Antibiotics in malaria therapy and their effect on the parasite apicoplast

Current Molecular Medicine

Volumn 10, Issue 3, 2010, Pages 335-349

  Pradel, G ^a   Schlitzer, M ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antibiotic; Antimalarial drug; Apicoplast; Delayed death; Malaria; Plasmodium; Target

Indexed keywords

ANTIBIOTIC AGENT; ARTESUNATE; ATOVAQUONE; AZITHROMYCIN; CERULENIN; CHLORAMPHENICOL; CHLOROQUINE; CHLORTETRACYCLINE; CIPROFLOXACIN; CLINDAMYCIN; COTRIFAZID; DALFOPRISTIN PLUS QUINUPRISTIN; DOXYCYCLINE; FOSMIDOMYCIN; ISONIAZID; MEFLOQUINE; OXYTETRACYCLINE; PROGUANIL; PYRIMETHAMINE; QUININE; RIFABUTIN; RIFAMPICIN; SUCCINYLACETONE; SULFADOXINE; SULFAMETHOXAZOLE; TELITHROMYCIN; TETRACYCLINE; THIOSTREPTON; TRICLOSAN; TRIMETHOPRIM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIMALARIAL ACTIVITY; APICOPLAST; DRUG EFFECT; DRUG SCREENING; HUMAN; MALARIA; MALARIA FALCIPARUM; MITOCHONDRION; NONHUMAN; PARASITE SURVIVAL; PHENOTYPE; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX MALARIA; REVIEW;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; CELL DEATH; HUMANS; MALARIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; ORGANELLES; PLASMODIUM;

PROKARYOTA;

EID: 77951062016     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652410791065273     Document Type: Review

References (167)

1. World Health Organization. World Malaria Report (2009). World Health Organization Press, Switzerland.
2. Hyde, J.E. (2005) Trends Parasitol., 21, 494-498.
3. Baird, J.K. (2009) Clin. Microbiol. Rev., 22, 508-534.
4. Baird, J.K. (2007) Trends Parasitol., 23, 533-539.
5. Baird, J.K. (2008) N. Engl. J. Med., 359, 2601-2603.
6. Price, R.N., Tjitra, E., Guerra, C.A., Yeung, S., White, N.J. and Anstey, N.M. (2007) Am. J. Trop. Med. Hyg., 77, 79-87.
7. Price, R.N., Douglas, N.M. and Anstey, N.M. (2009) Curr. Opin. Infect. Dis., 22, 430-435.
8. Schlitzer, M. (2007) Chem. Med. Chem., 2, 944-986.
9. Dahl, E.L., Shock, J.L., Shenai, B.R., Gut, J., DeRisi, J.L. and Rosenthal, P.J. (2006) Antimicrob. Agents Chemother., 50, 3124-3131.
10. Goodman, C.D., Su, V. and McFadden, G.I. (2007) Mol. Biochem. Parasitol., 152, 181-191.
11. Sidhu, A.B., Sun, Q., Nkrumah, L.J., Dunne, M.W., Sacchettini, J.C. and Fidock, D.A. (2007) J. Biol. Chem., 282, 2494-2504.
12. Barthel, D., Schlitzer, M. and Pradel, G. (2008) Antimicrob. Agents Chemother., 52, 774-777.
13. McFadden, G.I., Reith, M.E., Munholland, J. and Lang- Unnasch, N. (1996) Nature, 381, 482.
14. Gardner, M.J., Bates, P.A., Ling, I.T., Moore, D.J., McCready, S., Gunasekera, M.B., Wilson, R.J. and Williamson, D.H. (1988) Mol. Biochem. Parasitol., 31, 11-17.
15. Wilson, R.J., Denny, P.W., Preiser, P.R., Rangachari, K., Roberts, K., Roy, A., Whyte, A., Strath, M., Moore, D.J., Moore, P.W. and Williamson, D.H. (1996) J. Mol. Biol., 261, 155-172.
16. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S., Paulsen, I.T., James, K., Eisen, J.A., Rutherford, K., Salzberg, S.L., Craig, A., Kyes, S., Chan, M.S., Nene, V., Shallom, S.J., Suh, B., Peterson, J., Angiuoli, S., Pertea, M., Allen, J., Selengut, J., Haft, D., Mather, M.W., Vaidya, A.B., Martin, D.M., Fairlamb, A.H., Fraunholz, M.J., Roos, D.S., Ralph, S.A., McFadden, G.I., Cummings, L.M., Subramanian, G.M., Mungall, C., Venter, J.C., Carucci, D.J., Hoffman, S. L., Newbold, C., Davis, R.W., Fraser, C.M. and Barrell, B. (2002) Nature, 419, 498-511.
17. Waller, R.F. and McFadden, G.I. (2005) Curr. Issues Mol. Biol., 7, 57-79.
18. Coatney, G.R. and Greenberg, J. (1952) Ann. N. Y. Acad. Sci., 55, 1075-1081.
19. Rieckmann, K.H. (1983) Annu. Rev. Med., 34, 321-335.
20. Puri, S.K. and Dutta, G.P. (1982) Prog. Drug Res., 26, 167-205.
21. Akinyemi, K.O., Bamiro, B.S. and Coker, A.O. (2007) J. Health Popul. Nutr., 25, 351-358.
22. Esimone, C.O., Adikwu, M.U., Nwafor, S.V., Okoli, C.O., Ndu, O.O. and Nwoke, O.I. (2002) Boll. Chim. Farm., 141, 385-388.
23. Berkley, J., Mwarumba, S., Bramham, K., Lowe, B. and Marsh, K. (1999) Trans. R. Soc. Trop. Med. Hyg., 93, 283-286.
24. Sato, S., Clough, B., Coates, L. and Wilson, R.J. (2004) Protist, 155, 117-125.
25. van Dooren, G.G., Marti, M., Tonkin, C.J., Stimmler, L.M., Cowman, A.F. and McFadden, G.I. (2005) Mol. Microbiol., 57, 405-419.
26. van Dooren, G.G., Stimmler, L.M. and McFadden, G.I. (2006) FEMS Microbiol. Rev., 3, 596-630.
27. Barbrook, A.C., Howe, C.J. and Purton, S. (2006) Trends Plant Sci., 11, 101-108.
28. Richards, T.A. and van der Giezen, M. (2006) Mol. Biol. Evol., 23, 1341-1344.
29. Okamoto, N., Spurck, T.P., Goodman, C.D. and McFadden, G.I. (2009) Eukaryot. Cell, 8, 128-132.
30. Krungkrai, J. (2004) Parasitology, 129, 511-524.
31. Fry, M., Webb, E. and Pudney, M. (1990) Comp. Biochem. Physiol. B, 96, 775-782.
32. Lill, R. and Mühlenhoff, U. (2005) Trends Biochem. Sci., 30, 133-141.
33. Seeber, F., Limenitakis, J. and Soldati-Favre, D. (2008) Trends Parasitol., 24, 468-478.
34. Painter, H.J., Morrisey, J.M., Mather, M.W. and Vaidya, A.B. (2007) Nature, 446, 88-91.
35. de Souza, W., Attias, M. and Rodrigues, J.C. (2009) Int. J. Biochem. Cell Biol., 41, 2069-2080.
36. Dahl, E.L. and Rosenthal, P.J. (2008) Trends Parasitol., 24, 279-284.
37. Köhler, S., Delwiche, C.F., Denny, P.W., Tilney, L.G., Webster, P., Wilson, R.J., Palmer, J.D. and Roos, D.S. (1997) Science, 275, 1485-1489
38. McFadden, G.I. and Waller, R.F. (1997) Bioessays, 19, 1033-1040.
39. Moore, R.B., Oborník, M., Janouskovec, J., Chrudimský, T., Vancová, M., Green, D.H., Wright, S.W., Davies, N.W., Bolch, C.J., Heimann, K., Slapeta, J., Hoegh-Guldberg, O., Logsdon, J.M. and Carter, D.A. (2008) Nature, 451, 959-963.
