Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas

Anticancer Research

Volumn 25, Issue 5, 2005, Pages 3591-3596

  Pakos, Emilios E ^a   Goussia, Ann C ^a   Tsekeris, Pericles G ^a   Papachristou, Dionysios J ^a   Stefanou, Dimitrios ^a   Agnantis, Niki J ^a  

^a UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

Author keywords

Angiogenesis; Flk 1; MVD; Soft tissue sarcoma; VEGF

Indexed keywords

MONOCLONAL ANTIBODY; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ADULT; ARTICLE; CANCER GRADING; CAPILLARY DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; FEMALE; FIBROSARCOMA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; LIPOSARCOMA; MALE; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SOFT TISSUE SARCOMA; SYNOVIAL SARCOMA;

ADOLESCENT; ADULT; AGED; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; RETROSPECTIVE STUDIES; SARCOMA; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 23344435454     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
2. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
3. Hayes AJ, Mostyn-Jones A, Koban MU, A'Hern R, Burton P and Thomas JM: Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma. Br J Surg 91: 242-247, 2004.
4. Gospodarowicz D, Abraham JA and Schilling J: Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86: 7311-7315, 1989.
5. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS and Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 279: 983-985, 1983.
6. Alon T, Hemo I, Itin A, Pe'er J, Stone J and Keshet E: Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1: 1024-1028, 1995.
7. Benjamin LE and Keshet E: Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA 94: 8761-8766, 1997.
8. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N and Williams LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989-991, 1992.
9. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D and Bohlen P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187: 1579-1586, 1992.
10. Toi M, Hoshina S, Takayanagi T and Tominaga T: Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85: 1045-1049, 1994.
11. Kato H, Yoshikawa M, Miyazaki T, Nakajima M, Fukai Y, Masuda N, Fukuchi M, Manda R, Tsukada K and Kuwano H: Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) in esophageal squamous cell carcinoma. Anticancer Res 22: 3977-3984, 2002.
12. Takanami I, Tanaka F, Hashizume T and Kodaira S: Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma. Anticancer Res 17: 2811-2814, 1997.
13. Maeda K, Chung YS, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, Sawada T and Sowa M: Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77: 858-863, 1996.
14. Neitzel LT, Neitzel CD, Magee KL and Malafa MP: Angiogenesis correlates with metastasis in melanoma. Ann Surg Oncol 6: 70-74, 1999.
15. Dirix LY, Vermeulen P, De Wever I and Van Oosterom AT: Soft tissue sarcoma in adults. Curr Opin Oncol 9: 348-359, 1997.
16. Verheul HM, Hoekman K, Lupu F, Broxterman HJ, van der Valk P, Kakkar AK and Pinedo HM: Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas. Clin Cancer Res 6: 166-171, 2000.
17. Weidner N: Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147: 9-19, 1995.
18. Potti A, Ganti AK, Tendulkar K, Sholes K, Chitajallu S, Koch M and Kargas S: Determination of vascular endothelial growth factor (VEGF) overexpression in soft tissue sarcomas and the role of overexpression in leiomyosarcoma. J Cancer Res Clin Oncol 130: 52-56, 2004.
19. Chao C, Al-Saleem T, Brooks JJ, Rogatko A, Kraybill WG and Eisenberg B: Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade. Ann Surg Oncol 8: 260-267, 2001.
20. Yudoh K, Kanamori M, Ohmori K, Yasuda T, Aoki M and Kimura T: Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas. Br J Cancer 84: 1610-1615, 2001.
21. Potti A, Ganti AK, Foster H, Knox S, Hebert BJ, Tendulkar K, Sholes K, Koch M and Kargas S: Immunohistochemical detection of HER-2/neu, c-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in soft tissue sarcomas. Anticancer Res 24: 333-337, 2004.
22. Kaya M, Wada T, Akatsuka T, Kawaguchi S, Nagoya S, Shindoh M, Higashino F, Mezawa F, Okada F and Ishii S: Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res 6: 572-577, 2000.
23. Ichinoe M, Mikami T, Shiraishi H and Okayasu I: High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. Histopathology 45: 612-618, 2004.
24. Nakasaki T, Wada H, Shigemori C, Miki C, Gabazza EC, Nobori T, Nakamura S and Shiku H: Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Am J Hematol 69: 247-254, 2002.
25. Stefanou D, Goussia AC, Arkoumani E and Agnantis NJ: Expression of vascular endothelial growth factor and the adhesion molecule E-cadherin in non-small cell lung cancer. Anticancer Res 23: 4715-4720, 2003.
26. Strohmeyer D, Strauss F, Rossing C, Roberts C, Kaufmann O, Bartsch G and Effert P: Expression of bFGF, VEGF and c-met and their correlation with microvessel density and progression in prostate carcinoma. Anticancer Res 24: 1797-1804, 2004.
27. Iyoda A, Hiroshima K, Baba M, Fujisawa T, Yusa T and Ohwada H: Expression of vascular endothelial growth factor in thoracic sarcomas. Ann Thorac Surg 71: 1635-1639, 2001.
28. Kawauchi S, Fukuda T and Tsuneyoshi M: Angiogenesis does not correlate with prognosis or expression of vascular endothelial growth factor in synovial sarcomas. Oncol Rep 6: 959-964, 1999.
29. Ruka W, Rutkowski P, Kaminska J, Rysinska A and Steffen J: Alterations of routine blood tests in adult patients with soft tissue sarcomas: relationships to cytokine serum levels and prognostic significance. Ann Oncol 12: 1423-1432, 2001.
30. Yoon SS, Segal NH, Olshen AB, Brennan MF and Singer S: Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma. Ann Oncol 15: 1261-1266, 2004.