Trefoil factor 3 stimulates human and rodent pancreatic islet β-cell replication with retention of function

Molecular Endocrinology

Volumn 22, Issue 5, 2008, Pages 1251-1259

  Fueger, Patrick T ^a   Schisler, Jonathan C ^a   Lu, Danhong ^a   Babu, Daniella A ^b   Mirmira, Raghavendra G ^b   Newgard, Christopher B ^a   Hohmeier, Hans E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BROXURIDINE; EPIDERMAL GROWTH FACTOR; PROTEIN KINASE B; TREFOIL FACTOR 3; TREFOIL PEPTIDE; TRICIRIBINE;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL FUNCTION; CELL STIMULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; HUMANS; IMMUNOBLOTTING; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; NEUROPEPTIDES; ONCOGENE PROTEIN V-AKT; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDINE; TRANSFECTION;

LOTUS; RATTUS; RODENTIA;

EID: 43049101101     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2007-0500     Document Type: Article

References (31)

1. Hohmeier HE, Newgard CB 2005 Islets for all? Nat Biotechnol 23:1231-1232
2. Thim L, May FE 2005 Structure of mammalian trefoil factors and functional insights. Cell Mol Life Sci 62:2956-2973
3. Chadwick MP, Westley BR, May FE 1997 Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. Biochem J 327(Pt 1):117-123
4. Kinoshita K, Taupin DR, Itoh H, Podolsky DK 2000 Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. Mol Cell Biol 20:4680-4690
5. Muskett FW, May FE, Westley BR, Feeney J 2003 Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. Biochemistry 42:15139-15147
6. Hoffmann W 2005 Trefoil factors TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution. Cell Mol Life Sci 62:2932-2938
7. Jackerott M, Lee YC, Mollgard K, Kofod H, Jensen J, Rohleder S, Neubauer N, Gaarn LW, Lykke J, Dodge R, Dalgaard LT, Sostrup B, Jensen DB, Thim L, Nexo E, Thams P, Cathrine Bisgaard H, Nielsen JH 2006 Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Endocrinology 147:5752-5759
8. Becker TC, BeltrandelRio H, Noel RJ, Johnson JH, Newgard CB 1994 Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 269:21234-21238
9. Becker TC, Noel RJ, Johnson JH, Lynch RM, Hirose H, Tokuyama Y, Bell GI, Newgard CB 1996 Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes. J Biol Chem 271:390-394
10. Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA 2001 Islet beta cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 108:1631-1638
11. Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, Polonsky KS, Naji A, Birnbaum MJ 2001 Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nat Med 7:1133-1137
12. Wang Q, Li L, Xu E, Wong V, Rhodes C, Brubaker PL 2004 Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 β-cells. Diabetologia 47:478-487
13. Collier JJ, Fueger PT, Hohmeier HE, Newgard CB 2006 Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and β-cell lines. Diabetes 55:1398-1406
14. Taupin DR, Kinoshita K, Podolsky DK 2000 Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci USA 97:799-804
15. Yamamoto K, Miyagawa J, Waguri M, Sasada R, Igarashi K, Li M, Nammo T, Moriwaki M, Imagawa A, Yamagata K, Nakajima H, Namba M, Tochino Y, Hanafusa T, Matsuzawa Y 2000 Recombinant human betacellulin promotes the neogenesis of β-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. Diabetes 49:2021-2027
16. Huotari MA, Palgi J, Otonkoski T 1998 Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of beta-cellulin as a novel β-cell mitogen. Endocrinology 139:1494-1499
17. Kuntz E, Broca C, Komurasaki T, Kaltenbacher MC, Gross R, Pinget M, Damge C 2005 Effect of epiregulin on pancreatic β-cell growth and insulin secretion. Growth Factors 23:285-293
18. Rooman I, Bouwens L 2004 Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 47:259-265
19. Miettinen PJ, Ustinov J, Ormio P, Gao R, Palgi J, Hakonen E, Juntti-Berggren L, Berggren PO, Otonkoski T 2006 Downregulation of EGF receptor signaling in pancreatic islets causes diabetes due to impaired postnatal β-cell growth. Diabetes 55:3299-3308
20. + channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 49:424-430
21. Milburn Jr JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH 1995 Pancreatic β-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270:1295-1299
22. Naber SP, McDonald JM, Jarett L, McDaniel ML, Ludvigsen CW, Lacy PE 1980 Preliminary characterization of calcium binding in islet-cell plasma membranes. Diabetologia 19:439-444
23. Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB 2006 Compensatory responses to pyruvate carboxylase suppression in islet β-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem 281:22342-22351
24. Becker TC, Noel RJ, Coats WS, Gomez-Foix AM, Alam T, Gerard RD, Newgard CB 1994 Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol 43(Pt A):161-189
25. Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB 2005 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β-cells. Proc Natl Acad Sci USA 102:7297-7302
26. Jin P, Hardy S, Morgan DO 1998 Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol 141:875-885
27. Fujio Y, Guo K, Mano T, Mitsuuchi Y, Testa JR, Walsh K 1999 Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survival. Mol Cell Biol 19:5073-5082
28. Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF 2004 Induction of β-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 53:149-159
29. Haycock JW 1993 Polyvinylpyrrolidone as a blocking agent in immunochemical studies. Anal Biochem 208:397-399
30. Clark SA, Quaade C, Constandy H, Hansen P, Halban P, Ferber S, Newgard CB, Normington K 1997 Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. Diabetes 46:958-967
31. Hohmeier HE, BeltrandelRio H, Clark SA, Henkel-Rieger R, Normington K, Newgard CB 1997 Regulation of insulin secretion from novel engineered insulinoma cell lines. Diabetes 46:968-977