40. Vaishnava, S. and Striepen, B. (2006) Mol. Microbiol., 61, 1380-1387
41. Lau, A.O., McElwain, T.F., Brayton, K.A., Knowles, D.P. and Roalson, E.H. (2009) Exp. Parasitol., 123, 236-243.
42. Lang-Unnasch, N., Reith, M.E., Munholland, J. and Barta, J.R. (1998) Int. J. Parasitol., 28, 1743-1754.
43. Huang, J., Mullapudi, N., Lancto, C.A., Scott, M., Abrahamsen, M.S. and Kissinger, J.C. (2004) Genome Biol., 5, R88.
44. DeRocher, A., Gilbert, B., Feagin, J.E. and Parsons, M. (2005) J. Cell Sci., 118, 565-574.
45. Tonkin, C.J., Struck, N.S., Mullin, K.A., Stimmler, L.M. and McFadden, G.I. (2006) Mol. Microbiol., 61, 614-630.
46. Tonkin, C.J., Kalanon, M. and McFadden, G.I. (2008) Traffic, 9, 166-175.
47. Parsons, M., Karnataki, A. and Derocher, A.E. (2009) J. Eukaryot. Microbiol., 56, 214-220.
48. Bruce, B.D. (2001) Biochim. Biophys. Acta, 1541, 2-21.
49. Jarvis, P. and Soll, J. (2002) Biochim. Biophys. Acta, 1590, 177-189.
50. Kalanon, M., Tonkin, C.J. and McFadden, G.I. (2009) Eukaryot. Cell, 8, 1146-1154.
51. Spork, S., Hiss, J.A., Mandel, K., Sommer, M., Kooij, T.W., Chu, T., Schneider, G., Maier, U.G. and Przyborski, J.M. (2009) Eukaryot. Cell, 8, 1134-1145.
52. Waller, R.F., Reed, M.B., Cowman, A.F. and McFadden, G.I. (2000) EMBO J., 19, 1794-1802.
53. Stanway, R.R., Witt, T., Zobiak, B., Aepfelbacher, M. and Heussler, V.T. (2009) Biol. Cell, 101, 415-430.
54. Striepen, B., Crawford, M.J., Shaw, M.K., Tilney, L.G., Seeber, F. and Roos, D.S. (2000) J. Cell. Biol., 151, 1423-1434.
55. Fichera, M.E. and Roos, D.S. (1997) Nature, 390, 407-409.
56. He, C.Y., Shaw, M.K., Pletcher, C.H., Striepen, B., Tilney, L.G. and Roos, D.S. (2001) EMBO J., 20, 330-339.
57. Jomaa, H., Wiesner, J., Sanderbrand, S., Altincicek, B., Weidemeyer, C., Hintz, M., Türbachova, I., Eberl, M., Zeidler, J., Lichtenthaler, H.K., Soldati, D. and Beck, E. (1999) Science, 285, 1502-1503.
58. Mazumdar, J.H. Wilson, E., Masek, K. A., Hunter, C. and Striepen, B. (2006) Proc. Natl. Acad. Sci. USA, 103, 13192-112197
59. Vaughan, A.M., O'Neill, M.T., Tarun, A.S., Camargo, N., Phuong, T.M., Aly, A.S., Cowman, A.F. and Kappe, S.H. (2009) Cell. Microbiol., 11, 506-520.
