-
1
-
-
34250844475
-
Regression of experimental medulloblastoma following transfer of HER2-specific T cells
-
Ahmed N, Ratnayake M, Savoldo B et al (2007) Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res 67:5957-5964.
-
(2007)
Cancer Res
, vol.67
, pp. 5957-5964
-
-
Ahmed, N.1
Ratnayake, M.2
Savoldo, B.3
-
2
-
-
33745223518
-
T-cell antigenreceptor stoichiometry: Pre-clustering for sensitivity
-
Alarcon B, Swamy M, van Santen HM et al (2006) T-cell antigenreceptor stoichiometry: pre-clustering for sensitivity. EMBO Rep 7:490-495.
-
(2006)
EMBO Rep
, vol.7
, pp. 490-495
-
-
Alarcon, B.1
Swamy, M.2
Van Santen, H.M.3
-
3
-
-
0029948642
-
Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes
-
Altenschmidt U, Kahl R, Moritz D et al (1996) Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes. Clin Cancer Res 2:1001-1008.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1001-1008
-
-
Altenschmidt, U.1
Kahl, R.2
Moritz, D.3
-
4
-
-
0031306874
-
Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression
-
Altenschmidt U, Klundt E, Groner B (1997) Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression. J Immunol 159:5509-5515.
-
(1997)
J Immunol
, vol.159
, pp. 5509-5515
-
-
Altenschmidt, U.1
Klundt, E.2
Groner, B.3
-
5
-
-
0029841565
-
Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric singlechain antibody variable fragment-CD28 receptors
-
Alvarez-Vallina L, Hawkins RE (1996) Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric singlechain antibody variable fragment-CD28 receptors. Eur J Immunol 26:2304-2309.
-
(1996)
Eur J Immunol
, vol.26
, pp. 2304-2309
-
-
Alvarez-Vallina, L.1
Hawkins, R.E.2
-
6
-
-
0024435150
-
Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice
-
Becker ML, Near R, Mudgett-Hunter M et al (1989) Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell 58:911-921.
-
(1989)
Cell
, vol.58
, pp. 911-921
-
-
Becker, M.L.1
Near, R.2
Mudgett-Hunter, M.3
-
7
-
-
47549104068
-
Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance
-
Bennour E, Ferrand C, Remy-Martin JP et al (2008) Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance. Hum Gene Ther 19:699-709.
-
(2008)
Hum Gene Ther
, vol.19
, pp. 699-709
-
-
Bennour, E.1
Ferrand, C.2
Remy-Martin, J.P.3
-
8
-
-
33644750264
-
Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
-
Berger C, Flowers ME, Warren EH et al (2006) Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood 107:2294-2302.
-
(2006)
Blood
, vol.107
, pp. 2294-2302
-
-
Berger, C.1
Flowers, M.E.2
Warren, E.H.3
-
9
-
-
0030843493
-
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versusleukemia
-
Bonini C, Ferrari G, Verzeletti S et al (1997) HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versusleukemia. Science 276:1719-1724.
-
(1997)
Science
, vol.276
, pp. 1719-1724
-
-
Bonini, C.1
Ferrari, G.2
Verzeletti, S.3
-
10
-
-
0037348324
-
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
-
Brentjens RJ, Latouche JB, Santos E et al (2003) Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 9:279-286.
-
(2003)
Nat Med
, vol.9
, pp. 279-286
-
-
Brentjens, R.J.1
Latouche, J.B.2
Santos, E.3
-
11
-
-
34848842554
-
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
-
Brentjens RJ, Santos E, Nikhamin Y et al (2007) Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res 13:5426-5435.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5426-5435
-
-
Brentjens, R.J.1
Santos, E.2
Nikhamin, Y.3
-
12
-
-
0028902765
-
Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes
-
Brocker T, Karjalainen K (1995) Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181:1653-1659.
-
(1995)
J Exp Med
, vol.181
, pp. 1653-1659
-
-
Brocker, T.1
Karjalainen, K.2
-
13
-
-
0141596016
-
Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
-
Burt RK, Drobyski WR, Seregina T et al (2003) Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions. Exp Hematol 31:903-910.
-
(2003)
Exp Hematol
, vol.31
, pp. 903-910
-
-
Burt, R.K.1
Drobyski, W.R.2
Seregina, T.3
-
14
-
-
0026610881
-
Humanization of an antip185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM et al (1992) Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 89:4285-4289.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
-
15
-
-
17944370860
-
Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene
-
Chalmers D, Ferrand C, Apperley JF et al (2001) Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene. Mol Ther 4:146-148.
-
(2001)
Mol Ther
, vol.4
, pp. 146-148
-
-
Chalmers, D.1
Ferrand, C.2
Apperley, J.F.3
-
16
-
-
16444381331
-
Bcl-2 overexpression enhances tumor-specific T-cell survival
-
Charo J, Finkelstein SE, Grewal N et al (2005) Bcl-2 overexpression enhances tumor-specific T-cell survival. Cancer Res 65:2001-2008.
-
(2005)
Cancer Res
, vol.65
, pp. 2001-2008
-
-
Charo, J.1
Finkelstein, S.E.2
Grewal, N.3
-
17
-
-
44649197976
-
The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma
-
Cheadle EJ, Gilham DE, Hawkins RE (2008) The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma. Br J Haematol 142:65-68.
-
(2008)
Br J Haematol
, vol.142
, pp. 65-68
-
-
Cheadle, E.J.1
Gilham, D.E.2
Hawkins, R.E.3
-
18
-
-
23144455728
-
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
-
Choudhuri K, Wiseman D, Brown MH et al (2005) T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436:578-582.
-
(2005)
Nature
, vol.436
, pp. 578-582
-
-
Choudhuri, K.1
Wiseman, D.2
Brown, M.H.3
-
20
-
-
0037441593
-
T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
-
Cooper LJ, Topp MS, Serrano LM et al (2003) T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect. Blood 101:1637-1644.
-
(2003)
Blood
, vol.101
, pp. 1637-1644
-
-
Cooper, L.J.1
Topp, M.S.2
Serrano, L.M.3
-
21
-
-
13544273197
-
Enhanced antilymphoma efficacy of CD19-redirected influenza MP1- specific CTLs by cotransfer of T cells modified to present influenza MP1
-
Cooper LJ, Al-Kadhimi Z, Serrano LM et al (2005) Enhanced antilymphoma efficacy of CD19-redirected influenza MP1- specific CTLs by cotransfer of T cells modified to present influenza MP1. Blood 105:1622-1631.
