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Volumn 58, Issue 3, 2010, Pages 165-178

Adoptive T-cell immunotherapy of cancer using chimeric antigen receptor-grafted T Cells

Author keywords

Adoptive transfer; Cancer; Chimeric antigen receptor; Survival; T cell

Indexed keywords

CARBONATE DEHYDRATASE IX; CARCINOEMBRYONIC ANTIGEN; CD19 ANTIGEN; CD20 ANTIGEN; CD22 ANTIGEN; CD30 ANTIGEN; CD44V6 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPITHELIAL CELL ADHESION MOLECULE; FOLATE RECEPTOR; GANGLIOSIDE GD2; GANGLIOSIDE GD3; IMMUNOGLOBULIN KAPPA CHAIN; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; MAJOR HISTOCOMPATIBILITY ANTIGEN; MUCIN 1; NERVE CELL ADHESION MOLECULE; PROSTATE SPECIFIC MEMBRANE ANTIGEN; PROSTATE STEM CELL ANTIGEN; RITUXIMAB; T LYMPHOCYTE RECEPTOR; VASCULOTROPIN RECEPTOR 2;

EID: 77953026179     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-010-0074-1     Document Type: Review
Times cited : (14)

References (161)
  • 1
    • 34250844475 scopus 로고    scopus 로고
    • Regression of experimental medulloblastoma following transfer of HER2-specific T cells
    • Ahmed N, Ratnayake M, Savoldo B et al (2007) Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res 67:5957-5964.
    • (2007) Cancer Res , vol.67 , pp. 5957-5964
    • Ahmed, N.1    Ratnayake, M.2    Savoldo, B.3
  • 2
    • 33745223518 scopus 로고    scopus 로고
    • T-cell antigenreceptor stoichiometry: Pre-clustering for sensitivity
    • Alarcon B, Swamy M, van Santen HM et al (2006) T-cell antigenreceptor stoichiometry: pre-clustering for sensitivity. EMBO Rep 7:490-495.
    • (2006) EMBO Rep , vol.7 , pp. 490-495
    • Alarcon, B.1    Swamy, M.2    Van Santen, H.M.3
  • 3
    • 0029948642 scopus 로고    scopus 로고
    • Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes
    • Altenschmidt U, Kahl R, Moritz D et al (1996) Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes. Clin Cancer Res 2:1001-1008.
    • (1996) Clin Cancer Res , vol.2 , pp. 1001-1008
    • Altenschmidt, U.1    Kahl, R.2    Moritz, D.3
  • 4
    • 0031306874 scopus 로고    scopus 로고
    • Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression
    • Altenschmidt U, Klundt E, Groner B (1997) Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression. J Immunol 159:5509-5515.
    • (1997) J Immunol , vol.159 , pp. 5509-5515
    • Altenschmidt, U.1    Klundt, E.2    Groner, B.3
  • 5
    • 0029841565 scopus 로고    scopus 로고
    • Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric singlechain antibody variable fragment-CD28 receptors
    • Alvarez-Vallina L, Hawkins RE (1996) Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric singlechain antibody variable fragment-CD28 receptors. Eur J Immunol 26:2304-2309.
    • (1996) Eur J Immunol , vol.26 , pp. 2304-2309
    • Alvarez-Vallina, L.1    Hawkins, R.E.2
  • 6
    • 0024435150 scopus 로고
    • Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice
    • Becker ML, Near R, Mudgett-Hunter M et al (1989) Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell 58:911-921.
    • (1989) Cell , vol.58 , pp. 911-921
    • Becker, M.L.1    Near, R.2    Mudgett-Hunter, M.3
  • 7
    • 47549104068 scopus 로고    scopus 로고
    • Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance
    • Bennour E, Ferrand C, Remy-Martin JP et al (2008) Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance. Hum Gene Ther 19:699-709.
    • (2008) Hum Gene Ther , vol.19 , pp. 699-709
    • Bennour, E.1    Ferrand, C.2    Remy-Martin, J.P.3
  • 8
    • 33644750264 scopus 로고    scopus 로고
    • Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    • Berger C, Flowers ME, Warren EH et al (2006) Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation. Blood 107:2294-2302.
    • (2006) Blood , vol.107 , pp. 2294-2302
    • Berger, C.1    Flowers, M.E.2    Warren, E.H.3
  • 9
    • 0030843493 scopus 로고    scopus 로고
    • HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versusleukemia
    • Bonini C, Ferrari G, Verzeletti S et al (1997) HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versusleukemia. Science 276:1719-1724.
    • (1997) Science , vol.276 , pp. 1719-1724
    • Bonini, C.1    Ferrari, G.2    Verzeletti, S.3
  • 10
    • 0037348324 scopus 로고    scopus 로고
    • Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
    • Brentjens RJ, Latouche JB, Santos E et al (2003) Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. Nat Med 9:279-286.
    • (2003) Nat Med , vol.9 , pp. 279-286
    • Brentjens, R.J.1    Latouche, J.B.2    Santos, E.3
  • 11
    • 34848842554 scopus 로고    scopus 로고
    • Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
    • Brentjens RJ, Santos E, Nikhamin Y et al (2007) Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res 13:5426-5435.
    • (2007) Clin Cancer Res , vol.13 , pp. 5426-5435
    • Brentjens, R.J.1    Santos, E.2    Nikhamin, Y.3
  • 12
    • 0028902765 scopus 로고
    • Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes
    • Brocker T, Karjalainen K (1995) Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181:1653-1659.
    • (1995) J Exp Med , vol.181 , pp. 1653-1659
    • Brocker, T.1    Karjalainen, K.2
  • 13
    • 0141596016 scopus 로고    scopus 로고
    • Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    • Burt RK, Drobyski WR, Seregina T et al (2003) Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions. Exp Hematol 31:903-910.
    • (2003) Exp Hematol , vol.31 , pp. 903-910
    • Burt, R.K.1    Drobyski, W.R.2    Seregina, T.3
  • 14
    • 0026610881 scopus 로고
    • Humanization of an antip185HER2 antibody for human cancer therapy
    • Carter P, Presta L, Gorman CM et al (1992) Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 89:4285-4289.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4285-4289
    • Carter, P.1    Presta, L.2    Gorman, C.M.3
  • 15
    • 17944370860 scopus 로고    scopus 로고
    • Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene
    • Chalmers D, Ferrand C, Apperley JF et al (2001) Elimination of the truncated message from the herpes simplex virus thymidine kinase suicide gene. Mol Ther 4:146-148.
    • (2001) Mol Ther , vol.4 , pp. 146-148
    • Chalmers, D.1    Ferrand, C.2    Apperley, J.F.3
  • 16
    • 16444381331 scopus 로고    scopus 로고
    • Bcl-2 overexpression enhances tumor-specific T-cell survival
    • Charo J, Finkelstein SE, Grewal N et al (2005) Bcl-2 overexpression enhances tumor-specific T-cell survival. Cancer Res 65:2001-2008.
    • (2005) Cancer Res , vol.65 , pp. 2001-2008
    • Charo, J.1    Finkelstein, S.E.2    Grewal, N.3
  • 17
    • 44649197976 scopus 로고    scopus 로고
    • The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma
    • Cheadle EJ, Gilham DE, Hawkins RE (2008) The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B-cell lymphoma. Br J Haematol 142:65-68.
