Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin

European Journal of Pharmacology

Volumn 558, Issue 1-3, 2007, Pages 194-198

  Andrade, Anderson Assunção ^a   Varotti, Fernando de Pilla ^a   de Freitas, Isabela Oliveira ^a   de Souza, Marcus Vinícius Nora ^a   Vasconcelos, Thatyana Rocha Alves ^a   Boechat, Núbia ^a   Krettli, Antoniana Ursine ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antimalarial activity; Artesunic acid; Ciprofloxacin; Mefloquine

Indexed keywords

ARTESUNATE; CIPROFLOXACIN; HYPOXANTHINE; MEFLOQUINE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE REDUCTION; DRUG POTENTIATION; DRUG SENSITIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MOUSE; NONHUMAN; PARASITE; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CIPROFLOXACIN; DRUG SYNERGISM; MALARIA; MEFLOQUINE; MICE; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SUCCINATES;

EID: 33847410592     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.11.061     Document Type: Article

References (27)

1. Andrade-Neto V., Oliveira F.Q., Krettli A.U., and Brandão M.G.L. New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. J. Ethnopharmacol. 93 (2004) 39-42
2. Basco L.K., and Bras J.L.E. Activity in vitro of doxycycline against multidrug-resistant Plasmodium falciparum. Trans. R. Soc. Trop. Med. Hyg. 87 (1993) 469-470
3. Carvalho L.H., Rocha E.M.M., Raslan D.S., Oliveira A.B., and Krettli A.U. In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plasmodium falciparum Braz. J. Med. Biol. Res. 21 (1988) 485-487
4. Carvalho L.H., Brandão M.G.L., Santos-Filho D., Lopes J.L.C., and Krettli A.U. Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture. Braz. J. Med. Biol. Res. 24 (1991) 1113-1123
5. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Quantitative assessment of antimalarial activity in vitro a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16 6 (1979) 710-718
6. Díaz J.C.R., Ruiz M., López M., and Royo G. Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis. Int. J. Antimicrob. Agents 21 (2003) 354-356
7. Geary T.G., and Jensen J.B. Effects of antibiotics on Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 32 (1983) 221-225
8. Gingras B.A., and Jensen J.B. Activity of azithromycin (CP-62,993) and erythromycin against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 47 (1992) 378-382
9. Hamzah J., Skinner-Adams T., and Davis T.M.E. In vitro antimalarial activity of trovafloxacin, a fourth-generation fluoroquinolone. Acta Trop. 74 (2000) 39-42
10. Jambou R., Legrand E., Niang M., Khim N., Lim P., Volney B., Ekala M.T., Bouchier C., Esterre P., Fandeur T., and Mercereau-Puijalon G. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366 (2005) 1960-1963
11. Krishna S., and Kremsner P.G. Antimalarial combinations. Lancet 364 (2004) 285-294
12. Krettli A.U., and Brener Z. Therapeutic activity of some sulfonamide compounds on normal and chloroquine-resistant strains of Plasmodium berghei. Rev. Inst. Med. Trop. São Paulo 10 (1968) 389-393
13. Krishna S., Davis T.M.E., Chan P.C.Y., Wells R.A., and Robson K.J.H. Ciprofloxacin and malaria. Lancet 1 (1988) 1231-1232
14. Lambros C., and Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65 (1979) 418-420
15. Mahmoudi N., Ciceron L., Franetich J.F., Farhati K., Silvie O., Eling W., Sauerwein R., Danis M., Mazier D., and Derouin D. In vitro activities of 25 quinolones and fluoroquinolones against liver and blood stage Plasmodium spp. Antimicrob. Agents Chemother. 47 8 (2003) 2636-2639
16. Maxwell A. The molecular basis of quinolone action. Antimicrob. Agents Chemother. 30 (1992) 409-416
17. Midgley J.M., Keter D.W., Phillipson J.D., Grant S., and Warhurst D.C. Quinolones and multiresistant Plasmodium falciparum. Lancet 2 (1988) 281-282
18. Peters W. Drug resistance in Plasmodium berghei I. Chloroquine resistance. Exp. Parasitol. 17 (1965) 80-89
19. Pradines B., Rogier C., Fusai T., Mosnier J., Daries W., Barret E., and Parzy D. In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron. Antimicrob. Agents Chemother. 45 (2001) 1746-1750
20. Rieckmann K.E., Powell R.D., Mcnamara J.V., Willerson D., Kass L., Frischer H., and Carson P.E. Effects of tetracycline against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum. Am. J. Trop. Med. Hyg. 20 (1971) 811-815
21. Souza M.V.N., Almeida M.V., and Couri M.R.C. Biological activity and synthetic methodologies for the preparation of fluoroquinolones, a class of potent antibacterial agents. Curr. Med. Chem. 10 (2003) 21-40
22. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
23. Uhlemann A., Cameron A., Eckstein-Ludwig U., Fischbarg J., Iserovich P., Zuniga F.A., East M., Lee A., Brady L., and Haynes R.K. A single amino acid residue can determine the sensitivity of SERCAs to artemisinins. Nat. Struct. Biol. 12 (2005) 628-629
24. Watt G., Shanks G.D., Einstein M.D., Pavanand K., and Webster H.K. Ciprofloxacin treatment of drug-resistant falciparum malaria. J. Infect. Dis. 164 (1991) 602-604
25. World Health Organization (2006). http://www.who.int/topics/malaria/en/ (Accessed May 18th)
26. Yeo A.E.T., and Rieckmann K.H. Prolonged exposure of Plasmodium falciparum to ciprofloxacin increases anti-malarial activity. J. Parasitol. 80 (1994) 158-160
27. Zalis M.G., Pang L., Silveira M.S., Milhous W.K., and Wirth D.F. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. Am. J. Trop. Med. Hyg. 58 5 (1998) 630-637