Role of estrogen receptor (ER) α in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells

Journal of Molecular Endocrinology

Volumn 35, Issue 3, 2005, Pages 433-447

  Zhang, S ^a   Li, X ^a   Burghardt, R ^a   Smith III, R ^a   Safe, S H ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIN D1; CYCLIN E; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SOMATOMEDIN C;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; FLUORESCENCE ACTIVATED CELL SORTING; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLINS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; MITOGENS; PHOSPHOPROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 29744446942     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01858     Document Type: Article

References (59)

1. Ali S, Metzger D, Bornert JM & Chambon P 1993 Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBO Journal 12 1153-1160.
2. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254.
3. Bunone G, Briand PA, Miksicek RJ & Picard D 1996 Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO Journal 15 2174-2183.
4. Castro-Rivera E, Samudio I & Safe S 2001 Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. Journal of Biological Chemistry 276 30853-30861.
5. Cavailles V, Garcia M & Rochefort H 1989 Regulation of cathepsin D and pS2 gene expression by growth factors in MCF-7 human breast cancer cells. Molecular Endocrinology 3 552-558.
6. Chalbos D, Philips A, Galtier F & Rochefort H 1993 Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3′,5′-monophosphate in MCF7 cells. Endocrinology 133 571-576.
7. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH & Pollak M 1998 Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 279 563-566.
8. Cohen P 1998 Serum insulin-like growth factor-I levels and prostate cancer risk-interpreting the evidence. Journal of the National Cancer Institute 90 876-879.
9. Curtis SW, Washburn T, Sewall C, DiAugustine R, Lindzey J, Couse JF & Korach KS 1996 Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen- like response to epidermal growth factor. PNAS 93 12626-12630.
10. Dickson RB & Lippman ME 1995 Growth factors in breast cancer. Endocrine Reviews 16 559-589.
11. Duan R, Xie W, Burghardt R & Safe S 2001 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. Journal of Biological Chemistry 276 11590-11598.
12. Duan R, Xie W, Li X, McDougal A & Safe S 2002 Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochemistry and Biophysical Research Communications 294 384-394.
13. Dufourny B, Alblas J, van Teeffelen HA, van Schaik FM, Van der Burg B, Steenbergh PH & Sussenbachi JS 1997 Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. Journal of Biological Chemistry 272 31163-31171.
14. Dupont J, Karas M & LeRoith D 2000 The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. Journal of Biological Chemistry 275 35893-35901.
15. Fan M, Bigsby RM & Nephew KP 2003 The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-α and essential for the antiproliferative activity of ICI 182,780 in ERα-positive breast cancer cells. Molecular Endocrinology 17 356-365.
16. Grimberg A & Cohen P 2000 Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. Journal of Cell Physiology 183 1-9.
17. Gullick WJ, Bianco C, Normanno N, Martinez-Lacaci I, De Santis M, Ebert AD & Salomon DS 1998 Growth factors and their receptors. Women and Cancer 1 29-57.
18. Ignar-Trowbridge DM, Teng CT, Ross MJ, Parker MG, Korach KS & McLachlan JA 1993 Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Molecular Endocrinology 7 992-998.
19. Ignar-Trowbridge DM, Pimentel M, Parker MG, McLachlan JA & Korach KS 1996 Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol. Endocrinology 137 1735-1744.
20. Jackson JG, White MF & Yee D 1998 Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. Journal of Biological Chemistry 273 9994-10003.
21. rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Molecular and Cellular Biology 18 1978-1984.
22. Kahlert S, Nuedling S, Van Eickels M, Vetter H, Meyer R & Grohe C 2000 Estrogen receptor a rapidly activates the IGF-1 receptor pathway. Journal of Biological Chemistry 275 18447-18453.
23. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E & Kawashima H 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270 1491-1494.
24. Kato S, Masuhiro Y, Watanabe M, Kobayashi Y, Takeyama KI, Endoh H & Yanagisawa J 2000 Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways. Genes to Cells 5 593-601.
25. Katzenellenbogen BS & Norman MJ 1990 Multihormonal regulation of the progesterone receptor in human breast cancer cells: interrelationships among insulin/insulin- like growth factor-I, serum and estrogen. Endocrinology 126 891-898.
26. Klotz DM, Hewitt SC, Ciana P, Raviscioni M, Lindzey JK, Foley J, Maggi A, DiAugustine RP & Korach KS 2002 Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. Journal of Biological Chemistry 277 8531-8537.
27. Lee AV, Jackson JG, Gooch JL, Hilsenbeck SC, Coronado-Heinsohn E, Osborne CK & Yee D 1999 Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Molecular Endocrinology 13 787-796.
28. Levin ER 2002 Cellular functions of plasma membrane estrogen receptors. Steroids 67 471-475.
