Differential activation of c-JUN NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3321-3326

  Matsuda, Satoshi ^a   Minowa, Akiko ^a   Suzuki, Seiichi ^b   Koyasu, Shigeo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASPASE 3; DNA FRAGMENT; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TETRAPEPTIDE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGOPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROPYLENE GLYCOLS; SIGNAL TRANSDUCTION; SPHINGOSINE; T-LYMPHOCYTES;

EID: 0033559508     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Fujita, T., R. Hirose, M. Yoneta, S. Sasaki, K. Inoue, M. Kiuchi, S. Hirase, K. Chiba, H. Sakamoto, and M. Arita. 1996. Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols. J. Med. Chem. 39:4451.
2. Adachi, K., T. Kohara, N. Nakano, M. Arita, K. Chiba, T. Mishina, S. Sasaki, and T. Fujita. 1995. Design, synthesis, and structure activity relationships of 2-substituted-2-amino-1,3-propanediols: discovery of a novel immunosuppressant, FTY720. Biomed. Chem. Lett. 5:853.
3. Fujita, T., K. Inoue, S. Yamamoto, T. Ikumoto, S. Sasaki, R. Toyama, K, Chiba, Y. Hoshino, and T. Okumoto. 1994. Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J. Antibiot. 47: 208.
4. Suzuki, S., S. Enosawa, T. Kakefuda, T. Shinomiya, M. Amari, S. Naoe, Y. Hoshino, and K. Chiba. 1996. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61:200.
5. Steller, H. 1995. Mechanisms and genes of cellular suicide. Science 267:1445.
6. White, E. 1996. Life, death, and the pursuit of apoptosis. Genes Dev. 10:1.
7. Jacobson, M. D., M. Weil, and M. C. Raff. 1997. Programmed cell death in animal development. Cell 88:347.
8. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747.
9. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355.
10. Boldin, M., T. Goncharov, Y. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803.
11. Fernandes-Alnemri, T., R. C. Armstrong, J. Krebs, S. M. Srinivasula, L. Wang, F. Bullrich, L. C. Fritz, J. A. Trapani, K. J. Tomaselli, G. Litwack, and E. S. Alnemri. 1996. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA 93:7464.
12. Muzio, M., A. Chinnaiyan, F. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, J. Scaffidi, J. Bretz, M. Zhang, R. Gentz, M. Mann, et al. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/ APO-1) death-inducing signaling complex. Cell 85:817.
13. Enari, M., R. V. Talanian, W. W. Wong, and S. Nagata. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723.
14. Schlegel, J., I. Peters, S. Orrenius, D. K. Miller, N. A. Thornberry, T. Yamin, and D. W. Nicholson. 1996. CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis. J. Biol. Chem. 271:1841.
15. Dubrez, L., I. Savoy, A. Hamman, and E. Solary. 1996. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. EMBO J. 15:5504.
16. Derijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025.
17. Kyriakis, J. M., P. Banerjee, E. Nikolakaki, T. Dai, E.A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156.
18. Han, J., J. D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808.
19. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739.
20. Rouse, J., P. Cohen, S. Trigon, M. Morange, A. Alonso-Lamazares, D. Zamanillo, T. Hunt, and A.R. Nebreda. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027.
21. Verheij, M., R. Bose, X. H. Lin, B. Yao, W. D. Jarvis, S. Grant, M. J. Birrer, E. Szabo, L. I. Zon, J. M. Kyriakis, et al. 1996. Requirement for ceramide-initiated SAPK-JNK signalling in stress-induced apoptosis. Nature 380:75.
22. Cuvillier, O., G. Pirianov, B. Kleuser, P. G. Vanek, O. A. Coso, S. Gutkind, and S. Spiegel. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800.
23. Chen, Y.-R., X. Wang, D. Templeton, R. J. Davis, and T.-H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. J. Biol. Chem. 271:31929.
24. Latinis, K. M., and G. A. Koretzky. 1996. Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. Blood 87:871.
25. Wilson, D. J., K. A. Fortner, D. H. Lynch, R. R. Mattingly, I. G. Macara, J. A. Posada, and R. C. Budd. 1996. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur. J. Immunol. 26:989.
26. Juo, P., C. J. Kuo, S. E. Reynolds, R. F. Konz, J. Raingeaud, R. J. Davis, H.-P. Biemann, and J. Blenis. 1997. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE-CED-3 family proteases. Mol. Cell. Biol. 17:24.
