GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32d cl3 myeloid cells

Cancer Research

Volumn 56, Issue 14, 1996, Pages 3250-3256

  Friedman, Alan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; DIMERIZATION; DNA DAMAGE; ENHANCER REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA DAMAGE; DNA PRIMERS; DNA-BINDING PROTEINS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; INTERLEUKIN-3; METHYL METHANESULFONATE; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS;

EID: 0029901711     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Fornace, A. J., Jr., Nebert, D. W., Hollander, M. C., Luethy, J. D., Papapthanasiou, M., Fragoli, J., and Holbrook, N. J. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol. Cell Biol., 59: 675-680, 1989.
2. Habener, J. F , and Ron, D CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev., 6: 439-453, 1992.
3. Barone, M. V., Crozat, A. Y., Tabaee, A., Philipson, L., and Ron, D CHOP (GADD153) and its oncogenic variant, TLS-CHOP, differ in their ability to induce G1/S arrest Genes Dev., 8: 453-464, 1994.
4. 0-specific ts mutant cells at nonpermissive temperature. Exp. Cell Res., 217: 324-328, 1995.
5. Ron, D., and Habener, J. F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev , 6: 439-453, 1992.
6. Chen, Q., Yu, K., Holbrook, N. J , and Stevens, J. L. Activation of the growth arrest and DNA-damage inducible gene gadd153 by nephrotoxic cysteine conjugates and dithiothreitol. J. Biol. Chem., 267: 8207-8212, 1992.
7. Carlson, S. G., Fawcett, T. W., Bartlett, J. D., Berneir, M., and Holbrook, N. J Regulation of the C/EBP-related gene gadd153, by glucose deprivation. Mol. Cell Biol., 13: 4736-4744, 1993.
8. Ron, D. Inducible growth arrest: new mechanistic insights. Proc Natl. Acad. Sci. USA, 91: 1985-1986, 1994.
9. Friedman, A. D., Landschulz, W H., and McKnight, S. L. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev., 3: 1314-1322, 1989.
10. Park, E. A , Roesler, W. J., Liu, J. Klemm, D. J., Gurney, A. L , Thatcher, J. D , Shuman, J. D., Friedman, A. D., and Hanson, R. W. The role of CAAT/enhancer binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol. Cell. Biol., 10: 6264-6272, 1990
11. Christy, R J., Yang, V. W , Ntambi, J. M., Geiman, D. E., Landschulz, W. H., Friedman, A. D , Nakabeppu, Y., Kelly, T. J., and Lane, M. D. Differentiation induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev , 3: 1323-1335, 1989
12. Kaestner, K H, Christy, R J., and Lane, M. D. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/ enhancer binding protein. Proc. Natl Acad. Sci. USA, 87: 251-255, 1990.
13. Scott, L. M., Civin, C I., Rorth, P., and Friedman, A. D A novel temporal pattern of three C/EBP family members in differentiating myelomonocytic cells Blood, 80: 1725-1735, 1992.
14. Ness, S. A., Kowenz-Leutz, E , Casini, T. Graf, T., and Leutz, A Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types Genes Dev., 7 749-759, 1993.
15. Nuchprayoon, I., Meyers, S., Scott, L. M., Suzow, J., Hiebert, S , and Friedman, A. D. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol , 14: 5558-5568, 1994.
16. Hohaus, S , Petrovick, M. S , Voso, M. T., Sun, Z., Zhang, D-E., and Tenen, D G. PU 1 (Spi-1) and C/EBPα regulate expression of the granulocyte-macrophage colony stimulating factor receptor a gene Mol Cell. Biol., 15: 5830-5845, 1995.
17. Valtieri, M., Tweardy, D J., Caracciolo, D., Johnson, K , Mavilio, F., Altman, S., Snatoli, D., and Rovera, G. Regulation of proliferative and differentiative responses in a murine progenitor cell line J Immunol., 138: 3829-3835, 1987
18. Umek, R. M., Friedman, A D., and McKnight, S. L CCAAT-enhancer binding protein: a component of a differentiation switch. Science (Washington DC), 251: 288-292, 1991
19. Warner, N. L., Moore, M. A. S., and Metcalf, D. A transplantable myelomonocytic leukemia in Balb/c mice cytology, karyotype and muramidase content J. Natl Cancer Inst , 43: 963-982, 1969.
20. Danos, O , and Mulligan, R. C. Safe and efficient generation of recombinant retro-viruses with amphotropic and ecotropic host ranges. Proc Natl Acad. Sci USA, 85: 6460-6464, 1988
21. Morgenstern, J. P., and Land, H. Advanced mammalian gene transfer: high titre retroviral receptors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res., 18: 3587-3596, 1990.
22. McKnight, S. L , Graves, E. R., Kinsbury, R., and Axel, R. Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene. identification of an upstream control region. Cell, 25: 385-398, 1981.
23. van Zonneveld, A-J., Curriden, S. A., and Loskutoff, D J Type 1 plasminogen inactivator inhibitor gene. functional analysis and glucocorticoid regulation of its promoter Proc. Natl. Acad. Sci. USA, 85: 5525-5529, 1988.
24. Suzow, J., and Friedman, A D. The murine myeloperoxidase promoter contains several functional elements: one element binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNFI) Mol. Cell Biol., 13: 2141-2151, 1993.
25. Askew, D. S , Ashman, R. A., Simmons, B. C., and Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene, 6: 1915-1922, 1991
26. Zhan, Q , Lord, K. A , Alamo, I., Jr., Hollander, M. C., Carrier, F., Ron, D., Kohn, K. W., Hoffman, B., Lieberman, D. A., and Fornace, A. J., Jr. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth Mol. Cell. Biol., 14: 2361-2371, 1994.
27. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
28. Kuerbitz, S J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Cancer Res., 53: 3857-3859, 1992.
29. Clarke, A R., Purdie, C A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wylie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993.
30. Lowe, S. W., Schmitt, S W., Smith, S W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
31. Canman, C. E , Gilmer, T. M., Coutts, S. B., and Kastan, M. B Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev, 9: 600-611, 1995
32. Luethy, J. D., and Holbrook, N. J. Activation of the Gadd153 promoter by genotoxic agents. a rapid and specific response to DNA damage. Cancer Res , 52: 5-10, 1992
33. Sun, X., Shimizu, H., and Yamamoto, K-I. Identification of a novel p53 promoter element involved in genotoxic-inducible p53 gene expression. Mol. Cell. Biol., 15: 4489-4496, 1995.
34. Nelson, W. G., and Kastan, M. B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways Mol. Cell. Biol., 14: 1815-1823, 1994.
35. Aman, P , Ron, D., Mandahl, N , Fioretos, T., Heim, S , Arhenden, K., Willen, H., Rydholm, A , and Mitelman, F. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer, 5: 271-277, 1992.
36. Birkenmeier, E. H., Gwyenn, B., Howard, S., Jerry, J , Gordon, J. I., Landschulz, W. H , and McKnight, S L Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev , 3: 1146-1156, 1989.
37. Sylvester, S. L., Rhys, C. M. J , Luethy-Martindale, J. D , and Holbrook, N. J. Induction of gadd153, a CCAAT/enhancer-binding protein(C/EBP)-related gene, during the acute phase response in rats. J Biol. Chem., 269 20119-20125, 1994.
38. Koeffler, P p53 in hematologic malignancies. Blood, 84 2412-2421, 1994