메뉴 건너뛰기




Volumn 22, Issue 12, 2002, Pages 5204-5209

Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits

Author keywords

Androgen receptor; apoE; Dihydrotestosterone; Hydroxyflutamide; Novel object recognition; Spatial learning and memory; Testosterone

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; APOLIPOPROTEIN E4; NEUROPROTECTIVE AGENT; SEX HORMONE; TESTOSTERONE; ANTIANDROGEN; APOLIPOPROTEIN E; APOLIPOPROTEIN E3; DRUG DERIVATIVE; FLUTAMIDE; HYDROXYFLUTAMIDE;

EID: 0037096337     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-12-05204.2002     Document Type: Article
Times cited : (165)

References (52)
  • 1
    • 0030927941 scopus 로고    scopus 로고
    • Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat
    • Aggleton JP, Keen S, Warburton EC, Bussey TJ (1997) Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Res Bull 43:279-287.
    • (1997) Brain Res Bull , vol.43 , pp. 279-287
    • Aggleton, J.P.1    Keen, S.2    Warburton, E.C.3    Bussey, T.J.4
  • 2
    • 0032692942 scopus 로고    scopus 로고
    • Cognitive function and endogenous sex hormones in older women
    • Barrett-Connor E, Goodman-Gruen D (1999) Cognitive function and endogenous sex hormones in older women. J Am Geriatr Soc 47:1289-1293.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 1289-1293
    • Barrett-Connor, E.1    Goodman-Gruen, D.2
  • 3
    • 0018650204 scopus 로고
    • Gonadal hormones and sex differences in nonreproductive behaviors in rodents: Organizational and activational influences
    • Beatty WW (1979) Gonadal hormones and sex differences in nonreproductive behaviors in rodents: organizational and activational influences. Horm Behav 12:112-163.
    • (1979) Horm Behav , vol.12 , pp. 112-163
    • Beatty, W.W.1
  • 4
    • 0033222750 scopus 로고    scopus 로고
    • Hormone replacement therapy and Alzheimer's disease: An update on the issues
    • Benson S (1999) Hormone replacement therapy and Alzheimer's disease: an update on the issues. Health Care Women Int 20:619-638.
    • (1999) Health Care Women Int , vol.20 , pp. 619-638
    • Benson, S.1
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 7
    • 0034055035 scopus 로고    scopus 로고
    • Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
    • Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97:207-210.
    • (2000) Neuroscience , vol.97 , pp. 207-210
    • Buttini, M.1    Akeefe, H.2    Lin, C.3    Mahley, R.W.4    Pitas, R.E.5    Wyss-Coray, T.6    Mucke, L.7
  • 10
    • 0031839778 scopus 로고    scopus 로고
    • Exploring the role of sex steroids through studies of receptor deficient mice
    • Couse JF, Korach KS (1998) Exploring the role of sex steroids through studies of receptor deficient mice. J Mol Med 76:497-511.
    • (1998) J Mol Med , vol.76 , pp. 497-511
    • Couse, J.F.1    Korach, K.S.2
  • 11
    • 0031416975 scopus 로고    scopus 로고
    • Estrogen enhances performance of female rats during acquisition of a radial arm maze
    • Daniel JM, Fader AJ, Spencer AL, Dohanich GP (1998) Estrogen enhances performance of female rats during acquisition of a radial arm maze. Horm Behav 32:217-225.
    • (1998) Horm Behav , vol.32 , pp. 217-225
    • Daniel, J.M.1    Fader, A.J.2    Spencer, A.L.3    Dohanich, G.P.4
  • 12
    • 0034722050 scopus 로고    scopus 로고
    • Modelling cognitive dysfunctions with bilateral injections of ibotenic acid into the rat entorhinal cortex
    • Eijkenboom M, Blokland A, Staay FJVD (2000) Modelling cognitive dysfunctions with bilateral injections of ibotenic acid into the rat entorhinal cortex. Neuroscience 101:27-39.
    • (2000) Neuroscience , vol.101 , pp. 27-39
    • Eijkenboom, M.1    Blokland, A.2    Staay, F.J.V.D.3
  • 13
