-
1
-
-
0025120211
-
Regulation of the mevalonate pathway
-
Goldstein, J. L. and Brown, M. S. (1990) Regulation of the mevalonate pathway. Nature 343, 425-430.
-
(1990)
Nature
, vol.343
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
2
-
-
30344473341
-
Protein sensors for membrane sterols
-
Goldstein, J. L., DeBose-Boyd, R. A., and Brown, M. S. (2006) Protein sensors for membrane sterols. Cell 124, 35-46.
-
(2006)
Cell
, vol.124
, pp. 35-46
-
-
Goldstein, J.L.1
DeBose-Boyd, R.A.2
Brown, M.S.3
-
3
-
-
33745759439
-
Intracellular sterol transport and distribution
-
Maxfield, F. R. and Menon, A. K. (2006) Intracellular sterol transport and distribution. Curr. Opin. Cell Biol. 18, 379-385.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 379-385
-
-
Maxfield, F.R.1
Menon, A.K.2
-
4
-
-
33749073795
-
Cholesterol sensing, trafficking, and esterification
-
Chang, T. Y., Chang, C. C., Ohgami, N., and Yamauchi, Y. (2006) Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 22, 129-157.
-
(2006)
Annu. Rev. Cell Dev. Biol.
, vol.22
, pp. 129-157
-
-
Chang, T.Y.1
Chang, C.C.2
Ohgami, N.3
Yamauchi, Y.4
-
5
-
-
55949126769
-
Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
-
Urano, Y., Watanabe, H., Murphy, S. R., Shibuya, Y., Geng, Y., Peden, A. A., Chang, C. C., and Chang, T. Y. (2008) Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex. Proc. Natl. Acad. Sci. USA 105, 16513-16518.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 16513-16518
-
-
Urano, Y.1
Watanabe, H.2
Murphy, S.R.3
Shibuya, Y.4
Geng, Y.5
Peden, A.A.6
Chang, C.C.7
Chang, T.Y.8
-
6
-
-
0028964742
-
Cell toxicity induced by inhibition of acyl coenzyme A:cholessterol acyltransferase and accumulation of unesterified cholesterol
-
Warner, G. J., Stoudt, G., Bamberger, M., Johnson, W. J., and Rothblat, G. H. (1995) Cell toxicity induced by inhibition of acyl coenzyme A:cholessterol acyltransferase and accumulation of unesterified cholesterol. J. Biol. Chem. 270, 5772-5778.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5772-5778
-
-
Warner, G.J.1
Stoudt, G.2
Bamberger, M.3
Johnson, W.J.4
Rothblat, G.H.5
-
7
-
-
0036790413
-
Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications
-
Tabas, I. (2002) Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 110, 905-911.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 905-911
-
-
Tabas, I.1
-
8
-
-
0034672672
-
Oxysterol biosynthetic enzymes
-
Russell, D. W. (2000) Oxysterol biosynthetic enzymes. Biochim. Biophys. Acta 1529, 126-135.
-
(2000)
Biochim. Biophys. Acta
, vol.1529
, pp. 126-135
-
-
Russell, D.W.1
-
9
-
-
63849221643
-
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function
-
Karasinska, J. M., Rinninger, F., Lutjohann, D., Ruddle, P., Franciosi, S., Kruit, J. K., Singaraja, R. R., Hirsch-Reinshagen, V., Fan, J., Brunham, L. R., Bissada, N., Ramakrishnan, R., Wellington, C. L., Parks, J. S., and Hayden, M. R. (2009) Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J. Neurosci. 29, 3579-3589.
-
(2009)
J. Neurosci.
, vol.29
, pp. 3579-3589
-
-
Karasinska, J.M.1
Rinninger, F.2
Lutjohann, D.3
Ruddle, P.4
Franciosi, S.5
Kruit, J.K.6
Singaraja, R.R.7
Hirsch-Reinshagen, V.8
Fan, J.9
Brunham, L.R.10
Bissada, N.11
Ramakrishnan, R.12
Wellington, C.L.13
Parks, J.S.14
Hayden, M.R.15
-
10
-
-
0022346351
-
24(S),25-Epoxycholesterol: Evidence consistent with a role in the regulation of hepatic cholesterogenesis
-
Spencer, T. A., Gayen, A. K., Phirwa, S., Nelson, J. A., Taylor, F. R., Kandutsch, A. A., and Erickson, S. K. (1985) 24(S),25-Epoxycholesterol: Evidence consistent with a role in the regulation of hepatic cholesterogenesis. J. Biol. Chem. 260, 13391-13394.
