses J. Pharmacol. Exp. Ther. 316 2006 1262 1268
10. G. Ferjoux Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation Mol. Biol. Cell. 14 2003 3911 3928
11. S. Galandrin G. Oligny-Longpre M. Bouvier The evasive nature of drug efficacy: implications for drug discovery Trends Pharmacol. Sci. 28 2007 423 430
12. R.W. Hipkin J. Friedman R.B. Clark C.M. Eppler A. Schonbrunn Agonist-induced desensitization, internalization, and phosphorylation of the sst2a somatostatin receptor J. Biolog. Chem. 272 1997 13869 13876
13. N.D. Holliday I.R. Tough H.M. Cox A functional comparison of recombinant and native somatostatin sst(2) receptor variants in epithelia Br. J. Pharmacol. 152 2007 132 140
14. C. Hou R.L. Gilbert D.L. Barber Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2 J. Biolog. Chem. 269 1994 10357 10362
15. V.C. Jordan SERMs: meeting the promise of multifunctional medicines J. Natl. Cancer Inst. 99 2007 350 356
16. T. Kenakin Principles: receptor theory in pharmacology Trends Pharmacol. Sci. 25 2004 186 192
17. K. Komatsuzaki K. Terashita T.B. Kinane I. Nishimoto Somatostatin type V receptor activates c-Jun N-terminal kinases via Galpha(12) family G proteins Biochem. Biophys. Res. Commun. 289 2001 1211 1217
18. O.J. Kreuzer B. Krisch O. Dery N.W. Bunnett W. Meyerhof Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles J. Neuroendocrinol. 13 2001 279 287
19. H. Lahlou J. Guillermet M. Hortala F. Vernejoul S. Pyronnet C. Bousquet C. Susini Molecular signaling of somatostatin receptors Ann. NY. Acad. Sci. 1014 2004 121 131
20. X. Lin T.A. Voynoyasenetskaya R. Hooley C.Y. Lin J. Orlowski D.L. Barber G-alpha-12 differentially regulates Na+ to H+ exchanger isoforms J. Biolog. Chem. 271 1996 22604 22610
21. A.M. Liu Y.H. Wong Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src J. Biol. Chem. 280 2005 34617 34625
22. Q. Liu R. Cescato D.A. Dewi J. Rivier J.C. Reubi A. Schonbrunn Receptor signaling and endocytosis are differentially regulated by somatostatin analogs Mol. Pharmacol. 68 2005 90 101
23. Q. Liu A. Prejusa A. Schonbrunn Agonist induced phosphorylation of the sst1 somatostatin receptor: relationship to desensitization and internalization Proceedings of the 82nd Meeting of the Endocrine Society Toronto, Ontario 2000
24. Q. Liu A. Schonbrunn Agonist-induced phosphorylation of somatostatin receptor subtype 1 (sst1). Relationship to desensitization and internalization J. Biol. Chem. 276 2001 3709 3717
25. F. Lopez J.P. Esteve L. Buscail N. Delesque N. Saintlaurent N. Vaysse C. Susini Molecular mechanisms of antiproliferative effect of somatostatin—involvement of a tyrosine phosphatase Metab.: Clin. Exp. 45 1996 14 16
26. R.B. Mailman GPCR functional selectivity has therapeutic impact Trends Pharmacol. Sci. 28 2007 390 396
27. C.A. Moore S.K. Milano J.L. Benovic Regulation of receptor trafficking by GRKs and arrestins Ann. Rev. Physiol. 69 2007 451 482
28. K.S. Murthy D.H. Coy G.M. Makhlouf Somatostatin receptor-mediated signaling in smooth muscle. Activation of phospholipase C-beta3 by Gbetagamma and inhibition of adenylyl cyclase by Galphai1 and Galphao J. Biol. Chem. 271 1996 23458 23463
29. R.R. Neubig Missing links: mechanisms of protean agonism Mol. Pharmacol. 71 2007 1200 1202
30. G. Olias C. Viollet H. Kusserow J. Epelbaum W. Meyerhof Regulation and function of somatostatin receptors J. Neurochem. 89 2004 1057 1091
31. D.M. Perez S.S. Karnik Multiple signaling states of G-protein-coupled receptors Pharmacol. Rev. 57 2005 147 161
32. E. Reiter R.J. Lefkowitz GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling Trends Endocrinol. Metab. 17 2006 159 165
33. J.C. Reubi K.P. Eisenwiener H. Rink B. Waser H.R. Macke A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors Eur. J. Pharmacol. 456 2002 45 49
34. S.P. Rohrer Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry Science 282 1998 737 740
35. A. Roth H.J. Kreienkamp W. Meyerhof D. Richter Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization J. Biol. Chem. 272 1997 23769 23774
36. A. Schonbrunn Somatostatin receptors W.J. Lennarz M.D. Lane Encyclopedia of Biological Chemistry vol. 4 2004 Elsevier Oxford
37. S. Siehler D. Hoyer Characterisation of human recombinant somatostatin receptors, 2. Modulation of GTPgammaS binding Naunyn Schmiedebergs Arch. Pharmacol. 360 1999 500 509
38. S. Siehler D. Hoyer Characterisation of human recombinant somatostatin receptors, 3. Modulation of adenylate cyclase activity Naunyn Schmiedebergs Arch. Pharmacol. 360 1999 510 521
39. S. Siehler D. Hoyer Characterisation of human recombinant somatostatin receptors, 4. Modulation of phospholipase C activity Naunyn Schmiedebergs Arch. Pharmacol. 360 1999 522 532
40. S. Siehler C. Nunn G.K. Zupanc D. Hoyer Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures Auton. Autacoid. Pharmacol. 25 2005 1 16
41. K.S. Smalley W. Feniuk P.P. Humphrey Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors Br. J. Pharmacol. 125 1998 833 841
42. G. Tulipano R. Stumm M. Pfeiffer H.J. Kreienkamp V. Hollt S. Schulz Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes J. Biol. Chem. 279 2004 21374 21382
43. J.D. Urban Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320 2007 1 13
44. J.D. Violin R.J. Lefkowitz beta-Arrestin-biased ligands at seven-transmembrane receptors Trends Pharmacol. Sci. 28 2007 416 422