Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments

Molecular Immunology

Volumn 46, Issue 5, 2009, Pages 902-916

  Richman, Sarah A ^a   Aggen, David H ^a   Dossett, Michelle L ^b,c   Donermeyer, David L ^d   Allen, Paul M ^d   Greenberg, Philip D ^b,c   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Directed evolution; Single chain; T cell receptor; Yeast display

Indexed keywords

SCAFFOLD PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; T LYMPHOCYTE RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BACTERIOPHAGE; BETA CHAIN; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; YEAST;

ANIMALS; ESCHERICHIA COLI; HUMANS; MICE; MUTATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

ESCHERICHIA COLI; MUS;

EID: 59249094502     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.09.021     Document Type: Article

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