Lack of a pharmacokinetic interaction between azithromycin and chloroquine

American Journal of Tropical Medicine and Hygiene

Volumn 74, Issue 3, 2006, Pages 407-412

  Cook, Jack A ^a   Randinitis, Edward J ^a   Bramson, Candace R ^a   Wesche, David L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CHLOROQUINE; ANTIMALARIAL AGENT;

ABDOMINAL PAIN; ABNORMAL VISION; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DRUG ABSORPTION; DRUG SAFETY; DYSPEPSIA; ERUCTATION; FEMALE; FLATULENCE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; SOMNOLENCE; ANIMAL; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; DRUG INTERACTION; HALF LIFE TIME; MALARIA FALCIPARUM; MIDDLE AGED; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANIMALS; ANTIMALARIALS; AREA UNDER CURVE; AZITHROMYCIN; CHLOROQUINE; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FEMALE; HALF-LIFE; HUMANS; MALARIA, FALCIPARUM; MALE; MIDDLE AGED;

EID: 33646008301     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2006.74.407     Document Type: Article

References (13)

1. Ohrt C, Willingmyre GD, Lee P, Knirsch C, Milhous W, 2002. Assessment of azithromycin in combination with other antimalarial drugs against plasmodium falciparum in vitro. Antimicrob Agents Chemother 46: 2518-2524.
2. Dunne MW, Singh N, Shukla M, Valecha N, Bhattacharyya PC, Dev V, Patel K, Mohapatra MK, Lakhani J, Benner R, Lele C, Patki K, 2005. A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India. J Infect Dis 191: 1582-1588.
3. Bray PG, Boulter MK, Ritchie GY, Howells RE, Ward SA, 1994. Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. Mol Biochem Parasitol 63: 87-94.
4. Pachot JI, Botham RP, Haegele KD, Hwang K, 2003. Experimental estimation of the role of p-glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the caco-2 cell model. J Pharm Pharm Sci 6: 1-12.
5. Kouznetsov RL, Beals PF, 1996. Malaria: A Manual for Community Health Workers. Geneva: World Health Organization, 31.
6. Zithromax. United States Package Insert. Pfizer, Inc. January 2004.
7. Gustafsson LL, Walker O, Alván G, Beermann B, Estevez F, Gleisner L, Lindstrom B, Sjoqvist F, 1983. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol 15: 471-479.
8. Frisk-Holmberg M, Bergqvist Y, Termond E, Domeij-Nyberg B, 1984. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. Eur J Clin Pharmacol 26: 521-530.
9. Ofori-Adjei D, Ericsson O, Lindstrom B, Sjoqvist F, 1986. Protein binding of chloroquine enantiomers and desethylchloroquine. Br J Clin Pharmacol 22: 356-358.
10. Augustijns P, Geusens P, Verbeke N, 1992. Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis. Eur J Clin Pharmacol 42: 429-433.
11. Biswas S, 2001. In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. J Postgrad Med 47: 240-243.
12. Anderson SL, Berman J, Kuschner R, Wesche D, Magill A, Wellde B, Schneider I, Dunne M, Schuster BG, 1995. Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. Ann Intern Med. 123: 771-773.
13. Gray RH, Wabwire-Mangen F, Kigozi G, Sewankambo NK, Serwadda D, Moulton LH, Quinn TC, O'Brien KL, Meehan M, Abramowsky C, Robb M, Wawer MJ, 2001. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. Am J Obstet Gynecol 185: 1209-1217.