A fully human chimeric immune receptor for retargeting T-cells to CEA-expressing tumor cells

Anticancer Research

Volumn 26, Issue 6 A, 2006, Pages 4067-4072

  Shibaguchi, Hirotomo ^a   Luo, Nai Xiang ^a   Kuroki, Motomu ^a   Zhao, Jun ^a   Huang, Jian ^a   Hachimine, Ken ^a   Kinugasa, Tetsushi ^a   Kuroki, Masahide ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Antibody based therapy; Carcinoembryonic antigen; CEA; Chimeric immune receptor; Electroporation; scFv; T lymphocytes

Indexed keywords

ALLOPHYCOCYANIN; CARCINOEMBRYONIC ANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD8ALPHA ANTIGEN; CHIMERIC PROTEIN; RECOMBINANT RECEPTOR; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; FLOW CYTOMETRY; GENE INSERTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOGENICITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; T LYMPHOCYTE;

ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD8; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; EPITOPES; HUMANS; RECEPTORS, IMMUNOLOGIC; RECOMBINANT FUSION PROTEINS; STOMACH NEOPLASMS; T-LYMPHOCYTES; TRANSFECTION;

EID: 33845934649     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Greenberg PD: Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Adv Immunol 49: 281-355, 1991.
2. Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ, Topalian SL, Sherry R, Restifo NP, Hubicki AM, Robinson MR, Raffeld M, Duray P, Seipp CA, Rogers-Freezer L, Morton KE, Mavroukakis SA, White DE and Rosenberg SA: Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298: 850-854, 2002.
3. Ho WY, Blattman JN, Dossett ML, Yee C and Greenberg PD: Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction. Cancer Cell 3: 431-437,2003.
4. Rosenberg SA: Progress in human tumour immunology and immunotherapy. Nature 411: 380-384, 2001.
5. Cabrera T, Lopez-Nevot MA, Gaforio JJ, Ruiz-Cabello F and Garrido F: Analysis of HLA expression in human tumor tissues. Cancer Immunol Immunother 52: 1-9, 2003.
6. Garrido F, Ruiz-Cabello F, Cabrera T, Perez-Villar JJ, Lopez-Botet M, Duggan-Keen M and Stern PL: Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol Today 18: 89-95, 1997.
7. Bitton N, Verrier F, Debre P and Gorochov G: Characterization of T cell-expressed chimeric receptors with antibody-type specificity for the CD4 binding site of HIV-1 gp120. Eur J Immunol 28: 4177-4187, 1998.
8. Geiger TL and Jyothi MD: Development and application of receptor-modified T lymphocytes for adoptive immunotherapy. Transfus Med Rev 15: 21-34, 2001.
9. + T lymphocytes armed with universal T-cell receptors. Blood 84: 2878-2889, 1994.
10. Medema JP, de Jong J, Peltenburg LT, Verdegaal EM, Gorter A, Bres SA, Franken KL, Hahne M, Albar JP, Melief CJ and Offringa R: Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc Natl Acad Sci USA 98: 11515-11520, 2001.
11. Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J and Bleackley RC: Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell 103: 491-500, 2000.
12. Baxevanis CN and Papamichail M: Targeting of tumor cells by lymphocytes engineered to express chimeric receptor genes. Cancer Immunol Immunother 53: 893-903, 2004.
13. Lamers CH, Gratama JW, Warnaar SO, Stoter G and Bolhuis RL: Inhibition of bispecific monoclonal antibody (bsAb)-targeted cytolysis by human anti-mouse antibodies in ovarian carcinoma patients treated with bsAb-targeted activated T-lymphocytes. Int J Cancer 60: 450-457, 1995.
14. Imakiire T, Kuroki M, Shibaguchi H, Abe H, Yamauchi Y, Ueno A, Hirose Y, Yamada H, Yamashita Y, Shirakusa T, Ishida I and Kuroki M: Generation, immunologic characterization and antitumor effects of human monoclonal antibodies for carcinoembryonic antigen. Int J Cancer 108: 564-570, 2004.
15. Shibaguchi H, Kuroki M, Kuroki M, Badran A, Hachimine K and Kinugasa T: Cloning and sequencing of variable region cDNAs of a novel human monoclonal antibody to carcinoembryonic antigen, and generation of a single chain variable fragmented antibody. Anticancer Res 24: 3355-3360, 2004.
16. Arakawa F, Shibaguchi H, Xu Z and Kuroki M: Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity. Anticancer Res 22: 4285-4289, 2002.
17. de Bono JS, Rha SY, Stephenson J, Schultes BC, Monroe P, Eckhardt GS, Hammond LA, Whiteside TL, Nicodemus CF, Cermak JM, Rowinsky EK and Tolcher AW: Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity. Ann Oncol 15: 1825-1833, 2004.
18. Leonard JP, Coleman M, Kostakoglu L, Chadburn A, Cesarman E, Furman RR, Schuster MW, Niesvizky R, Muss D, Fiore J, Kroll S, Tidmarsh G, Vallabhajosula S and Goldsmith SJ: Abbreviated chemotherapy with fludarabine followed by tositumomab and iodine I 131 tositumomab for untreated follicular lymphoma. J Clin Oncol 23: 5696-5704, 2005.
19. Ritter G, Cohen LS, Williams C Jr, Richards EC, Old LJ and Welt S: Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33. Cancer Res 61: 6851-6859, 2001.
20. Alvarez-Vallina L and Hawkins RE: Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur J Immunol 26: 2304-2309, 1996.
21. Harding FA, McArthur JG, Gross JA, Raulet DH and Allison JP: CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356: 607-609, 1992.
22. Jenkins MK, Taylor PS, Norton SD and Urdahl KB: CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 147: 2461-2466, 1991.
23. Radvanyi LG, Shi Y, Vaziri H, Sharma A, Dhala R, Mills GB and Miller RG: CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J Immunol 156: 1788-1798, 1996.
24. Gilham DE, O'Neil A, Hughes C, Guest RD, Kirillova N, Lehane M and Hawkins RE: Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors. J Immunother 25: 139-151, 2002.
25. Haynes NM, Trapani JA, Teng MW, Jackson JT, Cerruti L, Jane SM, Kershaw MH, Smyth MJ and Darcy PK: Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood 700: 3155-3163, 2002.
26. Maher J, Brentjens RJ, Gunset G, Riviere I and Sadelain M: Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor. Nat Biotechnol 20: 70-75, 2002.
27. Bunnell BA, Muul LM, Donahue RE, Blaese RM and Morgan RA: High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. Proc Natl Acad Sci USA 92: 7739-7743, 1995.
28. Gallardo HF, Tan C, Ory D and Sadelain M: Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood 90: 952-957, 1997.
29. Mavilio F, Ferrari G, Rossini S, Nobili N, Bonini C, Casorati G, Traversari C and Bordignon C: Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer. Blood 83: 1988-1997, 1994.
30. Riviere I, Gallardo HF, Hagani AB and Sadelain M: Retroviral-mediated gene transfer in primary murine and human T-lymphocytes. Mol Biotechnol 75: 133-142, 2000.
31. Gyobu H, Tsuji T, Suzuki Y, Ohkuri T, Chamoto K, Kuroki M, Miyoshi H, Kawarada Y, Katoh H, Takeshima T and Nishimura T: Generation and targeting of human tumor-specific Tc1 and Th1 cells transduced with a lentivirus containing a chimeric immunoglobulin T-cell receptor. Cancer Res 64: 1490-1495, 2004.