    • 0030683616 scopus 로고    scopus 로고
    • The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat
    • Ennaceur A, Aggleton JP (1997) The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behav Brain Res 88:181-193.
    • (1997) Behav Brain Res , vol.88 , pp. 181-193
    • Ennaceur, A.1    Aggleton, J.P.2
  • 14
    • 0030970412 scopus 로고    scopus 로고
    • Alzheimer's disease: Clinical implications of the apolipoprotein E genotype
    • Farlow MR (1997) Alzheimer's disease: clinical implications of the apolipoprotein E genotype. Neurology 48:S30-S34.
    • (1997) Neurology , vol.48
    • Farlow, M.R.1
  • 16
    • 0033385115 scopus 로고    scopus 로고
    • Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition
    • Gibbs RB (1999) Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition. Horm Behav 36:222-233.
    • (1999) Horm Behav , vol.36 , pp. 222-233
    • Gibbs, R.B.1
  • 17
    • 0028790904 scopus 로고
    • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
    • Gordon I, Grauer E, Genis I, Sehayek E, Michaelson DM (1995) Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. Neurosci Lett 199:1-4.
    • (1995) Neurosci Lett , vol.199 , pp. 1-4
    • Gordon, I.1    Grauer, E.2    Genis, I.3    Sehayek, E.4    Michaelson, D.M.5
  • 18
    • 0030152121 scopus 로고    scopus 로고
    • Cognitive skills associated with estrogen replacement in women with Alzheimer's disease
    • Henderson VW, Watt L, Buckwalter JG (1996) Cognitive skills associated with estrogen replacement in women with Alzheimer's disease. Psychoneuroendocrinology 21:421-430.
    • (1996) Psychoneuroendocrinology , vol.21 , pp. 421-430
    • Henderson, V.W.1    Watt, L.2    Buckwalter, J.G.3
  • 19
    • 0028293411 scopus 로고
    • Testosterone influences spatial cognition in older men
    • Janowsky JS, Oviatt SK, Orwoll ES (1994) Testosterone influences spatial cognition in older men. Behav Neurosci 108:325-332.
    • (1994) Behav Neurosci , vol.108 , pp. 325-332
    • Janowsky, J.S.1    Oviatt, S.K.2    Orwoll, E.S.3
  • 21
    • 0029257309 scopus 로고
    • Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: In vivo comparison of distinct GFAP-lacZ transgenes
    • Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L (1995) Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes. Glia 13:174-184.
    • (1995) Glia , vol.13 , pp. 174-184
    • Johnson, W.B.1    Ruppe, M.D.2    Rockenstein, E.M.3    Price, J.4    Sarthy, V.P.5    Verderber, L.C.6    Mucke, L.7
  • 22
    • 0018168415 scopus 로고
    • Effects of hormone manipulations and exploration on sex differences in maze learning
    • Joseph R, Hess S, Birecree E (1978) Effects of hormone manipulations and exploration on sex differences in maze learning. Behav Biol 24:364-377.
    • (1978) Behav Biol , vol.24 , pp. 364-377
    • Joseph, R.1    Hess, S.2    Birecree, E.3
  • 23
    • 0027190946 scopus 로고
    • Memory for spatial locations, motor responses, and objects: Triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex
    • Kesner RP, Bolland BL, Dakis M (1993) Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Exp Brain Res 93:462-470.
    • (1993) Exp Brain Res , vol.93 , pp. 462-470
    • Kesner, R.P.1    Bolland, B.L.2    Dakis, M.3
  • 24
    • 0030473407 scopus 로고    scopus 로고
    • Sex-related differences in cortical function after medial frontal lesions in rats
    • Kolb B, Cioe J (1996) Sex-related differences in cortical function after medial frontal lesions in rats. Behav Neurosci 110:1271-1281.
    • (1996) Behav Neurosci , vol.110 , pp. 1271-1281
    • Kolb, B.1    Cioe, J.2
  • 25
    • 0032714056 scopus 로고    scopus 로고
    • Neural androgen receptor regulation: Effects of androgen and antiandrogen
