Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity

Carcinogenesis

Volumn 24, Issue 1, 2003, Pages 53-61

  Lin, Yun Wei ^a   Chuang, Show Mei ^a   Yang, Jia Ling ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEAD ACETATE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; EXCISION REPAIR; EXPOSURE; FIBROBLAST; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MAMMAL CELL; MUTAGENICITY; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; RODENT; SIGNAL TRANSDUCTION;

EID: 0037276697     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/24.1.53     Document Type: Article

References (68)

1. IARC (1987) Overall evaluation of carcinogenicity: an updating of IARC monographs. In IARC Monographs on the Evaluation of Carcinogenic Risks to Human, Volumes 1-42, Supplement 7. International Agency for Research on Cancer, Lyon, pp. 230-232.
2. Fu, H. and Boffetta, P. (1995) Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data. Occup. Environ. Med., 52, 73-81.
3. Anttila, A., Heikkila, P., Pukkala, E., Nykyri, E., Kauppinen, T., Hernberg, S. and Hemminki, K. (1995) Excess lung cancer among workers exposed to lead. Scand. J. Work. Environ. Health, 21, 460-469.
4. Steenland, K. and Boffetta, P. (2000) Lead and cancer in humans: where are we now? Am. J. Ind. Med., 38, 295-299.
5. Englyst, V., Lundstrom, N.G., Gerhardsson, L., Rylander, L. and Nordberg, G. (2001) Lung cancer risks among lead smelter workers also exposed to arsenic. Sci. Total Environ., 273, 77-82.
6. Gerber, G.B., Leonard, A. and Jacquet, P. (1980) Toxicity, mutagenicity and teratogenicity of lead. Mutat. Res., 76, 115-141.
7. Goyer, R.A. (1993) Lead toxicity: current concerns. Environ. Health Perspect., 100, 177-187.
8. Oberly, T.J., Piper, C.E. and McDonald, D.S. (1982) Mutagenicity of metal salts in the L5178Y mouse lymphoma assay. J. Toxicol. Environ. Health, 9, 367-376.
9. Zelikoff, J.T., Li, J.H., Hartwig, A., Wang, X.W., Costa, M. and Rossman, T.G. (1988) Genetic toxicology of lead compounds. Carcinogenesis, 9, 1727-1732.
10. Roy, N.K. and Rossman, T.G. (1992) Mutagenesis and comutagenesis by lead compounds. Mutat. Res., 298, 97-103.
11. Ariza, M.E. and Williams, M.V. (1996) Mutagenesis of AS52 cells by low concentrations of lead(II) and mercury(II). Environ. Mol. Mutagen., 27, 30-33.
12. Yang, J.-L., Yeh, S.-C. and Chang, C.-Y. (1996) Lead acetate mutagenicity and mutational spectrum in the hypoxanthine guanine phosphoribo-syltransferase gene of Chinese hamster ovary K1 cells. Mol. Carcinogen., 17, 181-191.
13. Hwua, Y.-S. and Yang, J.-L. (1998) Effect of 3-aminotriazole on anchorage independence and mutagenicity in cadmium- and lead-treated diploid human fibroblasts. Carcinogenesis, 19, 881-888.
14. Hartwig, A., Schlepegrell, R. and Beyersmann, D. (1990) Indirect mechanism of lead-induced genotoxicity in cultured mammalian cells. Mutat. Res., 241, 75-82.
15. 2+ on the solution structure of calf thymus DNA: DNA condensation and denaturation studied by Fourier transform IR difference spectroscopy. Biopolymers, 33, 1819-1827.
16. Yang, J.-L., Wang, L.-C., Chang, C.-Y. and Liu, T.-Y. (1999) Singlet oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate. Environ. Mol. Mutagen., 33, 194-201.
17. Garrington, T.P. and Johnson, G.L. (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell. Biol., 11, 211-218.
18. Kolch, W. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J., 351, 289-305.
19. Whitmarsh, A.J. and Davis, R.J. (2000) A central control for cell growth. Nature, 403, 255-256.
20. Davis, R.J. (2000) Signal transduction by the JNK group of MAP kinases. Cell, 103, 239-252.
21. Chang, L. and Karin, M. (2001) Mammalian MAP kinase signaling cascades. Nature, 410, 37-40.
