-
1
-
-
0028936902
-
Simple compounds, 2-alkyl-2-amino-1, 3-propanediols have potent immunosuppressive activity
-
FUJITA T., YONETA M., Hirose R. et al. (1995) Simple compounds, 2-alkyl-2-amino-1, 3-propanediols have potent immunosuppressive activity. BioMed Ch Lett 5, 847.
-
(1995)
BioMed Ch Lett
, vol.5
, pp. 847
-
-
Fujita, T.1
Yoneta, M.2
Hirose, R.3
-
2
-
-
0028943870
-
Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1, 3-propanediols: Discovery of a novel immunosuppressant, FTY720
-
ADACHI K., KOHARA T., NAKAO N. et al. (1995) Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1, 3-propanediols: discovery of a novel immunosuppressant, FTY720. BioMed Chem Lett 5, 853.
-
(1995)
BioMed Chem Lett
, vol.5
, pp. 853
-
-
Adachi, K.1
Kohara, T.2
Nakao, N.3
-
3
-
-
0028372227
-
Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite
-
FUJITA T., INOUE K., YAMAMOTO S. et al. (1994) Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot 47, 208.
-
(1994)
J Antibiot
, vol.47
, pp. 208
-
-
Fujita, T.1
Inoue, K.2
Yamamoto, S.3
-
4
-
-
0015298713
-
Myriocin, a new antifungal antibiotic from Myriococcum albomyces
-
KLUEPFEL D., BAGLI J., BAKER H., CHAREST M.P. & KUDELSKI A. (1972) Myriocin, a new antifungal antibiotic from Myriococcum albomyces. J Antibiot 25, 109.
-
(1972)
J Antibiot
, vol.25
, pp. 109
-
-
Kluepfel, D.1
Bagli, J.2
Baker, H.3
Charest, M.P.4
Kudelski, A.5
-
5
-
-
0015510136
-
Structure of thermozymocidin
-
ARAGOZZINI F., MANACHINI P.L., CRAVERI R., RINIDONE B. & SCOLASTICO C. (1972) Structure of thermozymocidin. Experientia 28, 881.
-
(1972)
Experientia
, vol.28
, pp. 881
-
-
Aragozzini, F.1
Manachini, P.L.2
Craveri, R.3
Rinidone, B.4
Scolastico, C.5
-
6
-
-
0030049234
-
A novel immunosuppressant, FTY720, with a unique mechanism of action induces long-term graft acceptance in rat and dog allotransplantation
-
SUZUKI S., ENOSAWA S., KAKEFUDA T. et al. (1996) A novel immunosuppressant, FTY720, with a unique mechanism of action induces long-term graft acceptance in rat and dog allotransplantation. Transplantation 61, 200.
-
(1996)
Transplantation
, vol.61
, pp. 200
-
-
Suzuki, S.1
Enosawa, S.2
Kakefuda, T.3
-
7
-
-
0031014480
-
The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720
-
SUZUKI S., LI X., SHINOMIYA T. et al. (1996) The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720. Clin Exp Immunol 107, 103.
-
(1996)
Clin Exp Immunol
, vol.107
, pp. 103
-
-
Suzuki, S.1
Li, X.2
Shinomiya, T.3
-
8
-
-
0029857032
-
A new immunosuppressant. FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
-
SUZUKI S., LI X., ENOSAWA S. & SHINOMIYA T. (1996) A new immunosuppressant. FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 89, 518.
-
(1996)
Immunology
, vol.89
, pp. 518
-
-
Suzuki, S.1
Li, X.2
Enosawa, S.3
Shinomiya, T.4
-
9
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
-
OKAZAKI T., BELL R.M. & HANNUN Y.A. (1989) Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem 264, 19 076.
-
(1989)
J Biol Chem
, vol.264
, pp. 19076
-
-
Okazaki, T.1
Bell, R.M.2
Hannun, Y.A.3
-
10
-
-
0025003424
-
Role of ceramide as a lipid mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation
-
OKAZAKI T., BIELAWSKA A., BELL R.M. & HANNUN Y.A. (1990) Role of ceramide as a lipid mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 265, 15 823.
-
(1990)
J Biol Chem
, vol.265
, pp. 15823
-
-
Okazaki, T.1
Bielawska, A.2
Bell, R.M.3
Hannun, Y.A.4
-
11
-
-
0027973628
-
A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils
-
OHTA H., YATOMI Y., SWEENEV E.A., HAKOMORI S. & IGARASHI Y. (1994) A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils. FEBS Lett 355, 267.
-
(1994)
FEBS Lett
, vol.355
, pp. 267
-
-
Ohta, H.1
Yatomi, Y.2
Sweenev, E.A.3
Hakomori, S.4
Igarashi, Y.5
-
12
-
-
0028900748
-
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
-
OHTA H., SWEENEY E.A., MASAMUNE A., YATOMI Y., HAKOMORI S. & IGARASHI Y. (1995) Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res 55, 691.
