Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in Western Kenya

Clinical Infectious Diseases

Volumn 26, Issue 1, 1998, Pages 146-150

  Andersen, S L ^a   Oloo, A J ^a   Gordon, D M ^a   Ragama, O B ^a   Aleman, G M ^a   Berman, J D ^a   Tang, D B ^a   Dunne, R I W ^a   Shanks, G D ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; DOXYCYCLINE; QUININE;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE TRANSMISSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSENTERY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KENYA; MAJOR CLINICAL STUDY; MALARIA; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT INDICATION; VAGINITIS; VOMITING;

EID: 0031889731     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/516281     Document Type: Article

References (19)

1. Fontanet AL, Johnston BD, Walker AM, et al. High prevalence of mefloquine-resistant falciparum malaria in eastern Thailand. Bull World Health Organ 1993;71:377-83.
2. Pang LW, Limsomwong N, Boudreau EF, Singharaj P. Doxycycline prophylaxis for falciparum malaria. Lancet 1987;l:1161-4.
3. Sanchcz JL, DeFraites RF, Sharp TW, Hanson RK. Mefloquine or doxycycline prophylaxis in US troops in Somalia. Lancet 1993;341:1021-2.
4. Shmuklarsky MJ, Boudreau EF, Pang LW, et al. Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers. Ann Intern Med 1994;120:294-9.
5. Hopkins S. Clinical toleration and safety of azithromycin. Am J Med 1991;91(3A):40s-5s.
6. Havlir DV, Dube MP, Sattler FR, et al. Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin, or both. N Engl J Med 1996;335:392-8.
7. Andersen SA, Ager AL, McGreevy P, Schuster BG, Ellis W, Berman JD. Efficacy of azithromycin as a causal prophylactic agent against murine malaria. Antimicrob Agents Chemother 1994;38:1862-3.
8. Kuschner RA, Heppner DG, Andersen SL, et al. Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum. Lancet 1994;343:1396-7.
9. Andersen SL, Berman JD, Kuschner RA, et al. Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. Ann Intern Med 1995;123:771-3.
10. Andersen SL, Oloo AJ, Gordon DM, et al. Azithromycin compared to doxycycline for malaria chemoprophylaxis in western Kenya [abstract no 355] In: Program and abstracts of the 44th meeting of the American Society of Tropical Medicine and Hygiene (San Antonio, TX). 1995.
11. Beier JC, Oster CN, Onyango FK, et al. Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am J Trop Med Hyg 1994;50: 529-36.
12. Oloo AJ, Adoyo A, Kariuki D, et al. Sensitivity of falciparum malaria to chloroquine and amodiaquine in four districts of western Kenya (1985-1987). East Afr Med J 1991;68:606-10.
13. Koopman PR. Confidence limits for the ratio of two binomial proportions. Biometrics 1984;40:513-7.
14. Blackwelder WC. Sample size and power for prospective analysis of relative risk. Stat Med 1993;12:691-8.
15. Armitage P. Statistical methods in medical research. Oxford: Blackwell Scientific Publications, 1971.
16. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990; 25(suppl A):73-82.
17. Shanks GD, Ragama OB, Aleman GM, et al. Azithromycin prophylaxis prevents epidemic dysentery. Trans R Soc Trop Med Hyg 1996;90:316.
18. Sadiq ST, Glasgow KW, Drakely CJ, et al. Effects of azithromycin on malariometric indices in The Gambia. Lancet 1995;346:881-2.
19. Weiss WR, Oloo AJ, Johnson A, Koech D, Hoffman SL. Daily primaquine is effective for prophylaxis against falciparum malaria in Kenya: comparison with mefloquine, doxycycline, and chloroquine plus proguanil. J Infect Dis 1995;171:1569-75.