-
(2005)
Blood
, vol.105
, pp. 1622-1631
-
-
Cooper, L.J.1
Al-Kadhimi, Z.2
Serrano, L.M.3
-
23
-
-
0031946483
-
Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma
-
Darcy PK, Kershaw MH, Trapani JA et al (1998) Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma. Eur J Immunol 28:1663-1672.
-
(1998)
Eur J Immunol
, vol.28
, pp. 1663-1672
-
-
Darcy, P.K.1
Kershaw, M.H.2
Trapani, J.A.3
-
24
-
-
42649106831
-
Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines
-
Daudt L, Maccario R, Locatelli F et al (2008) Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines. J Immunother 31:385-393.
-
(2008)
J Immunother
, vol.31
, pp. 385-393
-
-
Daudt, L.1
Maccario, R.2
Locatelli, F.3
-
25
-
-
33746114879
-
The kinetic-segregation model: TCR triggering and beyond
-
Davis SJ, van der Merwe PA (2006) The kinetic-segregation model: TCR triggering and beyond. Nat Immunol 7:803-809.
-
(2006)
Nat Immunol
, vol.7
, pp. 803-809
-
-
Davis, S.J.1
Van Der Merwe, P.A.2
-
26
-
-
0031567896
-
Costimulation of CD28- T lymphocytes by 4-1BB ligand
-
DeBenedette MA, Shahinian A, Mak TW et al (1997) Costimulation of CD28- T lymphocytes by 4-1BB ligand. J Immunol 158:551-559.
-
(1997)
J Immunol
, vol.158
, pp. 551-559
-
-
DeBenedette, M.A.1
Shahinian, A.2
Mak, T.W.3
-
27
-
-
0035989039
-
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
-
Deeks SG, Wagner B, Anton PA et al (2002) A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther 5:788-797.
-
(2002)
Mol Ther
, vol.5
, pp. 788-797
-
-
Deeks, S.G.1
Wagner, B.2
Anton, P.A.3
-
28
-
-
0022538117
-
Transfer of specificity by murine alpha and beta T-cell receptor genes
-
Dembic Z, Haas W, Weiss S et al (1986) Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature 320:232-238.
-
(1986)
Nature
, vol.320
, pp. 232-238
-
-
Dembic, Z.1
Haas, W.2
Weiss, S.3
-
29
-
-
37049008307
-
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft
-
Deschamps M, Mercier-Lethondal P, Certoux JM et al (2007) Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft. Blood 110:3842-3852.
-
(2007)
Blood
, vol.110
, pp. 3842-3852
-
-
Deschamps, M.1
Mercier-Lethondal, P.2
Certoux, J.M.3
-
30
-
-
20444425695
-
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
-
Dotti G, Savoldo B, Pule M et al (2005) Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood 105:4677-4684.
-
(2005)
Blood
, vol.105
, pp. 4677-4684
-
-
Dotti, G.1
Savoldo, B.2
Pule, M.3
-
31
-
-
85047696817
-
Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions
-
Eaton D, Gilham DE, O'Neill A et al (2002) Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions. Gene Ther 9:527-535.
-
(2002)
Gene Ther
, vol.9
, pp. 527-535
-
-
Eaton, D.1
Gilham, D.E.2
O'Neill, A.3
-
32
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
-
Eshhar Z, Waks T, Gross G et al (1993) Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 90:720-724.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 720-724
-
-
Eshhar, Z.1
Waks, T.2
Gross, G.3
-
33
-
-
0032531091
-
Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
-
Finney HM, Lawson AD, Bebbington CR et al (1998) Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 161:2791-2797.
-
(1998)
J Immunol
, vol.161
, pp. 2791-2797
-
-
Finney, H.M.1
Lawson, A.D.2
Bebbington, C.R.3
-
34
-
-
0347994955
-
Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
-
Finney HM, Akbar AN, Lawson AD (2004) Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 172:104-113.
-
(2004)
J Immunol
, vol.172
, pp. 104-113
-
-
Finney, H.M.1
Akbar, A.N.2
Lawson, A.D.3
-
35
-
-
17044378252
-
Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation
-
Friedmann-Morvinski D, Bendavid A, Waks T et al (2005) Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation. Blood 105:3087-3093.
-
(2005)
Blood
, vol.105
, pp. 3087-3093
-
-
Friedmann-Morvinski, D.1
Bendavid, A.2
Waks, T.3
-
36
-
-
25444524262
-
Targeted elimination of prostate cancer by genetically directed human T lymphocytes
-
Gade TP, Hassen W, Santos E et al (2005) Targeted elimination of prostate cancer by genetically directed human T lymphocytes. Cancer Res 65:9080-9088.
-
(2005)
Cancer Res
, vol.65
, pp. 9080-9088
-
-
Gade, T.P.1
Hassen, W.2
Santos, E.3
-
37
-
-
0035174929
-
Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene
-
Garin MI, Garrett E, Tiberghien P et al (2001) Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene. Blood 97:122-129.
-
(2001)
Blood
, vol.97
, pp. 122-129
-
-
Garin, M.I.1
Garrett, E.2
Tiberghien, P.3
-
38
-
-
31544442669
-
Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor
-
Gattenlohner S, Marx A, Markfort B et al (2006) Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor. Cancer Res 66:24-28.
-
(2006)
Cancer Res
, vol.66
, pp. 24-28
-
-
Gattenlohner, S.1
Marx, A.2
Markfort, B.3
-
39
-
-
20444499355
-
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
-
Gattinoni L, Klebanoff CA, Palmer DC et al (2005) Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest 115:1616-1626.
-
(2005)
J Clin Invest
, vol.115
, pp. 1616-1626
-
-
Gattinoni, L.1
Klebanoff, C.A.2
Palmer, D.C.3
-
40
-
-
0036193484
-
Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zetabased chimeric immune receptors
-
Gilham DE, O'Neil A, Hughes C et al (2002) Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zetabased chimeric immune receptors. J Immunother 25:139-151.
-
(2002)
J Immunother
, vol.25
, pp. 139-151
-
-
Gilham, D.E.1
O'Neil, A.2
Hughes, C.3
-
41
-
-
0033139686
-
Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen
-
Gong MC, Latouche JB, Krause A et al (1999) Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen. Neoplasia 1:123-127.