    • (2008) Br J Haematol , vol.142 , pp. 65-68
    • Cheadle, E.J.1    Gilham, D.E.2    Hawkins, R.E.3
  • 18
    • 23144455728 scopus 로고    scopus 로고
    • T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
    • Choudhuri K, Wiseman D, Brown MH et al (2005) T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436:578-582.
    • (2005) Nature , vol.436 , pp. 578-582
    • Choudhuri, K.1    Wiseman, D.2    Brown, M.H.3
  • 20
    • 0037441593 scopus 로고    scopus 로고
    • T-cell clones can be rendered specific for CD19: Toward the selective augmentation of the graft-versus-B-lineage leukemia effect
    • Cooper LJ, Topp MS, Serrano LM et al (2003) T-cell clones can be rendered specific for CD19: toward the selective augmentation of the graft-versus-B-lineage leukemia effect. Blood 101:1637-1644.
    • (2003) Blood , vol.101 , pp. 1637-1644
    • Cooper, L.J.1    Topp, M.S.2    Serrano, L.M.3
  • 21
    • 13544273197 scopus 로고    scopus 로고
    • Enhanced antilymphoma efficacy of CD19-redirected influenza MP1- specific CTLs by cotransfer of T cells modified to present influenza MP1
    • Cooper LJ, Al-Kadhimi Z, Serrano LM et al (2005) Enhanced antilymphoma efficacy of CD19-redirected influenza MP1- specific CTLs by cotransfer of T cells modified to present influenza MP1. Blood 105:1622-1631.
    • (2005) Blood , vol.105 , pp. 1622-1631
    • Cooper, L.J.1    Al-Kadhimi, Z.2    Serrano, L.M.3
  • 22
  • 23
    • 0031946483 scopus 로고    scopus 로고
    • Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma
    • Darcy PK, Kershaw MH, Trapani JA et al (1998) Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma. Eur J Immunol 28:1663-1672.
    • (1998) Eur J Immunol , vol.28 , pp. 1663-1672
    • Darcy, P.K.1    Kershaw, M.H.2    Trapani, J.A.3
  • 24
    • 42649106831 scopus 로고    scopus 로고
    • Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines
    • Daudt L, Maccario R, Locatelli F et al (2008) Interleukin-15 favors the expansion of central memory CD8+ T cells in ex vivo generated, antileukemia human cytotoxic T lymphocyte lines. J Immunother 31:385-393.
    • (2008) J Immunother , vol.31 , pp. 385-393
    • Daudt, L.1    Maccario, R.2    Locatelli, F.3
  • 25
    • 33746114879 scopus 로고    scopus 로고
    • The kinetic-segregation model: TCR triggering and beyond
    • Davis SJ, van der Merwe PA (2006) The kinetic-segregation model: TCR triggering and beyond. Nat Immunol 7:803-809.
    • (2006) Nat Immunol , vol.7 , pp. 803-809
    • Davis, S.J.1    Van Der Merwe, P.A.2
  • 26
    • 0031567896 scopus 로고    scopus 로고
    • Costimulation of CD28- T lymphocytes by 4-1BB ligand
    • DeBenedette MA, Shahinian A, Mak TW et al (1997) Costimulation of CD28- T lymphocytes by 4-1BB ligand. J Immunol 158:551-559.
    • (1997) J Immunol , vol.158 , pp. 551-559
    • DeBenedette, M.A.1    Shahinian, A.2    Mak, T.W.3
  • 27
    • 0035989039 scopus 로고    scopus 로고
    • A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
    • Deeks SG, Wagner B, Anton PA et al (2002) A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol Ther 5:788-797.
    • (2002) Mol Ther , vol.5 , pp. 788-797
    • Deeks, S.G.1    Wagner, B.2    Anton, P.A.3
  • 28
    • 0022538117 scopus 로고
    • Transfer of specificity by murine alpha and beta T-cell receptor genes
    • Dembic Z, Haas W, Weiss S et al (1986) Transfer of specificity by murine alpha and beta T-cell receptor genes. Nature 320:232-238.
    • (1986) Nature , vol.320 , pp. 232-238
    • Dembic, Z.1    Haas, W.2    Weiss, S.3
  • 29
    • 37049008307 scopus 로고    scopus 로고
    • Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft
    • Deschamps M, Mercier-Lethondal P, Certoux JM et al (2007) Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft. Blood 110:3842-3852.
    • (2007) Blood , vol.110 , pp. 3842-3852
    • Deschamps, M.1    Mercier-Lethondal, P.2    Certoux, J.M.3
  • 30
    • 20444425695 scopus 로고    scopus 로고
    • Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
    • Dotti G, Savoldo B, Pule M et al (2005) Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood 105:4677-4684.
    • (2005) Blood , vol.105 , pp. 4677-4684
    • Dotti, G.1    Savoldo, B.2    Pule, M.3
  • 31
    • 85047696817 scopus 로고    scopus 로고
    • Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions
    • Eaton D, Gilham DE, O'Neill A et al (2002) Retroviral transduction of human peripheral blood lymphocytes with Bcl-X(L) promotes in vitro lymphocyte survival in pro-apoptotic conditions. Gene Ther 9:527-535.
    • (2002) Gene Ther , vol.9 , pp. 527-535
    • Eaton, D.1    Gilham, D.E.2    O'Neill, A.3
  • 32
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • Eshhar Z, Waks T, Gross G et al (1993) Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 90:720-724.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, G.3
  • 33
    • 0032531091 scopus 로고    scopus 로고
    • Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product
    • Finney HM, Lawson AD, Bebbington CR et al (1998) Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product. J Immunol 161:2791-2797.
    • (1998) J Immunol , vol.161 , pp. 2791-2797
    • Finney, H.M.1    Lawson, A.D.2    Bebbington, C.R.3
  • 34
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • Finney HM, Akbar AN, Lawson AD (2004) Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol 172:104-113.
    • (2004) J Immunol , vol.172 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 35
    • 17044378252 scopus 로고    scopus 로고
    • Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation
    • Friedmann-Morvinski D, Bendavid A, Waks T et al (2005) Redirected primary T cells harboring a chimeric receptor require costimulation for their antigen-specific activation. Blood 105:3087-3093.
    • (2005) Blood , vol.105 , pp. 3087-3093
    • Friedmann-Morvinski, D.1    Bendavid, A.2    Waks, T.3
  • 36
    • 25444524262 scopus 로고    scopus 로고
    • Targeted elimination of prostate cancer by genetically directed human T lymphocytes
    • Gade TP, Hassen W, Santos E et al (2005) Targeted elimination of prostate cancer by genetically directed human T lymphocytes. Cancer Res 65:9080-9088.
    • (2005) Cancer Res , vol.65 , pp. 9080-9088
    • Gade, T.P.1    Hassen, W.2    Santos, E.3
  • 37
    • 0035174929 scopus 로고    scopus 로고
    • Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene
    • Garin MI, Garrett E, Tiberghien P et al (2001) Molecular mechanism for ganciclovir resistance in human T lymphocytes transduced with retroviral vectors carrying the herpes simplex virus thymidine kinase gene. Blood 97:122-129.