29. Luconi M, Forti G & Baldi E 2002 Genomic and nongenomic effects of estrogens: molecular mechanisms of action and clinical implications for male reproduction. Journal of Steroid Biochemistry and Molecular Biology 80 369-381.
30. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH & Stampfer MJ 1999 Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. Journal of the National Cancer Institute 91 620-625.
31. Martin MB, Franke TF, Stoica GE, Chambon P, Katzenellenbogen BS, Stoica BA, McLemore MS, Olivo SE & Stoica A 2000 A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I. Endocrinology 141 4503-4511.
32. Migliaccio A, Castoria G, Di Domenico M, de Falco A, Bilancio A, Lombardi M, Barone MV, Ametrano D, Zannini MS, Abbondanza C & Auricchio F 2000 Steroid-induced androgen receptor-oestradiol receptor β-Src complex triggers prostate cancer cell proliferation. EMBO Journal 19 5406-5417.
33. Ngwenya S & Safe S 2003 Cell context-dependent differences in the induction of E2F-1 gene expression by 17β-estradiol in MCF-7 and ZR-75 cells. Endocrinology 144 1675-1685.
34. Nolan MK, Jankowska L, Prisco M, Xu S, Guvakova MA & Surmacz E 1997 Differential roles of IRS-1 and SHC signaling pathways in breast cancer cells. International Journal of Cancer 72 828-834.
35. Oesterreich S, Zhang P, Guler RL, Sun X, Curran EM, Welshons WV, Osborne CK & Lee AV 2001 Re-expression of estrogen receptor α in estrogen receptor α-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Research 61 5771-5777.
36. Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R & Safe S 2002 Estrogen upregulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of an NFκB/CTF-1 complex. Molecular Endocrinology 16 1793-1809.
37. Razandi M, Oh P, Pedram A, Schnitzer J & Levin ER 2002 ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Molecular Endocrinology 16 100-115.
38. Segars JH & Driggers PH 2002 Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes. Trends in Endocrinology and Metabolism 13 349-354.
39. Simoncini T, Hafezl-Moghadam A, Brazil DP, Ley K, Chin, WW & Liao JK 2000 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407 538-541.
40. Singh P 2000 Insulin-like growth factor system in growth, development and carcinogenesis. Journal of Clinical Ligand Assay 23 214-232.
41. Smith CL 1998 Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biology of Reproduction 58 627-632.
42. Song RX, McPherson RA, Adam L, Bao Y, Shupnik M, Kumar R & Santen RJ 2002 Linkage of rapid estrogen action to MAPK activation by ERα-Shc association and Shc pathway activation. Molecular Endocrinology 16 116-127.
43. Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R & Santen RJ 2004 The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor α to the plasma membrane. PNAS 101 2076-2081.
44. Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith CL, O'Malley BW & Mancini MA 2001 FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent. Nature Cell Biology 3 15-23.
45. Stoica A, Saceda M, Fakhro A, Joyner M & Martin MB 2000 Role of insulin-like growth factor-I in regulating estrogen receptor-α gene expression. Journal of Cellular Biochemistry 76 605-614.
46. Sun M, Paciga JE, Feldman RI, Yuan Z-Q, Coppola D, Lu YY, Shelley SA, Nicosia SV & Cheng JQ 2001 Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K. Cancer Research 61 5985-5991.
47. Varma H & Conrad SE 2002 Antiestrogen ICI 182,780 decreases proliferation of insulin-like growth factor I (IGF-I)-treated MCF-7 cells without inhibiting IGF-I signaling. Cancer Research 62 3985-3991.
48. Wakeling AE, Newboult E & Peters SW 1989 Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells. Journal of Molecular Endocrinology 2 225-234.
49. Wang F, Duan R, Chirgwin J & Safe S 2000 Transcriptional activation of cathepsin D gene expression by growth factors. Journal of Molecular Endocrinology 24 193-202.
50. Watson CS, Gametchu B, Norfleet AM, Campbel CH & Thomas ML 1998 Rapid, nongenomic actions of estrogens. Women and Cancer 1 21-28.
51. Watson CS, Campbell CH & Gametchu B 2002 The dynamic and elusive membrane estrogen receptor-α. Steroids 67 429-437.
52. Weigel NL & Zhang Y 1998 Ligand-independent activation of steroid hormone receptors. Journal of Molecular Medicine 76 469-479.
53. Westley BR & May FEB 1994 Role of insulin-like growth factors in steroid-modulated proliferation. Journal of Steroid Biochemistry and Molecular Biology 51 1-9.
54. Wijayaratne AL & McDonnell DP 2001 The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. Journal of Biological Chemistry 276 35684-35692.
55. Wolk A, Mantzoros CS, Andersson SO, Bergstrom R, Signorello LB, Lagiou P, Adami HO & Trichopoulos D 1998 Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. Journal of the National Cancer Institute 90 911-915.
56. Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R & Safe S 2003 The aryl hydrocarbon receptor mediates degradation of the estrogen receptor α through activation of proteasomes. Molecular and Cellular Biology 23 1843-1855.
57. i. Journal of Biological Chemistry 276 27071-27076.
58. Xie W, Duan R & Safe S 2001 Activation of adenosine deaminase in MCF-7 cells through insulin-like growth factor-estrogen receptor α crosstalk. Journal of Molecular Endocrinology 26 217-228.
59. Yee D & Lee AV 2000 Crosstalk between the insulin-like growth factors and estrogens in breast cancer. Journal of Mammary Gland Biology and Neoplasia 5 107-115.