Iron-sulfur-protein biogenesis in eukaryotes

Trends in Biochemical Sciences

Volumn 30, Issue 3, 2005, Pages 133-141

  Lill, Roland ^a   Mühlenhoff, Ulrich ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; PROTEIN; SULFUR;

BIOGENESIS; BIOSYNTHESIS; CELL ACTIVITY; CELL NUCLEUS; CYTOSOL; EUKARYOTE; EVOLUTION; GENE; HUMAN; MITOCHONDRION; MUTATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW;

EID: 14744294785     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2005.01.006     Document Type: Review

References (86)

1. H. Beinert Iron-sulfur clusters: nature's modular, multipurpose structures Science 277 1997 653 659
2. D.C. Rees, and J.B. Howard The interface between the biological and inorganic worlds: iron-sulfur metalloclusters Science 300 2003 929 931
3. Beinert, H. et al. Iron-sulfur proteins. In Encyclopedia of Biological Chemistry (Vol. 2) (Lennarz, W.J. and Lane, M.D., eds), Academic Press (in press)
4. J. Frazzon, and D.R. Dean Formation of iron-sulfur clusters in bacteria - an emerging field in bioinorganic chemistry Curr. Opin. Chem. Biol. 7 2003 166 173
5. J. Frazzon, and D.R. Dean Biosynthesis of the nitrogenase iron-molybdenum-cofactor from Azotobacter vinelandii Met. Ions Biol. Syst. 39 2002 163 186
6. D.C. Rees, and J.B. Howard Nitrogenase: standing at the crossroads Curr. Opin. Chem. Biol. 4 2000 559 566
7. L. Zheng Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii J. Biol. Chem. 273 1998 13264 13272
8. M. Zheng DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide J. Bacteriol. 183 2001 4562 4570
9. Y. Takahashi, and U. Tokumoto A third bacterial system for the assembly of iron-sulfur clusters with homologs in archaea and plastids J. Biol. Chem. 277 2002 28380 28383
10. L. Nachin SufC: an unorthodox cytoplasmic ABC/ATPase required for [Fe-S] biogenesis under oxidative stress EMBO J. 22 2003 427 437
11. F.W. Outten A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli Mol. Microbiol. 52 2004 861 872
12. V. Ali An intestinal parasitic protist, Entamoeba histolytica, possesses a non-redundant nitrogen fixation-like system for iron-sulfur cluster assembly under anaerobic conditions J. Biol. Chem. 279 2004 16863 16874
13. R. Lill, and G. Kispal Maturation of cellular Fe/S proteins: the essential function of mitochondria Trends Biochem. Sci. 25 2000 352 356
14. X.M. Xu, and S.G. Moller AtNAP7 is a plastidic SufC-like ATP-binding cassette/ATPase essential for Arabidopsis embryogenesis Proc. Natl. Acad. Sci. U. S. A. 101 2004 9143 9148
15. G. Kispal The mitochondrial proteins Atm1p and Nfs1p are required for biogenesis of cytosolic Fe/S proteins EMBO J. 18 1999 3981 3989
16. U. Mühlenhoff Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae J. Biol. Chem. 279 2004 36906 36915
17. J. Strain Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly J. Biol. Chem. 273 1998 31138 31144
18. B. Schilke Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae Proc. Natl. Acad. Sci. U. S. A. 96 1999 10206 10211
19. J. Li Yeast mitochondrial protein Nfs1p coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution J. Biol. Chem. 274 1999 33025 33034
20. P. Yuvaniyama NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein Proc. Natl. Acad. Sci. U. S. A. 97 2000 599 604
21. L. Zheng Cysteine desulfurase acitivity indicates a role for NifS in metallocluster biosynthesis Proc. Natl. Acad. Sci. U. S. A. 90 1993 2754 2758
22. C.J. Schwartz The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli Proc. Natl. Acad. Sci. U. S. A. 97 2000 9009 9014
23. L. Loiseau Biogenesis of Fe-S cluster by the bacterial Suf system: SufS and SufE form a new type of cysteine desulfurase J. Biol. Chem. 278 2003 38352 38359
24. L. Zheng Mechanism for the desulfurization of L-cysteine catalyzed by the nifS gene product Biochemistry 33 1994 4714 4720
25. J.T. Kaiser Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron-sulfur cluster assembly J. Mol. Biol. 297 2000 451 464
