Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling

Anti-Cancer Drugs

Volumn 19, Issue 5, 2008, Pages 477-486

  Suwanjunee, Saipin ^a   Wongchana, Wipawee ^a   Palaga, Tanapat ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

secretase inhibitor; Apoptosis; c myc; HepG2; Jurkat; Notch signaling; Proliferation; Tumor

Indexed keywords

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; JAGGED1; MEMBRANE PROTEIN; MYC PROTEIN; N[N(3,5 DIFLUOROPHENACETYLALANYL)PHENYLGLYCINE TERT BUTYLESTER; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN DLK1; PROTEIN JAGGED2; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG INHIBITION; DRUG SENSITIVITY; ENZYME INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

AMYLOID PRECURSOR PROTEIN SECRETASES; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; LEUKEMIA, T-CELL; LIVER NEOPLASMS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 42349090918     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3282fc6cdd     Document Type: Article

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