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 13391-13394
-
-
Spencer, T.A.1
Gayen, A.K.2
Phirwa, S.3
Nelson, J.A.4
Taylor, F.R.5
Kandutsch, A.A.6
Erickson, S.K.7
-
11
-
-
36249006573
-
Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis
-
Wong, J., Quinn, C. M., Guillemin, G., and Brown, A. J. (2007) Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. J. Neurochem. 103, 1764-1773.
-
(2007)
J. Neurochem.
, vol.103
, pp. 1764-1773
-
-
Wong, J.1
Quinn, C.M.2
Guillemin, G.3
Brown, A.J.4
-
12
-
-
67349268463
-
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
-
Brown, A. J. and Jessup, W. (2009) Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. Mol. Aspects Med. 30, 111-122.
-
(2009)
Mol. Aspects Med.
, vol.30
, pp. 111-122
-
-
Brown, A.J.1
Jessup, W.2
-
13
-
-
0027527733
-
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
-
Chang, C. C. Y., Huh, H. Y., Cadigan, K. M., and Chang, T. Y. (1993) Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. J. Biol. Chem. 268, 20747-20755.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 20747-20755
-
-
Chang, C.C.Y.1
Huh, H.Y.2
Cadigan, K.M.3
Chang, T.Y.4
-
14
-
-
0029950683
-
Sterol esterification in yeast: A two-gene process
-
Yang, H., Bard, M., Bruner, D. A., Gleeson, A., Deckelbaum, R. J., Alijinovic, G., Pohl, T. M., Rothstein, R., and Sturley, S. L. (1996) Sterol esterification in yeast: a two-gene process. Science 272, 1353-1356.
-
(1996)
Science
, vol.272
, pp. 1353-1356
-
-
Yang, H.1
Bard, M.2
Bruner, D.A.3
Gleeson, A.4
Deckelbaum, R.J.5
Alijinovic, G.6
Pohl, T.M.7
Rothstein, R.8
Sturley, S.L.9
-
15
-
-
0032500641
-
Characterization of two human genes encoding acyl coenzyme A: Cholesterol acyltransferase-related enzymes
-
Oelkers, P., Behari, A., Cromley, D., Billheimer, J. T., and Sturley, S. L. (1998) Characterization of two human genes encoding acyl coenzyme A: cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273, 26765-26771.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26765-26771
-
-
Oelkers, P.1
Behari, A.2
Cromley, D.3
Billheimer, J.T.4
Sturley, S.L.5
-
16
-
-
0029835340
-
Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-coA:sterol acyltransferase
-
Yu, C., Kennedy, N. J., Chang, C. C. Y., and Rothblatt, J. A. (1996) Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-coA:sterol acyltransferase. J. Biol. Chem. 271, 24157-24163.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24157-24163
-
-
Yu, C.1
Kennedy, N.J.2
Chang, C.C.Y.3
Rothblatt, J.A.4
-
17
-
-
15444348784
-
ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
-
Cases, S., Novak, S., Zheng, Y. W., Myers, H., Lear, S. R., Sande, E., Welch, C. B., Lusis, A. J., Spencer, T. A., Krause, B. R., Erickson, S. K., and Farese, R. V., Jr. (1998) ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J. Biol. Chem. 273, 26755-26764.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26755-26764
-
-
Cases, S.1
Novak, S.2
Zheng, Y.W.3
Myers, H.4
Lear, S.R.5
Sande, E.6
Welch, C.B.7
Lusis, A.J.8
Spencer, T.A.9
Krause, B.R.10
Erickson, S.K.11
Farese Jr., R.V.12
-
18
-
-
0032500649
-
Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates
-
Anderson, R. A., Joyce, C., Davis, M., Reagan, J. W., Clark, M., Shelness, G. S., and Rudel, L. L. (1998) Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates. J. Biol. Chem. 273, 26747-26754.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26747-26754
-
-
Anderson, R.A.1
Joyce, C.2
Davis, M.3
Reagan, J.W.4
Clark, M.5
Shelness, G.S.6
Rudel, L.L.7
-
19
-
-
0034672691
-
Mammalian acyl-CoA:cholesterol acyltransferases
-
Buhman, K. F., Accada, M., and Farese, R. V. Jr. (2000) Mammalian acyl-CoA:cholesterol acyltransferases. Biochim. Biophys. Acta 1529, 142-154.