    • (2001) Blood , vol.97 , pp. 122-129
    • Garin, M.I.1    Garrett, E.2    Tiberghien, P.3
  • 38
    • 31544442669 scopus 로고    scopus 로고
    • Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor
    • Gattenlohner S, Marx A, Markfort B et al (2006) Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor. Cancer Res 66:24-28.
    • (2006) Cancer Res , vol.66 , pp. 24-28
    • Gattenlohner, S.1    Marx, A.2    Markfort, B.3
  • 39
    • 20444499355 scopus 로고    scopus 로고
    • Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
    • Gattinoni L, Klebanoff CA, Palmer DC et al (2005) Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. J Clin Invest 115:1616-1626.
    • (2005) J Clin Invest , vol.115 , pp. 1616-1626
    • Gattinoni, L.1    Klebanoff, C.A.2    Palmer, D.C.3
  • 40
    • 0036193484 scopus 로고    scopus 로고
    • Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zetabased chimeric immune receptors
    • Gilham DE, O'Neil A, Hughes C et al (2002) Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zetabased chimeric immune receptors. J Immunother 25:139-151.
    • (2002) J Immunother , vol.25 , pp. 139-151
    • Gilham, D.E.1    O'Neil, A.2    Hughes, C.3
  • 41
    • 0033139686 scopus 로고    scopus 로고
    • Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen
    • Gong MC, Latouche JB, Krause A et al (1999) Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen. Neoplasia 1:123-127.
    • (1999) Neoplasia , vol.1 , pp. 123-127
    • Gong, M.C.1    Latouche, J.B.2    Krause, A.3
  • 42
    • 13644250942 scopus 로고    scopus 로고
    • Genetic engineering of cytolytic T lymphocytes for adoptive T-cell therapy of neuroblastoma
    • Gonzalez S, Naranjo A, Serrano LM et al (2004) Genetic engineering of cytolytic T lymphocytes for adoptive T-cell therapy of neuroblastoma. J Gene Med 6:704-711.
    • (2004) J Gene Med , vol.6 , pp. 704-711
    • Gonzalez, S.1    Naranjo, A.2    Serrano, L.M.3
  • 43
    • 0025324449 scopus 로고
    • Chimeric immunoglobulin-T cell receptor proteins form functional receptors: Implications for T cell receptor complex formation and activation
    • Goverman J, Gomez SM, Segesman KD et al (1990) Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation. Cell 60:929-939.
    • (1990) Cell , vol.60 , pp. 929-939
    • Goverman, J.1    Gomez, S.M.2    Segesman, K.D.3
  • 44
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-Tcell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G, Waks T, Eshhar Z (1989) Expression of immunoglobulin-Tcell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 86:10024-10028.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 45
    • 20944439742 scopus 로고    scopus 로고
    • The role of extracellular spacer regions in the optimal design of chimeric immune receptors: Evaluation of four different scFvs and antigens
    • Guest RD, Hawkins RE, Kirillova N et al (2005) The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J Immunother 28:203-211.
    • (2005) J Immunother , vol.28 , pp. 203-211
    • Guest, R.D.1    Hawkins, R.E.2    Kirillova, N.3
  • 46
    • 36248951128 scopus 로고    scopus 로고
    • Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells
    • Habib-Agahi M, Phan TT, Searle PF (2007) Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int Immunol 19:1383-1394.
    • (2007) Int Immunol , vol.19 , pp. 1383-1394
    • Habib-Agahi, M.1    Phan, T.T.2    Searle, P.F.3
  • 47
    • 0035159470 scopus 로고    scopus 로고
    • Redirecting mouse CTL against colon carcinoma: Superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma
    • Haynes NM, Snook MB, Trapani JA et al (2001) Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol 166:182-187.
    • (2001) J Immunol , vol.166 , pp. 182-187
    • Haynes, N.M.1    Snook, M.B.2    Trapani, J.A.3
  • 48
    • 0036839589 scopus 로고    scopus 로고
    • Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors
    • Haynes NM, Trapani JA, Teng MW et al (2002a) Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood 100:3155-3163.
    • (2002) Blood , vol.100 , pp. 3155-3163
    • Haynes, N.M.1    Trapani, J.A.2    Teng, M.W.3
  • 49
    • 0037111240 scopus 로고    scopus 로고
    • Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
    • Haynes NM, Trapani JA, Teng MW et al (2002b) Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol 169:5780-5786.
    • (2002) J Immunol , vol.169 , pp. 5780-5786
    • Haynes, N.M.1    Trapani, J.A.2    Teng, M.W.3
  • 50
    • 0029823560 scopus 로고    scopus 로고
    • Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera
    • Hekele A, Dall P, Moritz D et al (1996) Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera. Int J Cancer 68:232-238.
    • (1996) Int J Cancer , vol.68 , pp. 232-238
    • Hekele, A.1    Dall, P.2    Moritz, D.3
  • 51
    • 45449087723 scopus 로고    scopus 로고
    • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
    • Hinrichs CS, Spolski R, Paulos CM et al (2008) IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood 111:5326-5333.
    • (2008) Blood , vol.111 , pp. 5326-5333
    • Hinrichs, C.S.1    Spolski, R.2    Paulos, C.M.3
  • 52
    • 63649112916 scopus 로고    scopus 로고
    • Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy
    • Hollyman D, Stefanski J, Przybylowski M et al (2009) Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. J Immunother 32:169-180.
    • (2009) J Immunother , vol.32 , pp. 169-180
    • Hollyman, D.1    Stefanski, J.2    Przybylowski, M.3
  • 53
    • 0030777395 scopus 로고    scopus 로고
    • T cell targeting of TAG72+ tumor cells by a chimeric receptorwith antibody-like specificity for a carbohydrate epitope
    • Hombach A, Heuser C, Sircar R et al (1997) T cell targeting of TAG72+ tumor cells by a chimeric receptorwith antibody-like specificity for a carbohydrate epitope. Gastroenterology 113:1163-1170.
    • (1997) Gastroenterology , vol.113 , pp. 1163-1170
    • Hombach, A.1    Heuser, C.2    Sircar, R.3
  • 54
    • 0032521416 scopus 로고    scopus 로고
    • An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30
    • Hombach A, Heuser C, Sircar R et al (1998) An anti-CD30 chimeric receptor that mediates CD3-zeta-independent T-cell activation against Hodgkin's lymphoma cells in the presence of soluble CD30. Cancer Res 58:1116-1119.
    • (1998) Cancer Res , vol.58 , pp. 1116-1119
    • Hombach, A.1    Heuser, C.2    Sircar, R.3
  • 55
    • 33947633597 scopus 로고    scopus 로고
    • T cell activation by antibody-like immunoreceptors: The position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
    • Hombach AA, Schildgen V, Heuser C et al (2007) T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunol 178:4650-4657.
    • (2007) J Immunol , vol.178 , pp. 4650-4657
    • Hombach, A.A.1    Schildgen, V.2    Heuser, C.3
  • 56
    • 0026639360 scopus 로고
    • The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation
    • Howard FD, Moingeon P, Moebius U et al (1992) The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation. J Exp Med 176:139-145.
    • (1992) J Exp Med , vol.176 , pp. 139-145
    • Howard, F.D.1    Moingeon, P.2    Moebius, U.3
  • 57
    • 0029117913 scopus 로고
    • Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28
    • Hurtado JC, Kim SH, Pollok KE et al (1995) Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J Immunol 155:3360-3367.
