메뉴 건너뛰기




Volumn 9, Issue 4, 2010, Pages 303-311

Analysis of HIF-1α and its regulator, PHD2, in retroperitoneal sarcomas: Clinico-pathologic implications

Author keywords

HIF; Hypoxia; Pathology; PHD2; Retroperitoneal sarcoma; Survival

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROLYL HYDROXYLASE DOMAIN PROTEIN 2; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; EGLN1 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE;

EID: 77953586434     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.9.4.10744     Document Type: Article
Times cited : (10)

References (35)
  • 1
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57:1009-14.
    • (2004) J Clin Pathol , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    Van Der Wall, E.2
  • 2
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol 2009; 19:12-6.
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 3
    • 0029088440 scopus 로고
    • Patterns and variability of tumor oxygenation in human soft tissue sarcomas cervical carcinomas and lymph node metastases
    • Brizel DM, Rosner GL, Prosnitz LR, Dewhirst MW. Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas and lymph node metastases. Int J Radiat Oncol Biol Phys 1995; 32:1121-5.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 1121-1125
    • Brizel, D.M.1    Rosner, G.L.2    Prosnitz, L.R.3    Dewhirst, M.W.4
  • 4
    • 0028839715 scopus 로고
    • Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl) acetamide]
    • Koch CJ, Evans SM, Lord EM. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N- (2,2,3,3,3- pentafluoropropyl) acetamide]. Br J Cancer 1995; 72:869-74.
    • (1995) Br J Cancer , vol.72 , pp. 869-874
    • Koch, C.J.1    Evans, S.M.2    Lord, E.M.3
  • 5
  • 7
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 8
    • 40949088476 scopus 로고    scopus 로고
    • Biology of hypoxia-inducible factor-2alpha in development and disease
    • Patel SA, Simon MC. Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ 2008; 15:628-34.
    • (2008) Cell Death Differ , vol.15 , pp. 628-634
    • Patel, S.A.1    Simon, M.C.2
  • 9
    • 0036122242 scopus 로고    scopus 로고
    • Involvement of hypoxia-inducible factor 1 in human cancer
    • Semenza GL. Involvement of hypoxia-inducible factor 1 in human cancer. Intern Med 2002; 41:79-83. (Pubitemid 34223708)
    • (2002) Internal Medicine , vol.41 , Issue.2 , pp. 79-83
    • Semenza, G.L.1
  • 10
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology 2004; 19:176-82.
    • (2004) Physiology , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 12
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
    • DOI 10.1093/emboj/cdg392
    • Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003; 22:4082-90. (Pubitemid 37021737)
    • (2003) EMBO Journal , vol.22 , Issue.16 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 15
    • 1542300383 scopus 로고    scopus 로고
    • The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen
    • DOI 10.1074/jbc.M308862200
    • del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, et al. The von Hippel Lindau/ hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem 2003; 278:48690-5. (Pubitemid 41079509)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.49 , pp. 48690-48695
    • Del Peso, L.1    Castellanos, M.C.2    Temes, E.3    Martin-Puig, S.4    Cuevas, Y.5    Olmos, G.6    Landazuri, M.O.7
  • 16
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • DOI 10.1101/gad.991402
    • Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16:1466-71. (Pubitemid 34686328)
    • (2002) Genes and Development , vol.16 , Issue.12 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 17
    • 0142043003 scopus 로고    scopus 로고
    • Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival
    • DOI 10.1097/01.LAB.0000090156.94795.48
    • Batra S, Perelman N, Luck LR, Shimada H, Malik P. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Lab Invest 2003; 83:1477-87. (Pubitemid 37267831)
    • (2003) Laboratory Investigation , vol.83 , Issue.10 , pp. 1477-1487
    • Batra, S.1    Perelman, N.2    Luck, L.R.3    Shimada, H.4    Malik, P.5
  • 18
    • 0035074474 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and soft tissue sarcomas: Tumor expression correlates with grade
    • DOI 10.1245/aso.2001.8.3.260
    • Chao C, Al-Saleem T, Brooks JJ, Rogatko A, Kraybill WG, Eisenberg B. Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade. Ann Surg Oncol 2001; 8:260-7. (Pubitemid 32294808)
    • (2001) Annals of Surgical Oncology , vol.8 , Issue.3 , pp. 260-267
    • Chao, C.1    Al-Saleem, T.2    Brooks, J.J.3    Rogatko, A.4    Kraybill, W.G.5    Eisenberg, B.6
  • 20
    • 1442326133 scopus 로고    scopus 로고
    • HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma
    • Rathmell WK, Acs G, Simon MC, Vaughn DJ. HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma. Anticancer Res 2004; 24:167-9. (Pubitemid 38279704)
