Effects of interruption of apicoplast function on malaria infection, development, and transmission

Molecular and Biochemical Parasitology

Volumn 109, Issue 1, 2000, Pages 17-23

  Sullivan, Margery ^a   Li, Jun ^a   Kumar, Sanjai ^b   Rogers, M John ^a   McCutchan, Thomas F ^a  

^a Sect Clin and Exp Neuropsychol   (United States)

^b NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

Anti malarial drugs; Guanosine triphosphatase site; Malaria transmission; Plastid; Thiopeptides; Thiostrepton

Indexed keywords

CHLOROQUINE; GUANOSINE TRIPHOSPHATASE; PRIMAQUINE; RIBOSOME RNA; THIOSTREPTON;

APICOMPLEXA; ARTICLE; LIFE CYCLE; MALARIA; NONHUMAN; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASTID; PRIORITY JOURNAL; SEXUAL DEVELOPMENT; TOXOPLASMA GONDII;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; CULICIDAE; DISEASE VECTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALARIA; MICE; MICE, INBRED BALB C; PLASMODIUM BERGHEI; THIOSTREPTON; TIME FACTORS;

EID: 0033868959     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00226-7     Document Type: Article

References (9)

1. Wilson R.J.M., Denny P.W., Preiser P.R., Rangachari K., Roberts K., Roy A., Whyte A., Strath M., Moore D.J., Moore P.W., Williamson D.H. Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J. Mol. Biol. 261:1996;155-172.
2. McFadden G.I., Reith M.E., Mulholland J., Lang-Unnasch N. Plastid in human parasites. Nature. 381:1996;482.
3. Kohler S., Delwiche C.F., Denny P.W., Tilney L.G., Webster P., Wilson R.J., Palmer J.D., Roos D.S. A plastid of probable green algal origin in Apicomplexan parasites. Science. 275:1997;1485-1489.
4. Fichera M.E., Roos D. A plastid organelle as a drug target in Apicomplexan parasites. Nature. 390:1997;407-409.
5. McConkey G.A., Rogers M.J., McCutchan T.F. Inhibition of Plasmodium falciparum protein synthesis: targeting the plastid-like organelle with thiostrepton. J. Biol. Chem. 272:1997;2046-2049.
6. Pfefferkorn E.R., Nothnagel R.F., Borotz S.E. Parasiticidal effect of clindamycin on Toxoplasma gondii grown in cultured cells and selection of a drug-resistant mutant. Antimicrob. Agents Chemother. 36:1992;1091-1096.
7. Killick-Kendrick R. Rodent Malaria. 1978;Academic Press, New York.
8. el Wakeel E.S., Homeida M.M., Ali H.M., Geary T.G., Jensen J.B. Clindamycin for the treatment of falciparum malaria in Sudan. Am. J. Trop. Med. Hyg. 34:1985;1065-1068.
9. Rogers M.J., Cundliffe E., McCutchan T.F. The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite. Antimicrob. Agents Chemother. 42:1998;715-716.