60. Günther, S., Storm, J. and Müller, S. (2009) Int. J. Biochem. Cell Biol., 41, 748-752.
61. Toler, S. (2005) Med. Hypotheses, 65, 683-690.
62. Ralph, S.A., D'Ombrain, M.C. and McFadden, G.I. (2001) Drug Resist. Updat., 4, 145-151.
63. Dahl, E.L. and Rosenthal, P.J. (2007) Antimicrob. Agents Chemother., 51, 3485-3490.
64. Imboden, C.A. Jr., Cooper. W.C., Coatney, G.R. and Jeffery, G.M. (1950) J. Natl. Malar. Soc., 9, 3773-3780.
65. Divo, A.A., Geary, T.G. and Jensen, J.B. (1985) Antimicrob. Agents Chemother., 27, 21-27.
66. Yeo, A.E. and Rieckmann, K.H. (1994) J. Parasitol., 80, 158-160.
67. Yeo, A.E. and Rieckmann, K.H. (1995) Int. J. Parasitol., 25, 531-532.
68. Sato, S. and Wilson, R.J. (2005) Curr. Top. Microbiol. Immunol., 295, 251-273.
69. Burkhardt, D., Wiesner, J., Stoesser, N., Ramharter, M., Uhlemann, A.C., Issifou, S., Jomaa, H., Krishna, S., Kremsner, P.G. and Borrmann, S. (2007) Int. J. Parasitol., 37, 777-785.
70. Ramya, T.N., Karmodiya, K., Surolia, A. and Surolia, N. (2007) J. Biol. Chem., 282, 6388-6397.
71. Bagley, M.C., Dale, J.W., Merritt, E.A. and Xiong, X. (2005) Chem. Rev., 105, 685-714.
72. Arndt, H.D., Schoof, S. and Lu, J.Y. (2009) Angew. Chem. Int. Ed. Engl., 48, 6770-6773.
73. Bhat, U.G., Halasi, M. and Gartel, A.L. (2009) PLoS One, 4, e6593.
74. Mordmüller, B., Fendel, R., Kreidenweiss, A., Gille, C., Hurwitz, R., Metzger, W.G., Kun, J.F., Lamkemeyer, T., Nordheim, A. and Kremsner, P.G. (2006) Mol. Biochem. Parasitol., 148, 79-85.
75. Paugam, A., Bulteau, A.L., Dupouy-Camet, J., Creuzet, C. and Friguet, B. (2003) Trends Parasitol., 19, 55-59.
76. Gantt, S.M., Myung, J.M., Briones, M.R., Li, W.D., Corey, E.J., Omura, S., Nussenzweig, V. and Sinnis, P. (1998) Antimicrob. Agents Chemother., 42, 2731-2738.
77. Reynolds, J.M., El Bissati, K., Brandenburg, J., Günzl, A. and Mamoun, C.B. (2007) BMC Clin. Pharmacol., 23, 13.
78. Kreidenweiss, A., Kremsner, P.G. and Mordmüller, B. (2008) Malar. J., 7, 187.
79. Ramya, T.N., Mishra, S., Karmodiya, K., Surolia, N. and Surolia, A. (2007) Antimicrob. Agents Chemother., 51, 307-316.
80. Goodman, C.D. and McFadden, G.I. (2007) Curr. Drug Targets, 8, 15-30.
81. Surolia, A., Ramya, T.N., Ramya, V. and Surolia, N. (2004) Biochem. J., 383, 401-412.
82. Waller, R.F., Ralph, S.A., Reed, M.B., Su, V., Douglas, J.D., Minnikin, D.E., Cowman, A.F., Besra, G.S. and McFadden, G.I. (2003) Antimicrob. Agents Chemother., 47, 297-301.
83. Wiesner, J., Reichenberg, A., Heinrich, S., Schlitzer, M. and Jomaa H. (2008) Curr. Pharm. Des., 14, 855-871.
84. Wiesner, J. and Jomaa, H. (2007) Curr. Drug Targets, 8, 3-13.
85. Chulay, J.D., Haynes, J.D. and Diggs C.L. (1983) Exp. Parasitol., 5, 138-146.
86. Mazier, D., Rénia, L. and Snounou, G. (2009) Nat. Rev. Drug Discov., 8, 854-864.
87. Hawkey, P.M. (2003) J. Antimicrob. Chemother., 51, 29-35.
88. Raghu Ram, E.V.S., Kumar, A., Biwas, S., Kumar, A., Chaubey, S., Siddiqi, M.I. and Habib, S. (2007) Mol. Biochem. Parasitol., 154, 30-39.