    • (2004) Anticancer Research , vol.24 , Issue.1 , pp. 167-169
    • Rathmell, W.K.1    Acs, G.2    Simon, M.C.3    Vaughn, D.J.4
  • 22
    • 65649138377 scopus 로고    scopus 로고
    • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
    • Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009; 15:527-38.
    • (2009) Cancer Cell , vol.15 , pp. 527-538
    • Chan, D.A.1    Kawahara, T.L.2    Sutphin, P.D.3    Chang, H.Y.4    Chi, J.T.5    Giaccia, A.J.6
  • 23
    • 51049097730 scopus 로고    scopus 로고
    • The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential
    • Lee KA, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 2008; 6:829-42.
    • (2008) Mol Cancer Res , vol.6 , pp. 829-842
    • Lee, K.A.1    Lynd, J.D.2    O'Reilly, S.3    Kiupel, M.4    McCormick, J.J.5    LaPres, J.J.6
  • 24
    • 0037131159 scopus 로고    scopus 로고
    • Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
    • DOI 10.1074/jbc.M206955200
    • Huang J, Zhao Q, Mooney SM, Lee FS. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2 and PHD3. J Biol Chem 2002; 277:39792-800. (Pubitemid 35190963)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39792-39800
    • Huang, J.1    Zhao, Q.2    Mooney, S.M.3    Lee, F.S.4
  • 25
    • 0021329546 scopus 로고
    • The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases
    • Costa J, Wesley RA, Glatstein E, Rosenberg SA. The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases. Cancer 1984; 53:530-41.
    • (1984) Cancer , vol.53 , pp. 530-541
    • Costa, J.1    Wesley, R.A.2    Glatstein, E.3    Rosenberg, S.A.4
  • 26
    • 33344461329 scopus 로고    scopus 로고
    • Anti-Epo receptor antibodies do not predict Epo receptor expression
    • Elliott S, Busse L, Bass MB, Lu H, Sarosi I, Sinclair AM, et al. Anti-Epo receptor antibodies do not predict Epo receptor expression. Blood 2006; 107:1892-5.
    • (2006) Blood , vol.107 , pp. 1892-1895
    • Elliott, S.1    Busse, L.2    Bass, M.B.3    Lu, H.4    Sarosi, I.5    Sinclair, A.M.6
  • 28
    • 28844470450 scopus 로고    scopus 로고
    • Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues
    • DOI 10.1111/j.1365-2559.2005.02280.x
    • Soilleux EJ, Turley H, Tian YM, Pugh CW, Gatter KC, Harris AL. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology 2005; 47:602-10. (Pubitemid 41775183)
    • (2005) Histopathology , vol.47 , Issue.6 , pp. 602-610
    • Soilleux, E.J.1    Turley, H.2    Tian, Y.M.3    Pugh, C.W.4    Gatter, K.C.5    Harris, A.L.6
  • 29
    • 33644781737 scopus 로고    scopus 로고
    • Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness
    • DOI 10.1158/1078-0432.CCR-05-2022
    • Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin Cancer Res 2006; 12:1080-7. (Pubitemid 43342495)
    • (2006) Clinical Cancer Research , vol.12 , Issue.4 , pp. 1080-1087
    • Jokilehto, T.1    Rantanen, K.2    Luukkaa, M.3    Heikkinen, P.4    Grenman, R.5    Minn, H.6    Kronqvist, P.7    Jaakkola, P.M.8
  • 30
    • 33947528891 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Kaelin WG. Von Hippel-Lindau disease. Annu Rev Pathol 2007; 2:145-73.
    • (2007) Annu Rev Pathol , vol.2 , pp. 145-173
    • Kaelin, W.G.1
  • 31
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Oliveira RL, Loges S, Schmidt R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136:839-51.
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    Oliveira, R.L.3    Loges, S.4    Schmidt, R.5
  • 32
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007; 17:71-7.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 33
    • 34248216623 scopus 로고    scopus 로고
    • Phosphoprotein pathway mapping: Akt/ mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
    • Emanuel F, Petricoin I, Espina V, Araujo RP, Midura B, Yeung C, et al. Phosphoprotein pathway mapping: Akt/ mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. Cancer Res 2007; 67:3431-40.
    • (2007) Cancer Res , vol.67 , pp. 3431-3440
    • Emanuel, F.1    Petricoin, I.2    Espina, V.3    Araujo, R.P.4    Midura, B.5    Yeung, C.6
  • 34
    • 39749126103 scopus 로고    scopus 로고
    • Phospho-S6 ribosomal protein: A potential new predictive sarcoma marker for targeted mTOR therapy
    • Iwenofu O, Goodwin D, Staddon A, Haupt H, Brooks J. Phospho-S6 ribosomal protein: a potential new predictive sarcoma marker for targeted mTOR therapy. Mod Pathol 2008; 3:231-7.
    • (2008) Mod Pathol , vol.3 , pp. 231-237
    • Iwenofu, O.1    Goodwin, D.2    Staddon, A.3    Haupt, H.4    Brooks, J.5
  • 35
    • 20544472845 scopus 로고    scopus 로고
    • Targeting metastatic leiomyosarcoma by rapamycin plus gemcitabine: An intriguing clinical observation
    • Merimsky O. Targeting metastatic leiomyosarcoma by rapamycin plus gemcitabine: an intriguing clinical observation. Int J Mol Med 2004; 14:931-5.
    • (2004) Int J Mol Med , vol.14 , pp. 931-935
    • Merimsky, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.