Alzheimer's disease βA4 protein release and amyloid precursor protein sorting are regulated by alternative splicing

Journal of Biological Chemistry

Volumn 271, Issue 22, 1996, Pages 13208-13214

  Hartmann, Tobias ^a   Bergsdorf, Christian ^a   Sandbrink, Rupert ^a   Tienari, Pentti J ^a   Multhaup, Gerd ^a   Ida, Nobuo ^a   Bieger, Sophie ^a   Dyrks, Thomas ^b   Weidemann, Andreas ^a   Masters, Colin L ^c   Beyreuther, Konrad ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b BAYER PHARMA AG   (Germany)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; CELL CULTURE; ENZYME ACTIVITY; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN TARGETING; RNA SPLICING;

EID: 15844404020     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.22.13208     Document Type: Article

References (33)

1. Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K., and Muller, H. B. (1987) Nature 325, 733-736
2. Weidemann, A., König, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C. L., and Beyreuther, K. (1989) Cell 57, 115-126
3. Dyrks, T., Weidemann, A., Multhaup, G., Salbaum, J. M., Lemaire, H. G., Rang, J., Muller-Hill, B., Masters, C. L., and Beyreuther, K. (1988) EMBO J. 7, 949-957
4. Sandbrink, R., Masters, C. L., and Beyreuther, K. (1994) J. Biol. Chem. 269, 1510-1517
5. König, G., Mönning, U., Czech, C., Prior, R., Banati, R., Schreiter Gasser, U., Bauer, J., Masters, C. L., and Beyreuther, K. (1992) J. Biol. Chem. 267, 10804-10809
6. Sandbrink, R., Masters, C. L., and Beyreuther, K. (1994) J. Biol. Chem. 269, 14227-14234
7. Wasco, W., Gurubhagavatula, S., Paradis, M. D., Romano, D. M., Sisodia, S. S., Hyman, B. T., Neve, R. L., and Tanzi, R. E. (1993) Nat. Genet. 5, 95-100
8. Thinakaran, G., and Sisodia, S. S. (1994) J. Biol. Chem. 269, 22099-22104
9. Pangalos, M. N., Efthimiopoulos, S., Shioi, J., and Robakis, N. K. (1995) J. Biol Chem. 270, 10388-10391
10. Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) Ann. N. Y. Acad. Sci., 777, 281-287
11. Evin, G., Beyreuther, K., and Masters, C. L. (1994) Amyloid: Int. J. Exp. Clin. Invest. 1, 263-280
12. Haass, C., and Selkoe, D. J. (1993) Cell 75, 1039-1042
13. Haass, C., Koo, E. H., Teplow, D. B., and Selkoe, D. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1564-1568
14. Haass, C., Koo, E. H., Capell, A., Teplow, D. B., and Selkoe, D. J. (1995) J. Cell Biol. 128, 537-547
15. De Strooper, B., Craessaerts, K., Bewachter, I., Moechars, D., Greenberg, B., Van Leuven, F., and Van Den Berghe, H. (1995) J. Biol. Chem. 270, 4058-4065
16. Matter, K., Yamamoto, E. M., and Mellman, I. (1994) J. Cell Biol. 126, 991-1004
17. Fiedler, K., and Simons, K. (1995) Cell 81, 309-312
18. Lo, A. C., Haass, C., Wagner, S. L., Teplow, D. B., and Sisodia, S. S. (1994) J. Biol. Chem. 269, 30966-30973
19. Müller, G., Ruppert, S., Schmid, E., and Schütz, G. (1988) EMBO J. 7, 2723-2730
20. Dyrks, T., Dyrks, E., Hartmann, T., Masters, C., and Beyreuther, K. (1992) J. Biol. Chem. 267, 18210-18217
21. Hartmann, T., Dyrks, T., Weidemann, A., Masters, C. L., and Beyreuther, K. (1994) Neurobiol. Aging 15, 551
22. Maruyama, K., Kawamura, Y., Asada, H., Ishiura, S., and Obata, K. (1994) Biochem. Biophys. Res. Commun. 202, 1517-1523
23. Simons, K., and Virta, H. (1994) in Cell Biology-A Laboratory Handbook (Celis, J. E., ed) Vol. 1, pp. 225-231, Academic Press, San Diego
24. Hunziker, W., and Mellman, I. (1989) J. Cell Biol. 109, 3291-3302
25. Hilbich, C., Monning, U., Grund, C., Masters, C. L., and Beyreuther, K. (1993) J. Biol Chem. 268, 26571-26577
26. Dyrks, T., Dyrks, E., Monning, U., Urmoneit, B., Turner, J., and Beyreuther, K. (1993) FEES Lett 335, 89-93
27. Laemmli, U. K. (1970) Nature 227, 680-685
28. Schägger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
29. Shioi, J., Pangalos, M. N., Ripellino, J. A., Vassilacopoulou, D., Mytilineou, C., Margolis, R. U., and Robakis, N. K. (1995) J. Biol. Chem. 270, 11839-11844
30. Haass, C., Hung, A. Y., Schlossmacher, M. G., Teplow, D. B., and Selkoe, D. J. (1993) J. Biol. Chem. 268, 3021-3024
31. Selkoe, D. J. (1994) J. Neuropathol. Exp. Neurol. 53, 438-447
32. Chanat, E., Weiss, U., Huttner, W. B., and Tooze, S. A. (1993) EMBO J. 12, 2159-2168
33. Loo, A. C. Y., Thinakaran, G., Slunt, H. H., and Sisodia, S. S. (1995) J. Biol. Chem. 270, 12641-12645