-
(2000)
Biochim. Biophys. Acta
, vol.1529
, pp. 142-154
-
-
Buhman, K.F.1
Accada, M.2
Farese Jr., R.V.3
-
20
-
-
0034161499
-
A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling
-
Hofmann, K. (2000) A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling. Trends Biochem. Sci. 25, 111-112.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 111-112
-
-
Hofmann, K.1
-
21
-
-
27844475676
-
The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
-
Guo, Z. Y., Lin, S., Heinen, J. A., Chang, C. C., and Chang, T. Y. (2005) The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. J. Biol. Chem. 280, 37814-37826.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37814-37826
-
-
Guo, Z.Y.1
Lin, S.2
Heinen, J.A.3
Chang, C.C.4
Chang, T.Y.5
-
22
-
-
38849090670
-
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
-
Yang, J., Brown, M. S., Liang, G., Grishin, N. V., and Goldstein, J. L. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387-396.
-
(2008)
Cell
, vol.132
, pp. 387-396
-
-
Yang, J.1
Brown, M.S.2
Liang, G.3
Grishin, N.V.4
Goldstein, J.L.5
-
23
-
-
0031969718
-
Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease
-
Ray, W. J., Ashall, F., and Goate, A. M. (1998) Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease. Mol. Med. Today 4, 151-157.
-
(1998)
Mol. Med. Today
, vol.4
, pp. 151-157
-
-
Ray, W.J.1
Ashall, F.2
Goate, A.M.3
-
24
-
-
44049094269
-
Ghrelin octanoylation mediated by an orphan lipid transferase
-
Gutierrez, J. A., Solenberg, P. J., Perkins, D. R., Willency, J. A., Knierman, M. D., Jin, Z., Witcher, D. R., Luo, S., Onyia, J. E., and Hale, J. E. (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. USA 105, 6320-6325.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 6320-6325
-
-
Gutierrez, J.A.1
Solenberg, P.J.2
Perkins, D.R.3
Willency, J.A.4
Knierman, M.D.5
Jin, Z.6
Witcher, D.R.7
Luo, S.8
Onyia, J.E.9
Hale, J.E.10
-
25
-
-
58649098789
-
Acyl-CoA:lysophospholipid acyltransferases
-
Shindou, H. and Shimizu, T. (2009) Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem. 284, 1-5.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 1-5
-
-
Shindou, H.1
Shimizu, T.2
-
26
-
-
0035081589
-
Structure, function, and regulation of ACAT
-
Rudel, L., Lee, R., and Cockman, T. (2001) Structure, function, and regulation of ACAT. Curr. Opin. Lipidol. 12, 121-127.
-
(2001)
Curr. Opin. Lipidol.
, vol.12
, pp. 121-127
-
-
Rudel, L.1
Lee, R.2
Cockman, T.3
-
27
-
-
67650032647
-
Acyl-coenzyme A:cholesterol acyltransferases
-
Chang, T. Y., Li, B. L., Chang, C. C., and Urano, Y. (2009) Acyl-coenzyme A:cholesterol acyltransferases. Am. J. Physiol. Endocrinol. Metab. 297, E1-E9.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
-
-
Chang, T.Y.1
Li, B.L.2
Chang, C.C.3
Urano, Y.4
-
28
-
-
0034623070
-
Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine
-
Chang, C. C. Y., Sakashita, N., Ornvold, K., Lee, O., Chang, E. T., Dong, R., Lin, S., Lee, C. Y., Strom, S. C., Kashyap, R., Fung, J. J., Farese, R. V., Jr., Patoiseau, J. F., Delhon, A., and Chang, T. Y. (2000) Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275, 28083-28092.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28083-28092
-
-
Chang, C.C.Y.1
Sakashita, N.2
Ornvold, K.3
Lee, O.4
Chang, E.T.5
Dong, R.6
Lin, S.7
Lee, C.Y.8
Strom, S.C.9
Kashyap, R.10
Fung, J.J.11
Farese Jr., R.V.12
Patoiseau, J.F.13
Delhon, A.14
Chang, T.Y.15
-
29
-
-
20844451381
-
ACAT2 is localized to hepatocytes and is the major cholesterol- esterifying enzyme in human liver
-
Parini, P., Davis, M., Lada, A. T., Erickson, S. K., Wright, T. L., Gustafsson, U., Sahlin, S., Einarsson, C., Eriksson, M., Angelin, B., Tomoda, H., Omura, S., Willingham, M. C., and Rudel, L. L. (2004) ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation 110, 2017-2023.