    • (1995) J Immunol , vol.155 , pp. 3360-3367
    • Hurtado, J.C.1    Kim, S.H.2    Pollok, K.E.3
  • 58
    • 0004198722 scopus 로고
    • Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
    • Huston JS, Levinson D, Mudgett-Hunter M et al (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85:5879-5883.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5879-5883
    • Huston, J.S.1    Levinson, D.2    Mudgett-Hunter, M.3
  • 59
    • 0027283443 scopus 로고
    • Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
    • Hwu P, Shafer GE, Treisman J et al (1993) Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain. J Exp Med 178:361-366.
    • (1993) J Exp Med , vol.178 , pp. 361-366
    • Hwu, P.1    Shafer, G.E.2    Treisman, J.3
  • 60
    • 0029134048 scopus 로고
    • In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes
    • Hwu P, Yang JC, Cowherd R et al (1995) In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res 55:3369-3373.
    • (1995) Cancer Res , vol.55 , pp. 3369-3373
    • Hwu, P.1    Yang, J.C.2    Cowherd, R.3
  • 61
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • Imai C, Mihara K, Andreansky M et al (2004) Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 18:676-684.
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Andreansky, M.3
  • 62
    • 0034054579 scopus 로고    scopus 로고
    • Genetic modification of human T cells with CD20: A strategy to purify and lyse transduced cells with anti-CD20 antibodies
    • IntronaM, Barbui AM, Bambacioni F et al (2000) Genetic modification of human T cells with CD20: a strategy to purify and lyse transduced cells with anti-CD20 antibodies. Hum Gene Ther 11:611-620.
    • (2000) Hum Gene Ther , vol.11 , pp. 611-620
    • Intronam1    Barbui, A.M.2    Bambacioni, F.3
  • 63
    • 0026064305 scopus 로고
    • The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways
    • Irving BA, Weiss A (1991) The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64:891-901.
    • (1991) Cell , vol.64 , pp. 891-901
    • Irving, B.A.1    Weiss, A.2
  • 64
    • 0029123613 scopus 로고
    • Defective major histocompatibility complex class I expression in a sarcomatoid renal cell carcinoma cell line
    • Jakobsen MK, Restifo NP, Cohen PA et al (1995) Defective major histocompatibility complex class I expression in a sarcomatoid renal cell carcinoma cell line. J Immunother Emphas Tumor Immunol 17:222-228.
    • (1995) J Immunother Emphas Tumor Immunol , vol.17 , pp. 222-228
    • Jakobsen, M.K.1    Restifo, N.P.2    Cohen, P.A.3
  • 65
    • 45549093089 scopus 로고    scopus 로고
    • Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
    • James SE, Greenberg PD, Jensen MC et al (2008) Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol 180:7028-7038.
    • (2008) J Immunol , vol.180 , pp. 7028-7038
    • James, S.E.1    Greenberg, P.D.2    Jensen, M.C.3
  • 66
    • 0031610524 scopus 로고    scopus 로고
    • CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: Implications for cellular immunotherapy of CD20+ malignancy
    • Jensen M, Tan G, Forman S et al (1998) CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy. Biol Blood Marrow Transplant 4:75-83.
    • (1998) Biol Blood Marrow Transplant , vol.4 , pp. 75-83
    • Jensen, M.1    Tan, G.2    Forman, S.3
  • 67
    • 10844296758 scopus 로고    scopus 로고
    • Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
    • Kahlon KS, Brown C, Cooper LJ et al (2004) Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res 64:9160-9166.
    • (2004) Cancer Res , vol.64 , pp. 9160-9166
    • Kahlon, K.S.1    Brown, C.2    Cooper, L.J.3
  • 68
    • 0034634865 scopus 로고    scopus 로고
    • Generation of genemodified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature
    • Kershaw MH, Westwood JA, Zhu Z et al (2000) Generation of genemodified T cells reactive against the angiogenic kinase insert domain-containing receptor (KDR) found on tumor vasculature. Hum Gene Ther 11:2445-2452.
    • (2000) Hum Gene Ther , vol.11 , pp. 2445-2452
    • Kershaw, M.H.1    Westwood, J.A.2    Zhu, Z.3
  • 69
    • 0036905078 scopus 로고    scopus 로고
    • Dual-specific T cells combine proliferation and antitumor activity
    • Kershaw MH, Westwood JA, Hwu P (2002) Dual-specific T cells combine proliferation and antitumor activity. Nat Biotechnol 20:1221-1227.
    • (2002) Nat Biotechnol , vol.20 , pp. 1221-1227
    • Kershaw, M.H.1    Westwood, J.A.2    Hwu, P.3
  • 70
    • 3242765879 scopus 로고    scopus 로고
    • Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer
    • Kershaw MH, Jackson JT, Haynes NM et al (2004) Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol 173:2143-2150.
    • (2004) J Immunol , vol.173 , pp. 2143-2150
    • Kershaw, M.H.1    Jackson, J.T.2    Haynes, N.M.3
  • 71
    • 33750699642 scopus 로고    scopus 로고
    • A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL et al (2006) A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 12:6106-6115.
    • (2006) Clin Cancer Res , vol.12 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3
  • 72
    • 38649127824 scopus 로고    scopus 로고
    • A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
    • Kieback E, Charo J, Sommermeyer D et al (2008) A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer. Proc Natl Acad Sci USA 105:623-628.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 623-628
    • Kieback, E.1    Charo, J.2    Sommermeyer, D.3
  • 73
    • 10744226452 scopus 로고    scopus 로고
    • IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
    • Klebanoff CA, Finkelstein SE, Surman DR et al (2004) IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci USA 101:1969-1974.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1969-1974
    • Klebanoff, C.A.1    Finkelstein, S.E.2    Surman, D.R.3
  • 74
    • 58149218516 scopus 로고    scopus 로고
    • The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells
    • Kober J, Leitner J, Klauser C et al (2008) The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells. Eur J Immunol 38:2678-2688.
    • (2008) Eur J Immunol , vol.38 , pp. 2678-2688
    • Kober, J.1    Leitner, J.2    Klauser, C.3
  • 75
    • 0032541385 scopus 로고    scopus 로고
    • Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes
    • Krause A, Guo HF, Latouche JB et al (1998) Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes. J Exp Med 188:619-626.
    • (1998) J Exp Med , vol.188 , pp. 619-626
    • Krause, A.1    Guo, H.F.2    Latouche, J.B.3
  • 76
    • 0023568155 scopus 로고
    • Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions
    • Kuwana Y, Asakura Y, Utsunomiya N et al (1987) Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions. Biochem Biophys Res Commun 149:960-968.
    • (1987) Biochem Biophys Res Commun , vol.149 , pp. 960-968
    • Kuwana, Y.1    Asakura, Y.2    Utsunomiya, N.3
  • 77
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG et al (2006) Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 24:e20-e22.
    • (2006) J Clin Oncol , vol.24
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3
  • 78
    • 59649119936 scopus 로고    scopus 로고
    • Knockdown of human bid gene expression enhances survival of CD8(+) T cells
    • Lei XY, Xu YM, Wang T et al (2009) Knockdown of human bid gene expression enhances survival of CD8(+) T cells. Immunol Lett 122:30-36.