89. Dar, M.A., Sharma, A., Mondal, N. and Dhar, S.K. (2007) Eukaryot. Cell, 6, 398-412.
90. Khor, V., Yowell, C., Dame, J.B. and Rowe, T.C. (2005) Mol. Biochem. Parasitol., 140, 107-117.
91. Weissig, V., Vetro-Widenhouse, T.S. and Rowe, T.C. (1997) DNA Cell Biol., 16, 1483-1492.
92. Mahmoudi, N., Ciceron, L., Franetich, J.-F., Farhati, K., Silvie, O., Eling, W., Sauerwein, R., Danis, M., Mazier, D. and Derouin, F. (2003) Antimicrob. Agents Chemother., 47, 2636-2639.
93. Divo, A.A., Sartorelli, A.C., Patton, C.L. and Bia, F.J. (1988) Antimicrob. Agents Chemother., 32, 1182-1186.
94. Kazzim, O.J., Adegbolagun, O.M., Osho, O. and Anumudu, C.I. (2006) Ann. Trop. Med. Parasitol., 100, 579-584.
95. Soares, R.P., Krettli, A.U., de Souza, M.V., Vasconcelos, T.R. and Boechat, N. (2006) Int. J. Antimicrob. Agents, 28, 271-272.
96. Andrade, A.A., de Pilla, V.F., de Freitas, I.O., de Souza, M.V., Vasconcelos, T.R., Boechat, N. and Krettli, A.U. (2007) Eur. J. Pharmacol., 8, 194-198.
97. Strömberg, A. and Bjorkman, A. (1992) Trans. R. Soc. Trop. Med., 86, 373.
98. Watt, G., Shanks, G.D., Edstein, M.D., Pavanand, K., Webster, H.K. and Wechgritaya, S. (1991) J. Infect. Dis., 164, 602-604.
99. Martindale Pharma. (2007) Royal Pharmaceutical Society of Great Britain, Pharmaceutical Press, pp. 218-222.
100. Ilo, C.E., Ilondu, N.A., Okwoli, N., Brown, S.A., Elo-Ilo, J.C., Agbasi, P.U. and Orisakwe, O.E. (2006) Am. J. Ther., 13, 432-435.
101. Campbell, E.A., Korzheva, N., Mustaev, A., Murakami, K., Nair, S., Goldfarb, A. and Darst, S.A. (2001) Cell, 104, 901-912.
102. Gardner, M.J., Williamson, D.H. and Wilson, R.J. (1991) Mol. Biochem. Parasitol., 44, 115-124.
103. Pradines, B., Rogier, C., Fusai, T., Mosnier, J., Daries, W., Barret, E. and Parzy, D. (2001) Antimicrob. Agents Chemother., 45, 1746-1750.
104. Tarun, A.S., Peng, X., Dumpit, R.F., Ogata, Y., Silva-Rivera, H., Camargo, N., Daly, T.M., Bergman, L.W. and Kappe, S.H (2008) Proc. Natl. Acad. Sci. USA, 105, 305-310.
105. Hou, L.J., Raju, S.S., Abdulah, M.S., Nor, N.M. and Ravichandran, M. (2004) Jpn. J. Infect. Dis., 57, 198-202.
106. Pukrittayakamee, S., Viravan, C., Charoenlarp, P., Yeamput, C., Wilson, R.J. and White, N.J. (1994) Antimicrob. Agents Chemother., 38, 511-514.
107. Goerg, H., Ochola, S.A. and Goerg, R. (1999) Chemotherapy, 45, 68-76.
108. Genton, B., Mueller, I., Betuela, I., Casey, G., Ginny, M., Alpers, M.P. and Reeder, J.C. (2006) PLoS Clin. Trials, e38.