26. S.A. Garland Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly J. Mol. Biol. 294 1999 897 907
27. A.D. Smith Sulfur transfer from IscS to IscU: the first step in iron-sulfur cluster biosynthesis J. Am. Chem. Soc. 123 2001 11103 11104
28. H.D. Urbina Transfer of sulfur from IscS to IscU during Fe/S cluster assembly J. Biol. Chem. 276 2001 44521 44526
29. S. Kato Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: implications for the mechanism of iron-sulfur cluster assembly Proc. Natl. Acad. Sci. U. S. A. 99 2002 5948 5952
30. U. Mühlenhoff Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p EMBO J. 22 2003 4815 4825
31. T.A. Ramelot Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site J. Mol. Biol. 344 2004 567 583
32. S. Adinolfi Bacterial IscU is a well folded and functional single domain protein Eur. J. Biochem. 271 2004 2093 2100
33. J.N. Agar IscU as a scaffold for iron-sulfur cluster biosynthesis: sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU Biochemistry 39 2000 7856 7862
34. H. Puccio Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits Nat. Genet. 27 2001 181 186
35. U. Mühlenhoff The yeast frataxin homologue Yfh1p plays a specific role in the maturation of cellular Fe/S proteins Hum. Mol. Genet. 11 2002 2025 2036
36. G. Duby A non-essential function for yeast frataxin in iron-sulfur cluster assembly Hum. Mol. Genet. 11 2002 2635 2643
37. O.S. Chen Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis Proc. Natl. Acad. Sci. U. S. A. 99 2002 12321 12326
38. O. Stehling Iron-sulfur protein maturation in human cells: evidence for a function of frataxin Hum. Mol. Genet. 13 2004 3007 3015
39. H. Lange The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase J. Biol. Chem. 279 2004 29101 29108
40. K. Aloria Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo EMBO Rep. 5 2004 1096 1101
41. J. Gerber An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1 EMBO Rep. 4 2003 906 911
42. T. Yoon, and J.A. Cowan Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins J. Am. Chem. Soc. 125 2003 6078 6084
43. H. Puccio, and M. Koenig Friedreich ataxia: a paradigm for mitochondrial diseases Curr. Opin. Genet. Dev. 12 2002 272 277
44. H. Lange A mitochondrial ferredoxin is essential for biogenesis of intra- and extra-mitochondrial Fe/S proteins Proc. Natl. Acad. Sci. U. S. A. 97 2000 1050 1055
45. J. Li Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis J. Biol. Chem. 276 2001 1503 1509
46. U. Mühlenhoff Characterization of iron-sulfur protein assembly in isolated mitochondria: a requirement for ATP, NADH and reduced iron J. Biol. Chem. 277 2002 29810 29816
47. M.H. Barros Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae J. Biol. Chem. 277 2002 9997 10002
48. R. Dutkiewicz Ssq1, a mitochondrial Hsp70 involved in iron-sulfur (Fe/S) center biogenesis: similarities to and differences from its bacterial counterpart J. Biol. Chem. 278 2003 29719 29727
49. M.T. Rodriguez-Manzaneque Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes Mol. Biol. Cell 13 2002 1109 1121
50. K.G. Hoff Interaction of the iron-sulfur cluster assembly protein IscU with the Hsc66/Hsc20 molecular chaperone system of Escherichia coli Proc. Natl. Acad. Sci. U. S. A. 97 2000 7790 7795
51. E.A. Craig, and J. Marszalek A specialized mitochondrial molecular chaperone system: a role in formation of Fe/S centers Cell. Mol. Life Sci. 59 2002 1658 1665
52. K.G. Hoff Contributions of the LPPVK motif of the iron-sulfur template protein IscU to interactions with the Hsc66-Hsc20 chaperone system J. Biol. Chem. 278 2003 37582 37589
53. R. Dutkiewicz Sequence-specific interaction between mitochondrial Fe-S scaffold protein Isu and Hsp70 Ssq1 is essential for their in vivo function J. Biol. Chem. 279 2004 29167 29174
54. A. Kaut Isa1p is a component of the mitochondrial machinery for maturation of cellular iron-sulfur proteins and requires conserved cysteine residues for function J. Biol. Chem. 275 2000 15955 15961
