Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs

British Journal of Cancer

Volumn 74, Issue SUPPL. XXVII, 1996, Pages

  Wardman, P ^a   Priyadarsini, K I ^a,d   Dennis, M F ^a   Everett, S A ^a   Naylor, M A ^b   Patel, K B ^a   Stratford, I J ^b,e   Stratford, M R L ^a   Tracy, M ^c  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c SRI INTERNATIONAL   (United States)

^d BHABHA ATOMIC RESEARCH CENTRE   (India)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Hydrogen abstraction; N oxides; Radicals; Rate constants; RB90740; Tirapazamine

Indexed keywords

1,2,4 BENZOTRIAZINE 1,4 DIOXIDE; 2 PROPANOL; AROMATIC COMPOUND; DEOXYRIBOSE; FORMIC ACID; FREE RADICAL; QUINOXALINE DERIVATIVE; TIRAPAZAMINE; ANTINEOPLASTIC AGENT; OXIDE; PYRAZINE DERIVATIVE; RB 90740; TRIAZINE DERIVATIVE;

ANOXIA; CONFERENCE PAPER; DRUG CYTOTOXICITY; DRUG SELECTIVITY; HYPOXIC CELL; PH; PKA; PRIORITY JOURNAL; PULSE RADIOLYSIS; REDUCTION; ARTICLE; CHEMISTRY; OXIDATION REDUCTION REACTION;

ANTINEOPLASTIC AGENTS; FREE RADICALS; HYDROGEN-ION CONCENTRATION; OXIDATION-REDUCTION; OXIDES; PULSE RADIOLYSIS; PYRAZINES; TRIAZINES;

EID: 0029931346     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

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