Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: A unified mechanism of estrogen action

Journal of Neuroscience

Volumn 26, Issue 37, 2006, Pages 9439-9447

  Mannella, Paolo ^a   Brinton, Roberta Diaz ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Akt; Alzheimer's disease; Estrogen receptor; Estrogen signaling; Estrogen therapy; MAPK; PI3K; Therapeutic development

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P85;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL ACTIVITY; CELL POPULATION; EMBRYO; ENZYME ACTIVATION; ESTROGEN ACTIVITY; FEMALE; FETUS; IMMUNOCYTOCHEMISTRY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME ACTIVATION; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAP KINASE SIGNALING SYSTEM; NEURONS; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN;

EID: 33748681724     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1443-06.2006     Document Type: Article

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