    • (2009) Immunol Lett , vol.122 , pp. 30-36
    • Lei, X.Y.1    Xu, Y.M.2    Wang, T.3
  • 79
    • 0025998529 scopus 로고
    • T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins
    • Letourneur F, Klausner RD (1991) T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci USA 88:8905-8909.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8905-8909
    • Letourneur, F.1    Klausner, R.D.2
  • 80
    • 38049120319 scopus 로고    scopus 로고
    • IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
    • Li Y, Yee C (2008) IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes. Blood 111:229-235.
    • (2008) Blood , vol.111 , pp. 229-235
    • Li, Y.1    Yee, C.2
  • 81
    • 0038181099 scopus 로고    scopus 로고
    • Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy
    • Li Q, Carr A, Ito F et al (2003) Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy. Cancer Res 63:2546-2552.
    • (2003) Cancer Res , vol.63 , pp. 2546-2552
    • Li, Q.1    Carr, A.2    Ito, F.3
  • 82
    • 34247891493 scopus 로고    scopus 로고
    • Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody
    • Li B, Wang H, Zhang D et al (2007a) Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody. Biochem Biophys Res Commun 357:951-956.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 951-956
    • Li, B.1    Wang, H.2    Zhang, D.3
  • 83
    • 37249088549 scopus 로고    scopus 로고
    • Adjuvant effect of anti- 4-1BB mAb administration in adoptive T cell therapy of cancer
    • Li Q, Iuchi T, Jure-Kunkel MN et al (2007b) Adjuvant effect of anti- 4-1BB mAb administration in adoptive T cell therapy of cancer. Int J Biol Sci 3:455-462.
    • (2007) Int J Biol Sci , vol.3 , pp. 455-462
    • Li, Q.1    Iuchi, T.2    Jure-Kunkel, M.N.3
  • 84
    • 0041976988 scopus 로고    scopus 로고
    • The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
    • Lin J, Weiss A (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol 162:673-682.
    • (2003) J Cell Biol , vol.162 , pp. 673-682
    • Lin, J.1    Weiss, A.2
  • 85
    • 0035575701 scopus 로고    scopus 로고
    • Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity
    • Liu K, Rosenberg SA (2001) Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity. J Immunol 167:6356-6365.
    • (2001) J Immunol , vol.167 , pp. 6356-6365
    • Liu, K.1    Rosenberg, S.A.2
  • 86
    • 37449024076 scopus 로고    scopus 로고
    • Harnessing the tumour derived cytokine, CSF-1, to co-stimulate T-cell growth and activation
    • Lo AS, Taylor JR, Farzaneh F et al (2008) Harnessing the tumour derived cytokine, CSF-1, to co-stimulate T-cell growth and activation. Mol Immunol 45:1276-1287.
    • (2008) Mol Immunol , vol.45 , pp. 1276-1287
    • Lo, A.S.1    Taylor, J.R.2    Farzaneh, F.3
  • 87
    • 33750061330 scopus 로고    scopus 로고
    • Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    • Loskog A, Giandomenico V, Rossig C et al (2006) Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia 20:1819-1828.
    • (2006) Leukemia , vol.20 , pp. 1819-1828
    • Loskog, A.1    Giandomenico, V.2    Rossig, C.3
  • 88
    • 40949151469 scopus 로고    scopus 로고
    • Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival
    • Lou Y, Basha G, Seipp RP et al (2008) Combining the antigen processing components TAP and Tapasin elicits enhanced tumor-free survival. Clin Cancer Res 14:1494-1501.
    • (2008) Clin Cancer Res , vol.14 , pp. 1494-1501
    • Lou, Y.1    Basha, G.2    Seipp, R.P.3
  • 89
    • 4143084967 scopus 로고    scopus 로고
    • Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy
    • Ma Q, Safar M, Holmes E et al (2004) Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy. Prostate 61:12-25.
    • (2004) Prostate , vol.61 , pp. 12-25
    • Ma, Q.1    Safar, M.2    Holmes, E.3
  • 90
    • 0036137615 scopus 로고    scopus 로고
    • Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor
    • Maher J, Brentjens RJ, Gunset G et al (2002) Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta/CD28 receptor. Nat Biotechnol 20:70-75.
    • (2002) Nat Biotechnol , vol.20 , pp. 70-75
    • Maher, J.1    Brentjens, R.J.2    Gunset, G.3
  • 91
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V et al (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3
  • 92
    • 0033585433 scopus 로고    scopus 로고
    • Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor
    • McGuinness RP, Ge Y, Patel SD et al (1999) Anti-tumor activity of human T cells expressing the CC49-zeta chimeric immune receptor. Hum Gene Ther 10:165-173.
    • (1999) Hum Gene Ther , vol.10 , pp. 165-173
    • McGuinness, R.P.1    Ge, Y.2    Patel, S.D.3
  • 93
    • 0031039315 scopus 로고    scopus 로고
    • Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
    • Mendez MJ, Green LL, Corvalan JR et al (1997) Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 15:146-156.
    • (1997) Nat Genet , vol.15 , pp. 146-156
    • Mendez, M.J.1    Green, L.L.2    Corvalan, J.R.3
  • 94
    • 0032201554 scopus 로고    scopus 로고
    • Transfer of chimeric receptor gene made of variable regions of tumor specific antibody confers anticarbohydrate specificity on T cells
    • Mezzanzanica D, Canevari S, Mazzoni A et al (1998) Transfer of chimeric receptor gene made of variable regions of tumor specific antibody confers anticarbohydrate specificity on T cells. Cancer Gene Ther 5:401-407.
    • (1998) Cancer Gene Ther , vol.5 , pp. 401-407
    • Mezzanzanica, D.1    Canevari, S.2    Mazzoni, A.3
  • 95
    • 55349086931 scopus 로고    scopus 로고
    • Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment
    • Milano F, Jorritsma T, Rygiel AM et al (2008) Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. Scand J Immunol 68:616-623.
    • (2008) Scand J Immunol , vol.68 , pp. 616-623
    • Milano, F.1    Jorritsma, T.2    Rygiel, A.M.3
  • 96
    • 0034254611 scopus 로고    scopus 로고
    • Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects
    • Mitsuyasu RT, Anton PA, Deeks SG et al (2000) Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta genemodified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects. Blood 96:785-793.
    • (2000) Blood , vol.96 , pp. 785-793
    • Mitsuyasu, R.T.1    Anton, P.A.2    Deeks, S.G.3
  • 97
    • 2342534535 scopus 로고    scopus 로고
    • A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells
    • Moeller M, Haynes NM, Trapani JA et al (2004) A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells. Cancer Gene Ther 11:371-379.
    • (2004) Cancer Gene Ther , vol.11 , pp. 371-379
    • Moeller, M.1    Haynes, N.M.2    Trapani, J.A.3
  • 98
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR et al (2006) Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314:126-129.
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 99
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • in press
    • Morgan RA, Yang JC, Kitano M et al (2010) Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther (in press).
    • (2010) Mol Ther
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 100
    • 34250839415 scopus 로고    scopus 로고
    • Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells
    • Morgenroth A, Cartellieri M, Schmitz M et al (2007) Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells. Prostate 67:1121-1131.
