Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor α-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of β-catenin signaling

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 8743-8758

  Sunters, Andrew ^a   Armstrong, Victoria J ^a   Zaman, Gul ^a   Kypta, Robert M ^b,c   Kawano, Yoshiaki ^b   Lanyon, Lance E ^a   Price, Joanna S ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CIC BIOGUNE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BONE CELLS; CATENIN SIGNALING; CONCENTRATION OF; DYNAMIC STRAIN; EFFECT OF STRAIN; ESTROGEN RECEPTOR; IN-VITRO; INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR-I; MECHANOTRANSDUCTION; MEDIATED TRANSCRIPTION; OSTEOBLAST-LIKE CELLS; OSTEOBLASTIC CELLS; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; RESIDENT CELL; SINGLE PERIOD;

BIOACTIVITY; BONE; INSULIN; NITRIC OXIDE; OSTEOBLASTS; PEPTIDES; PHOSPHORYLATION; TRANSCRIPTION;

STRAIN;

BETA CATENIN; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTANOID; PROTEIN KINASE B; SOMATOMEDIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR 7; WNT PROTEIN; DRUG DERIVATIVE; ESTRADIOL; H 1356; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; OLIGOPEPTIDE;

ANIMAL CELL; ARTICLE; BONE STRESS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; BONE; CYTOLOGY; METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA CATENIN; BINDING SITES; BONE AND BONES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; INSULIN-LIKE GROWTH FACTOR I; LDL-RECEPTOR RELATED PROTEINS; NITRIC OXIDE; OLIGOPEPTIDES; OSTEOBLASTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 77950567146     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.027086     Document Type: Article

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