메뉴 건너뛰기




Volumn 26, Issue 1, 2010, Pages 67-78

Phosphorylation of the immunomodulator fty720 inhibits programmed cell death of fibroblasts via the s1p 3 receptor subtype and bcl-2 activation

Author keywords

Bcl 2; Fibroblasts; FTY720; Mitochondria; S1P 3

Indexed keywords

FINGOLIMOD; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; UNCLASSIFIED DRUG;

EID: 77952937151     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000315107     Document Type: Article
Times cited : (20)

References (65)
  • 4
    • 0141566600 scopus 로고    scopus 로고
    • Egress: A receptor-regulated step in lymphocyte trafficking
    • Rosen H, Sanna G, Alfonso C: Egress: a receptor-regulated step in lymphocyte trafficking. Immunol Rev 2003;195:160-177.
    • (2003) Immunol Rev , vol.195 , pp. 160-177
    • Rosen, H.1    Sanna, G.2    Alfonso, C.3
  • 6
    • 0035022841 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptors
    • Hla T: Sphingosine 1-phosphate receptors. Prostaglandins 2001;64:135-142.
    • (2001) Prostaglandins , vol.64 , pp. 135-142
    • Hla, T.1
  • 7
    • 70350133784 scopus 로고    scopus 로고
    • Sphingolipids in inflammation: Pathological implications and potential therapeutic targets
    • Nixon GF: Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br J Pharmacol 2009;158:982-993.
    • (2009) Br J Pharmacol , vol.158 , pp. 982-993
    • Nixon, G.F.1
  • 9
    • 33747170186 scopus 로고    scopus 로고
    • The role of the lysophospholipid sphingosine 1-phos-phate in immune cell biology
    • von Wenckstern H, Zimmermann K, Kleuser B: The role of the lysophospholipid sphingosine 1-phos-phate in immune cell biology. Arch Immunol Ther Exp (Warsz) 2006;54:239-251.
    • (2006) Arch Immunol Ther Exp (Warsz) , vol.54 , pp. 239-251
    • Von Wenckstern, H.1    Zimmermann, K.2    Kleuser, B.3
  • 10
    • 0042318707 scopus 로고    scopus 로고
    • Apoptosis-an introduction
    • Lawen A: Apoptosis-an introduction. Bioessays 2003;25:888-896.
    • (2003) Bioessays , vol.25 , pp. 888-896
    • Lawen, A.1
  • 11
    • 0033519705 scopus 로고    scopus 로고
    • Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mito-chondrial channel VDAC
    • Shimizu S, Narita M, Tsujimoto Y: Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mito-chondrial channel VDAC. Nature 1999;399:483-487.
    • (1999) Nature , vol.399 , pp. 483-487
    • Shimizu, S.1    Narita, M.2    Tsujimoto, Y.3
  • 12
    • 0031037897 scopus 로고    scopus 로고
    • The release of cyto-chrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cyto-chrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997;275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 13
    • 37549049697 scopus 로고    scopus 로고
    • Anti-apoptotic effect of sphin-gosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells
    • Wong RC, Tellis I, Jamshidi P, Pera M, Pebay A: Anti-apoptotic effect of sphin-gosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells. Stem Cells Dev 2007;16:989-1001.
    • (2007) Stem Cells Dev , vol.16 , pp. 989-1001
    • Wong, R.C.1    Tellis, I.2    Jamshidi, P.3    Pera, M.4    Pebay, A.5
  • 14
    • 57749196164 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
    • Maeurer C, Holland S, Pierre S, Potstada W, Scholich K: Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal 2009;21:293-300.
    • (2009) Cell Signal , vol.21 , pp. 293-300
    • Maeurer, C.1    Holland, S.2    Pierre, S.3    Potstada, W.4    Scholich, K.5
  • 15
    • 17644404054 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat
    • Sauer B, Gonska H, Manggau M, Kim DS, Schraut C, Schafer-Korting M, Kleuser B: Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. Pharmazie 2005;60:298-304.
    • (2005) Pharmazie , vol.60 , pp. 298-304
    • Sauer, B.1    Gonska, H.2    Manggau, M.3    Kim, D.S.4    Schraut, C.5    Schafer-Korting, M.6    Kleuser, B.7
  • 17
    • 67349170614 scopus 로고    scopus 로고
    • Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone
    • Nieuwenhuis B, Luth A, Chun J, Huwiler A, Pfeilschifter J, Schafer-Korting M, Kleuser B: Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med 2009;87:645-657.
    • (2009) J Mol Med , vol.87 , pp. 645-657
    • Nieuwenhuis, B.1    Luth, A.2    Chun, J.3    Huwiler, A.4    Pfeilschifter, J.5    Schafer-Korting, M.6    Kleuser, B.7
  • 18
    • 67650263679 scopus 로고    scopus 로고
    • Thoma A, Frantz S, Ertl G, Ritter O, Bonz A: Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion
    • Hofmann U, Burkard N, Vogt C, Thoma A, Frantz S, Ertl G, Ritter O, Bonz A: Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. Cardiovasc Res 2009;83:285-293.
    • (2009) Cardiovasc Res , vol.83 , pp. 285-293
    • Hofmann, U.1    Burkard, N.2    Vogt, C.3
  • 19
    • 53149089045 scopus 로고    scopus 로고
    • Soliven B, Antel JP: Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
    • Miron VE, Hall JA, Kennedy TE, Soliven B, Antel JP: Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am J Pathol 2008;173:1143-1152.
    • (2008) Am J Pathol , vol.173 , pp. 1143-1152
    • Miron, V.E.1    Hall, J.A.2    Kennedy, T.E.3
  • 22
    • 0033559508 scopus 로고    scopus 로고
    • Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway
    • Matsuda S, Minowa A, Suzuki S, Koyasu S: Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway. J Immunol 1999;162:3321-3326.
    • (1999) J Immunol , vol.162 , pp. 3321-3326
    • Matsuda, S.1    Minowa, A.2    Suzuki, S.3    Koyasu, S.4
  • 23
    • 0037739755 scopus 로고    scopus 로고
    • A novel immunosuppres-sive agent FTY720 induced Akt dephos-phorylation in leukemia cells
    • Matsuoka Y, Nagahara Y, Ikekita M, Shinomiya T: A novel immunosuppres-sive agent FTY720 induced Akt dephos-phorylation in leukemia cells. Br J Pharmacol 2003;138:1303-1312.
    • (2003) Br J Pharmacol , vol.138 , pp. 1303-1312
    • Matsuoka, Y.1    Nagahara, Y.2    Ikekita, M.3    Shinomiya, T.4
  • 28
    • 34547408777 scopus 로고    scopus 로고
    • FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells
    • Shen Y, Cai M, Xia W, Liu J, Zhang Q, Xie H, Wang C, Wang X, Zheng S: FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett 2007;254:288-297.
    • (2007) Cancer Lett , vol.254 , pp. 288-297
    • Shen, Y.1    Cai, M.2    Xia, W.3    Liu, J.4    Zhang, Q.5    Xie, H.6    Wang, C.7    Wang, X.8    Zheng, S.9
  • 30
    • 0035674643 scopus 로고    scopus 로고
    • FTY720: Dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects
    • Brinkmann V, Wilt C, Kristofic C, Nikolova Z, Hof RP, Chen S, Albert R, Cottens S: FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects. Transplant Proc 2001;33:3078-3080.
    • (2001) Transplant Proc , vol.33 , pp. 3078-3080
    • Brinkmann, V.1    Wilt, C.2    Kristofic, C.3    Nikolova, Z.4    Hof, R.P.5    Chen, S.6    Albert, R.7    Cottens, S.8
  • 31
    • 16544371726 scopus 로고    scopus 로고
    • Role of extracellular regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937
    • Li D, Zhang Y, Hu X, Cao W, Huang W: Role of extracellular regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937. J Huazhong Univ Sci Technolog Med Sci 2004;24:45-47.
    • (2004) J Huazhong Univ Sci Technolog Med Sci , vol.24 , pp. 45-47
    • Li, D.1    Zhang, Y.2    Hu, X.3    Cao, W.4    Huang, W.5
  • 32
    • 45749139274 scopus 로고    scopus 로고
    • Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells
    • Nagaoka Y, Otsuki K, Fujita T, Uesato S: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Biol Pharm Bull 2008;31:1177-1181.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1177-1181
    • Nagaoka, Y.1    Otsuki, K.2    Fujita, T.3    Uesato, S.4
  • 34
    • 32244448999 scopus 로고    scopus 로고
    • FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
    • Zhou C, Ling MT, Kin-Wah Lee T, Man K, Wang X, Wong YC: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett 2006;233:36-47.
    • (2006) Cancer Lett , vol.233 , pp. 36-47
    • Zhou, C.1    Ling, M.T.2    Kin-Wah Lee, T.3    Man, K.4    Wang, X.5    Wong, Y.C.6
  • 35
    • 0034665512 scopus 로고    scopus 로고
    • Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cyto-chrome c from mitochondria
    • Nagahara Y, Ikekita M, Shinomiya T: Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cyto-chrome c from mitochondria. J Immunol 2000;165:3250-3259.
    • (2000) J Immunol , vol.165 , pp. 3250-3259
    • Nagahara, Y.1    Ikekita, M.2    Shinomiya, T.3
  • 36
    • 35548984947 scopus 로고    scopus 로고
    • The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
    • Coelho RP, Payne SG, Bittman R, Spiegel S, Sato-Bigbee C: The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J Pharmacol Exp Ther 2007;323:626-635.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 626-635
    • Coelho, R.P.1    Payne, S.G.2    Bittman, R.3    Spiegel, S.4    Sato-Bigbee, C.5
  • 37
    • 0035823477 scopus 로고    scopus 로고
    • Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3
    • Ishii I, Friedman B, Ye X, Kawamura S, McGiffert C, Contos JJ, Kingsbury MA, Zhang G, Brown JH, Chun J: Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem 2001;276:33697-33704.
    • (2001) J Biol Chem , vol.276 , pp. 33697-33704
    • Ishii, I.1    Friedman, B.2    Ye, X.3    Kawamura, S.4    McGiffert, C.5    Contos, J.J.6    Kingsbury, M.A.7    Zhang, G.8    Brown, J.H.9    Chun, J.10
  • 38
    • 33749983984 scopus 로고    scopus 로고
    • Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction
    • Andreani P, Graler MH: Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. Anal Biochem 2006;358:239-246.
    • (2006) Anal Biochem , vol.358 , pp. 239-246
    • Andreani, P.1    Graler, M.H.2
  • 39
    • 4344702204 scopus 로고    scopus 로고
    • Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation
    • Hammer S, Sauer B, Spika I, Schraut C, Kleuser B, Schafer-Korting M: Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. J Cell Biochem 2004;91:840-851.
    • (2004) J Cell Biochem , vol.91 , pp. 840-851
    • Hammer, S.1    Sauer, B.2    Spika, I.3    Schraut, C.4    Kleuser, B.5    Schafer-Korting, M.6
  • 41
    • 13944280988 scopus 로고    scopus 로고
    • G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
    • Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH: G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 2004;92:949-966.
    • (2004) J Cell Biochem , vol.92 , pp. 949-966
    • Radeff-Huang, J.1    Seasholtz, T.M.2    Matteo, R.G.3    Brown, J.H.4
  • 42
    • 0029857032 scopus 로고    scopus 로고
    • A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
    • Suzuki S, Li XK, Enosawa S, Shinomiya T: A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 1996;89:518-523.
    • (1996) Immunology , vol.89 , pp. 518-523
    • Suzuki, S.1    Li, X.K.2    Enosawa, S.3    Shinomiya, T.4
  • 43
    • 0030794189 scopus 로고    scopus 로고
    • An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
    • Shinomiya T, Li XK, Amemiya H, Suzuki S: An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60. Immunology 1997;91:594-600.
    • (1997) Immunology , vol.91 , pp. 594-600
    • Shinomiya, T.1    Li, X.K.2    Amemiya, H.3    Suzuki, S.4
  • 45
    • 33644697587 scopus 로고    scopus 로고
    • Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepa-tocellular carcinoma
    • Ho JW, Man K, Sun CK, Lee TK, Poon RT, Fan ST: Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepa-tocellular carcinoma. Mol Cancer Ther 2005;4:1430-1438.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1430-1438
    • Ho, J.W.1    Man, K.2    Sun, C.K.3    Lee, T.K.4    Poon, R.T.5    Fan, S.T.6
  • 47
    • 0035344941 scopus 로고    scopus 로고
    • Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count
    • Nikolova Z, Hof RP: Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count. Transplant Proc 2001;33:2184-2185.
    • (2001) Transplant Proc , vol.33 , pp. 2184-2185
    • Nikolova, Z.1    Hof, R.P.2
  • 48
    • 0344443651 scopus 로고    scopus 로고
    • Phos-phorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T: Phos-phorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem 2003;278:47281-47290.
    • (2003) J Biol Chem , vol.278 , pp. 47281-47290
    • Sanchez, T.1    Estrada-Hernandez, T.2    Paik, J.H.3    Wu, M.T.4    Venkataraman, K.5    Brinkmann, V.6    Claffey, K.7    Hla, T.8
  • 49
    • 34250809874 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
    • Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH: Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2007;292:H2944-2951.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Means, C.K.1    Xiao, C.Y.2    Li, Z.3    Zhang, T.4    Omens, J.H.5    Ishii, I.6    Chun, J.7    Brown, J.H.8
  • 50
    • 33645211015 scopus 로고    scopus 로고
    • Modulation of total Akt kinase by increased expression of a single isoform: Requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothe-lial cells
    • Fieber CB, Eldridge J, Taha TA, Obeid LM, Muise-Helmericks RC: Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothe-lial cells. Exp Cell Res 2006;312:1164-1173.
    • (2006) Exp Cell Res , vol.312 , pp. 1164-1173
    • Fieber, C.B.1    Eldridge, J.2    Taha, T.A.3    Obeid, L.M.4    Muise-Helmericks, R.C.5
  • 51
    • 51249090123 scopus 로고    scopus 로고
    • The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells
    • Ramos JW: The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 2008;40:2707-2719.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2707-2719
    • Ramos, J.W.1
  • 53
    • 34047253376 scopus 로고    scopus 로고
    • Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors
    • Osinde M, Mullershausen F, Dev KK: Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology 2007;52:1210-1218.
    • (2007) Neuropharmacology , vol.52 , pp. 1210-1218
    • Osinde, M.1    Mullershausen, F.2    Dev, K.K.3
  • 54
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995;376:599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 55
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 56
    • 1442265704 scopus 로고    scopus 로고
    • S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    • Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y: S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). Faseb J 2004;18:341-343.
    • (2004) Faseb J , vol.18 , pp. 341-343
    • Baudhuin, L.M.1    Jiang, Y.2    Zaslavsky, A.3    Ishii, I.4    Chun, J.5    Xu, Y.6
  • 57
    • 60549096247 scopus 로고    scopus 로고
    • Akt-depend-ent and-independent mechanisms of mTOR regulation in cancer
    • Memmott RM, Dennis PA: Akt-depend-ent and-independent mechanisms of mTOR regulation in cancer. Cell Signal 2009;21:656-664.
    • (2009) Cell Signal , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 58
    • 0031036888 scopus 로고    scopus 로고
    • ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate
    • Chung T, Crilly KS, Anderson WH, Mukherjee JJ, Kiss Z: ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatidylinositol 3'-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. J Biol Chem 1997;272:3064-3072.
    • (1997) J Biol Chem , vol.272 , pp. 3064-3072
    • Chung, T.1    Crilly, K.S.2    Anderson, W.H.3    Mukherjee, J.J.4    Kiss, Z.5
  • 59
    • 0033150727 scopus 로고    scopus 로고
    • Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc-and calcium-dependent mechanism in fibroblasts
    • Huang JS, Mukherjee JJ, Kiss Z: Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc-and calcium-dependent mechanism in fibroblasts. Arch Biochem Biophys 1999;366:131-138.
    • (1999) Arch Biochem Biophys , vol.366 , pp. 131-138
    • Huang, J.S.1    Mukherjee, J.J.2    Kiss, Z.3
  • 60
    • 0035860831 scopus 로고    scopus 로고
    • Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
    • Kluk MJ, Hla T: Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 2001;89:496-502.
    • (2001) Circ Res , vol.89 , pp. 496-502
    • Kluk, M.J.1    Hla, T.2
  • 62
    • 0036899017 scopus 로고    scopus 로고
    • T cell selective apoptosis by a novel im-munosuppressant, FTY720, is closely regulated with Bcl-2
    • Nagahara Y, Ikekita M, Shinomiya T: T cell selective apoptosis by a novel im-munosuppressant, FTY720, is closely regulated with Bcl-2. Br J Pharmacol 2002;137:953-962.
    • (2002) Br J Pharmacol , vol.137 , pp. 953-962
    • Nagahara, Y.1    Ikekita, M.2    Shinomiya, T.3
  • 63
    • 33748178875 scopus 로고    scopus 로고
    • Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate
    • Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B: Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 2006;108:1635-1642.
    • (2006) Blood , vol.108 , pp. 1635-1642
    • Weigert, A.1    Johann, A.M.2    Von Knethen, A.3    Schmidt, H.4    Geisslinger, G.5    Brune, B.6
  • 64
    • 77950629530 scopus 로고    scopus 로고
    • Dex-amethasone protects human fibroblasts from apoptosis via an S1P(3)-receptor subtype dependent activation of PKB/Akt and Bcl(XL)
    • Nieuwenhuis B, Lüth A, Kleuser B: Dex-amethasone protects human fibroblasts from apoptosis via an S1P(3)-receptor subtype dependent activation of PKB/Akt and Bcl(XL). Pharmacol Res 2010;61:449-459.
    • (2010) Pharmacol Res , vol.61 , pp. 449-459
    • Nieuwenhuis, B.1    Lüth, A.2    Kleuser, B.3
  • 65
    • 0035542735 scopus 로고    scopus 로고
    • 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingo-sine-1-phosphate
    • Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC, Schafer-Korting M, Kleuser B: 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingo-sine-1-phosphate. J Invest Dermatol 2001;117:1241-1249.
    • (2001) J Invest Dermatol , vol.117 , pp. 1241-1249
    • Manggau, M.1    Kim, D.S.2    Ruwisch, L.3    Vogler, R.4    Korting, H.C.5    Schafer-Korting, M.6    Kleuser, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.