109. Urbaschek, R., Männel, D.N. and Urbanczik, R. (1991) Antimicrob. Agents Chemother., 35, 1666-1668.
110. Pukrittayakamee, S., Prakongpan, S., Wanwimolruk, S., Clemens, R., Looareesuwan, S. and White, N.J. (2003) Antimirob. Agents Chemother., 47, 1509-1513.
111. Sousa, M., Pozniak, A., Boffito, M. (2008) J. Antimicrob. Chemother., 62, 872-878.
112. Brodersen, D.E., Clemons, W.M. Jr., Carter, A.P., Morgan-Warren, R.J., Wimberly, B.T. and Ramakrishnan, V. (2000) Cell, 103, 1143-1154.
113. Lin, Q., Katakura, K. and Suzuki, M. (2002) FEBS Lett., 515, 71-74.
114. Pradines, B., Spiegel, A., Rogier, C., Tall, A., Mosnier, J., Fusai, T., Trape, J. F. and Parzy, D. (2000) Am. J. Trop. Med. Hyg., 62, 82-85.
115. Briolant, S., Baragatti, M., Parola, P., Simon, F., Tall, A., Sokhna, C., Hovette, P., Mamfoumbi, M.M., Koeck, J.L., Delmont, J., Spiegel, A., Castello, J., Gardair, J.P., Trape, J.F., Kombila, M., Minodier, P., Fusai, T., Rogier, C. and Pradines, B. (2009) Antimicrob. Agents Chemother., 53, 688-695.
116. Briolant, S., Wurtz, N., Zettor, A., Rogier, C. and Pradines, B. (2010) J. Infect. Dis., 201, 153-159.
117. Newton, P.N., Chaulet, J.F, Brockman, A., Chierakul, W., Dondorp, A., Ruangveerayuth, R., Looareesuwan, S., Mounier, C. and White, N.J. (2005) Antimicrob. Agents Chemother., 49, 1622-1625.
118. Shmuklarsky, M.J., Boudreau, E.F., Pang, L.W., Smith, J.I., Schneider, I., Fleckenstein, L., Abdelrahim, M.M., Canfield, C.J. and Schuster, B. (1994) Ann. Intern. Med., 120, 294-299.
119. Uchiyama, H., Okamoto, A., Sato, K., Yamada, T., Murakami, S., Yoneda, S., Kajita, Y., Tegoshi, T. and Arizono, N. (2004) Int. Med., 43, 624-627.
120. Kast, R.E. (2008) J. Neurosci. Res., 86, 3257.
121. Ashley, E.A. and White, N.J. (2005) Curr. Opin. Infect. Dis., 18, 531-536.
122. Ohrt, C., Richie, T.L., Widjaja, H., Shanks, G.D., Fitriadi, J., Fryauff, D.J., Handschin, J., Tang, D., Sandjaja, B., Tjitra, E., Hadiarso, L., Watt, G. and Wignall, F.S. (1997) Ann. Intern. Med., 126, 963-972.
123. Olson, M.W., Ruzin, A., Feyfant, E., Rush III, T.S., O'Connell, J. and Bradford, P.A. (2006) Antimicrob. Agents Chemother., 50, 2156-2166.
124. Starzengruber, P., Thriemer, K., Haque, R., Khan, W.A., Fuehrer, H.P., Siedl, A., Hofecker, V., Ley, B., Wernsdorfer, W.H. and Noedl, H. (2009) Antimicrob. Agents Chemother., 53, 4040-4042.