-
(2004)
Circulation
, vol.110
, pp. 2017-2023
-
-
Parini, P.1
Davis, M.2
Lada, A.T.3
Erickson, S.K.4
Wright, T.L.5
Gustafsson, U.6
Sahlin, S.7
Einarsson, C.8
Eriksson, M.9
Angelin, B.10
Tomoda, H.11
Omura, S.12
Willingham, M.C.13
Rudel, L.L.14
-
30
-
-
33645008981
-
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma
-
Song, B. L., Wang, C. H., Yao, X. M., Yang, L., Zhang, W. J., Wang, Z. Z., Zhao, X. N., Yang, J. B., Qi, W., Yang, X. Y., Inoue, K., Lin, Z. X., Zhang, H. Z., Kodama, T., Chang, C. C., Liu, Y. K., Chang, T. Y., and Li, B. L. (2006) Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma. Biochem. J. 394, 617-626.
-
(2006)
Biochem. J.
, vol.394
, pp. 617-626
-
-
Song, B.L.1
Wang, C.H.2
Yao, X.M.3
Yang, L.4
Zhang, W.J.5
Wang, Z.Z.6
Zhao, X.N.7
Yang, J.B.8
Qi, W.9
Yang, X.Y.10
Inoue, K.11
Lin, Z.X.12
Zhang, H.Z.13
Kodama, T.14
Chang, C.C.15
Liu, Y.K.16
Chang, T.Y.17
Li, B.L.18
-
31
-
-
0037632868
-
Human acyl-coenzyme A: Cholesterol acyltransferase 2 (hACAT2) expressed in Chinese hamster ovary cells: Membrane topology and active site location
-
Lin, S., Lu, X., Chang, C. C. Y., and Chang, T. Y. (2003) Human acyl-coenzyme A: cholesterol acyltransferase 2 (hACAT2) expressed in Chinese hamster ovary cells: membrane topology and active site location. Mol. Biol. Cell 14, 2447-2460.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 2447-2460
-
-
Lin, S.1
Lu, X.2
Chang, C.C.Y.3
Chang, T.Y.4
-
32
-
-
0032567506
-
Recombinant human acyl-CoA:cholesterol acyltransferase 1 (ACAT1) purified to essential homogeneity utilizes cholesterol in mixed micelles or vesicles in a highly cooperative manner
-
Chang, C. C. Y., Lee, C. Y. G., Chang, E. T., Cruz, J. C., Levesque, M. C., and Chang, T. Y. (1998) Recombinant human acyl-CoA:cholesterol acyltransferase 1 (ACAT1) purified to essential homogeneity utilizes cholesterol in mixed micelles or vesicles in a highly cooperative manner. J. Biol. Chem. 273, 35132-35141.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35132-35141
-
-
Chang, C.C.Y.1
Lee, C.Y.G.2
Chang, E.T.3
Cruz, J.C.4
Levesque, M.C.5
Chang, T.Y.6
-
33
-
-
0028928737
-
Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system
-
Cheng, D., Chang, C. C., Qu, X., and Chang, T. Y. (1995) Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system. J. Biol. Chem. 270, 685-695.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 685-695
-
-
Cheng, D.1
Chang, C.C.2
Qu, X.3
Chang, T.Y.4
-
34
-
-
0038175518
-
Cholesterol is superior to 7-ketocholesterol or 7alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A: Cholesterol acyltransferase 1
-
Zhang, Y., Yu, C., Liu, J., Spencer, T. A. J., Chang, C. C. Y., and Chang, T. Y. (2003) Cholesterol is superior to 7-ketocholesterol or 7alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A: cholesterol acyltransferase 1. J. Biol. Chem. 278, 11642-11647.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11642-11647
-
-
Zhang, Y.1
Yu, C.2
Liu, J.3
Spencer, T.A.J.4
Chang, C.C.Y.5
Chang, T.Y.6
-
35
-
-
27444431715
-
Investigating the allosterism of acyl coenzyme A: Cholesterol acyltransferase (ACAT) by using various sterols: In vitro and intact cell studies
-
Liu, J., Chang, C. C., Westover, E. J., Covey, D. F., and Chang, T. Y. (2005) Investigating the allosterism of acyl coenzyme A: cholesterol acyltransferase (ACAT) by using various sterols: In vitro and intact cell studies. Biochem. J. 391, 389-397.
-
(2005)
Biochem. J.
, vol.391
, pp. 389-397
-
-
Liu, J.1
Chang, C.C.2
Westover, E.J.3
Covey, D.F.4
Chang, T.Y.5
-
36
-
-
0031668254
-
Expression of ACAT1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages
-
Miyazaki, A., Sakashita, N., Lee, O., Takahashi, K., Horiuchi, S., Hakamata, H., Morganelli, P. M., Chang, C. C., and Chang, T. Y. (1998) Expression of ACAT1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages. Arterioscler. Thromb. Vasc. Biol. 18, 1568-1574.