22. Nebreda, A.R. and Porras, A. (2000) p38 MAP kinases: beyond the stress response. Trends Biochem. Sci., 25, 257-260.
23. Kyriakis, J.M. and Avruch, J. (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev., 81, 807-869.
24. Scheid, M.P. and Woodgett, J.R. (2001) PKB/AKT: functional insights from genetic models. Nature Rev. Mol. Cell. Biol., 2, 760-768.
25. Brazil, D.P. and Hemmings, B.A. (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci., 26, 657-664.
26. Blume-Jensen, P. and Hunter, T. (2001) Oncogenic kinase signalling. Nature, 411, 355-365.
27. Ramesh, G.T., Manna, S.K., Aggarwal, B.B. and Jadhav, A.L. (1999) Lead activates nuclear transcription factor-κB, activator protein-1, and amino-terminal c-Jun kinase in pheochromocytoma cells. Toxicol. Appl. Pharmacol., 155, 280-286.
28. Lu, H., Guizzetti, M. and Costa, L.G. (2002) Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90RSK signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism. J. Pharmacol. Exp. Ther., 300, 818-823.
29. Leal, R.B., Cordova, F.M., Herd, L., Bobrovskaya, L. and Dunkley, P.R. (2002) Lead-stimulated p38MAPK-dependent Hsp27 phosphorylation. Toxicol. Appl. Pharmacol., 178, 44-51.
30. Clarkson, J.M., Mitchell, D.L. and Adair, G.M. (1983) The use of an immunological probe to measure the kinetics of DNA repair in normal and UV-sensitive mammalian cell lines. Mutat. Res., 112, 287-299.
31. MacLeod, M.C., Adair, G. and Humphrey, R.M. (1988) Differential efficiency of mutagenesis at three genetic loci in CHO cells by a benzo[a]pyrene diol epoxide. Mutat. Res., 199, 243-254.
32. Rolig, R.L., Lowery, M.P., Adair, G.M. and Nairn, R.S. (1998) Characterization and analysis of Chinese hamster ovary cell ERCC1 mutant alleles. Mutagenesis, 13, 357-365.
33. Chuang, S.-M., Wang, I-C. and Yang,-J.L. (2000) Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis, 21, 1423-1432.
34. Whalen, A.M., Galasinski, S.C., Shapiro, P.S., Nahreini, T.S. and Ahn, N.G. (1997) Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol. Cell. Biol., 17, 1947-1958.
35. Wood, R.D., Robins, P. and Lindahl, T. (1988) Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell, 53, 97-106.
36. Aboussekhra, A., Biggerstaff, M., Shivji, M.K., Vilpo, J.A., Moncollin, V., Podust, V.N., Protic, M., Hubscher, U., Egly, J.M. and Wood, R.D. (1995) Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell, 80, 859-868.
37. Rommel, C., Clarke, B.A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G.D. and Glass, D.J. (1999) Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science, 286, 1738-1741.
38. Zimmermann, S. and Moelling, K. (1999) Phosphorylation and regulation of Raf by Akt (protein kinase B). Science, 286, 1741-1744.
39. Karin, M., Liu, Z. and Zandi, E. (1997) AP-1 function and regulation. Curr. Opin. Cell. Biol., 9, 240-246.
40. Tulchinsky, E. (2000) Fos family members: regulation, structure and role in oncogenic transformation. Histol. Histopathol., 15, 921-928.
41. Murphy, L.O., Smith, S., Chen, R.H., Fingar, D.C. and Blenis, J. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nature Cell Biol., 4, 556-564.
42. Mody, N., Leitch, J., Armstrong, C., Dixon, J. and Cohen, P. (2001) Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett., 502, 21-24.
43. Suzaki, Y., Yoshizumi, M., Kagami, S., Koyama, A.H., Taketani, Y., Houchi, H., Tsuchiya, K., Takeda, E. and Tamaki, T. (2002) Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J. Biol. Chem., 277, 9614-9621.
44. Friedberg, E.C. (2001) How nucleotide excision repair protects against cancer. Nature Rev. Cancer, 1, 22-33.
45. Hoeijmakers, J.H. (2001) Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-374.