125. Poehlsgaard, J. and Douthwaite, S. (2005) Nat. Rev. Microbiol., 3, 870-881.
126. Nakornchai, S. and Konthiang, P. (2006) Acta Trop., 185-191.
127. Cook, J.A., Randinitis, E.J., Bramson, C.R. and Wesche, D.L. (2006) Am. J. Trop. Med. Hyg., 74, 407-412.
128. Ohrt, C., Willingmyre, G.D., Lee, P., Knirsch, C. and Milhous, W. (2002) Antimicrob. Agents Chemother., 46, 2518-2524
129. Puri, S.K. and Singh, N. (2000) Exp. Parasitol., 94, 8-14.
130. Tripathi, R., Dhawan, S. and Dutta, G.P. (2005) Parasitology, 131, 295-301.
131. Chico, R.M., Pittrof, R., Greenwood, B. and Chandramohan, D. (2008) Malar. J., 7, 255.
132. Min, T.H., Khairul, M.F., Low, J.H., Che Nasriyyah, C.H., A'shikin, A.N., Norazmi, M.N., Ravichandran, M. and Raju, S.S. (2007) Exp. Parasitol., 115, 387-392.
133. Taylor, W.R., Richie, T.L., Fryauff, D.J., Picarima, H., Ohrt, C., Tang, D., Braitman, D., Murphy, G.S., Widjaja, H., Tjitra, E., Ganjar, A., Jones, T.R., Basri, H. and Berman, J. (1999) Clin. Infect. Dis., 28, 74-81.
134. Andersen, S.L., Oloo, A.J., Gordon, D.M., Ragama, O.B., Aleman, G.M., Berman J.D., Tang, D.B., Dunne, M. W. and Shanks, G. D. (1998) Clin. Infect. Dis., 26, 146-150.
135. Heppner, D.G., Walsh, Jr., D.S., Uthaimongkol, N., Tang, D.B., Tulyayon, S., Permpanich, B., Wimonwattrawatee, T., Chuanak, N., Laoboonchai, A., Sookto, P., Brewer, T. G., McDaniel, P., Eamsila, C., Yongvanitchit, K., Uhl, K., Kyle, D. E., Keep, L. W., Miller, R. E. and Wongsrichanalai, C. (2005) Am. J. Trop. Med. Hyg., 73, 842-849.
136. Dunne, M.W. Singh, N., Shukla, M., Valecha, N., Bhattacharyya, P.C., Patel, K., Mohapatra, M.K., Lakhani, J., Devi, C.U., Adak, T., Dev, V., Yadav, R.S., Lele, C. and Patki, K. (2005) Am. J. Trop. Med. Hyg., 73, 1108-1111.
137. Ranque, S., Badiaga, S., Delmont, J. and Brouqui, P. (2002) Malar. J., 1, 13.
138. Krudsood, S., Buchachart, K., Chalermrut, K., Charusabha, C., Treeprasertsuk, S., Haoharn, O., Duangdee, C. and Looareesuwan, S. (2002) Southeast Asian J. Trop. Med. Public Health, 33, 525-531.
139. Miller, R.S., Wongsrichanalai, C., Buathong, N., McDaniel, P., Walsh, D.S., Knirsch, C. and Ohrt, C. (2006) Am. J. Trop. Med. Hyg., 74, 401-406.
140. Noedl, H., Krudsood, S., Chalermratana, K., Silachamroon, U., Leowattana, W., Tangpukdee, N., Looareesuwan, S., Miller, R.S., Fukuda, M., Jongsakul, K., Sriwichai, S., Rowan, J., Bhattacharyya, H., Ohrt, C. and Knirsch, C. (2006) Clin. Infect. Dis., 43, 1264-1271.
141. Dunne, M.W., Singh, N., Shukla, M., Valecha, N., Bhattacharyya, P.C., Dev, V., Patel, K., Mohapatra, M.K., Lakhani, J., Benner, R., Lele, C. and Patki, K. (2005) J. Infect. Dis., 191, 1582-1588.
142. Sykes, A. Hendriksen, I., Mtove, G., Mandea, V., Mrema, H., Rutta, B., Mapunda, E., Manjurano, A., Amos, B., Reyburn, H. and Whitty, C.J. (2009) Clin. Infect. Dis., 49, 1195-1201.
143. Schlünzen, F., Zarlvach, R., Harms, J., Bashan, A., Toclij, A. Albrecht, R., Yonath, A. and Franceschi, F. (2001) Nature, 413, 814-821.