-
(1998)
Arterioscler. Thromb. Vasc. Biol.
, vol.18
, pp. 1568-1574
-
-
Miyazaki, A.1
Sakashita, N.2
Lee, O.3
Takahashi, K.4
Horiuchi, S.5
Hakamata, H.6
Morganelli, P.M.7
Chang, C.C.8
Chang, T.Y.9
-
37
-
-
77951109960
-
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in AD mice
-
in press
-
Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., Hickey, W. F., and Chang, T. Y. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in AD mice. Proc. Natl. Acad. Sci. USA, in press.
-
Proc. Natl. Acad. Sci. USA
-
-
Bryleva, E.Y.1
Rogers, M.A.2
Chang, C.C.Y.3
Buen, F.4
Harris, B.T.5
Rousselet, E.6
Seidah, N.G.7
Oddo, S.8
Laferla, F.M.9
Spencer, T.A.10
Hickey, W.F.11
Chang, T.Y.12
-
38
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J. and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
39
-
-
84880185178
-
Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now
-
Lee, V. M. and Trojanowski, J. Q. (2006) Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. J. Alzheimers Dis. 9, 257-262.
-
(2006)
J. Alzheimers Dis.
, vol.9
, pp. 257-262
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
40
-
-
33847724188
-
The amyloid precursor protein: Beyond amyloid
-
Zheng, H. and Koo, E. H. (2006) The amyloid precursor protein: beyond amyloid. Mol. Neurodegener. 1, 5.
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 5
-
-
Zheng, H.1
Koo, E.H.2
-
41
-
-
1342321775
-
More than just two peas in a pod: Common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases
-
Lee, V. M., Giasson, B. I., and Trojanowski, J. Q. (2004) More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends Neurosci. 27, 129-134.
-
(2004)
Trends Neurosci.
, vol.27
, pp. 129-134
-
-
Lee, V.M.1
Giasson, B.I.2
Trojanowski, J.Q.3
-
42
-
-
57649221135
-
Amyloid precursor protein trafficking, processing, and function
-
Thinakaran, G. and Koo, E. H. (2008) Amyloid precursor protein trafficking, processing, and function. J. Biol. Chem. 283, 29615-29619.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 29615-29619
-
-
Thinakaran, G.1
Koo, E.H.2
-
44
-
-
33645808672
-
Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
-
Mahley, R. W., Weisgraber, K. H., and Huang, Y. (2006) Inaugural Article: Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci USA 103, 5644-5651.
-
(2006)
Proc. Natl. Acad. Sci USA
, vol.103
, pp. 5644-5651
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
45
-
-
57449084208
-
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
-
Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., and Zlokovic, B. V. (2008) apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J. Clin. Invest. 118, 4002-4013.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
Lane, S.5
Finn, M.B.6
Holtzman, D.M.7
Zlokovic, B.V.8
-
46
-
-
48649110601
-
Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis
-
Anstey, K. J., Lipnicki, D. M., and Low, L. F. (2008) Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. Am. J. Geriatr. Psychiatry 16, 343-354.
-
(2008)
Am. J. Geriatr. Psychiatry
, vol.16
, pp. 343-354
-
-
Anstey, K.J.1
Lipnicki, D.M.2
Low, L.F.3
-
47
-
-
0347318065
-
Cholesterol and the biology of Alzheimer's disease
-
Wolozin, B. (2004) Cholesterol and the biology of Alzheimer's disease. Neuron 41, 7-10.
-
(2004)
Neuron
, vol.41
, pp. 7-10
-
-
Wolozin, B.1
-
48
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang, Q., Lee, C. Y., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., Richardson, J. C., Smith, J. D., Comery, T. A., Riddell, D., Holtzman, D. M., Tontonoz, P., and Landreth, G. E. (2008) ApoE promotes the proteolytic degradation of Abeta. Neuron 58, 681-693.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
Wilkinson, B.4
Cramer, P.5
Zelcer, N.6
Mann, K.7
Lamb, B.8
Willson, T.M.9
Collins, J.L.10
Richardson, J.C.11
Smith, J.D.12
Comery, T.A.13
Riddell, D.14
Holtzman, D.M.15
Tontonoz, P.16
Landreth, G.E.17
-
49
-
-
3242701593
-
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
-
Wellington, C. L. (2004) Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism. Clin. Genet. 66, 1-16.
-
(2004)
Clin. Genet.
, vol.66
, pp. 1-16
-
-
Wellington, C.L.1
-
50
-
-
0042810567
-
Cholesterol, a beta and Alzheimer's disease
-
Hartmann, T. (2001) Cholesterol, A beta and Alzheimer's disease. Trends Neurosci. 24, S45-S48.