-
(1995)
Cancer Res
, vol.55
, pp. 691
-
-
Ohta, H.1
Sweeney, E.A.2
Masamune, A.3
Yatomi, Y.4
Hakomori, S.5
Igarashi, Y.6
-
13
-
-
0028859436
-
2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids
-
2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids. J Biol Chem 270, 26 332.
-
(1995)
J Biol Chem
, vol.270
, pp. 26332
-
-
Okajima, F.1
Kondo, Y.2
-
15
-
-
0025201019
-
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils
-
BLEASDALE J.E., THAKUR N.R., GREMBAN R.S. et al. (1990) Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther 255, 756.
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 756
-
-
Bleasdale, J.E.1
Thakur, N.R.2
Gremban, R.S.3
-
16
-
-
0023095571
-
The calcium mobilizing tumor promoting agent, thapsigargin elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumor promotion
-
THASTRUP O., FODER B. & SCHARFF O. (1987) The calcium mobilizing tumor promoting agent, thapsigargin elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumor promotion. Biochem Biophys Res Commun 142, 654.
-
(1987)
Biochem Biophys Res Commun
, vol.142
, pp. 654
-
-
Thastrup, O.1
Foder, B.2
Scharff, O.3
-
18
-
-
0018379821
-
Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores
-
KATADA T. & UI M. (1979) Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores. J Biol Chem 254, 469.
-
(1979)
J Biol Chem
, vol.254
, pp. 469
-
-
Katada, T.1
Ui, M.2
-
19
-
-
0020137319
-
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein
-
KATADA T. & UI M. (1982) Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci USA 79, 3129.
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 3129
-
-
Katada, T.1
Ui, M.2
-
20
-
-
0022839148
-
Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein
-
SASAGURI T., HIRATA M., ITOH T., KOGA T. & KURIYAMA H. (1986) Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein. Biochem J 239, 567.
-
(1986)
Biochem J
, vol.239
, pp. 567
-
-
Sasaguri, T.1
Hirata, M.2
Itoh, T.3
Koga, T.4
Kuriyama, H.5
-
21
-
-
0017782474
-
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
-
COLLINS S.J., GALLO R.C. & GALLAGHER R.E. (1977) Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 270, 347.
-
(1977)
Nature
, vol.270
, pp. 347
-
-
Collins, S.J.1
Gallo, R.C.2
Gallagher, R.E.3
-
22
-
-
0028075254
-
Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line
-
TORIGOE T., MILLAN J.A., TAKAYAMA S., TAICHMAN R., MIYASHITA T. & REED J.C. (1994) Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line. Cancer Res 54, 4851.
-
(1994)
Cancer Res
, vol.54
, pp. 4851
-
-
Torigoe, T.1
Millan, J.A.2
Takayama, S.3
Taichman, R.4
Miyashita, T.5
Reed, J.C.6
-
25
-
-
0018830636
-
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
-
WYLLIE A.H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555.
-
(1980)
Nature
, vol.284
, pp. 555
-
-
Wyllie, A.H.1
-
27
-
-
84965822602
-
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
-
ALLEY M.C., SCUDIERO D.A., MONKS A. et al. (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 48, 589.
-
(1988)
Cancer Res
, vol.48
, pp. 589
-
-
Alley, M.C.1
Scudiero, D.A.2
Monks, A.3
-
28
-
-
0017072249
-
Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity
-
RUEGGER A., KUHN M., LICHTI H. et al. (1976) [Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity]. Helv Chim Acta 59, 1075.
-
(1976)
Helv Chim Acta
, vol.59
, pp. 1075
-
-
Ruegger, A.1
Kuhn, M.2
Lichti, H.3
-
29
-
-
0023205385
-
Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity
-
QUESNIAUX V.F., SCHREIER M.H., WENGER R.M., HIESTAND P.C., HARDING M.W. & VAN REGENMORTEL M.H. (1987) Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity. Eur J Immunol 17, 1359.
-
(1987)
Eur J Immunol
, vol.17
, pp. 1359
-
-
Quesniaux, V.F.1
Schreier, M.H.2
Wenger, R.M.3
Hiestand, P.C.4
Harding, M.W.5
Van Regenmortel, M.H.6
-
30
-
-
0023619772
-
Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis
-
TANAKA H., KURODA A., MARUSAWA H. et al. (1987) Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc 19, 11.
-
(1987)
Transplant Proc
, vol.19
, pp. 11
-
-
Tanaka, H.1
Kuroda, A.2
Marusawa, H.3
-
31
-
-
0023568088
-
Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats
-
OCHIAI T., NAKAJIMA K., NAGATA M., HORI S., ASANO T. & ISONO K. (1987) Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation 44, 734.