46. Lindahl, T. and Wood, R.D. (1999) Quality control by DNA repair. Science, 286, 1897-1905.
47. Tai, E.C.H. and Lee, T.-C. (1990) Induction of sister chromatid exchanges by lead compounds in Chinese hamster ovary cells. Bull. Inst. Zool. Acad. Sin., 29, 121-125.
48. Lin, R.H., Lee, C.H., Chen, W.K. and Lin-Shiau, S.Y. (1994) Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in Chinese hamster ovary cells. Environ. Mol. Mutagen., 23, 143-149.
49. Lewis, T.S., Hunt, J.B., Aveline, L.D., Jonscher, K.R., Louie, D.F., Yeh, J.M., Nahreini, T.S., Resing, K.A. and Ahn, N.G. (2000) Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol. Cell, 6, 1343-1354.
50. Price, M.A., Cruzalegui, F.H. and Treisman, R. (1996) The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. EMBO J., 15, 6552-6563.
51. Haas, S. and Kaina, B. (1995) c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation. Carcinogenesis, 16, 985-991.
52. Kaina, B., Haas, S. and Kappes, H. (1997) A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs. Cancer Res., 57, 2721-2731.
53. Chao, J.-I. and Yang, J.-L. (2001) Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem. Res. Toxicol., 14, 1193-1202.
54. Abbott, D.W. and Holt, J.T. (1999) Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J. Biol. Chem., 274, 2732-2742.
55. Buckley, S., Driscoll, B., Barsky, L., Weinberg, K., Anderson, K. and Warburton, D. (1999) ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2. Am. J. Physiol., 277, L159-166.
56. Yacoub, A., Park, J.S., Qiao, L., Dent, P. and Hagan, M.P. (2001) MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion. Int. J. Radiat. Biol., 77, 1067-1078.
57. Fukasawa, K. and Vande Woude, G.F. (1997) Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol. Cell. Biol., 17, 506-518.
58. Saavedra, H.I., Fukasawa, K., Conn, C.W. and Stambrook, P.J. (1999) MAPK mediates RAS-induced chromosome instability. J. Biol. Chem., 274, 38083-38090.
59. Saavedra, H.I., Knauf, J.A., Shirokawa, J.M., Wang, J., Ouyang, B., Elisei, R., Stambrook, P.J. and Fagin, J.A. (2000) The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway. Oncogene, 19, 3948-3954.
60. Yang, T., Namba, H., Hara, T., Takmura, N., Nagayama, Y., Fukata, S., Ishikawa, N., Kuma, K., Ito, K. and Yamashita, S. (1997) p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells. Oncogene, 14, 1511-1519.
61. Belloni-Olivi, L., Annadata, M., Goldstein, G.W. and Bressler, J.P. (1996) Phosphorylation of membrane proteins in erythrocytes treated with lead. Biochem. J., 315, 401-406.
62. He, L., Poblenz, A.T., Medrano, C.J. and Fox, D.A. (2000) Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J. Biol. Chem., 275, 12175-12184.
63. Costa, L.G., Guizzetti, M., Lu, H., Bordi, F., Vitalone, A., Tita, B., Palmery, M., Valeri, P. and Silvestrini, B. (2001) Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology, 160, 19-26.
64. Bressler, J., Kim, K.A., Chakraborti, T. and Goldstein, G. (1999) Molecular mechanisms of lead neurotoxicity. Neurochem. Res., 24, 595-600.
65. Chakraborti, T., Kim, K.A., Goldstein, G.G. and Bressler, J.P. (1999) Increased AP-1 DNA binding activity in PC12 cells treated with lead. J. Neurochem., 73, 187-194.
66. Kim, K.A., Chakraborti, T., Goldstein, G.W. and Bressler, J.P. (2000) Immediate early gene expression in PC12 cells exposed to lead: requirement for protein kinase C. J. Neurochem., 74, 1140-1146.
67. Calsou, P., Frit, P., Bozzato, C. and Salles, B. (1996) Negative interference of metal(II) ions with nucleotide excision repair in human cell-free extracts. Carcinogenesis, 17, 2779-2782.
68. Asmuss, M., Mullenders, L.H., Eker, A. and Hartwig, A. (2000) Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair. Carcinogenesis, 21, 2097-2104.