-
(1999)
Neoplasia
, vol.1
, pp. 123-127
-
-
Gong, M.C.1
Latouche, J.B.2
Krause, A.3
-
42
-
-
13644250942
-
Genetic engineering of cytolytic T lymphocytes for adoptive T-cell therapy of neuroblastoma
-
Gonzalez S, Naranjo A, Serrano LM et al (2004) Genetic engineering of cytolytic T lymphocytes for adoptive T-cell therapy of neuroblastoma. J Gene Med 6:704-711.
-
(2004)
J Gene Med
, vol.6
, pp. 704-711
-
-
Gonzalez, S.1
Naranjo, A.2
Serrano, L.M.3
-
43
-
-
0025324449
-
Chimeric immunoglobulin-T cell receptor proteins form functional receptors: Implications for T cell receptor complex formation and activation
-
Goverman J, Gomez SM, Segesman KD et al (1990) Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation. Cell 60:929-939.
-
(1990)
Cell
, vol.60
, pp. 929-939
-
-
Goverman, J.1
Gomez, S.M.2
Segesman, K.D.3
-
44
-
-
0024834988
-
Expression of immunoglobulin-Tcell receptor chimeric molecules as functional receptors with antibody-type specificity
-
Gross G, Waks T, Eshhar Z (1989) Expression of immunoglobulin-Tcell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 86:10024-10028.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 10024-10028
-
-
Gross, G.1
Waks, T.2
Eshhar, Z.3
-
45
-
-
20944439742
-
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: Evaluation of four different scFvs and antigens
-
Guest RD, Hawkins RE, Kirillova N et al (2005) The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J Immunother 28:203-211.
-
(2005)
J Immunother
, vol.28
, pp. 203-211
-
-
Guest, R.D.1
Hawkins, R.E.2
Kirillova, N.3
-
46
-
-
36248951128
-
Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells
-
Habib-Agahi M, Phan TT, Searle PF (2007) Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int Immunol 19:1383-1394.
-
(2007)
Int Immunol
, vol.19
, pp. 1383-1394
-
-
Habib-Agahi, M.1
Phan, T.T.2
Searle, P.F.3
-
47
-
-
0035159470
-
Redirecting mouse CTL against colon carcinoma: Superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma
-
Haynes NM, Snook MB, Trapani JA et al (2001) Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol 166:182-187.
-
(2001)
J Immunol
, vol.166
, pp. 182-187
-
-
Haynes, N.M.1
Snook, M.B.2
Trapani, J.A.3
-
48
-
-
0036839589
-
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors
-
Haynes NM, Trapani JA, Teng MW et al (2002a) Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood 100:3155-3163.
-
(2002)
Blood
, vol.100
, pp. 3155-3163
-
-
Haynes, N.M.1
Trapani, J.A.2
Teng, M.W.3
-
49
-
-
0037111240
-
Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
-
Haynes NM, Trapani JA, Teng MW et al (2002b) Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol 169:5780-5786.
-
(2002)
J Immunol
, vol.169
, pp. 5780-5786
-
-
Haynes, N.M.1
Trapani, J.A.2
Teng, M.W.3
-
50
-
-
0029823560
-
Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera
-
Hekele A, Dall P, Moritz D et al (1996) Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera. Int J Cancer 68:232-238.
-
(1996)
Int J Cancer
, vol.68
, pp. 232-238
-
-
Hekele, A.1
Dall, P.2
Moritz, D.3
-
51
-
-
45449087723
-
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
-
Hinrichs CS, Spolski R, Paulos CM et al (2008) IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 111:5326-5333.
-
(2008)
Blood
, vol.111
, pp. 5326-5333
-
-
Hinrichs, C.S.1
Spolski, R.2
Paulos, C.M.3
-
52
-
-
63649112916
-
Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
-
Hollyman D, Stefanski J, Przybylowski M et al (2009) Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J Immunother 32:169-180.
-
(2009)
J Immunother
, vol.32
, pp. 169-180
-
-
Hollyman, D.1
Stefanski, J.2
Przybylowski, M.3
-
53
-
-
0030777395
-
T cell targeting of TAG72+ tumor cells by a chimeric receptorwith antibody-like specificity for a carbohydrate epitope
-
Hombach A, Heuser C, Sircar R et al (1997) T cell targeting of TAG72+ tumor cells by a chimeric receptorwith antibody-like specificity for a carbohydrate epitope. Gastroenterology 113:1163-1170.
-
(1997)
Gastroenterology
, vol.113
, pp. 1163-1170
-
-
Hombach, A.1
Heuser, C.2
Sircar, R.3
-
54
-
-
0032521416
-
An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30
-
Hombach A, Heuser C, Sircar R et al (1998) An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30. Cancer Res 58:1116-1119.
-
(1998)
Cancer Res
, vol.58
, pp. 1116-1119
-
-
Hombach, A.1
Heuser, C.2
Sircar, R.3
-
55
-
-
33947633597
-
T cell activation by antibody-like immunoreceptors: The position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
-
Hombach AA, Schildgen V, Heuser C et al (2007) T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunol 178:4650-4657.
-
(2007)
J Immunol
, vol.178
, pp. 4650-4657
-
-
Hombach, A.A.1
Schildgen, V.2
Heuser, C.3
-
56
-
-
0026639360
-
The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation
-
Howard FD, Moingeon P, Moebius U et al (1992) The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation. J Exp Med 176:139-145.
-
(1992)
J Exp Med
, vol.176
, pp. 139-145
-
-
Howard, F.D.1
Moingeon, P.2
Moebius, U.3
-
57
-
-
0029117913
-
Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28
-
Hurtado JC, Kim SH, Pollok KE et al (1995) Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J Immunol 155:3360-3367.
-
(1995)
J Immunol
, vol.155
, pp. 3360-3367
-
-
Hurtado, J.C.1
Kim, S.H.2
Pollok, K.E.3
-
58
-
-
0004198722
-
Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
-
Huston JS, Levinson D, Mudgett-Hunter M et al (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85:5879-5883.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
Levinson, D.2
Mudgett-Hunter, M.3
-
59
-
-
0027283443
-
Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
-
Hwu P, Shafer GE, Treisman J et al (1993) Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain. J Exp Med 178:361-366.
-
(1993)
J Exp Med
, vol.178
, pp. 361-366
-
-
Hwu, P.1
Shafer, G.E.2
Treisman, J.3
-
60
-
-
0029134048
-
In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes
-
Hwu P, Yang JC, Cowherd R et al (1995) In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res 55:3369-3373.
-
(1995)
Cancer Res
, vol.55
, pp. 3369-3373
-
-
Hwu, P.1
Yang, J.C.2
Cowherd, R.3
-
61
-
-
3042551216
-
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
-
Imai C, Mihara K, Andreansky M et al (2004) Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 18:676-684.