-
(1987)
Transplantation
, vol.44
, pp. 734
-
-
Ochiai, T.1
Nakajima, K.2
Nagata, M.3
Hori, S.4
Asano, T.5
Isono, K.6
-
32
-
-
0016724057
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
VEZINA C., KUDELSKI A. & SEHGAL S.N. (1975) Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot 28, 721.
-
(1975)
J Antibiot
, vol.28
, pp. 721
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
33
-
-
0017362502
-
Inhibition of the immune response by rapamycin, a new antifungal antibiotic
-
MARTEL R.R., KLICIUS J. & GALET S. (1977) Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can J Physiol Pharmacol 55, 48.
-
(1977)
Can J Physiol Pharmacol
, vol.55
, pp. 48
-
-
Martel, R.R.1
Klicius, J.2
Galet, S.3
-
34
-
-
0017346329
-
Calcium dependence of glucocorticoid-induced lymphocytolysis
-
KAISER N. & EDELMAN I.S. (1977) Calcium dependence of glucocorticoid-induced lymphocytolysis. Proc Natl Acad Sci USA 74, 638.
-
(1977)
Proc Natl Acad Sci USA
, vol.74
, pp. 638
-
-
Kaiser, N.1
Edelman, I.S.2
-
37
-
-
0028987863
-
An evaluation of the role of calcium in cell injury
-
HARMAN A.W. & MAXWELL M.J. (1995) An evaluation of the role of calcium in cell injury. Annu Rev Pharmacol Toxicol 35, 129.
-
(1995)
Annu Rev Pharmacol Toxicol
, vol.35
, pp. 129
-
-
Harman, A.W.1
Maxwell, M.J.2
-
38
-
-
0023062987
-
Inositol trisphosphate and diacyglycerol: Two interacting second messengers
-
BERRIDGE M.J. (1987) Inositol trisphosphate and diacyglycerol: two interacting second messengers. Annu Rev Biochem 56, 159.
-
(1987)
Annu Rev Biochem
, vol.56
, pp. 159
-
-
Berridge, M.J.1
-
39
-
-
0025873842
-
Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis
-
LIU Y.J., MASON D.Y., JOHNSON G.D. et al. (1991) Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur J Immunol 21 (1905).
-
(1991)
Eur J Immunol
, vol.21
, Issue.1905
-
-
Liu, Y.J.1
Mason, D.Y.2
Johnson, G.D.3
-
40
-
-
0029015588
-
A novel protein expressed in mammalian cells undergoing apoptosis
-
GRAND R.J., MILNER A.E., MUSTOE T. et al. (1995) A novel protein expressed in mammalian cells undergoing apoptosis. Exp. Cell Res 218, 439.
-
(1995)
Exp. Cell Res
, vol.218
, pp. 439
-
-
Grand, R.J.1
Milner, A.E.2
Mustoe, T.3
-
41
-
-
0027397544
-
Inositol trisphosphate and calcium signalling
-
BERRIDGE M.J. (1993) Inositol trisphosphate and calcium signalling. Nature 361, 315.
-
(1993)
Nature
, vol.361
, pp. 315
-
-
Berridge, M.J.1
-
42
-
-
0022974603
-
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
-
HANNUN Y.A., LOOMIS C.R., MERRILL A.J. & BELL R.M. (1986) Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 261, 12 604.
-
(1986)
J Biol Chem
, vol.261
, pp. 12604
-
-
Hannun, Y.A.1
Loomis, C.R.2
Merrill, A.J.3
Bell, R.M.4
-
43
-
-
0025055260
-
Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock
-
PEROTTI M., TODDEL F., MIRABELLI F. et al. (1990) Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock. FEBS Lett 259, 331.
-
(1990)
FEBS Lett
, vol.259
, pp. 331
-
-
Perotti, M.1
Toddel, F.2
Mirabelli, F.3
-
44
-
-
0028900748
-
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
-
OHTA H., SWEENEY E.A., MASAMUNE A., YATOMI Y., HAKOMORI S. & IGARASHI Y. (1995) Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res 55, 691.
-
(1995)
Cancer Res
, vol.55
, pp. 691
-
-
Ohta, H.1
Sweeney, E.A.2
Masamune, A.3
Yatomi, Y.4
Hakomori, S.5
Igarashi, Y.6
-
45
-
-
0029075192
-
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
-
MIYAKE Y., KOZUTSUMI Y., NAKAMURA S., FUJITA T. & KAWASAKI T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun 211, 396.
-
(1995)
Biochem Biophys Res Commun
, vol.211
, pp. 396
-
-
Miyake, Y.1
Kozutsumi, Y.2
Nakamura, S.3
Fujita, T.4
Kawasaki, T.5
|