Mechanical strain and estrogen activate estrogen receptor α in bone cells

Journal of Bone and Mineral Research

Volumn 16, Issue 6, 2001, Pages 1045-1055

  Jessop, H L ^a   Sjoberg M ^b   Cheng, M Z ^c   Zaman, G ^b   Wheeler Jones, C P D ^c   Lanyon, L E ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MIDDLESEX UNIVERSITY   (United Kingdom)

Author keywords

ERK; Estrogen receptor; Mechanical strain; Osteoblasts; Osteoporosis

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BONE CELL; BONE STRESS; CONTROLLED STUDY; ENZYME INHIBITION; ESTROGEN ACTIVITY; HORMONAL REGULATION; IMMUNOBLOTTING; MECHANICAL STRESS; NONHUMAN; PROTEIN PHOSPHORYLATION;

EID: 0035017768     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.6.1045     Document Type: Article

References (7)

1. Lanyon LE 1992 Control of bone architecture by functional load bearing. J Bone Miner Res 7:S2;S369-S375.
2. Duncan RL, Turner CH 1995 Mechanotransduction and the functional response, of bone to mechanical strain. Calcif Tissue Int 57:344-358.
3. 2, in organ cultures of rat ulnae. J Bone Miner Res 9:805-816.
4. Zaman G, Dallas SL, Lanyon LE 1992 Cultured embryonic bone shafts show osteogenic responses to mechanical loading. Calcif Tissue Int 51:132-136.
5. Damien E, Price JS, Lanyon LE 1998 The estrogen receptor's involvement in osteoblasts adaptive response to mechanical strain. J Bone Miner Res 13:1275-1282.
6. Damien E, Price JS, Lanyon LE 2000 Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females. J Bone Miner Res 15:2169-2177.
7. Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE 1999 Mechanical strain stimulates ROS cells proliferation through IGF-II and mechanical estrogen through IGF-I. J Bone Miner Res 10:1742-1750.