    • Lu S, Simon NG, Wang Y, Hu S (1999) Neural androgen receptor regulation: effects of androgen and antiandrogen. J Neurobiol 41:505-512.
    • (1999) J Neurobiol , vol.41 , pp. 505-512
    • Lu, S.1    Simon, N.G.2    Wang, Y.3    Hu, S.4
  • 26
    • 0031765501 scopus 로고    scopus 로고
    • Androgen receptor in mouse brain: Sex differences and similarities in autoregulation
    • Lu SF, McKenna SE, Cologer-Clifford A, Nau EA, Simon NG (1998) Androgen receptor in mouse brain: sex differences and similarities in autoregulation. Endocrinology 139:1594-1601.
    • (1998) Endocrinology , vol.139 , pp. 1594-1601
    • Lu, S.F.1    McKenna, S.E.2    Cologer-Clifford, A.3    Nau, E.A.4    Simon, N.G.5
  • 27
    • 0023520433 scopus 로고
    • Estrogen formation in the mammalian brain: Possible role of aromatase in sexual differentiation of the hippocampus and neocortex
    • MacLusky NJ, Clark AS, Naftolin F, Goldman-Rakic PS (1987) Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex. Steroids 50:459-474.
    • (1987) Steroids , vol.50 , pp. 459-474
    • MacLusky, N.J.1    Clark, A.S.2    Naftolin, F.3    Goldman-Rakic, P.S.4
  • 28
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240:622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 29
    • 0031829427 scopus 로고    scopus 로고
    • Blockade of the in vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-E proliferation by pretreatment of the donor rats with cyproterone and flutamide
    • Malgor LA, Valsecia M, Verges E, De Markowsky EE (1998) Blockade of the in vitro effects of testosterone and erythropoietin on Cfu-E and Bfu-E proliferation by pretreatment of the donor rats with cyproterone and flutamide. Acta Physiol Pharmacol Ther Latinoam 48:99-105.
    • (1998) Acta Physiol Pharmacol Ther Latinoam , vol.48 , pp. 99-105
    • Malgor, L.A.1    Valsecia, M.2    Verges, E.3    De Markowsky, E.E.4
  • 31
    • 0020545987 scopus 로고
    • In vitro measurement of cytosol and cell nuclear androgen receptors in male rat brain and pituitary
    • McGinnis MY, Davis PG, Meaney MJ, Singer M, McEwen BS (1983) In vitro measurement of cytosol and cell nuclear androgen receptors in male rat brain and pituitary. Brain Res 275:75-82.
    • (1983) Brain Res , vol.275 , pp. 75-82
    • McGinnis, M.Y.1    Davis, P.G.2    Meaney, M.J.3    Singer, M.4    McEwen, B.S.5
  • 33
    • 0028969073 scopus 로고
    • Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer's type: 7 Case reports
    • Ohkura T, Isse K, Akazawa K, Hamamoto M, Yaoi Y, Hagino N (1995) Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer's type: 7 case reports. Dementia 6:99-107.
    • (1995) Dementia , vol.6 , pp. 99-107
    • Ohkura, T.1    Isse, K.2    Akazawa, K.3    Hamamoto, M.4    Yaoi, Y.5    Hagino, N.6
  • 35
    • 0029618124 scopus 로고
    • Apolipoprotein E, synaptic plasticity and Alzheimer's disease
    • Poirier J, Minnich A, Davignon J (1995) Apolipoprotein E, synaptic plasticity and Alzheimer's disease. Ann Med 27:663-670.
    • (1995) Ann Med , vol.27 , pp. 663-670
    • Poirier, J.1    Minnich, A.2    Davignon, J.3
  • 36
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci USA 95:10914-10919.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6    Mahley, R.W.7    Mucke, L.8
  • 39
    • 0034006822 scopus 로고    scopus 로고
    • Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    • Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 3:238-244.
    • (2000) Nat Neurosci , vol.3 , pp. 238-244
    • Rampon, C.1    Tang, Y.P.2    Goodhouse, J.3    Shimizu, E.4    Kyin, M.5    Tsien, J.Z.6
  • 41
    • 0030891121 scopus 로고    scopus 로고
    • Photothrombotic lesions of the rat cortex impair acquisition of the water maze
