Hypoxia-inducible factor 1α (HIF-1α) is a non-heme iron protein. Implications for oxygen sensing

Journal of Biological Chemistry

Volumn 273, Issue 29, 1998, Pages 18019-18022

  Srinivas, V ^a   Zhu, X ^a   Salceda, Susana ^a   Nakamura, R ^a   Caro, Jaime ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; HEME; IRON DERIVATIVE; OXYGEN; PROTEIN; PROTEIN SYNTHESIS INHIBITOR;

ARTICLE; CHEMOSENSITIVITY; GENE CONTROL; HEME SYNTHESIS; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION;

CARBON MONOXIDE; CELL HYPOXIA; CELL LINE; DEFEROXAMINE; DNA-BINDING PROTEINS; HELIX-LOOP-HELIX MOTIFS; HEME; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; IRON CHELATING AGENTS; LUCIFERASES; NUCLEAR PROTEINS; OXYGEN; TRANSCRIPTION FACTORS;

EID: 0032540956     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.29.18019     Document Type: Article

References (29)

1. Bunn, H. F., and Poyton, R. O. (1996) Physiol. Rev. 76, 839-885
2. Wenger, R. H., and Gassmann, M. (1997) Biol. Chem. 378, 609-616
3. Beck, I., Weinmann, R., and Caro, J. (1993) Blood 82, 704-711
4. Wang, G. L., and Semenza, G. L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 4304-4308
5. Wang, G. L., Jiang, B.-H., Rue, E. A., and Semenza, G. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 5510-5514
6. Salceda, S., and Caro, J. (1997) J. Biol. Chem. 272, 22642-22647
7. Goldberg, M. A., Dunning, S. P., and Bunn, H. F. (1988) Science 242, 1412-1415
8. Acker, H., and Xue, D. (1995) News Physiol. Sci. 10, 211-216
9. Fandrey, J., Frede, S., and Jelkmann, W. (1994) Biochem. J. 303, 507-510
10. Ehleben, W., Porwol., T., Fandrey, J., Kummer, W., and Acker, H. (1997) Kidney Int. 51, 483-491
11. Beru, N., and Goldwasser, E. (1985) J. Biol. Chem. 260, 9251-9257
12. Fish, W. W. (1988) Methods Enzymol. 158, 357-364
13. Slavin, W. (1988) Methods Enzymol. 158, 117-140
14. Steyermark, A. L. (1961) Quantitative Organic Microanalysis, Academic Press, New York
15. Tschudy, D. P., Hess, R. A., and Frykholm, B. C. (1981) J. Biol. Chem. 256, 9915-9923
16. Beck, I., Ramirez, S., Weinmann, R., and Caro, J. (1991) J. Biol. Chem. 266, 15563-15566
17. Semenza, G. L., Nejfelt, M. K., Chi, S. M., and Antonarakis, S. E. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5680-5684
18. Pugh, C. W., Tan, C. C., Jones, R. W., and Ratcliffe, P. J. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10553-10557
19. Ratcliffe, P. J., Maxwell, P. H., and Pugh, C. W. (1997) Nephrol. Dial. Transplant. 12, 1842-1848
20. Eckardt, K.-U., Pugh, C. W., Ratcliffe, P. J., and Kurtz, A. (1993) Pflügers Arch. 423, 356-364
21. Graven, K. K., McDonald, R. J., and Farber, H. W. (1998) Am. J. Physiol. 274, C347-C355
22. O'Donnell, V. B., Tew, D. G., Jones, O. T. G., and England, P. J. (1993) Biochem. J. 290, 41:49
23. Gleadle, J. M., Ebert, B. L., and Ratcliffe, P. J. (1995) Eur. J. Biochem. 234, 92-99
24. Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., and Semenza, G. L. (1996) J. Biol. Chem. 271, 1771-1778
25. Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M., and Ratcliffe, P. J. (1997) J. Biol. Chem. 272, 11205-11214
26. Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Klausner, R. D., Levine, R. L., and Rouault, T. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 4924-4928
27. Biaglow, J. E., and Kachur, A. V. (1997) Radiat. Res. 148, 181-187
28. Howard, J. B., and Rees, D. C. (1991) Adv. Protein Chem. 2, 199-280
29. Freeman, J. H., Ciriolo, M. R., and Peisach, J. (1989) J. Biol. Chem. 264, 5598-5605