-
(2001)
Trends Neurosci.
, vol.24
-
-
Hartmann, T.1
-
51
-
-
3543104951
-
Thematic review series: Brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
-
Dietschy, J. M. and Turley, S. D. (2004) Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397.
-
(2004)
J. Lipid Res.
, vol.45
, pp. 1375-1397
-
-
Dietschy, J.M.1
Turley, S.D.2
-
52
-
-
0034518420
-
The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
-
Repa, J. J. and Mangelsdorf, D. J. (2000) The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu. Rev. Cell Dev. Biol. 16, 459-481.
-
(2000)
Annu. Rev. Cell Dev. Biol.
, vol.16
, pp. 459-481
-
-
Repa, J.J.1
Mangelsdorf, D.J.2
-
53
-
-
32944473282
-
Nuclear receptors in lipid metabolism: Targeting the heart of dyslipidemia
-
Beaven, S. W. and Tontonoz, P. (2006) Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu. Rev. Med. 57, 313-329.
-
(2006)
Annu. Rev. Med.
, vol.57
, pp. 313-329
-
-
Beaven, S.W.1
Tontonoz, P.2
-
54
-
-
42049122331
-
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
-
Wang, N., Yvan-Charvet, L., Lutjohann, D., Mulder, M., Vanmierlo, T., Kim, T. W., and Tall, A. R. (2008) ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 22, 1073-1082.
-
(2008)
FASEB J.
, vol.22
, pp. 1073-1082
-
-
Wang, N.1
Yvan-Charvet, L.2
Lutjohann, D.3
Mulder, M.4
Vanmierlo, T.5
Kim, T.W.6
Tall, A.R.7
-
55
-
-
38049098102
-
ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2
-
Tarr, P. T. and Edwards, P. A. (2008) ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J. Lipid Res. 49, 169-182.
-
(2008)
J. Lipid Res.
, vol.49
, pp. 169-182
-
-
Tarr, P.T.1
Edwards, P.A.2
-
56
-
-
67650751079
-
Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain
-
Russell, D. W., Halford, R. W., Ramirez, D. M., Shah, R., and Kotti, T. (2009) Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 78, 1017-1040.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 1017-1040
-
-
Russell, D.W.1
Halford, R.W.2
Ramirez, D.M.3
Shah, R.4
Kotti, T.5
-
57
-
-
0029835410
-
Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
-
Lutjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Siden, A., Diczfalusy, U., and Bjorkhem, I. (1996) Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93, 9799-9804.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9799-9804
-
-
Lutjohann, D.1
Breuer, O.2
Ahlborg, G.3
Nennesmo, I.4
Siden, A.5
Diczfalusy, U.6
Bjorkhem, I.7
-
58
-
-
33751096969
-
Crossing the barrier: Oxysterols as cholesterol transporters and metabolic modulators in the brain
-
Bjorkhem, I. (2006) Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J. Intern. Med. 260, 493-508.
-
(2006)
J. Intern. Med.
, vol.260
, pp. 493-508
-
-
Bjorkhem, I.1
-
59
-
-
34147118488
-
Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols
-
Karu, K., Hornshaw, M., Woffendin, G., Bodin, K., Hamberg, M., Alvelius, G., Sjovall, J., Turton, J., Wang, Y., and Griffiths, W. J. (2007) Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. J. Lipid Res. 48, 976-987.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 976-987
-
-
Karu, K.1
Hornshaw, M.2
Woffendin, G.3
Bodin, K.4
Hamberg, M.5
Alvelius, G.6
Sjovall, J.7
Turton, J.8
Wang, Y.9
Griffiths, W.J.10
-
60
-
-
0038265008
-
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
-
Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., and Russell, D. W. (2003) Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278, 22980-22988.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22980-22988
-
-
Lund, E.G.1
Xie, C.2
Kotti, T.3
Turley, S.D.4
Dietschy, J.M.5
Russell, D.W.6
-
61
-
-
18544378347
-
Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
-
Song, B. L., Javitt, N. B., and DeBose-Boyd, R. A. (2005) Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 1, 179-189.
-
(2005)
Cell Metab.
, vol.1
, pp. 179-189
-
-
Song, B.L.1
Javitt, N.B.2
Debose-Boyd, R.A.3
-
62
-
-
45549102514
-
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: Quantitative changes to the cortical neuron proteome
-
Wang, Y., Muneton, S., Sjovall, J., Jovanovic, J. N., and Griffiths, W. J. (2008) The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. J. Proteome Res. 7, 1606-1614.
