Androgens modulate β-amyloid levels in male rat brain

Journal of Neurochemistry

Volumn 87, Issue 4, 2003, Pages 1052-1055

  Ramsden, M ^a   Nyborg, A C ^c   Murphy, M P ^c   Chang, L ^b   Stanczyk, F Z ^b   Golde, T E ^c   Pike, Christian J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c MAYO CLINIC   (United States)

Author keywords

amyloid; Aging; Alzheimer's disease; Androgen; Dihydrotestosterone; Estrogen

Indexed keywords

AMYLOID BETA PROTEIN; ANDROGEN; ANDROSTANOLONE; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GONADECTOMY; HORMONE ACTION; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

AMYLOID BETA-PROTEIN; ANDROGENS; ANIMALS; BRAIN; DIHYDROTESTOSTERONE; DRUG IMPLANTS; ESTRADIOL; HORMONE REPLACEMENT THERAPY; MALE; ORCHIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; SEPTAL NUCLEI;

ANIMALIA;

EID: 0344393072     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02114.x     Document Type: Article

References (26)

1. Bimonte-Nelson H. A., Singleton R. S., Nelson M. E., Eckman, C. B., Barber J., Scott T. Y. and Granholm A. C. (2003) Testosterone, but not nonatomatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats. Exp. Neurol. 181, 301-312.
2. Carro E., Trejo J. L., Gomez-Isla T., LeRoith D. and Torres-Aleman I. (2002) Serum insulin-like growth factor 1 regulates brain amyloid-beta levels. Nat. Medical 1390-1397.
3. Gandy S., Almeida O. P., Fonte J., Lim D., Waterrus A., Spry N., Flicker L. and Martins R. N. (2001) Chemical andropause and amyloid-beta peptide. JAMA 285, 2195-2196.
4. Goodenough S., Engert S. and Behl C. (2000) Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci. Lett. 296, 49-52.
5. Gouras G. K., Xu H., Gross R. S., Greenfield J. P., Hai B., Wang R. and Greengard P. (2000) Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. PNAS 97, 1202-1205.
6. Greenfield J. P., Leung L. W., Cai D., Kaasik K., Gross R. S., Rodriguez-Boulan E., Greengard P. and Xu H. (2002) Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J. Biol. Chem. 277, 12128-12136.
7. Hogervorst E., Williams J., Budge M., Riedel W. and Jolles J. (2000) The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience 101, 485-512.
8. Hogervorst E., Williams J., Budge M., Barnetson L., Combrinck M. and Smith A. D. (2001) Serum total testosterone is lower in men with Alzheimer's disease. Neuroendocrinol. Lett. 22, 163-168.
9. Jaffe A. B., Toran-Allerand C. D., Greengard P. and Gandy S. E. (1994) Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. J. Biol. Chem. 269, 13065-13068.
10. Kaiser F. E. and Morley J. E. (1995) Reproductive hormonal changes in the aging male. In: Hormones and Aging (Timiras, P. S., Quay, W. B., Vernadakis, A., eds), pp. 153-166. CRC Press, Inc. Boca Raton, FL.
11. Korenman S. G., Morley J. E., Mooradian A. D., Davis S. S., Kaiser F. E., Silver A. J., Viosca S. P. and Garza D. (1990) Secondary hypogonadism in older men: its relation to impotence. J. Clin. Endocrinol. Metab. 71, 963-969.
12. Leranth C., Petnehazy O. and MacLusky N. J. (2003) Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J. Neurosci. 23, 1588-1592.
13. Levm-Allerhaud J. A., Lominska C. E., Wang J. and Smith J. D. (2002) 17alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice. J. Alzheimers Dis 4, 449-457.
14. Lu S. F., McKenna S. E., Cologer-Clifford A., Nau E. A. and Simon N. G. (1998) Androgen receptor in mouse brain: sex differences and similarities in autoregulation. Endocrinology 139, 1594-1601.
15. Morley S. E. and Perry H. M. (2000) Androgen deficiency in aging men: role of testosterone replacement therapy. J. Laboratory Clin. Med. 135, 370-378.
16. Papasozomenos S. C. and Shanavas A. (2002) Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. Proc. Natl Acad. Sci. U.S.A. 99, 1140-1145.
17. Petanceska S. S., Nagy V., Frail D. and Gandy S. (2000) Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain. Neurology 54, 2212-2217.
18. Pike C. J. (2001) Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons. Brain Res. 919, 160-165.
19. Poletti A. and Martini L. (1999) Androgen-activating enzymes in the central nervous system. J. Steroid Biochem. Mol. Biol. 69, 117-122.
20. Ramsden M., Berchtold N. C., Kesslak J. P., Cotman C. W. and Pike C. J. (2003) Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 971, 239-244.
21. Savage M. J., Trusko S. P., Howland D. S., Pinsker L. R., Mistretta S., Reaume A. G., Greenberg B. D., Siman R. and Scott R. W. (1998) Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18, 1743-1752.
22. Slater C. C., Zhang C., Hodis H. N., Mack W. J., Boostanfar R., Shoupe D., Paulson R. J. and Stanczyk F. Z. (2001) Comparison of estrogen and androgen levels after oral estrogen replacement therapy. J. Reprod Med. 46, 1052-1056.
23. 717) mutants. Science 264, 1336-1340.
24. Woolley C. S. and McEwen B. S. (1992) Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J. Neurosci. 12, 2549-2554.
25. Xu H., Gouras G. K., Greenfield J. P. et al. (1998) Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides. Nature Medical 4, 447-451.
26. Zheng H., Xu H., Uljon S. N., et al. (2002) Modulation of A(beta) peptides by estrogen in mouse models. J. Neurochem. 80, 191-196.