    • Rogers DC, Hunter AJ (1997) Photothrombotic lesions of the rat cortex impair acquisition of the water maze. Pharmacol Biochem Behav 56:747-754.
    • (1997) Pharmacol Biochem Behav , vol.56 , pp. 747-754
    • Rogers, D.C.1    Hunter, A.J.2
  • 42
    • 0030481305 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease: A rapidly expanding field with medical and epidemiological consequences
    • Roses AD (1996) Apolipoprotein E and Alzheimer's disease: a rapidly expanding field with medical and epidemiological consequences. Ann NY Acad Sci 802:50-57.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 50-57
    • Roses, A.D.1
  • 43
    • 0033624422 scopus 로고    scopus 로고
    • Understanding the role of estrogen on cognition and dementia
    • Sano M (2000) Understanding the role of estrogen on cognition and dementia. J Neural Transm Suppl 59:223-229.
    • (2000) J Neural Transm Suppl , vol.59 , pp. 223-229
    • Sano, M.1
  • 44
    • 0023770991 scopus 로고
    • Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women
    • Sherwin BB (1988) Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 13:345-357.
    • (1988) Psychoneuroendocrinology , vol.13 , pp. 345-357
    • Sherwin, B.B.1
  • 45
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
    • Sun YL, Wu S, Bu GJ, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM (1998) Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18:3261-3272.
    • (1998) J Neurosci , vol.18 , pp. 3261-3272
    • Sun, Y.L.1    Wu, S.2    Bu, G.J.3    Onifade, M.K.4    Patel, S.N.5    LaDu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 47
    • 0034650799 scopus 로고    scopus 로고
    • Andropause
    • Vermeulen A (2000) Andropause. Maturitas 34:5-15.
    • (2000) Maturitas , vol.34 , pp. 5-15
    • Vermeulen, A.1
  • 49
    • 0034705091 scopus 로고    scopus 로고
    • Estrogen use, APOE, and cognitive decline: Evidence of gene-environment interaction
    • Yaffe K, Haan M, Byers A, Tangen C, Kuller L (2000) Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology 54:1949-1953.
    • (2000) Neurology , vol.54 , pp. 1949-1953
    • Yaffe, K.1    Haan, M.2    Byers, A.3    Tangen, C.4    Kuller, L.5
  • 50
    • 0032807501 scopus 로고    scopus 로고
    • Apolipoprotein E peptide stimulation of rat ovarian theca cell androgen synthesis is mediated by members of the low density receptor superfamily
    • Zerbinatti CV, Dyer CA (1999) Apolipoprotein E peptide stimulation of rat ovarian theca cell androgen synthesis is mediated by members of the low density receptor superfamily. Biol Reprod 61:665-672.
    • (1999) Biol Reprod , vol.61 , pp. 665-672
    • Zerbinatti, C.V.1    Dyer, C.A.2
  • 51
    • 0035081714 scopus 로고    scopus 로고
    • Apolipoprotein E is a putative autocrine regulator of the rat ovarian theca cell compartment
    • Zerbinatti CV, Mayer LP, Audet RG, Dyer CA (2001) Apolipoprotein E is a putative autocrine regulator of the rat ovarian theca cell compartment. Biol Reprod 64:1080-1089.
    • (2001) Biol Reprod , vol.64 , pp. 1080-1089
    • Zerbinatti, C.V.1    Mayer, L.P.2    Audet, R.G.3    Dyer, C.A.4
  • 52
    • 0032440082 scopus 로고    scopus 로고
    • An apolipoprotein E synthetic peptide selectively modulates the transcription of the gene for rat ovarian theca and interstitial cell P450 17-alpha-hydroxylase, C17-20 lyase
    • Zhang G, Curtiss LK, Wade RL, Dyer CA (1998) An apolipoprotein E synthetic peptide selectively modulates the transcription of the gene for rat ovarian theca and interstitial cell P450 17-alpha-hydroxylase, C17-20 lyase. J Lipid Res 39:2406-2414.
    • (1998) J Lipid Res , vol.39 , pp. 2406-2414
    • Zhang, G.1    Curtiss, L.K.2    Wade, R.L.3    Dyer, C.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.