    • (2007) Prostate , vol.67 , pp. 1121-1131
    • Morgenroth, A.1    Cartellieri, M.2    Schmitz, M.3
  • 101
    • 58149240223 scopus 로고    scopus 로고
    • Efficacy of IL-2-versus IL-15-stimulated CD8 T cells in adoptive immunotherapy
    • Mueller K, Schweier O, Pircher H (2008) Efficacy of IL-2-versus IL-15-stimulated CD8 T cells in adoptive immunotherapy. Eur J Immunol 38:2874-2885.
    • (2008) Eur J Immunol , vol.38 , pp. 2874-2885
    • Mueller, K.1    Schweier, O.2    Pircher, H.3
  • 102
    • 0033974799 scopus 로고    scopus 로고
    • Ligandmediated cytolysis of tumor cells: Use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes
    • Muniappan A, Banapour B, Lebkowski J et al (2000) Ligandmediated cytolysis of tumor cells: use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes. Cancer Gene Ther 7:128-134.
    • (2000) Cancer Gene Ther , vol.7 , pp. 128-134
    • Muniappan, A.1    Banapour, B.2    Lebkowski, J.3
  • 103
    • 0037108529 scopus 로고    scopus 로고
    • Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases
    • Murata K, Nose M, Ndhlovu LC et al (2002) Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol 169:4628-4636.
    • (2002) J Immunol , vol.169 , pp. 4628-4636
    • Murata, K.1    Nose, M.2    Ndhlovu, L.C.3
  • 104
    • 34247123205 scopus 로고    scopus 로고
    • Antitumor activity of dual-specific T cells and influenza virus
    • Murphy A, Westwood JA, Brown LE et al (2007) Antitumor activity of dual-specific T cells and influenza virus. Cancer Gene Ther 14:499-508.
    • (2007) Cancer Gene Ther , vol.14 , pp. 499-508
    • Murphy, A.1    Westwood, J.A.2    Brown, L.E.3
  • 105
    • 0037076297 scopus 로고    scopus 로고
    • Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors
    • Niederman TM, Ghogawala Z, Carter BS et al (2002) Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors. Proc Natl Acad Sci USA 99:7009-7014.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7009-7014
    • Niederman, T.M.1    Ghogawala, Z.2    Carter, B.S.3
  • 106
    • 0033385052 scopus 로고    scopus 로고
    • Bypassing immunization: Optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA
    • Nolan KF, Yun CO, Akamatsu Y et al (1999) Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA. Clin Cancer Res 5:3928-3941.
    • (1999) Clin Cancer Res , vol.5 , pp. 3928-3941
    • Nolan, K.F.1    Yun, C.O.2    Akamatsu, Y.3
  • 107
    • 0029808372 scopus 로고    scopus 로고
    • The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
    • O'Connell J, O'Sullivan GC, Collins JK et al (1996) The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med 184:1075-1082.
    • (1996) J Exp Med , vol.184 , pp. 1075-1082
    • O'Connell, J.1    O'Sullivan, G.C.2    Collins, J.K.3
  • 108
    • 33845618133 scopus 로고    scopus 로고
    • Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor
    • Pameijer CR, Navanjo A, Meechoovet B et al (2007) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor. Cancer Gene Ther 14:91-97.
    • (2007) Cancer Gene Ther , vol.14 , pp. 91-97
    • Pameijer, C.R.1    Navanjo, A.2    Meechoovet, B.3
  • 109
    • 33947265424 scopus 로고    scopus 로고
    • Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    • Park JR, Digiusto DL, Slovak M et al (2007) Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. Mol Ther 15:825-833.
    • (2007) Mol Ther , vol.15 , pp. 825-833
    • Park, J.R.1    Digiusto, D.L.2    Slovak, M.3
  • 110
    • 51549100478 scopus 로고    scopus 로고
    • Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo
    • Pegram HJ, Jackson JT, Smyth MJ et al (2008) Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo. J Immunol 181:3449-3455.
    • (2008) J Immunol , vol.181 , pp. 3449-3455
    • Pegram, H.J.1    Jackson, J.T.2    Smyth, M.J.3
  • 111
    • 0038181188 scopus 로고    scopus 로고
    • Immuno-gene therapy of established prostate tumors using chimeric receptorredirected human lymphocytes
    • Pinthus JH, Waks T, Kaufman-Francis K et al (2003) Immuno-gene therapy of established prostate tumors using chimeric receptorredirected human lymphocytes. Cancer Res 63:2470-2476.
    • (2003) Cancer Res , vol.63 , pp. 2470-2476
    • Pinthus, J.H.1    Waks, T.2    Kaufman-Francis, K.3
  • 112
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • Pollok KE, Kim YJ, Zhou Z et al (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 150:771-781.
    • (1993) J Immunol , vol.150 , pp. 771-781
    • Pollok, K.E.1    Kim, Y.J.2    Zhou, Z.3
  • 113
    • 0028946371 scopus 로고
    • Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4
    • Pollok KE, Kim SH, Kwon BS (1995) Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4. Eur J Immunol 25:488-494.
    • (1995) Eur J Immunol , vol.25 , pp. 488-494
    • Pollok, K.E.1    Kim, S.H.2    Kwon, B.S.3
  • 114
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • Pule MA, Straathof KC, Dotti G et al (2005) A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 12:933-941.
    • (2005) Mol Ther , vol.12 , pp. 933-941
    • Pule, M.A.1    Straathof, K.C.2    Dotti, G.3
  • 115
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD et al (2008) Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 14:1264-1270.
    • (2008) Nat Med , vol.14 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 116
    • 35549007239 scopus 로고    scopus 로고
    • Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes
    • Quintarelli C, Vera JF, Savoldo B et al (2007) Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes. Blood 110:2793-2802.
    • (2007) Blood , vol.110 , pp. 2793-2802
    • Quintarelli, C.1    Vera, J.F.2    Savoldo, B.3
  • 117
    • 38849164304 scopus 로고    scopus 로고
    • Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
    • Redmond WL, Gough MJ, Charbonneau B et al (2007) Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol 179:7244-7253.
    • (2007) J Immunol , vol.179 , pp. 7244-7253
    • Redmond, W.L.1    Gough, M.J.2    Charbonneau, B.3
  • 118
    • 0036047663 scopus 로고    scopus 로고
    • Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis
    • Ren-Heidenreich L, Mordini R, Hayman GT et al (2002) Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis. Cancer Immunol Immunother 51:417-423.
    • (2002) Cancer Immunol Immunother , vol.51 , pp. 417-423
    • Ren-Heidenreich, L.1    Mordini, R.2    Hayman, G.T.3
  • 119
    • 59249094502 scopus 로고    scopus 로고
    • Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain Valpha Vbeta fragments
    • Richman SA, Aggen DH, Dossett ML et al (2009) Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain Valpha Vbeta fragments. Mol Immunol 46:902-916.
    • (2009) Mol Immunol , vol.46 , pp. 902-916
    • Richman, S.A.1    Aggen, D.H.2    Dossett, M.L.3
  • 120
    • 10344261422 scopus 로고    scopus 로고
    • Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy
    • Robbins PF, Dudley ME, Wunderlich J et al (2004) Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J Immunol 173:7125-7130.