-
(2004)
Leukemia
, vol.18
, pp. 676-684
-
-
Imai, C.1
Mihara, K.2
Andreansky, M.3
-
62
-
-
0034054579
-
Genetic modification of human T cells with CD20: A strategy to purify and lyse transduced cells with anti-CD20 antibodies
-
IntronaM, Barbui AM, Bambacioni F et al (2000) Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies. Hum Gene Ther 11:611-620.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 611-620
-
-
Intronam1
Barbui, A.M.2
Bambacioni, F.3
-
63
-
-
0026064305
-
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways
-
Irving BA, Weiss A (1991) The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64:891-901.
-
(1991)
Cell
, vol.64
, pp. 891-901
-
-
Irving, B.A.1
Weiss, A.2
-
64
-
-
0029123613
-
Defective major histocompatibility complex class I expression in a sarcomatoid renal cell carcinoma cell line
-
Jakobsen MK, Restifo NP, Cohen PA et al (1995) Defective major histocompatibility complex class I expression in a sarcomatoid renal cell carcinoma cell line. J Immunother Emphas Tumor Immunol 17:222-228.
-
(1995)
J Immunother Emphas Tumor Immunol
, vol.17
, pp. 222-228
-
-
Jakobsen, M.K.1
Restifo, N.P.2
Cohen, P.A.3
-
65
-
-
45549093089
-
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
-
James SE, Greenberg PD, Jensen MC et al (2008) Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol 180:7028-7038.
-
(2008)
J Immunol
, vol.180
, pp. 7028-7038
-
-
James, S.E.1
Greenberg, P.D.2
Jensen, M.C.3
-
66
-
-
0031610524
-
CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: Implications for cellular immunotherapy of CD20+ malignancy
-
Jensen M, Tan G, Forman S et al (1998) CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy. Biol Blood Marrow Transplant 4:75-83.
-
(1998)
Biol Blood Marrow Transplant
, vol.4
, pp. 75-83
-
-
Jensen, M.1
Tan, G.2
Forman, S.3
-
67
-
-
10844296758
-
Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
-
Kahlon KS, Brown C, Cooper LJ et al (2004) Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res 64:9160-9166.
-
(2004)
Cancer Res
, vol.64
, pp. 9160-9166
-
-
Kahlon, K.S.1
Brown, C.2
Cooper, L.J.3
-
68
-
-
0034634865
-
Generation of genemodified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature
-
Kershaw MH, Westwood JA, Zhu Z et al (2000) Generation of genemodified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature. Hum Gene Ther 11:2445-2452.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2445-2452
-
-
Kershaw, M.H.1
Westwood, J.A.2
Zhu, Z.3
-
69
-
-
0036905078
-
Dual-specific T cells combine proliferation and antitumor activity
-
Kershaw MH, Westwood JA, Hwu P (2002) Dual-specific T cells combine proliferation and antitumor activity. Nat Biotechnol 20:1221-1227.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 1221-1227
-
-
Kershaw, M.H.1
Westwood, J.A.2
Hwu, P.3
-
70
-
-
3242765879
-
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer
-
Kershaw MH, Jackson JT, Haynes NM et al (2004) Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol 173:2143-2150.
-
(2004)
J Immunol
, vol.173
, pp. 2143-2150
-
-
Kershaw, M.H.1
Jackson, J.T.2
Haynes, N.M.3
-
71
-
-
33750699642
-
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
-
Kershaw MH, Westwood JA, Parker LL et al (2006) A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 12:6106-6115.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6106-6115
-
-
Kershaw, M.H.1
Westwood, J.A.2
Parker, L.L.3
-
72
-
-
38649127824
-
A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
-
Kieback E, Charo J, Sommermeyer D et al (2008) A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer. Proc Natl Acad Sci USA 105:623-628.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 623-628
-
-
Kieback, E.1
Charo, J.2
Sommermeyer, D.3
-
73
-
-
10744226452
-
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
-
Klebanoff CA, Finkelstein SE, Surman DR et al (2004) IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci USA 101:1969-1974.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1969-1974
-
-
Klebanoff, C.A.1
Finkelstein, S.E.2
Surman, D.R.3
-
74
-
-
58149218516
-
The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells
-
Kober J, Leitner J, Klauser C et al (2008) The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur J Immunol 38:2678-2688.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2678-2688
-
-
Kober, J.1
Leitner, J.2
Klauser, C.3
-
75
-
-
0032541385
-
Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes
-
Krause A, Guo HF, Latouche JB et al (1998) Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes. J Exp Med 188:619-626.
-
(1998)
J Exp Med
, vol.188
, pp. 619-626
-
-
Krause, A.1
Guo, H.F.2
Latouche, J.B.3
-
76
-
-
0023568155
-
Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions
-
Kuwana Y, Asakura Y, Utsunomiya N et al (1987) Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions. Biochem Biophys Res Commun 149:960-968.
-
(1987)
Biochem Biophys Res Commun
, vol.149
, pp. 960-968
-
-
Kuwana, Y.1
Asakura, Y.2
Utsunomiya, N.3
-
77
-
-
33646440024
-
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
-
Lamers CH, Sleijfer S, Vulto AG et al (2006) Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 24:e20-e22.
-
(2006)
J Clin Oncol
, vol.24
-
-
Lamers, C.H.1
Sleijfer, S.2
Vulto, A.G.3
-
78
-
-
59649119936
-
Knockdown of human bid gene expression enhances survival of CD8(+) T cells
-
Lei XY, Xu YM, Wang T et al (2009) Knockdown of human bid gene expression enhances survival of CD8(+) T cells. Immunol Lett 122:30-36.
-
(2009)
Immunol Lett
, vol.122
, pp. 30-36
-
-
Lei, X.Y.1
Xu, Y.M.2
Wang, T.3
-
79
-
-
0025998529
-
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins
-
Letourneur F, Klausner RD (1991) T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci USA 88:8905-8909.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8905-8909
-
-
Letourneur, F.1
Klausner, R.D.2
-
80
-
-
38049120319
-
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
-
Li Y, Yee C (2008) IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 111:229-235.
-
(2008)
Blood
, vol.111
, pp. 229-235
-
-
Li, Y.1
Yee, C.2
-
81
-
-
0038181099
-
Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy
-
Li Q, Carr A, Ito F et al (2003) Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy. Cancer Res 63:2546-2552.
