Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult

Biochemical Pharmacology

Volumn 73, Issue 6, 2007, Pages 782-792

  Yeh, Ting Chun ^a   Chiang, Po Cheng ^a   Li, Tsai Kun ^b   Hsu, Jui Ling ^a   Lin, Chun Jung ^a   Wang, Shih Wei ^b   Peng, Chieh Yu ^b   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Endoplasmic reticulum; Flavonoid; GADD153; Genistein; Hepatocellular carcinoma; Mitochondria

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; CALPAIN; CASPASE 12; CASPASE 2; COMPLEMENTARY DNA; CYCLOSPORIN A; ETOPOSIDE; FLAVONOID; GENISTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; ISOFLAVONE; PROTEIN BAD; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; TROLOX C;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA DAMAGE; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; GENISTEIN; HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; MITOCHONDRIA; MOLECULAR CHAPERONES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP;

EID: 33846879204     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.11.027     Document Type: Article

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