    • (2004) J Immunol , vol.173 , pp. 7125-7130
    • Robbins, P.F.1    Dudley, M.E.2    Wunderlich, J.3
  • 121
    • 0028079896 scopus 로고
    • Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors
    • Roberts MR, Qin L, Zhang D et al (1994) Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors. Blood 84:2878-2889.
    • (1994) Blood , vol.84 , pp. 2878-2889
    • Roberts, M.R.1    Qin, L.2    Zhang, D.3
  • 122
    • 0036990306 scopus 로고    scopus 로고
    • Targeting CD19 with genetically modified EBV-specific human T lymphocytes
    • Roessig C, Scherer SP, Baer A et al (2002) Targeting CD19 with genetically modified EBV-specific human T lymphocytes. Ann Hematol 81(Suppl 2):S42-S43.
    • (2002) Ann Hematol , vol.81 , Issue.SUPPL. 2
    • Roessig, C.1    Scherer, S.P.2    Baer, A.3
  • 123
    • 0026083035 scopus 로고
    • Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
    • Romeo C, Seed B (1991) Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64:1037-1046.
    • (1991) Cell , vol.64 , pp. 1037-1046
    • Romeo, C.1    Seed, B.2
  • 124
    • 65249173447 scopus 로고    scopus 로고
    • Adoptive cell therapy for the treatment of patients with metastatic melanoma
    • Rosenberg SA, Dudley ME (2009) Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr Opin Immunol 21:233-240.
    • (2009) Curr Opin Immunol , vol.21 , pp. 233-240
    • Rosenberg, S.A.1    Dudley, M.E.2
  • 125
    • 0035888244 scopus 로고    scopus 로고
    • Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes
    • Rossig C, Bollard CM, Nuchtern JG et al (2001) Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes. Int J Cancer 94:228-236.
    • (2001) Int J Cancer , vol.94 , pp. 228-236
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3
  • 126
    • 0037085804 scopus 로고    scopus 로고
    • Epstein-Barr virusspecific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherapy
    • Rossig C, Bollard CM, Nuchtern JG et al (2002) Epstein-Barr virusspecific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood 99:2009-2016.
    • (2002) Blood , vol.99 , pp. 2009-2016
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3
  • 127
    • 34948860624 scopus 로고    scopus 로고
    • Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
    • Savoldo B, Rooney CM, Di Stasi A et al (2007) Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 110:2620-2630.
    • (2007) Blood , vol.110 , pp. 2620-2630
    • Savoldo, B.1    Rooney, C.M.2    Di, S.A.3
  • 128
    • 0037093844 scopus 로고    scopus 로고
    • Cutting edge: Requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    • Schluns KS, Williams K, Ma A et al (2002) Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168:4827-4831.
    • (2002) J Immunol , vol.168 , pp. 4827-4831
    • Schluns, K.S.1    Williams, K.2    Ma, A.3
  • 129
    • 0742290162 scopus 로고    scopus 로고
    • Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease
    • Serafini M, Manganini M, Borleri G et al (2004) Characterization of CD20-transduced T lymphocytes as an alternative suicide gene therapy approach for the treatment of graft-versus-host disease. Hum Gene Ther 15:63-76.
    • (2004) Hum Gene Ther , vol.15 , pp. 63-76
    • Serafini, M.1    Manganini, M.2    Borleri, G.3
  • 130
    • 0038185191 scopus 로고    scopus 로고
    • T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches
    • Sheen AJ, Sherlock DJ, Irlam J et al (2003) T lymphocytes isolated from patients with advanced colorectal cancer are suitable for gene immunotherapy approaches. Br J Cancer 88:1119-1127.
    • (2003) Br J Cancer , vol.88 , pp. 1119-1127
    • Sheen, A.J.1    Sherlock, D.J.2    Irlam, J.3
  • 131
    • 33845934649 scopus 로고    scopus 로고
    • A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells
    • Shibaguchi H, Luo NX, Kuroki M et al (2006) A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells. Anticancer Res 26:4067-4072.
    • (2006) Anticancer Res , vol.26 , pp. 4067-4072
    • Shibaguchi, H.1    Luo, N.X.2    Kuroki, M.3
  • 132
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, Klussman K, Tritchler DD et al (1997) 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47-55.
    • (1997) J Exp Med , vol.186 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3
  • 133
    • 33947285535 scopus 로고    scopus 로고
    • Immunoediting sculpts tumor epitopes during immunotherapy
    • Singh R, Paterson Y (2007) Immunoediting sculpts tumor epitopes during immunotherapy. Cancer Res 67:1887-1892.
    • (2007) Cancer Res , vol.67 , pp. 1887-1892
    • Singh, R.1    Paterson, Y.2
  • 134
    • 0035964621 scopus 로고    scopus 로고
    • Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: An active mode of immune evasion in colon cancer
    • Song E, Chen J, Ouyang N et al (2001) Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer. Br J Cancer 85:1047-1054.
    • (2001) Br J Cancer , vol.85 , pp. 1047-1054
    • Song, E.1    Chen, J.2    Ouyang, N.3
  • 135
    • 0027501259 scopus 로고
    • Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors
    • Stancovski I, Schindler DG, Waks T et al (1993) Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J Immunol 151:6577-6582.
    • (1993) J Immunol , vol.151 , pp. 6577-6582
    • Stancovski, I.1    Schindler, D.G.2    Waks, T.3
  • 136
    • 36849021712 scopus 로고    scopus 로고
    • T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
    • Stephan MT, Ponomarev V, Brentjens RJ et al (2007) T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med 13:1440-1449.
    • (2007) Nat Med , vol.13 , pp. 1440-1449
    • Stephan, M.T.1    Ponomarev, V.2    Brentjens, R.J.3
  • 137
    • 20144365643 scopus 로고    scopus 로고
    • Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes
    • Straathof KC, Bollard CM, Popat U et al (2005a) Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes. Blood 105:1898-1904.
    • (2005) Blood , vol.105 , pp. 1898-1904
    • Straathof, K.C.1    Bollard, C.M.2    Popat, U.3
  • 138
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • Straathof KC, Pule MA, Yotnda P et al (2005b) An inducible caspase 9 safety switch for T-cell therapy. Blood 105:4247-4254.
    • (2005) Blood , vol.105 , pp. 4247-4254
    • Straathof, K.C.1    Pule, M.A.2    Yotnda, P.3
  • 139
    • 3142726124 scopus 로고    scopus 로고
    • Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes
    • Teng MW, Kershaw MH, Moeller M et al (2004) Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes. Hum Gene Ther 15:699-708.
    • (2004) Hum Gene Ther , vol.15 , pp. 699-708
    • Teng, M.W.1    Kershaw, M.H.2    Moeller, M.3
  • 140
    • 34447310075 scopus 로고    scopus 로고
    • Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
    • Tey SK, Dotti G, Rooney CM et al (2007) Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant 13:913-924.
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 913-924
    • Tey, S.K.1    Dotti, G.2    Rooney, C.M.3
  • 141
    • 0035282726 scopus 로고    scopus 로고
    • A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
    • Thomis DC, Marktel S, Bonini C et al (2001) A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood 97:1249-1257.
    • (2001) Blood , vol.97 , pp. 1249-1257
    • Thomis, D.C.1    Marktel, S.2    Bonini, C.3
  • 142
    • 0035161228 scopus 로고    scopus 로고
    • Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
    • Tiberghien P, Ferrand C, Lioure B et al (2001) Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97:63-72.