-
(2003)
Cancer Res
, vol.63
, pp. 2546-2552
-
-
Li, Q.1
Carr, A.2
Ito, F.3
-
82
-
-
34247891493
-
Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody
-
Li B, Wang H, Zhang D et al (2007a) Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody. Biochem Biophys Res Commun 357:951-956.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 951-956
-
-
Li, B.1
Wang, H.2
Zhang, D.3
-
83
-
-
37249088549
-
Adjuvant effect of anti- 4-1BB mAb administration in adoptive T cell therapy of cancer
-
Li Q, Iuchi T, Jure-Kunkel MN et al (2007b) Adjuvant effect of anti- 4-1BB mAb administration in adoptive T cell therapy of cancer. Int J Biol Sci 3:455-462.
-
(2007)
Int J Biol Sci
, vol.3
, pp. 455-462
-
-
Li, Q.1
Iuchi, T.2
Jure-Kunkel, M.N.3
-
84
-
-
0041976988
-
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
-
Lin J, Weiss A (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol 162:673-682.
-
(2003)
J Cell Biol
, vol.162
, pp. 673-682
-
-
Lin, J.1
Weiss, A.2
-
85
-
-
0035575701
-
Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
-
Liu K, Rosenberg SA (2001) Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity. J Immunol 167:6356-6365.
-
(2001)
J Immunol
, vol.167
, pp. 6356-6365
-
-
Liu, K.1
Rosenberg, S.A.2
-
86
-
-
37449024076
-
Harnessing the tumour derived cytokine, CSF-1, to co-stimulate T-cell growth and activation
-
Lo AS, Taylor JR, Farzaneh F et al (2008) Harnessing the tumour derived cytokine, CSF-1, to co-stimulate T-cell growth and activation. Mol Immunol 45:1276-1287.
-
(2008)
Mol Immunol
, vol.45
, pp. 1276-1287
-
-
Lo, A.S.1
Taylor, J.R.2
Farzaneh, F.3
-
87
-
-
33750061330
-
Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
-
Loskog A, Giandomenico V, Rossig C et al (2006) Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia 20:1819-1828.
-
(2006)
Leukemia
, vol.20
, pp. 1819-1828
-
-
Loskog, A.1
Giandomenico, V.2
Rossig, C.3
-
88
-
-
40949151469
-
Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival
-
Lou Y, Basha G, Seipp RP et al (2008) Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival. Clin Cancer Res 14:1494-1501.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1494-1501
-
-
Lou, Y.1
Basha, G.2
Seipp, R.P.3
-
89
-
-
4143084967
-
Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy
-
Ma Q, Safar M, Holmes E et al (2004) Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy. Prostate 61:12-25.
-
(2004)
Prostate
, vol.61
, pp. 12-25
-
-
Ma, Q.1
Safar, M.2
Holmes, E.3
-
90
-
-
0036137615
-
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
-
Maher J, Brentjens RJ, Gunset G et al (2002) Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol 20:70-75.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 70-75
-
-
Maher, J.1
Brentjens, R.J.2
Gunset, G.3
-
91
-
-
0036669298
-
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
-
Malek TR, Yu A, Vincek V et al (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17:167-178.
-
(2002)
Immunity
, vol.17
, pp. 167-178
-
-
Malek, T.R.1
Yu, A.2
Vincek, V.3
-
92
-
-
0033585433
-
Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor
-
McGuinness RP, Ge Y, Patel SD et al (1999) Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor. Hum Gene Ther 10:165-173.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 165-173
-
-
McGuinness, R.P.1
Ge, Y.2
Patel, S.D.3
-
93
-
-
0031039315
-
Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
-
Mendez MJ, Green LL, Corvalan JR et al (1997) Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 15:146-156.
-
(1997)
Nat Genet
, vol.15
, pp. 146-156
-
-
Mendez, M.J.1
Green, L.L.2
Corvalan, J.R.3
-
94
-
-
0032201554
-
Transfer of chimeric receptor gene made of variable regions of tumor specific antibody confers anticarbohydrate specificity on T cells
-
Mezzanzanica D, Canevari S, Mazzoni A et al (1998) Transfer of chimeric receptor gene made of variable regions of tumor specific antibody confers anticarbohydrate specificity on T cells. Cancer Gene Ther 5:401-407.
-
(1998)
Cancer Gene Ther
, vol.5
, pp. 401-407
-
-
Mezzanzanica, D.1
Canevari, S.2
Mazzoni, A.3
-
95
-
-
55349086931
-
Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment
-
Milano F, Jorritsma T, Rygiel AM et al (2008) Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. Scand J Immunol 68:616-623.
-
(2008)
Scand J Immunol
, vol.68
, pp. 616-623
-
-
Milano, F.1
Jorritsma, T.2
Rygiel, A.M.3
-
96
-
-
0034254611
-
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects
-
Mitsuyasu RT, Anton PA, Deeks SG et al (2000) Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood 96:785-793.
-
(2000)
Blood
, vol.96
, pp. 785-793
-
-
Mitsuyasu, R.T.1
Anton, P.A.2
Deeks, S.G.3
-
97
-
-
2342534535
-
A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells
-
Moeller M, Haynes NM, Trapani JA et al (2004) A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther 11:371-379.
-
(2004)
Cancer Gene Ther
, vol.11
, pp. 371-379
-
-
Moeller, M.1
Haynes, N.M.2
Trapani, J.A.3
-
98
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
Morgan RA, Dudley ME, Wunderlich JR et al (2006) Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314:126-129.
-
(2006)
Science
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
-
99
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
in press
-
Morgan RA, Yang JC, Kitano M et al (2010) Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther (in press).
-
(2010)
Mol Ther
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
-
100
-
-
34250839415
-
Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells
-
Morgenroth A, Cartellieri M, Schmitz M et al (2007) Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. Prostate 67:1121-1131.
-
(2007)
Prostate
, vol.67
, pp. 1121-1131
-
-
Morgenroth, A.1
Cartellieri, M.2
Schmitz, M.3
-
101
-
-
58149240223
-
Efficacy of IL-2-versus IL-15-stimulated CD8 T cells in adoptive immunotherapy
-
Mueller K, Schweier O, Pircher H (2008) Efficacy of IL-2-versus IL-15-stimulated CD8 T cells in adoptive immunotherapy. Eur J Immunol 38:2874-2885.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2874-2885
-
-
Mueller, K.1
Schweier, O.2
Pircher, H.3
-
102
-
-
0033974799
-
Ligandmediated cytolysis of tumor cells: Use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes
-
Muniappan A, Banapour B, Lebkowski J et al (2000) Ligandmediated cytolysis of tumor cells: use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes. Cancer Gene Ther 7:128-134.
