A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor

Genes and Development

Volumn 17, Issue 7, 2003, Pages 826-831

  Hua, Qing xin ^a   Nakagawa, Satoe H ^b   Wilken, Jill ^c   Ramos, Rowena R ^d   Jia, Wenhua ^a   Bass, Joseph ^d   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c Gryphon Therapeutics   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hormone; Metabolism; NMR; Protein evolution; Protein structure; Senescence

Indexed keywords

INSULIN; INSULIN RECEPTOR; ISOPROTEIN; PROTEIN INS 6; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BRAIN NERVE CELL; CAENORHABDITIS ELEGANS; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; HUMANS; INSULIN; MAMMALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VERTEBRATES;

CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 0345073631     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1058003     Document Type: Article

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