    • (2001) Blood , vol.97 , pp. 63-72
    • Tiberghien, P.1    Ferrand, C.2    Lioure, B.3
  • 143
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till BG, Jensen MC, Wang J et al (2008) Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 112:2261-2271.
    • (2008) Blood , vol.112 , pp. 2261-2271
    • Till, B.G.1    Jensen, M.C.2    Wang, J.3
  • 144
    • 34249748406 scopus 로고    scopus 로고
    • The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
    • Traversari C, Marktel S, Magnani Z et al (2007) The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies. Blood 109:4708-4715.
    • (2007) Blood , vol.109 , pp. 4708-4715
    • Traversari, C.1    Marktel, S.2    Magnani, Z.3
  • 145
    • 14844322786 scopus 로고    scopus 로고
    • Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor
    • Turatti F, Figini M, Alberti P et al (2005) Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor. J Gene Med 7:158-170.
    • (2005) J Gene Med , vol.7 , pp. 158-170
    • Turatti, F.1    Figini, M.2    Alberti, P.3
  • 146
    • 33645964652 scopus 로고    scopus 로고
    • The CD20/alphaCD20 'suicide' system: Novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells
    • van Meerten T, Claessen MJ, Hagenbeek A et al (2006) The CD20/alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells. Gene Ther 13:789-797.
    • (2006) Gene Ther , vol.13 , pp. 789-797
    • Van Meerten, T.1    Claessen, M.J.2    Hagenbeek, A.3
  • 147
    • 33845256434 scopus 로고    scopus 로고
    • T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
    • Vera J, Savoldo B, Vigouroux S et al (2006) T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood 108:3890-3897.
    • (2006) Blood , vol.108 , pp. 3890-3897
    • Vera, J.1    Savoldo, B.2    Vigouroux, S.3
  • 148
    • 67349252824 scopus 로고    scopus 로고
    • Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7
    • Vera JF, Hoyos V, Savoldo B et al (2009) Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol Ther 17:880-888.
    • (2009) Mol Ther , vol.17 , pp. 880-888
    • Vera, J.F.1    Hoyos, V.2    Savoldo, B.3
  • 149
    • 0023920595 scopus 로고
    • Reshaping human antibodies: Grafting an antilysozyme activity
    • Verhoeyen M, Milstein C, Winter G (1988) Reshaping human antibodies: grafting an antilysozyme activity. Science 239:1534-1536.
    • (1988) Science , vol.239 , pp. 1534-1536
    • Verhoeyen, M.1    Milstein, C.2    Winter, G.3
  • 150
    • 18344406935 scopus 로고    scopus 로고
    • Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection
    • Walker RE, Bechtel CM, Natarajan V et al (2000) Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96:467-474.
    • (2000) Blood , vol.96 , pp. 467-474
    • Walker, R.E.1    Bechtel, C.M.2    Natarajan, V.3
  • 151
    • 52449122955 scopus 로고    scopus 로고
    • Transforming growth factorbeta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers
    • Wallace A, Kapoor V, Sun J et al (2008) Transforming growth factorbeta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14:3966-3974.
    • (2008) Clin Cancer Res , vol.14 , pp. 3966-3974
    • Wallace, A.1    Kapoor, V.2    Sun, J.3
  • 152
    • 2342655822 scopus 로고    scopus 로고
    • Cellular immunotherapy for follicular lymphoma using genetically modified CD20- specific CD8+ cytotoxic T lymphocytes
    • Wang J, Press OW, Lindgren CG et al (2004) Cellular immunotherapy for follicular lymphoma using genetically modified CD20- specific CD8+ cytotoxic T lymphocytes. Mol Ther 9:577-586.
    • (2004) Mol Ther , vol.9 , pp. 577-586
    • Wang, J.1    Press, O.W.2    Lindgren, C.G.3
  • 153
    • 34548485103 scopus 로고    scopus 로고
    • Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains
    • Wang J, Jensen M, Lin Y et al (2007) Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains. Hum Gene Ther 18:712-725.
    • (2007) Hum Gene Ther , vol.18 , pp. 712-725
    • Wang, J.1    Jensen, M.2    Lin, Y.3
  • 154
    • 54549114445 scopus 로고    scopus 로고
    • Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded HSVTK suicide genes
    • Wang X, Olszewska M, Capacio V et al (2008) Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded HSVTK suicide genes. Gene Ther 15:1454-1459.
    • (2008) Gene Ther , vol.15 , pp. 1454-1459
    • Wang, X.1    Olszewska, M.2    Capacio, V.3
  • 155
    • 0043128070 scopus 로고    scopus 로고
    • Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules
    • Weijtens ME, Willemsen RA, van Krimpen BA et al (1998) Chimeric scFv/gamma receptor-mediated T-cell lysis of tumor cells is coregulated by adhesion and accessory molecules. Int J Cancer 77:181-187.
    • (1998) Int J Cancer , vol.77 , pp. 181-187
    • Weijtens, M.E.1    Willemsen, R.A.2    Van Krimpen, B.A.3
  • 156
    • 30044442768 scopus 로고    scopus 로고
    • Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice
    • Westwood JA, Smyth MJ, Teng MW et al (2005) Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice. Proc Natl Acad Sci USA 102:19051-19056.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19051-19056
    • Westwood, J.A.1    Smyth, M.J.2    Teng, M.W.3
  • 157
    • 44449162630 scopus 로고    scopus 로고
    • Retargeting of human T cells to tumor-associated MUC1: The evolution of a chimeric antigen receptor
    • Wilkie S, Picco G, Foster J et al (2008) Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J Immunol 180:4901-4909.
    • (2008) J Immunol , vol.180 , pp. 4901-4909
    • Wilkie, S.1    Picco, G.2    Foster, J.3
  • 158
    • 20444377728 scopus 로고    scopus 로고
    • T cell retargeting with MHC class I-restricted antibodies: The CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production
    • Willemsen RA, Ronteltap C, Chames P et al (2005) T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production. J Immunol 174:7853-7858.
    • (2005) J Immunol , vol.174 , pp. 7853-7858
    • Willemsen, R.A.1    Ronteltap, C.2    Chames, P.3
  • 159
    • 67349189462 scopus 로고    scopus 로고
    • Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model
    • Yoon SH, Lee JM, Cho HI et al (2009) Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model. Cancer Gene Ther 16:489-497.
    • (2009) Cancer Gene Ther , vol.16 , pp. 489-497
    • Yoon, S.H.1    Lee, J.M.2    Cho, H.I.3
  • 160
    • 0034526330 scopus 로고    scopus 로고
    • Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors
    • Yun CO, Nolan KF, Beecham EJ et al (2000) Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Neoplasia 2:449-459.
    • (2000) Neoplasia , vol.2 , pp. 449-459
    • Yun, C.O.1    Nolan, K.F.2    Beecham, E.J.3
  • 161
    • 3142576998 scopus 로고    scopus 로고
    • Transgenic TCR expression: Comparison of single chain with full-length receptor constructs for T-cell function
    • Zhang T, He X, Tsang TC et al (2004) Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther 11:487-496.
    • (2004) Cancer Gene Ther , vol.11 , pp. 487-496
    • Zhang, T.1    He, X.2    Tsang, T.C.3


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