-
(2008)
J. Proteome Res.
, vol.7
, pp. 1606-1614
-
-
Wang, Y.1
Muneton, S.2
Sjovall, J.3
Jovanovic, J.N.4
Griffiths, W.J.5
-
63
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRB
-
Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J., and Mangelsdorf, D. J. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRa and LXRB. Proc. Natl. Acad. Sci. USA 96, 266-271.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 266-271
-
-
Janowski, B.A.1
Grogan, M.J.2
Jones, S.A.3
Wisely, G.B.4
Kliewer, S.A.5
Corey, E.J.6
Mangelsdorf, D.J.7
-
64
-
-
4544255297
-
Differential expression of cholesterol hydroxylases in Alzheimer's disease
-
Brown, J., 3rd, Theisler, C., Silberman, S., Magnuson, D., Gottardi-Littell, N., Lee, J. M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M. M., Reiss, A. B., Eckman, C. B., and Wolozin, B. (2004) Differential expression of cholesterol hydroxylases in Alzheimer's disease. J. Biol. Chem. 279, 34674-34681.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34674-34681
-
-
Brown III, J.1
Theisler, C.2
Silberman, S.3
Magnuson, D.4
Gottardi-Littell, N.5
Lee, J.M.6
Yager, D.7
Crowley, J.8
Sambamurti, K.9
Rahman, M.M.10
Reiss, A.B.11
Eckman, C.B.12
Wolozin, B.13
-
65
-
-
0842303768
-
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
-
Heverin, M., Bogdanovic, N., Lutjohann, D., Bayer, T., Pikuleva, I., Bretillon, L., Diczfalusy, U., Winblad, B., and Bjorkhem, I. (2004) Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J. Lipid Res. 45, 186-193.
-
(2004)
J. Lipid Res.
, vol.45
, pp. 186-193
-
-
Heverin, M.1
Bogdanovic, N.2
Lutjohann, D.3
Bayer, T.4
Pikuleva, I.5
Bretillon, L.6
Diczfalusy, U.7
Winblad, B.8
Bjorkhem, I.9
-
67
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98, 5856-5861.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
Stroick, M.4
Lutjohann, D.5
Keller, P.6
Runz, H.7
Kuhl, S.8
Bertsch, T.9
Von Bergmann, K.10
Hennerici, M.11
Beyreuther, K.12
Hartmann, T.13
-
68
-
-
66349112615
-
Cholesterol-modifying strategies for Alzheimer's disease
-
Solomon, A. and Kivipelto, M. (2009) Cholesterol-modifying strategies for Alzheimer's disease. Expert Rev. Neurother. 9, 695-709.
-
(2009)
Expert Rev. Neurother.
, vol.9
, pp. 695-709
-
-
Solomon, A.1
Kivipelto, M.2
-
69
-
-
73849152706
-
Therapy of Alzheimer disease
-
Kovacs, T. (2009) Therapy of Alzheimer disease. Neuropsychopharmacol. Hung. 11, 27-33.
-
(2009)
Neuropsychopharmacol. Hung.
, vol.11
, pp. 27-33
-
-
Kovacs, T.1
-
70
-
-
66149141822
-
Long-term statin therapy and CSF cholesterol levels: Implications for Alzheimer's disease
-
Evans, B. A., Evans, J. E., Baker, S. P., Kane, K., Swearer, J., Hinerfeld, D., Caselli, R., Rogaeva, E., St George-Hyslop, P., Moonis, M., and Pollen, D. A. (2009) Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 27, 519-524.
-
(2009)
Dement. Geriatr. Cogn. Disord.
, vol.27
, pp. 519-524
-
-
Evans, B.A.1
Evans, J.E.2
Baker, S.P.3
Kane, K.4
Swearer, J.5
Hinerfeld, D.6
Caselli, R.7
Rogaeva, E.8
St George-Hyslop, P.9
Moonis, M.10
Pollen, D.A.11
-
71
-
-
5144227934
-
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
-
Hutter-Paier, B., Huttunen, H. J., Puglielli, L., Eckman, C. B., Kim, D. Y., Hofmeister, A., Moir, R. D., Domnitz, S. B., Frosch, M. P., Windisch, M., and Kovacs, D. M. (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron 44, 227-238.
