Chloramphenicol pharmacokinetics in African children with severe malaria

Journal of Tropical Pediatrics

Volumn 52, Issue 4, 2006, Pages 239-243

  Kokwaro, Gilbert O ^a,b   Muchohi, Simon N ^b   Ogutu, Benhards R ^b   Newton, Charles R J C ^b,c  

^a UNIVERSITY OF NAIROBI   (Kenya)

^b KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CHLORAMPHENICOL HEMISUCCINATE; PARACETAMOL; PHENYTOIN;

AFRICA; AREA UNDER THE CURVE; ARTICLE; BACTERIAL MENINGITIS; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; MAINTENANCE DRUG DOSE; MALARIA; MALE; MULTIPLE DRUG DOSE;

AFRICA; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CHLORAMPHENICOL; FEMALE; HUMANS; INFANT; INJECTIONS, INTRAVENOUS; MALARIA; MALE; MENINGITIS, BACTERIAL;

EID: 33748114943     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fmi082     Document Type: Article

References (25)

1. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, et al. Indicators of life-threatening malaria in African children. N Engl J Med 1995; 332: 1399-404.
2. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: A study of 131 comatose Malawian children. Quart J Med 1989; 71: 441-59.
3. Berkley JA, Mwangi I, Mellington F, Mwarumba S, Marsh K, Cerebral malaria versus bacterial meningitis in children with impaired consciousness. Quart J Med 1999; 92: 151-57.
4. Wright PW, Avery WG, Ardill WD, McLarty JW. Initial clinical assessment of the comatose patient: Cerebral malaria vs. meningitis. Pediatr Infect Dis J 1993; 12: 37-41.
5. Newton CR, Crawley J, Sowumni A, Waruiru C, Mwangi I, English M, Murphy S, et al. Intracranial hypertension in Africans with cerebral malaria. Arch Dis Child 1997; 76: 219-26.
6. Nahata MC, Powell DA. Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate. Clin Pharmacol Ther 1981; 30: 368-72.
7. Kauffman RE, Miceli JN, Strebel L, Buckley JA, Done AK, Dajani, AS. Pharmacokinetics of chloram-phenicol and chloramphenicol succinate in infants and children. J Pediatr 1981; 98: 315-20.
8. Slaughter RL, Pieper JA, Cerra B, Brodsky B, Koup, JR. Chloramphenicol sodium succinate kinetics in critically ill patients. Clin Pharmacol Ther 1980; 28: 69-77.
9. Acharya GP, Davis TM, Ho M, Harris S, Chataut C, Acharya S, et al. Factors affecting the pharmaco-kinetics of parenteral chloramphenicol in enteric fever. J Antimicrob Chemother 1997; 40: 91-8.
10. Mulhall A, de Louvois J, Hurley R, The pharmaco-kinetics of chloramphenicol in the neonate and young infant. J Antimicrob Chemother 1983; 12: 629-39.
11. Smith AL, Weber A. Pharmacology of chloramphenicol. Pediatr Clin North Am 1983; 30: 209-36.
12. McCurdy P. Plasma concentrations of chloramphenicol and bone marrow suppression. Blood 1963; 21: 363-72.
13. Weber MW, Gatchalian SR, Ogunlesi O, Smith A, McCracken GH Jr, Qazi S, et al. Chloramphenicol pharmacokinetics in infants less than three months of age in the Philippines and The Gambia. Pediatr Infect Dis J 1999; 18, 896-901.
14. Ashton M, Bolme P, Alemayehu E, Eriksson M, Paalzow L. Decreased chloramphenicol clearance in malnourished Ethiopian children. Eur J Clin Pharmacol 1993; 45: 181-86.
15. Eriksson M, Paalzow L, Bolme P, Mariam TW. Chloramphenicol pharmacokinetics in Ethiopian children of differing nutritional status. Eur J Clin Pharmacol 1983; 24: 819-23.
16. Ballek RE, Reidenberg MM, Orr L. Inhibition of diphenylhydantoin metabolism by chloramphenicol. Lancet 1973; 1: 150.
17. Christensen LK, Skovsted L. Inhibition of drug metabolism by chloramphenicol. Lancet 1969; 2: 1397-99.
18. Buchanan N, Moodley G. Interaction between chloramphenicol and paracetamol. Brit Med J 1979; 2: 307-08.
19. Powell DA, Nahata MC, Durrell DC, Glazer JP, Hilty MD. Interactions among chloramphenicol, phenytoin and phenobarbital in a pediatric patient. J Pediatr 1981; 98: 1001-03.
20. Ogutu BR, Newton CR, Muchohi SN, Otieno GO, Kokwaro GO. Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. Br J Clin Pharmacol 2002; 54: 635-41.
21. Velagapudi R, Smith RV, Ludden TM, Sagraves R. Simultaneous determination of chloramphenicol and chloramphenicol succinate in plasma using high-performance liquid chromatography. J Chromatogr 1982; 228: 423-28.
22. Heinzel, G, Woloszczak R, Thomann P. TopFit 2.0: Pharmacokinetic and Pharmacodynamic data analysis for PC, Gustav Fischer (1993), pp. 372-379.
23. Altman D, Machin D, Bryant T, Gardner M. Statistics with Confidence. BMJ Books, Bristol (2000).
24. Mwangi I, Berkley J, Lowe B, Peshu N, Marsh K, Newton CR. Acute bacterial meningitis in children admitted to a rural Kenyan hospital: increasing antibiotic resistance and outcome. Pediatr Infect Dis J 2002; 21: 10421-1048.
25. Koup JR, Sack CM, Smith AL, Neely NN, Gibaldi M. Rapid estimation of chloramphenicol clearance in infants and children. Clin Pharmacokin 1981; 6: 83-8.