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 128-134
-
-
Muniappan, A.1
Banapour, B.2
Lebkowski, J.3
-
103
-
-
0037108529
-
Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases
-
Murata K, Nose M, Ndhlovu LC et al (2002) Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol 169:4628-4636.
-
(2002)
J Immunol
, vol.169
, pp. 4628-4636
-
-
Murata, K.1
Nose, M.2
Ndhlovu, L.C.3
-
104
-
-
34247123205
-
Antitumor activity of dual-specific T cells and influenza virus
-
Murphy A, Westwood JA, Brown LE et al (2007) Antitumor activity of dual-specific T cells and influenza virus. Cancer Gene Ther 14:499-508.
-
(2007)
Cancer Gene Ther
, vol.14
, pp. 499-508
-
-
Murphy, A.1
Westwood, J.A.2
Brown, L.E.3
-
105
-
-
0037076297
-
Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors
-
Niederman TM, Ghogawala Z, Carter BS et al (2002) Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors. Proc Natl Acad Sci USA 99:7009-7014.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 7009-7014
-
-
Niederman, T.M.1
Ghogawala, Z.2
Carter, B.S.3
-
106
-
-
0033385052
-
Bypassing immunization: Optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA
-
Nolan KF, Yun CO, Akamatsu Y et al (1999) Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA. Clin Cancer Res 5:3928-3941.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3928-3941
-
-
Nolan, K.F.1
Yun, C.O.2
Akamatsu, Y.3
-
107
-
-
0029808372
-
The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
-
O'Connell J, O'Sullivan GC, Collins JK et al (1996) The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med 184:1075-1082.
-
(1996)
J Exp Med
, vol.184
, pp. 1075-1082
-
-
O'Connell, J.1
O'Sullivan, G.C.2
Collins, J.K.3
-
108
-
-
33845618133
-
Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor
-
Pameijer CR, Navanjo A, Meechoovet B et al (2007) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor. Cancer Gene Ther 14:91-97.
-
(2007)
Cancer Gene Ther
, vol.14
, pp. 91-97
-
-
Pameijer, C.R.1
Navanjo, A.2
Meechoovet, B.3
-
109
-
-
33947265424
-
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
-
Park JR, Digiusto DL, Slovak M et al (2007) Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther 15:825-833.
-
(2007)
Mol Ther
, vol.15
, pp. 825-833
-
-
Park, J.R.1
Digiusto, D.L.2
Slovak, M.3
-
110
-
-
51549100478
-
Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo
-
Pegram HJ, Jackson JT, Smyth MJ et al (2008) Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo. J Immunol 181:3449-3455.
-
(2008)
J Immunol
, vol.181
, pp. 3449-3455
-
-
Pegram, H.J.1
Jackson, J.T.2
Smyth, M.J.3
-
111
-
-
0038181188
-
Immuno-gene therapy of established prostate tumors using chimeric receptorredirected human lymphocytes
-
Pinthus JH, Waks T, Kaufman-Francis K et al (2003) Immuno-gene therapy of established prostate tumors using chimeric receptorredirected human lymphocytes. Cancer Res 63:2470-2476.
-
(2003)
Cancer Res
, vol.63
, pp. 2470-2476
-
-
Pinthus, J.H.1
Waks, T.2
Kaufman-Francis, K.3
-
112
-
-
0027285735
-
Inducible T cell antigen 4-1BB. Analysis of expression and function
-
Pollok KE, Kim YJ, Zhou Z et al (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 150:771-781.
-
(1993)
J Immunol
, vol.150
, pp. 771-781
-
-
Pollok, K.E.1
Kim, Y.J.2
Zhou, Z.3
-
113
-
-
0028946371
-
Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4
-
Pollok KE, Kim SH, Kwon BS (1995) Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4. Eur J Immunol 25:488-494.
-
(1995)
Eur J Immunol
, vol.25
, pp. 488-494
-
-
Pollok, K.E.1
Kim, S.H.2
Kwon, B.S.3
-
114
-
-
27744566329
-
A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
-
Pule MA, Straathof KC, Dotti G et al (2005) A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 12:933-941.
-
(2005)
Mol Ther
, vol.12
, pp. 933-941
-
-
Pule, M.A.1
Straathof, K.C.2
Dotti, G.3
-
115
-
-
55549145071
-
Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
-
Pule MA, Savoldo B, Myers GD et al (2008) Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 14:1264-1270.
-
(2008)
Nat Med
, vol.14
, pp. 1264-1270
-
-
Pule, M.A.1
Savoldo, B.2
Myers, G.D.3
-
116
-
-
35549007239
-
Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
-
Quintarelli C, Vera JF, Savoldo B et al (2007) Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood 110:2793-2802.
-
(2007)
Blood
, vol.110
, pp. 2793-2802
-
-
Quintarelli, C.1
Vera, J.F.2
Savoldo, B.3
-
117
-
-
38849164304
-
Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
-
Redmond WL, Gough MJ, Charbonneau B et al (2007) Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol 179:7244-7253.
-
(2007)
J Immunol
, vol.179
, pp. 7244-7253
-
-
Redmond, W.L.1
Gough, M.J.2
Charbonneau, B.3
-
118
-
-
0036047663
-
Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis
-
Ren-Heidenreich L, Mordini R, Hayman GT et al (2002) Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis. Cancer Immunol Immunother 51:417-423.
-
(2002)
Cancer Immunol Immunother
, vol.51
, pp. 417-423
-
-
Ren-Heidenreich, L.1
Mordini, R.2
Hayman, G.T.3
-
119
-
-
59249094502
-
Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain Valpha Vbeta fragments
-
Richman SA, Aggen DH, Dossett ML et al (2009) Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain Valpha Vbeta fragments. Mol Immunol 46:902-916.
-
(2009)
Mol Immunol
, vol.46
, pp. 902-916
-
-
Richman, S.A.1
Aggen, D.H.2
Dossett, M.L.3
-
120
-
-
10344261422
-
Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy
-
Robbins PF, Dudley ME, Wunderlich J et al (2004) Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J Immunol 173:7125-7130.
-
(2004)
J Immunol
, vol.173
, pp. 7125-7130
-
-
Robbins, P.F.1
Dudley, M.E.2
Wunderlich, J.3
-
121
-
-
0028079896
-
Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors
-
Roberts MR, Qin L, Zhang D et al (1994) Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors. Blood 84:2878-2889.