-
(2004)
Neuron
, vol.44
, pp. 227-238
-
-
Hutter-Paier, B.1
Huttunen, H.J.2
Puglielli, L.3
Eckman, C.B.4
Kim, D.Y.5
Hofmeister, A.6
Moir, R.D.7
Domnitz, S.B.8
Frosch, M.P.9
Windisch, M.10
Kovacs, D.M.11
-
72
-
-
70350558667
-
Inhibition of acyl-coenzyme A: Cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway
-
Huttunen, H. J., Peach, C., Bhattacharyya, R., Barren, C., Pettingell, W., Hutter-Paier, B., Windisch, M., Berezovska, O., and Kovacs, D. M. (2009) Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J. 23, 3819-3828.
-
(2009)
FASEB J.
, vol.23
, pp. 3819-3828
-
-
Huttunen, H.J.1
Peach, C.2
Bhattacharyya, R.3
Barren, C.4
Pettingell, W.5
Hutter-Paier, B.6
Windisch, M.7
Berezovska, O.8
Kovacs, D.M.9
-
73
-
-
40449110086
-
ACAT as a drug target for Alzheimer's disease
-
Huttunen, H. J. and Kovacs, D. M. (2008) ACAT as a drug target for Alzheimer's disease. Neurodegener. Dis. 5, 212-214.
-
(2008)
Neurodegener. Dis.
, vol.5
, pp. 212-214
-
-
Huttunen, H.J.1
Kovacs, D.M.2
-
74
-
-
0018346660
-
Raised level of cholesterol esters in the brain of protein undernourished mice
-
Yusuf, H. K. and Mozaffar, Z. (1979) Raised level of cholesterol esters in the brain of protein undernourished mice. J. Neurochem. 32, 273-275.
-
(1979)
J. Neurochem.
, vol.32
, pp. 273-275
-
-
Yusuf, H.K.1
Mozaffar, Z.2
-
75
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
76
-
-
77951119928
-
Cyclodextrin overcomes the transport defect in nearly every organ of the newborn or mature NPC1 mouse leading to excretion of the sequestered cholesterol as bile acid
-
Liu, B., Ramirez, C. M., Miller, A. M., Repa, J. J., Turley, S. D., and Dietschy, J. M. (2009) Cyclodextrin overcomes the transport defect in nearly every organ of the newborn or mature NPC1 mouse leading to excretion of the sequestered cholesterol as bile acid. J. Lipid Res.
-
(2009)
J. Lipid Res.
-
-
Liu, B.1
Ramirez, C.M.2
Miller, A.M.3
Repa, J.J.4
Turley, S.D.5
Dietschy, J.M.6
-
77
-
-
0034623160
-
Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture
-
Brown, A. J., Watts, G. F., Burnett, J. R., Dean, R. T., and Jessup, W. (2000) Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. J. Biol. Chem. 275, 27627-27633.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27627-27633
-
-
Brown, A.J.1
Watts, G.F.2
Burnett, J.R.3
Dean, R.T.4
Jessup, W.5
-
78
-
-
44849131929
-
Feedback regulation of cholesterol synthesis: Sterol-accelerated ubiquitination and degradation of HMG CoA reductase
-
DeBose-Boyd, R. A. (2008) Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res. 18, 609-621.
-
(2008)
Cell Res.
, vol.18
, pp. 609-621
-
-
DeBose-Boyd, R.A.1
-
79
-
-
0035149586
-
Influence of membrane partitioning on inhibitors of membrane-bound enzymes
-
Homan, R. and Hamelehle, K. L. (2001) Influence of membrane partitioning on inhibitors of membrane-bound enzymes. J. Pharm. Sci. 90, 1859-1867.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 1859-1867
-
-
Homan, R.1
Hamelehle, K.L.2
-
80
-
-
66349136255
-
Are side-chain oxidized oxysterols regulators also in vivo?
-
Bjorkhem, I. (2009) Are side-chain oxidized oxysterols regulators also in vivo? J. Lipid Res. 50 Suppl, S213-S218.
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Bjorkhem, I.1
-
81
-
-
62549132123
-
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan
-
Halford, R. W. and Russell, D. W. (2009) Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. Proc. Natl. Acad. Sci. USA 106, 3502-3506.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3502-3506
-
-
Halford, R.W.1
Russell, D.W.2
-
82
-
-
74149083432
-
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease
-
Hudry, E., Van Dam, D., Kulik, W., De Deyn, P. P., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougneres, P., Aubourg, P., and Cartier, N. (2010) Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol. Ther. 18, 44-53.
-
(2010)
Mol. Ther.
, vol.18
, pp. 44-53
-
-
Hudry, E.1
Van Dam, D.2
Kulik, W.3
De Deyn, P.P.4
Stet, F.S.5
Ahouansou, O.6
Benraiss, A.7
Delacourte, A.8
Bougneres, P.9
Aubourg, P.10
Cartier, N.11
|