144. Wiesner, J., Henschker, D., Hutchinson, D. B., Beck, E. and Jomaa, H. (2002) Antimicrob. Agents Chemother., 46, 2889-2894.
145. Kremsner, P.G. (1990) J. Antimicrobial Chemother., 25, 9-14.
146. Lell, B. and Kremsner, P.G. (2002) Antimicrob. Agents Chemother., 46, 2315-2320.
147. Ramharter, M., Noedl, H., Winkler, H., Graninger, W., Wernsdorfer, W. H., Kremsner, P. G. and Winkler, S. (2003) Antimicrob. Agents Chemother., 47, 3494-3499.
148. Ramharter, M., Oyakhirome S., Klein Klouwenberg, P., Adégnika, A.A., Agnandji, S.T., Missinou, M.A., Matsiégui, P.-B., Mordmüller, B., Borrmann, S., Kun, J.F., Lell, B., Krishna, S., Graninger, W., Issifou, S. and Kremsner, P.G. (2005) Clin. Infect. Dis., 40, 1777-1784.
149. Wiström, J., Norrby, S.R., Myhre E.B., Eriksson, S., Ganström, G., Lagergren, L., Englund, G., Nord, C.E. and Svenungsson, B. (2001) J. Antimicrob. Chemother., 47, 43-50.
150. Schmidt, L.H. (1985) Antimicrob. Agents Chemother., 27, 151-157.
151. th ASTMH Annual Meeting, American Society of Tropical Medicine and Hygiene, vol. 758, pp. 223-224.
152. Held, J., Westerman, R., Kremsner, P.G. and Mordmüller, B. (2010) Antimicrob. Agents Chemother., 54, 540-542.
153. Kokwaro, G.O., Muchohi, S.N., Ogutu, B.R. and Newton, C.R.J.C. (2005) J. Trop. Pedriatr., 52, 239-243.
154. Clough, B., Strath, M., Preiser, P., Denny, P. and Wilson, I.R. (1997) FEBS Lett., 406, 123-125.
155. McConkey, G.A., Rogers, M.J. and McCutchan, T.F. (1997) J. Biol. Chem., 272, 2046-2049.
156. Sullivan, M., Li, J., Kumar, S., Rogers, M.J. and McCutchan, T.F. (2000) Mol. Biochem. Parasitol., 109, 17-23.
157. Clough, B., Rangachari, K., Strath, M., Preiser, P.R. and Wilson, R.J. (1999) Protist, 150, 189-195.
158. Black, F.T., Wildfang, I.L. and Borgbjerg, K. (1985) Lancet, 1, 578-579.
159. Rautenbach, M., Vlok, N.M., Stander, M. and Hoppe, H.C. (2007) Biochim. Biophys. Acta, 1768, 1488-1497.
160. Gumila, C., Ancelin, M.L., Delort, A.M., Jeminet, G. and Vial, H.J. (1997) Antimicrob. Agents Chemother., 41, 523-529.
161. Wiehart, U.I., Rautenbach, M. and Hoppe, H.C. (2006) Biochem. Pharmacol., 71, 779-790.
162. Weisman, J.L., Liou, A.P., Shelat, A.A., Cohen, F.E., Guy, R.K. and DeRisi, J.L. (2006) Chem. Biol. Drug Des., 67, 409-416.
163. McColm, A.A. and McHardy, N. (1984) Ann. Trop. Med. Parasitol., 78, 345-354.
164. Wilson, D.N., Schluenzen, F., Harms, J.M., Starosta, A.L., Connell, S.R. and Fucini, P. (2008) Proc. Natl. Acad. Sci. USA, 105, 13339-13344.
165. Kremsner, P.G. and Krishna, S. (2004) Lancet, 364, 285-294.
166. Mordmüller, B. and Kremsner, P.G. (2006) Curr. Mol. Med., 6, 247-251.
167. Noedl, H. (2009) Trends Parasitol., 25, 540-544.