-
(1994)
Blood
, vol.84
, pp. 2878-2889
-
-
Roberts, M.R.1
Qin, L.2
Zhang, D.3
-
122
-
-
0036990306
-
Targeting CD19 with genetically modified EBV-specific human T lymphocytes
-
Roessig C, Scherer SP, Baer A et al (2002) Targeting CD19 with genetically modified EBV-specific human T lymphocytes. Ann Hematol 81(Suppl 2):S42-S43.
-
(2002)
Ann Hematol
, vol.81
, Issue.SUPPL. 2
-
-
Roessig, C.1
Scherer, S.P.2
Baer, A.3
-
123
-
-
0026083035
-
Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
-
Romeo C, Seed B (1991) Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64:1037-1046.
-
(1991)
Cell
, vol.64
, pp. 1037-1046
-
-
Romeo, C.1
Seed, B.2
-
124
-
-
65249173447
-
Adoptive cell therapy for the treatment of patients with metastatic melanoma
-
Rosenberg SA, Dudley ME (2009) Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr Opin Immunol 21:233-240.
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 233-240
-
-
Rosenberg, S.A.1
Dudley, M.E.2
-
125
-
-
0035888244
-
Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes
-
Rossig C, Bollard CM, Nuchtern JG et al (2001) Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes. Int J Cancer 94:228-236.
-
(2001)
Int J Cancer
, vol.94
, pp. 228-236
-
-
Rossig, C.1
Bollard, C.M.2
Nuchtern, J.G.3
-
126
-
-
0037085804
-
Epstein-Barr virusspecific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
-
Rossig C, Bollard CM, Nuchtern JG et al (2002) Epstein-Barr virusspecific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood 99:2009-2016.
-
(2002)
Blood
, vol.99
, pp. 2009-2016
-
-
Rossig, C.1
Bollard, C.M.2
Nuchtern, J.G.3
-
127
-
-
34948860624
-
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
-
Savoldo B, Rooney CM, Di Stasi A et al (2007) Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 110:2620-2630.
-
(2007)
Blood
, vol.110
, pp. 2620-2630
-
-
Savoldo, B.1
Rooney, C.M.2
Di, S.A.3
-
128
-
-
0037093844
-
Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
-
Schluns KS, Williams K, Ma A et al (2002) Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168:4827-4831.
-
(2002)
J Immunol
, vol.168
, pp. 4827-4831
-
-
Schluns, K.S.1
Williams, K.2
Ma, A.3
-
129
-
-
0742290162
-
Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease
-
Serafini M, Manganini M, Borleri G et al (2004) Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease. Hum Gene Ther 15:63-76.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 63-76
-
-
Serafini, M.1
Manganini, M.2
Borleri, G.3
-
130
-
-
0038185191
-
T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches
-
Sheen AJ, Sherlock DJ, Irlam J et al (2003) T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches. Br J Cancer 88:1119-1127.
-
(2003)
Br J Cancer
, vol.88
, pp. 1119-1127
-
-
Sheen, A.J.1
Sherlock, D.J.2
Irlam, J.3
-
131
-
-
33845934649
-
A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells
-
Shibaguchi H, Luo NX, Kuroki M et al (2006) A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells. Anticancer Res 26:4067-4072.
-
(2006)
Anticancer Res
, vol.26
, pp. 4067-4072
-
-
Shibaguchi, H.1
Luo, N.X.2
Kuroki, M.3
-
132
-
-
0030845586
-
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
-
Shuford WW, Klussman K, Tritchler DD et al (1997) 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47-55.
-
(1997)
J Exp Med
, vol.186
, pp. 47-55
-
-
Shuford, W.W.1
Klussman, K.2
Tritchler, D.D.3
-
133
-
-
33947285535
-
Immunoediting sculpts tumor epitopes during immunotherapy
-
Singh R, Paterson Y (2007) Immunoediting sculpts tumor epitopes during immunotherapy. Cancer Res 67:1887-1892.
-
(2007)
Cancer Res
, vol.67
, pp. 1887-1892
-
-
Singh, R.1
Paterson, Y.2
-
134
-
-
0035964621
-
Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: An active mode of immune evasion in colon cancer
-
Song E, Chen J, Ouyang N et al (2001) Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer. Br J Cancer 85:1047-1054.
-
(2001)
Br J Cancer
, vol.85
, pp. 1047-1054
-
-
Song, E.1
Chen, J.2
Ouyang, N.3
-
135
-
-
0027501259
-
Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors
-
Stancovski I, Schindler DG, Waks T et al (1993) Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J Immunol 151:6577-6582.
-
(1993)
J Immunol
, vol.151
, pp. 6577-6582
-
-
Stancovski, I.1
Schindler, D.G.2
Waks, T.3
-
136
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
-
Stephan MT, Ponomarev V, Brentjens RJ et al (2007) T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med 13:1440-1449.
-
(2007)
Nat Med
, vol.13
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
-
137
-
-
20144365643
-
Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes
-
Straathof KC, Bollard CM, Popat U et al (2005a) Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes. Blood 105:1898-1904.
-
(2005)
Blood
, vol.105
, pp. 1898-1904
-
-
Straathof, K.C.1
Bollard, C.M.2
Popat, U.3
-
138
-
-
19344365874
-
An inducible caspase 9 safety switch for T-cell therapy
-
Straathof KC, Pule MA, Yotnda P et al (2005b) An inducible caspase 9 safety switch for T-cell therapy. Blood 105:4247-4254.
-
(2005)
Blood
, vol.105
, pp. 4247-4254
-
-
Straathof, K.C.1
Pule, M.A.2
Yotnda, P.3
-
139
-
-
3142726124
-
Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes
-
Teng MW, Kershaw MH, Moeller M et al (2004) Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes. Hum Gene Ther 15:699-708.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 699-708
-
-
Teng, M.W.1
Kershaw, M.H.2
Moeller, M.3
-
140
-
-
34447310075
-
Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
-
Tey SK, Dotti G, Rooney CM et al (2007) Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant 13:913-924.
-
(2007)
Biol Blood Marrow Transplant
, vol.13
, pp. 913-924
-
-
Tey, S.K.1
Dotti, G.2
Rooney, C.M.3
-
141
-
-
0035282726
-
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
-
Thomis DC, Marktel S, Bonini C et al (2001) A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood 97:1249-1257.
-
(2001)
Blood
, vol.97
, pp. 1249-1257
-
-
Thomis, D.C.1
Marktel, S.2
Bonini, C.3
-
142
-
-
0035161228
-
Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
-
Tiberghien P, Ferrand C, Lioure B et al (2001) Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97:63-72.