55. W. Pelzer Mitochondrial Isa2p plays a crucial role in the maturation of cellular iron-sulfur proteins FEBS Lett. 476 2000 134 139
56. L.T. Jensen, and V.C. Culotta Role of Saccharomyces cerevisiae ISA1 and ISA2 in iron homeostasis Mol. Cell. Biol. 20 2000 3918 3927
57. S. Ollagnier-de-Choudens Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin J. Biol. Chem. 276 2001 22604 22607
58. C. Krebs IscA, an alternate scaffold for Fe-S cluster biosynthesis Biochemistry 40 2001 14069 14080
59. P.W. Bilder Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold Biochemistry 43 2004 133 139
60. J.R. Cupp-Vickery Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli J. Mol. Biol. 338 2004 127 137
61. H. Ding IscA mediates iron delivery for assembly of iron-sulfur clusters in IscU under the limited accessible free iron conditions J. Biol. Chem. 279 2004 37499 37504
62. S. Leon Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana Biochem. J. 371 2003 823 830
63. T. Yabe The Arabidopsis chloroplastic NifU-like protein CnfU, which can act as an iron-sulfur cluster scaffold protein, is required for biogenesis of ferredoxin and photosystem I Plant Cell 16 2004 993 1007
64. K. Nishio, and M. Nakai Transfer of iron-sulfur cluster from NifU to apoferredoxin J. Biol. Chem. 275 2000 22615 22618
65. Y. Nakai Nuclear localization of yeast Nfs1p is required for cell survival J. Biol. Chem. 276 2001 8314 8320
66. Y. Nakai Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs J. Biol. Chem. 279 2004 12363 12368
67. J. Gerber The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins Mol. Cell. Biol. 24 2004 4848 4857
68. W.H. Tong Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster Proc. Natl. Acad. Sci. U. S. A. 100 2003 9762 9767
69. S. Bekri Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia (XLSA/A) with disruption of cytosolic iron-sulfur protein maturation Blood 96 2000 3256 3264
70. S. Kushnir A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik Plant Cell 13 2001 89 100
71. R. Lill, and G. Kispal ABC transporters in mitochondria B.I. Holland ABC Proteins: From Bacteria to Man 2003 Academic Press 515 531
72. J. Balk, and R. Lill The cell's cookbook for iron-sulfur clusters: recipes for fool's gold? Chembiochem 5 2004 1044 1049
73. H. Lange An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins EMBO Rep. 2 2001 715 720
74. K. Sipos Maturation of cytosolic iron-sulfur proteins requires glutathione J. Biol. Chem. 277 2002 26944 26949
75. O.S. Chen Transcription of the yeast iron regulon responds not directly to iron but rather to iron-sulfur cluster biosynthesis J. Biol. Chem. 279 2004 29513 29518
76. A. Roy A novel eukaryotic factor for cytosolic Fe-S cluster assembly EMBO J. 22 2003 4826 4835
77. E. Skovran, and D.M. Downs Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium J. Bacteriol. 185 2003 98 106
78. J. Balk The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins EMBO J. 23 2004 2105 2115
79. S.D. Dyall Ancient invasions: from endosymbionts to organelles Science 304 2004 253 257
80. M.D. Katinka Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi Nature 414 2001 450 453
81. J. Tovar Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation Nature 426 2003 172 176
82. R. Sutak Mitochondrial-type assembly of FeS centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis Proc. Natl. Acad. Sci. U. S. A. 101 2004 10368 10373
83. Kispal, G. et al. (2005) Biogenesis of ribosomes requires the essential iron-sulfur protein Rli1p and mitochondria. EMBO J. 24, 589-598
84. Yarunin, A. et al. (2005) Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 24, 580-588
85. D.S. Horner Iron hydrogenases - ancient enzymes in modern eukaryotes Trends Biochem. Sci. 27 2002 148 153
86. Y. Nicolet Fe-only hydrogenases: structure, function and evolution J. Inorg. Biochem. 91 2002 1 8