27. Lenczowski, J. M., L. Dominguez, A. M. Eder, L. B. King, C. M. Zacharchuk, and J. D. Ashwell. 1997. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol. Cell. Biol. 17:170.
28. Toyoshima, F., T. Moriguchi, and E. Nishida. 1997. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases. J. Cell Biol. 139:1005.
29. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326.
30. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
31. Matsuda, S., T. Moriguchi, S. Koyasu, and E. Nishida. 1998. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273:12378.
32. Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:365.
33. Gotoh, Y., E. Nishida, T. Yamashita, M. Hoshi, M. Kawakami, and H. Sakai. 1990. Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Eur. J. Biochem. 193:661.
34. Gotoh, Y., S. Matsuda, K. Takenaka, S. Hattori, A. Iwamatsu, M. Ishikawa, H. Kosako, and E. Nishida. 1994. Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites. Oncogene 9:1891.
35. Tewari, M., L. T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salvesen, and V. M. Dixit. 1995. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81:801.
36. Casciola-Rosen, L., D. W. Nicholson, T. Chong, K. R. Rowan, N. A. Thornberry, D. K. Miller, and A. Rosen. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J. Exp. Med. 183:1957.
37. Wang, X., N. G. Zelenski, J. Yang, J. Sakai, M. S. Brown, and J. L. Goldstein. 1996. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15:1012.
38. Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966.
39. Keyse, S. M., and E. A. Emslie. 1992. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature 359:644.
40. Suzuki, S., X.-K. Li, T. Shinomiya, S. Enosawa, H. Amemiya, M. Amari, and S. Naoe. 1996. The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. Clin. Exp. Immunol. 107:103.
41. Rudel, T., and G. M. Bokoch. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276:1571.
42. Sells, M. A., and J. Chernoff. 1997. Emerging from the PAK: the p21-activated protein kinase family. Trends Cell Biol. 7:162.
43. Knaus, U. G., S. Morris, H.-J. Dong, J. Chernoff, and G. M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269:221.
44. Johnson, N. L., A. M. Gardner, K. M. Diener, C. A. Lange-Carter, J. Gleavy, M. B. Jarpe, A. Minden, M. Karin, L. I. Zon, and G. L. Johnson. 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J. Biol. Chem. 271:3229.
45. MAPK cascade. J. Biol. Chem. 272:1368.
46. Nishida, E., and Y. Gotoh. 1993. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18:128.
47. Avruch, J., X. F. Zhang, and J. M. Kyriakis. 1994. Raf meets Ras: completing the framework of a signal transduction pathway. Trends Biochem. Sci. 19:279.
48. Davis, R. J. 1994. MAPKs: new JNK expands the group. Trends Biochem. Sci. 19:470.
49. Cobb, M. H., and E. J. Goldsmith. 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843.
50. Suzuki, S., X.-K. Li, S. Enosawa, and T. Shinomiya. 1996. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 89:518.
51. L. Cell 87:619.
52. Wang, H.-G., U. R. Rapp, and J. C. Reed. 1996. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87:629.
53. Gajewski, T. F., and C. B. Thompson. 1996. Apoptosis meets signal transduction: elimination of a BAD influence. Cell 87:589.
54. Zou, H., W. J. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405.
55. Khan, A. A., J. Soloski, A. H. Sharp, G. Schilling, D. M. Sabatini, S.-H. Li, C. A. Ross, and S. H. Snyder. 1996. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor Science 273:503.
56. Graves, J. D., K. E. Draves, A. Craxton, J. Saklatvala, E. G. Krebs, and E. A. Clark. 1996. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc. Natl. Acad. Sci. USA 93:13814.
57. Jayaraman, T., and A. R. Marks. 1997. T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol. Cell. Biol. 17:3005.
58. 2+ elevation and cyclosporin A synergistically induce TGF-β1-mediated apoptosis in lymphocytes. J. Immunol. 158:2527.
59. Hannun, Y. A., and L. M. Obeid. 1995. Ceramide: an intracellular signal for apoptosis. Trends Biochem. Sci. 20:73.
60. Nakamura, S., Y. Kozutsumi, Y. Sun, Y. Miyake, T. Fujita, and T. Kawasaki, 1996. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. J. Biol. Chem. 271:1255.