-
(2001)
Blood
, vol.97
, pp. 63-72
-
-
Tiberghien, P.1
Ferrand, C.2
Lioure, B.3
-
143
-
-
50549096284
-
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
-
Till BG, Jensen MC, Wang J et al (2008) Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112:2261-2271.
-
(2008)
Blood
, vol.112
, pp. 2261-2271
-
-
Till, B.G.1
Jensen, M.C.2
Wang, J.3
-
144
-
-
34249748406
-
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
-
Traversari C, Marktel S, Magnani Z et al (2007) The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood 109:4708-4715.
-
(2007)
Blood
, vol.109
, pp. 4708-4715
-
-
Traversari, C.1
Marktel, S.2
Magnani, Z.3
-
145
-
-
14844322786
-
Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor
-
Turatti F, Figini M, Alberti P et al (2005) Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor. J Gene Med 7:158-170.
-
(2005)
J Gene Med
, vol.7
, pp. 158-170
-
-
Turatti, F.1
Figini, M.2
Alberti, P.3
-
146
-
-
33645964652
-
The CD20/alphaCD20 'suicide' system: Novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells
-
van Meerten T, Claessen MJ, Hagenbeek A et al (2006) The CD20/alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells. Gene Ther 13:789-797.
-
(2006)
Gene Ther
, vol.13
, pp. 789-797
-
-
Van Meerten, T.1
Claessen, M.J.2
Hagenbeek, A.3
-
147
-
-
33845256434
-
T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
-
Vera J, Savoldo B, Vigouroux S et al (2006) T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood 108:3890-3897.
-
(2006)
Blood
, vol.108
, pp. 3890-3897
-
-
Vera, J.1
Savoldo, B.2
Vigouroux, S.3
-
148
-
-
67349252824
-
Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7
-
Vera JF, Hoyos V, Savoldo B et al (2009) Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol Ther 17:880-888.
-
(2009)
Mol Ther
, vol.17
, pp. 880-888
-
-
Vera, J.F.1
Hoyos, V.2
Savoldo, B.3
-
149
-
-
0023920595
-
Reshaping human antibodies: Grafting an antilysozyme activity
-
Verhoeyen M, Milstein C, Winter G (1988) Reshaping human antibodies: grafting an antilysozyme activity. Science 239:1534-1536.
-
(1988)
Science
, vol.239
, pp. 1534-1536
-
-
Verhoeyen, M.1
Milstein, C.2
Winter, G.3
-
150
-
-
18344406935
-
Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
-
Walker RE, Bechtel CM, Natarajan V et al (2000) Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96:467-474.
-
(2000)
Blood
, vol.96
, pp. 467-474
-
-
Walker, R.E.1
Bechtel, C.M.2
Natarajan, V.3
-
151
-
-
52449122955
-
Transforming growth factorbeta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers
-
Wallace A, Kapoor V, Sun J et al (2008) Transforming growth factorbeta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14:3966-3974.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3966-3974
-
-
Wallace, A.1
Kapoor, V.2
Sun, J.3
-
152
-
-
2342655822
-
Cellular immunotherapy for follicular lymphoma using genetically modified CD20- specific CD8+ cytotoxic T lymphocytes
-
Wang J, Press OW, Lindgren CG et al (2004) Cellular immunotherapy for follicular lymphoma using genetically modified CD20- specific CD8+ cytotoxic T lymphocytes. Mol Ther 9:577-586.
-
(2004)
Mol Ther
, vol.9
, pp. 577-586
-
-
Wang, J.1
Press, O.W.2
Lindgren, C.G.3
-
153
-
-
34548485103
-
Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
-
Wang J, Jensen M, Lin Y et al (2007) Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum Gene Ther 18:712-725.
-
(2007)
Hum Gene Ther
, vol.18
, pp. 712-725
-
-
Wang, J.1
Jensen, M.2
Lin, Y.3
-
154
-
-
54549114445
-
Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded HSVTK suicide genes
-
Wang X, Olszewska M, Capacio V et al (2008) Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded HSVTK suicide genes. Gene Ther 15:1454-1459.
-
(2008)
Gene Ther
, vol.15
, pp. 1454-1459
-
-
Wang, X.1
Olszewska, M.2
Capacio, V.3
-
155
-
-
0043128070
-
Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules
-
Weijtens ME, Willemsen RA, van Krimpen BA et al (1998) Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules. Int J Cancer 77:181-187.
-
(1998)
Int J Cancer
, vol.77
, pp. 181-187
-
-
Weijtens, M.E.1
Willemsen, R.A.2
Van Krimpen, B.A.3
-
156
-
-
30044442768
-
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice
-
Westwood JA, Smyth MJ, Teng MW et al (2005) Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci USA 102:19051-19056.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 19051-19056
-
-
Westwood, J.A.1
Smyth, M.J.2
Teng, M.W.3
-
157
-
-
44449162630
-
Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
-
Wilkie S, Picco G, Foster J et al (2008) Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J Immunol 180:4901-4909.
-
(2008)
J Immunol
, vol.180
, pp. 4901-4909
-
-
Wilkie, S.1
Picco, G.2
Foster, J.3
-
158
-
-
20444377728
-
T cell retargeting with MHC class I-restricted antibodies: The CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production
-
Willemsen RA, Ronteltap C, Chames P et al (2005) T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production. J Immunol 174:7853-7858.
-
(2005)
J Immunol
, vol.174
, pp. 7853-7858
-
-
Willemsen, R.A.1
Ronteltap, C.2
Chames, P.3
-
159
-
-
67349189462
-
Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model
-
Yoon SH, Lee JM, Cho HI et al (2009) Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model. Cancer Gene Ther 16:489-497.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 489-497
-
-
Yoon, S.H.1
Lee, J.M.2
Cho, H.I.3
-
160
-
-
0034526330
-
Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors
-
Yun CO, Nolan KF, Beecham EJ et al (2000) Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Neoplasia 2:449-459.
-
(2000)
Neoplasia
, vol.2
, pp. 449-459
-
-
Yun, C.O.1
Nolan, K.F.2
Beecham, E.J.3
-
161
-
-
3142576998
-
Transgenic TCR expression: Comparison of single chain with full-length receptor constructs for T-cell function
-
Zhang T, He X, Tsang TC et al (2004) Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther 11:487-496.
-
(2004)
Cancer Gene Ther
, vol.11
, pp. 487-496
-
-
Zhang, T.1
He, X.2
Tsang, T.C.3
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